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Journal Article
by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 12/2014, Volume 10, Issue 12, pp. 3700 - 3710
HIV-infected patients remain at higher risk for pneumococcal disease than the general population despite immune reconstitution and suppression of HIV... 
OPA, opsonophagocytic activity | PPV, pneumococcal polysaccharide vaccine | PPV23, 23-valent pneumococcal polysaccharide vaccine | pneumococcal disease | invasive pneumococcal disease | ELISA, enzyme-linked immunosorbent assay | GMT, geometric mean titer | EACS, European AIDS Clinical Society | cART, combination antiretroviral therapy | immunodeficiency | IPD, invasive pneumococcal disease | ART, antiretroviral therapy | pneumococcal conjugate vaccine | TLR, toll-like receptor | PCV13, 13-valent pneumococcal conjugate vaccine | PCV7, 7-valent pneumococcal conjugate vccine | ACIP, Advisory Committee on Immunization Practices | AIDS | NA, not available | PVL, plasma HIV RNA load | immunogenicity | Streptococcus pneumoniae | DHHS, Department of Health and Human Services | pneumococcal polysaccharide vaccine | PCV, pneumococcal conjugate vaccine | Pneumococcal conjugate vaccine | Immunogenicity | Pneumococcal polysaccharide vaccine | Immunodeficiency | Invasive pneumococcal disease | Pneumococcal disease | UNITED-STATES | CONJUGATE VACCINE | FOLLOW-UP | RANDOMIZED-TRIAL | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CHANGING EPIDEMIOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEROLOGIC RESPONSE | POLYSACCHARIDE VACCINE | ANTIBODY-RESPONSE | UGANDAN ADULTS | Anti-HIV Agents - administration & dosage | HIV Infections - immunology | Vaccines, Conjugate - immunology | Virus Replication | Humans | Vaccination | Pneumococcal Vaccines - immunology | Adult | HIV Infections - drug therapy | CD4 Lymphocyte Count | Drug Therapy, Combination | Practice Guidelines as Topic
Journal Article
Pneumonia (Nathan Qld.), ISSN 2200-6133, 2017, Volume 9, Issue 1, pp. 20 - 15
Children in third-world settings including Papua New Guinea (PNG) experience early onset of carriage with a broad range of pneumococcal serotypes, resulting in... 
Pneumococcal | Pneumococcal conjugate vaccine | PCV | Vaccine | Pneumococcal polysaccharide vaccine | PPV
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 02/2019, Volume 37, Issue 10, pp. 1350 - 1355
Interpretation of the responses to the pneumococcal polysaccharide vaccine (Pneumovax®23, PPV) has proven challenging. In addition, there are few studies... 
Pneumococcal | IgA | PPV | IgG | Pneumovax | Normal | IgM | Medical research | Polysaccharides | Immunoglobulin G | Vaccination | Immunodeficiency | Medicine, Experimental | Adults | Immunoglobulin A | Health aspects | Immunoglobulin M | Immunoglobulins | Capsular polysaccharides | IgG antibody | Infections | Vaccines | Patients | Biological variation | Isotypes | Population | Age | Binding sites | Volunteers
Journal Article
VACCINE, ISSN 0264-410X, 02/2019, Volume 37, Issue 10, pp. 1350 - 1355
Background: Interpretation of the responses to the pneumococcal polysaccharide vaccine (Pneumovax (R) 23, PPV) has proven challenging. In addition, there are... 
MEDICINE, RESEARCH & EXPERIMENTAL | IgA | ASSAY | PROTECTION | IgG | Pneumovax | IMMUNOLOGY | Normal | CHILDREN | Pneumococcal | CAPSULAR POLYSACCHARIDE | INFLUENZAE TYPE-B | PPV | 1gM | AGE
Journal Article
Journal Article
The Journal for Nurse Practitioners, ISSN 1555-4155, 2007, Volume 3, Issue 3, pp. 178 - 179
Predictors of severe reaction to polyvalent pneumococcal vaccine (PPV) are not established. In the absence of prospective studies, revaccination within 5 years... 
Polyvalent pneumococcal vaccine | reaction | revaccination | PPV | Human immunodeficiency virus--HIV | Fever | Vaccines
Journal Article
06/2011, ISBN 0470655291, 22
This chapter provides guidelines for diagnostic procedures to be performed on admission and the following period until a diagnosis is clear. It is divided... 
diagnostic tests and procedures | CNS infections, meningitis and encephalitis ‐ key diagnostic tests, lumbar puncture to obtain CSF, serologic assays and CT | microbiological diagnosis of gastrointestinal infections | guidelines for diagnostic procedures ‐ performed on admission, diagnosis clear | tests, analyzed by predictive value ‐ and positive predictive value (PPV) | fever without focal symptoms ‐ classical definition of fever of unknown origin (FUO) | hepatobiliary infections ‐ biochemistry/cytology | endocarditis, clinical diagnosis ‐ associated with bacteremia or fungemia | antibodies directed against Epstein–Barr virus (EBV) ‐ early antigens and IgM antibody against EBV viral capsid antigen (VCA) | understanding diagnostic tests ‐ microorganisms, subunit part of pathogen in patient's blood tissue | Endocarditis, clinical diagnosis - associated with bacteremia or fungemia | Understanding diagnostic tests - microorganisms, subunit part of pathogen in patient's blood tissue | Hepatobiliary infections - biochemistry/cytology | Tests, analyzed by predictive value - and positive predictive value (PPV) | Microbiological diagnosis of gastrointestinal infections | CNS infections, meningitis and encephalitis - key diagnostic tests, lumbar puncture to obtain CSF, serologic assays and CT | Guidelines for diagnostic procedures - performed on admission, diagnosis clear | Diagnostic tests and procedures | Antibodies directed against Epstein-Barr virus (EBV) - early antigens and IgM antibody against EBV viral capsid antigen (VCA) | Fever without focal symptoms - classical definition of fever of unknown origin (FUO)
Book Chapter
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