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biochemistry & molecular biology (47) 47
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Biochemical Journal, ISSN 0264-6021, 12/2015, Volume 472, Issue 3, pp. 275 - 286
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 1, pp. 73 - 89
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite... 
Natural product | Nuclear receptor | Diabetes | Nutrition | PPAR gamma | INSULIN ACTION ENHANCER | NECROSIS-FACTOR-ALPHA | LOWERS BLOOD-PRESSURE | IMPROVES GLYCEMIC CONTROL | ADIPOCYTE DIFFERENTIATION | PHARMACOLOGY & PHARMACY | RED-CLOVER EXTRACT | GLUCOSE-UPTAKE | NF-KAPPA-B | LIVER-X-RECEPTOR | ADIPOSE-TISSUE | Biological Products - chemistry | Humans | PPAR gamma - agonists | Models, Molecular | Protein Binding | Biological Products - pharmacology | Molecular Structure | PPAR gamma - metabolism | Energy Metabolism - drug effects | DIO, diet-induced obesity | PPAR, peroxisome proliferator-activated receptor | TNF-α, tumor necrosis factor alpha | RXR, retinoid X receptor | CAP, c-Cbl-associated protein | DCM, dichloromethane | NF-κB, nuclear factor-kappaB | 9-(S)-HODE, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | AF-2, activation function-2 | Part of the Special Issue | MeOH, methanol | LDL, low-density lipoprotein | Cdk5, cyclin-dependent kinase 5 | DPP-4, dipeptidylpeptidase 4 | HUVEC, human umbilical vein endothelial cells | Glut4, glucose transporter type 4 | FDA, Food and Drug Administration | LBD, ligand-binding domain | EMA, European Medicines Agency | TCM, traditional Chinese medicine | PPRE, peroxisome proliferator response element | Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets | PDB, protein data bank | SPPARMs, selective PPARγ modulators | HDL, high-density lipoprotein | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 382, Issue 1, pp. 239 - 245
Retinoic acids and long-chain fatty acids are lipophilic agonists of nuclear receptors such as RXRs (retinoic X receptors) and PPARs... 
Peroxisome-proliferator-response element | Reporter gene assay | Peroxisome-proliferator-activated receptor | Dynabead streptavidin solid-phase method | Fatty acid-binding protein | GAMMA | PPAR-ALPHA | GROWTH INHIBITOR | peroxisome-proliferator-response element | BIOCHEMISTRY & MOLECULAR BIOLOGY | reporter gene assay | ACTIVATED RECEPTORS | fatty acid-binding protein | RETINOIC ACID | ADULT-RAT | TISSUE DISTRIBUTION | LIVER | EPIDERMAL-TYPE | peroxisome-proliferator-activated receptor | EXPRESSION | Myoblasts - chemistry | Fatty Acid-Binding Proteins | Peroxisome Proliferator-Activated Receptors - physiology | Transcriptional Activation - genetics | Humans | Retinoid X Receptors - physiology | Genes - physiology | Myoblasts - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Response Elements - physiology | Dimerization | Retinoid X Receptors - metabolism | Carrier Proteins - physiology | Liver Neoplasms - genetics | Base Composition - physiology | Gene Expression Regulation - physiology | Genes, Reporter - genetics | DNA - metabolism | DNA - genetics | Carrier Proteins - genetics | Animals | Promoter Regions, Genetic - physiology | Carcinoma, Hepatocellular - pathology | Peroxisome Proliferator-Activated Receptors - metabolism | Cell Line, Tumor | Mice | Transcriptional Activation - physiology | Peroxisome Proliferators - metabolism | DR-1, direct repeat with one spacer nucleotide | PPRE, peroxisome-proliferator-responsive element | CRABP, cellular retinoic acid-binding protein | PPAR, peroxisome-proliferator-activated receptor | iLBP, intracellular lipid-binding protein | I-BABP, intestinal bile acid-binding protein | RXR, retinoic X receptor | FABP, fatty acid-binding protein | RAR, retinoic acid receptor
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2006, Volume 395, Issue 1, pp. 81 - 88
Recent evidence indicates that PPAR (peroxisome-proliferator-activated receptor) alpha ligands possess anti-inflammatory and antitumoural properties owing to... 
