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activated phosphoinositide 3-kinase δ syndrome, pik3cd gene, bronchiectasis, hematopoietic stem cell transplantation, immunodeficiency, p110δ-activating mutation causing senescent t cells, lymphadenopathy, and immunodeficiency, phosphoinositide 3-kinase inhibitor, phosphoinositide 3-kinase δ (1) 1
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1. Full Text The 23-Valent Pneumococcal Polysaccharide Vaccine. Part I. Efficacy of PPV in the Elderly: A Comparison of Meta-Analyses
by Alessia Melegaro and W. John Edmunds
European Journal of Epidemiology, ISSN 0393-2990, 1/2004, Volume 19, Issue 4, pp. 353 - 363
A 23-valent polysaccharide pneumococcal vaccine (PPV) has been available in the UK for more than 20 years and is currently recommended for use in high-risk... 
Pneumonia | Disease models | Pneumococcal pneumonia | Vaccination | Chronic diseases | Clinical trials | Disease risk | Experimentation | Infectious Diseases | Pneumococcal vaccine | Older adults | Medicine & Public Health | Oncology | Public Health/Gesundheitswesen | Cardiology | Epidemiology | Elderly | High-risk | Polysaccharide pneumococcal vaccine (PPV) | Vaccine efficacy (VE) | Meta-analysis | TRIALS | COST-EFFECTIVENESS | elderly | meta-analysis | ADULTS | high-risk | PNEUMONIA | PROTECTIVE EFFICACY | vaccine efficacy (VE) | IMMUNIZATION | OBSTRUCTIVE PULMONARY-DISEASE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CLINICAL EFFECTIVENESS | PEOPLE | polysaccharide pneumococcal vaccine (PPV) | Confidence Intervals | Risk Assessment | Humans | Pneumococcal Infections - prevention & control | Pneumonia, Pneumococcal - prevention & control | Aged | Odds Ratio | Pneumococcal Vaccines | Randomized Controlled Trials as Topic | Vaccines | Older people
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2. Full Text Differences in homing potentials of streptococcus pneumoniae-specific plasmablasts in pneumococcal pneumonia and after pneumococcal polysaccharide and pneumococcal conjugate vaccinations
by Palkola, Nina V and Pakkanen, Sari H and Kantele, Jussi M and Pakarinen, Laura and Puohiniemi, Ritvaleena and Kantele, Anu
Journal of Infectious Diseases, ISSN 0022-1899, 10/2015, Volume 212, Issue 8, pp. 1279 - 1287
Background. Mucosal immune mechanisms in the upper and lower respiratory tracts may serve a critical role in preventing pneumonia due to Streptococcus... 
pneumococcus | homing receptor | PCV | pneumonia | PPV | mucosal immune response | pneumococcal polysaccharide vaccine | lymphocyte homing | pneumococcal conjugate vaccine | Streptococcus pneumoniae | INFECTIOUS DISEASES | COMMUNITY-ACQUIRED PNEUMONIA | NASOPHARYNGEAL COLONIZATION | CUTANEOUS LYMPHOCYTE ANTIGEN | MICROBIOLOGY | ADHESION MOLECULES | IMMUNOLOGY | B-CELLS | IMMUNE-SYSTEM | ANTIBODY-SECRETING CELLS | TISSUE BALT | EXPRESSION | T-CELLS | Pneumonia, Pneumococcal - immunology | Humans | Middle Aged | Vaccination | Immunity, Mucosal | Male | Polysaccharides - immunology | Respiratory System - cytology | Streptococcus pneumoniae - immunology | Young Adult | Vaccines, Conjugate - immunology | L-Selectin - immunology | Pneumococcal Vaccines - immunology | Adult | Antibodies, Bacterial - immunology | Female | Pneumonia, Pneumococcal - prevention & control | Aged | Respiratory System - immunology | Plasma Cells - immunology | Major and Brief Reports
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3. Full Text Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
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4. Full Text Pneumococcal vaccination among HIV-infected adult patients in the era of combination antiretroviral therapy
by Lee, Kuan-Yeh and Tsai, Mao-Song and Kuo, Kuang-Che and Tsai, Jen-Chih and Sun, Hsin-Yun and Cheng, Aristine C and Chang, Sui-Yuan and Lee, Chen-Hsiang and Hung, Chien-Ching
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 12/2014, Volume 10, Issue 12, pp. 3700 - 3710
HIV-infected patients remain at higher risk for pneumococcal disease than the general population despite immune reconstitution and suppression of HIV... 