SW620 cell | Peroxisome-proliferator-activated receptor α (PPARα) | LY-171883 | Vascular endothelial growth factor (VEGF) | WY-14,643 | Cyclo-oxygenase 2 (COX-2) | Caco-2 Cells | Tetradecanoylphorbol Acetate - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Humans | RNA, Messenger - genetics | Transcriptional Activation - drug effects | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Promoter Regions, Genetic - genetics | Transcription Factor AP-1 - metabolism | Transcription Factor AP-1 - antagonists & inhibitors | Signal Transduction - drug effects | Cyclooxygenase 2 - genetics | Cyclooxygenase 2 - metabolism | Ligands | PPAR alpha - agonists | Gene Expression Regulation, Neoplastic - drug effects | PPAR alpha - metabolism | Tumor Cells, Cultured | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Apc, adenomatous polyposis coli | DBD, DNA-binding domain | COX, cyclo-oxygenase | AP-1, activator protein-1 | NF-κB, nuclear factor κB | VEGF, vascular endothelial growth factor | vascular endothelial growth factor (VEGF) | Ion, A23187 calcium ionophore | 15d-PGJ2, 15-deoxy-Δ12,14-prostaglandin J2 | RT, reverse transcription | JNK, c-Jun N-terminal kinase | PPAR, peroxisome-proliferator-activated receptor | PPRE, peroxisome-proliferator-response element | EMSA, electrophoretic mobility-shift assay | RLU, relative luciferase units | peroxisome-proliferator-activated receptor α (PPARα) | FBS, foetal bovine serum | cyclo-oxygenase 2 (COX-2) | NSAID, non-steroidal anti-inflammatory drug | MEM, minimal essential medium
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 07/2003, Volume 44, Issue 7, pp. 1287 - 1300
Trans- 10, cis-12 conjugated linoleic acid (CLA) has previously been shown to be the CLA isomer responsible for CLA-induced reductions in body fat in animal... 
Conjugated linoleic acid | Glucose metabolism | Peroxisome proliferator-activated receptor gamma | Triglycerides | Lipid metabolism | Fatty acids | fatty acids | CONJUGATED LINOLEIC-ACID | PROLIFERATOR-ACTIVATED RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | REDUCES BODY-FAT | STEAROYL-COA DESATURASE-1 | triglycerides | TRANS-10,CIS-12 ISOMER | conjugated linoleic acid | 3T3-L1 PREADIPOCYTES | GENE-EXPRESSION | ADIPOCYTE DIFFERENTIATION | STROMAL-VASCULAR CELLS | glucose metabolism | peroxisome proliferator-activated receptor gamma | ADIPOSE-TISSUE | ACC, acetyl-CoA carboxylase | aP2 | GLUT4, insulin-dependent glucose transporter 4 | ORO, oil red O | PPAR, peroxisome proliferator-activated receptor | ACBP, acyl-CoA binding protein | LA, linoleic acid | SV, stromal vascular | BMI, body mass index | IBMX, isobutylmethylxanthine | TG, triglyceride | GPDH, glycerol-3-phosphate dehydrogenase | enhancer binding protein α | GC, gas chromatography | CLA, conjugated linoleic acid | SCD-1, stearoyl-CoA desaturase-1 | BSA, bovine serum albumin | EBPα, CAAT | FABP, adipocyte fatty acid binding protein | CD-36, fatty acid translocase | BCA, bicinchoninic acid | MUFA, monounsaturated fatty acid | LPL, lipoprotein lipase | SFA, saturated fatty acid | PPRE, peroxisome proliferator response element | HSL, hormone-sensitive lipase
Journal Article
Progress in Lipid Research, ISSN 0163-7827, 01/2016, Volume 61, pp. 149 - 162
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated... 
Lipoxygenases | Cyclooxygenases | Reactive oxygen species | Polyunsaturated fatty acids | PPARγ | Adipogenesis | AF-1 ligand-independent activation function | NOS nitric oxide synthase | ADH alcohol dehydrogenase | ELOVL3 elongation of very long chain fatty acids 3 | FFA free fatty acid | DPEP dipeptidase | LNO | RXR retinoic X receptor | PTM post-translational modification | prostaglandin J | NOX4 NADPH oxidase 4 | azPC azelayol phosphatidylcholine | HPETE hydroperoxyeicosatetraenoic acid | GGT gamma-glutamyltransferase | MEF mouse embryonic fibroblast | C/EBP CCAAT/enhancer binding protein | TZD thiazolidinedione | Mo-Co molybdenum cofactor | CBR carbonyl reductase | HPODE hydroperoxyoctadecadienoic acid | AA arachidonic acid | HETE hydroxyeicosatrienoic acid | MAPK mitogen-activated protein kinase | PL phospholipase | pRB retinoblastoma protein | Abbreviations NO nitric oxide | cPLA | PTGR prostaglandin reductase | EET epoxyeicosatrienoic | PPARγ peroxisome proliferator-activated receptor γ | ROS reactive oxygen species | cytosolic PLA | EH epoxide hydrolase | BAT Brown adipose tissue | HODE hydroxyoctdecenonic acid | PTGES prostaglandin E synthase | LOX lipoxygenase | Epac exchange protein directly activated by cAMP | LPA lysophosphatidic acid | ChREBP carbohydrate element binding protein | NR nuclear receptor | LA linoleic acid | XOR xanthine oxidoreductase | CPA cyclic phosphatidic acid | AF-2 ligand-dependent activation function | TX thromboxane | 15-deoxy-Δ | PGDH 15-hydroxyprostaglandin dehydrogenase | PGFS prostaglandin F synthase | KETE ketoeicosatetraenoic acid | SREBP-1c sterol-regulatory element binding protein 1c | eLOX3 epidermis lipoxygenase type 3 | GPC glycerophosphocholine | LBD ligand binding domain | nitrolinoleic acid | PTGIS prostacyclin synthase | ONO | PG prostaglandin | RetSat retinol saturase | dioxide radical | EPA eicosapentaenoic acid | MUFA monounsaturated fatty acid | GPx glutathione peroxidase | LTC4S leukotriene C4 synthase | COX cyclooxygenase | IBMX isobutyl-methylxanthine | peroxynitrite | PPRE peroxisome proliferator response element | HPGD 15-hydroxyprostaglandin dehydrogenase | 15-dPGJ | DHET dihydroxyeicosatrienoic acid | FAS fatty acid synthase | PTGDS prostaglandin D2 synthase | sEH soluble epoxide hydrolase | UCP1 uncoupling protein 1 | CYP cytochrome P450 monooxygenase | WAT white adipose tissue | superoxide | FAD flavin adenine dinucleotide | PUFA polyunsaturated fatty acid | TBXAS thromboxane A synthase | INHIBITS ADIPOCYTE DIFFERENTIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMINANT-NEGATIVE MUTATIONS | CELL-DERIVED ADIPOCYTES | MITOTIC CLONAL EXPANSION | PROLIFERATOR-ACTIVATED-RECEPTOR | PPAR gamma | WHITE ADIPOSE-TISSUE | NUTRITION & DIETETICS | 3T3-L1 PREADIPOCYTE DIFFERENTIATION | POLYUNSATURATED FATTY-ACIDS | LIGAND-BINDING DOMAIN | PROSTAGLANDIN F-2 ALPHA | PPAR gamma - physiology | Prostaglandins | Animals | Oxidation-Reduction | Humans | Lipid Metabolism | Adipocytes - physiology | Fatty Acids - metabolism
Journal Article