OPA, opsonophagocytic activity | PPV, pneumococcal polysaccharide vaccine | PPV23, 23-valent pneumococcal polysaccharide vaccine | pneumococcal disease | invasive pneumococcal disease | ELISA, enzyme-linked immunosorbent assay | GMT, geometric mean titer | EACS, European AIDS Clinical Society | cART, combination antiretroviral therapy | immunodeficiency | IPD, invasive pneumococcal disease | ART, antiretroviral therapy | pneumococcal conjugate vaccine | TLR, toll-like receptor | PCV13, 13-valent pneumococcal conjugate vaccine | PCV7, 7-valent pneumococcal conjugate vccine | ACIP, Advisory Committee on Immunization Practices | AIDS | NA, not available | PVL, plasma HIV RNA load | immunogenicity | Streptococcus pneumoniae | DHHS, Department of Health and Human Services | pneumococcal polysaccharide vaccine | PCV, pneumococcal conjugate vaccine | Pneumococcal conjugate vaccine | Immunogenicity | Pneumococcal polysaccharide vaccine | Immunodeficiency | Invasive pneumococcal disease | Pneumococcal disease | UNITED-STATES | CONJUGATE VACCINE | FOLLOW-UP | RANDOMIZED-TRIAL | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CHANGING EPIDEMIOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEROLOGIC RESPONSE | POLYSACCHARIDE VACCINE | ANTIBODY-RESPONSE | UGANDAN ADULTS | Anti-HIV Agents - administration & dosage | HIV Infections - immunology | Vaccines, Conjugate - immunology | Virus Replication | Humans | Vaccination | Pneumococcal Vaccines - immunology | Adult | HIV Infections - drug therapy | CD4 Lymphocyte Count | Drug Therapy, Combination | Practice Guidelines as Topic
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5. Full Text Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea
by Lehmann, Deborah and Kirarock, Wendy and van den Biggelaar, Anita H J and Passey, Megan and Jacoby, Peter and Saleu, Gerard and Masiria, Geraldine and Nivio, Birunu and Greenhill, Andrew and Orami, Tilda and Francis, Jacinta and Ford, Rebecca and Kirkham, Lea-Ann and Solomon, Vela and Richmond, Peter C and Pomat, William S and 10v13v PCV trial team and for the 10v13v PCV trial team
Pneumonia (Nathan Qld.), ISSN 2200-6133, 2017, Volume 9, Issue 1, pp. 20 - 15
Children in third-world settings including Papua New Guinea (PNG) experience early onset of carriage with a broad range of pneumococcal serotypes, resulting in... 
Pneumococcal | Pneumococcal conjugate vaccine | PCV | Vaccine | Pneumococcal polysaccharide vaccine | PPV
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6. Full Text The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly
by Baxendale, Helen E and Keating, Sheila M and Johnson, Marina and Southern, Jo and Miller, Elizabeth and Goldblatt, David
Vaccine, ISSN 0264-410X, 2010, Volume 28, Issue 30, pp. 4763 - 4770
Abstract In young children, polyvalent pneumococcal polysaccharide conjugate vaccines (PCVs) have been shown to offer advantage over plain polysaccharide... 
Allergy and Immunology | 7vCRM | Immunogenicity | PPV | Vaccine | Aged | Pneumococcus | B cell memory | ELISpot | MEDICINE, RESEARCH & EXPERIMENTAL | ADULTS | IMMUNOLOGY | CHILDREN | STREPTOCOCCUS-PNEUMONIAE | CAPSULAR POLYSACCHARIDES | IMMUNE-RESPONSES | DISEASE | ANTIBODY-RESPONSES | ANTIGEN | AGE | Antibody Specificity | Age Factors | Immunoglobulin A - biosynthesis | Humans | Immunoglobulin M - analysis | Middle Aged | Vaccination | Male | Antibodies, Bacterial - analysis | Immunoglobulin G - biosynthesis | Female | Vaccines, Conjugate | Immunoglobulin G - analysis | Pneumococcal Vaccines - therapeutic use | Polysaccharides, Bacterial - immunology | Heptavalent Pneumococcal Conjugate Vaccine | Immunoglobulins - analysis | B-Lymphocytes - immunology | Sex Factors | Pneumococcal Vaccines - immunology | Immunologic Memory | Kinetics | Immunoglobulin A - analysis | Immunoglobulin M - biosynthesis | Plasma Cells - immunology | Polysaccharides | Vaccines | Pneumonia | Older people | Immune system
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7. Full Text The host immune dynamics of pneumococcal colonization: Implications for novel vaccine development
by Khan, M Nadeem and Pichichero, Michael E
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 12/2014, Volume 10, Issue 12, pp. 3688 - 3699
The human nasopharynx (NP) microbiota is complex and diverse and Streptococcus pneumoniae (pneumococcus) is a frequent member. In the first few years of life,... 
vaccines | IPDs, invasive pneumococcal diseases | immunity | PPS, pneumococcal polysaccharides | T cells | WCV, whole cell vaccine | MHC, major histocompatibility complex | PcpA, pneumococcal choline-binding protein A | Streptococcus pneumoniae | NP, nasopharynx | OPAs, opsonophagocytic antibodies | colonization | PPVs, pneumococcal polysaccharide vaccines | Vaccines | Immunity | Colonization | NONTYPABLE HAEMOPHILUS-INFLUENZAE | CONJUGATE VACCINE | HISTIDINE TRIAD PROTEINS | IMMUNOLOGY | T-CELL RESPONSES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACUTE OTITIS-MEDIA | CHOLINE-BINDING-PROTEINS | CROSS-REACTIVE ANTIBODIES | SURFACE PROTEIN-A | STREPTOCOCCUS-PNEUMONIAE INFECTION | RESPIRATORY SYNCYTIAL VIRUS | CD4-Positive T-Lymphocytes - immunology | Vaccines, Conjugate - immunology | Streptococcus pneumoniae - classification | Animals | Humans | Serogroup | Pneumococcal Vaccines - immunology | Th17 Cells - immunology | Infant | Mice | Nasopharynx - microbiology | Streptococcus pneumoniae - immunology
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8. Full Text Demand for pneumococcal vaccination under subsidy program for the elderly in Japan
by Kondo, Masahide and Yamamura, Mariko and Hoshi, Shu-Ling and Okubo, Ichiro
BMC Health Services Research, ISSN 1472-6963, 2012, Volume 12, Issue 1, pp. 313 - 313
Background: Vaccination programs often organize subsidies and public relations in order to obtain high uptake rates and coverage. However, effects of subsidies... 
Demand | Public relations | Vaccination program | Pneumococcal polysaccharide vaccine (PPV) | Price elasticity | Subsidy | Elderly | RATES | COMMUNITY-ACQUIRED PNEUMONIA | HEALTH CARE SCIENCES & SERVICES | INFLUENZA VACCINATION | HOSPITALIZED ADULTS | Pneumococcal Vaccines - economics | Financing, Government - economics | Health Services Needs and Demand | Humans | Japan | Immunization Programs | Pneumonia, Pneumococcal - prevention & control | Surveys and Questionnaires | Aged | Models, Statistical | Pneumococcal Vaccines - supply & distribution | Surveys | Subsidies | Supply and demand | Elasticity (Economics) | Pneumococcal vaccine | Vaccination | Studies | Immunization | Pneumonia | Vaccines | Influenza
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9. Full Text The total IgM, IgA and IgG antibody responses to pneumococcal polysaccharide vaccination (Pneumovax®23) in a healthy adult population and patients diagnosed with primary immunodeficiencies
by Parker, Antony R and Park, Miguel A and Harding, Stephen and Abraham, Roshini S
Vaccine, ISSN 0264-410X, 02/2019, Volume 37, Issue 10, pp. 1350 - 1355
Interpretation of the responses to the pneumococcal polysaccharide vaccine (Pneumovax®23, PPV) has proven challenging. In addition, there are few studies... 
Pneumococcal | IgA | PPV | IgG | Pneumovax | Normal | IgM | Medical research | Polysaccharides | Immunoglobulin G | Vaccination | Immunodeficiency | Medicine, Experimental | Adults | Immunoglobulin A | Health aspects | Immunoglobulin M | Immunoglobulins | Capsular polysaccharides | IgG antibody | Infections | Vaccines | Patients | Biological variation | Isotypes | Population | Age | Binding sites | Volunteers
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10. Full Text The total IgM, IgA and IgG antibody responses to pneumococcal polysaccharide vaccination (Pneumovax (R) 23) in a healthy adult population and patients diagnosed with primary immunodeficiencies
by Parker, AR and Park, MA and Harding, S and Abraham, RS
VACCINE, ISSN 0264-410X, 02/2019, Volume 37, Issue 10, pp. 1350 - 1355
Background: Interpretation of the responses to the pneumococcal polysaccharide vaccine (Pneumovax (R) 23, PPV) has proven challenging. In addition, there are... 
MEDICINE, RESEARCH & EXPERIMENTAL | IgA | ASSAY | PROTECTION | IgG | Pneumovax | IMMUNOLOGY | Normal | CHILDREN | Pneumococcal | CAPSULAR POLYSACCHARIDE | INFLUENZAE TYPE-B | PPV | 1gM | AGE
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11. Full Text Adult invasive pneumococcal disease pre- and peri-pneumococcal conjugate vaccine introduction in a tertiary hospital in Singapore
by Hsu, Li-Yang and Lui, See Weng and Lee, Jia Ling and Hedzlyn, Hazwany Md Mahrom and Kong, Debra Han-Lin and Shameen, Suku and Siti, Nur Puteri Mohammad and Tan, Wei Yu and Toh, Xin Yi and Koh, Tse-Yuen and Koh, Tse-Hsien
Journal of Medical Microbiology, ISSN 0022-2615, 01/2009, Volume 58, Issue 1, pp. 101 - 104
1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2 School of Life Sciences & Chemical Technology, Ngee Ann Polytechnic, Singapore... 
ACIP, Advisory Committee on Immunization Practices | PCV7, heptavalent conjugate vaccine | PPV, 23-valent polysaccharide vaccine | MICROBIOLOGY | SEROTYPES | STREPTOCOCCUS-PNEUMONIAE | ANTIMICROBIAL RESISTANCE | BACTEREMIA | EPIDEMIOLOGY | Humans | Middle Aged | Vaccination | Male | Streptococcus pneumoniae - immunology | Pneumococcal Infections - epidemiology | Vaccines, Conjugate - immunology | Hospitals | Time Factors | Singapore - epidemiology | Adolescent | Aged, 80 and over | Pneumococcal Infections - prevention & control | Pneumococcal Vaccines - immunology | Adult | Female | Aged
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12. Full Text Drug Treatment of Pneumococcal Pneumonia in the Elderly
by Sridhar Neralla and Keith C. Meyer
Drugs & Aging, ISSN 1170-229X, 2004, Volume 21, Issue 13, pp. 851 - 864
Streptococcus pneumoniae has been recognised as a major cause of pneumonia since the time of Sir William Osler. Drug-resistant S. pneumoniae (DRSP), which have... 
Beta lactams, therapeutic use | Pneumonia, treatment | Azithromycin, therapeutic use | Macrolides, therapeutic use | Pneumococcal vaccine conjugate PPV 23, therapeutic | Elderly | Antibacterial vaccines, therapeutic use | Protein 30S ribosomal subunit inhibitors, therapeu | Research and development | Community acquired pneumonia, treatment | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Geriatrics/Gerontology | UNITED-STATES | COMMUNITY-ACQUIRED PNEUMONIA | RESPIRATORY-TRACT | OLDER-ADULTS | ANTIBIOTIC-RESISTANCE | PHARMACOLOGY & PHARMACY | HAEMOPHILUS-INFLUENZAE | MACROLIDE RESISTANCE | RESISTANT STREPTOCOCCUS-PNEUMONIAE | SURFACE PROTEIN-A | ANTIMICROBIAL RESISTANCE | GERIATRICS & GERONTOLOGY | Community-Acquired Infections - diagnosis | Streptococcus pneumoniae - drug effects | Community-Acquired Infections - etiology | Pneumonia, Pneumococcal - etiology | Humans | Risk Factors | Pneumonia, Pneumococcal - diagnosis | Anti-Bacterial Agents - therapeutic use | Drug Resistance, Microbial | Streptococcus pneumoniae - pathogenicity | Community-Acquired Infections - drug therapy | Penicillin Resistance | Aged | Pneumonia, Pneumococcal - drug therapy | Geriatrics
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13. Full Text Severe Systemic Reaction to the Pneumococcal Revaccination
by Scholoff, Audrey and Obi-Anyadike, Gloria and Phalak, Kanchan and Carrum, George and May, Romelia and Kamble, Rammurti
The Journal for Nurse Practitioners, ISSN 1555-4155, 2007, Volume 3, Issue 3, pp. 178 - 179
Predictors of severe reaction to polyvalent pneumococcal vaccine (PPV) are not established. In the absence of prospective studies, revaccination within 5 years... 
Polyvalent pneumococcal vaccine | reaction | revaccination | PPV | Human immunodeficiency virus--HIV | Fever | Vaccines
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14. Full Text Diagnostic Tests and Procedures
by Lutwick, Larry I and Mendelson, Marc and Petersen, Eskild
06/2011, ISBN 0470655291, 22
This chapter provides guidelines for diagnostic procedures to be performed on admission and the following period until a diagnosis is clear. It is divided... 
diagnostic tests and procedures | CNS infections, meningitis and encephalitis ‐ key diagnostic tests, lumbar puncture to obtain CSF, serologic assays and CT | microbiological diagnosis of gastrointestinal infections | guidelines for diagnostic procedures ‐ performed on admission, diagnosis clear | tests, analyzed by predictive value ‐ and positive predictive value (PPV) | fever without focal symptoms ‐ classical definition of fever of unknown origin (FUO) | hepatobiliary infections ‐ biochemistry/cytology | endocarditis, clinical diagnosis ‐ associated with bacteremia or fungemia | antibodies directed against Epstein–Barr virus (EBV) ‐ early antigens and IgM antibody against EBV viral capsid antigen (VCA) | understanding diagnostic tests ‐ microorganisms, subunit part of pathogen in patient's blood tissue | Endocarditis, clinical diagnosis - associated with bacteremia or fungemia | Understanding diagnostic tests - microorganisms, subunit part of pathogen in patient's blood tissue | Hepatobiliary infections - biochemistry/cytology | Tests, analyzed by predictive value - and positive predictive value (PPV) | Microbiological diagnosis of gastrointestinal infections | CNS infections, meningitis and encephalitis - key diagnostic tests, lumbar puncture to obtain CSF, serologic assays and CT | Guidelines for diagnostic procedures - performed on admission, diagnosis clear | Diagnostic tests and procedures | Antibodies directed against Epstein-Barr virus (EBV) - early antigens and IgM antibody against EBV viral capsid antigen (VCA) | Fever without focal symptoms - classical definition of fever of unknown origin (FUO)
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