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prak (8) 8
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American Journal of Physiology: Cell Physiology, ISSN 0363-6143, 09/2019, Volume 317, Issue 3, pp. C525 - C533
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
Theoretical biology and medical modelling, ISSN 1742-4682, 2013, Volume 10, Issue 1, pp. 56 - 56
Background: Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway... 
Molecular dynamics | ICM program package | Docking | PRAK | MAPKAPK5 | Homology modeling | Life Sciences & Biomedicine | Science & Technology | Mathematical & Computational Biology | Amino Acid Sequence | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Static Electricity | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adenosine Triphosphate - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Inhibitory Concentration 50 | Ligands | ROC Curve | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Structural Homology, Protein | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Vertebrates | Plant physiology | Crystals | Structure | Gene expression | Invertebrates | Mitogen-activated protein kinases | Health sciences | Cell division | Amino acids | Biology | Kinases | Molecular weight | Cell adhesion & migration | Studies | Proteins | Cell growth | Binding sites | Crystal structure | Index Medicus | VDP | Basic medical, dental and veterinary science disciplines: 710 | Physiopathology: 721 | Medical molecular biology: 711 | Medisinske Fag: 700 | Medisinsk molekylærbiologi: 711 | Patofysiologi: 721 | Medical disciplines: 700 | Basale medisinske, odontologiske og veterinærmedisinske fag: 710
Journal Article
Journal of molecular signaling, ISSN 1750-2187, 07/2012, Volume 7, Issue 1, pp. 9 - 9
...) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established... 
Angiogenesis | Senescence | RAS | HSP27 | IGB2PB | PRAK | C-myc | FOXO3a | Physiological aspects | Tumor suppressor genes | Reports | Genetic aspects | Genetic transcription | Mitogen-activated protein kinases | Cancer | Proteins | Enzymes | Kinases | Rodents | VDP | Oncology: 762 | Klinisk medisinske fag: 750 | Onkologi: 762 | Medisinske Fag: 700 | Clinical medical disciplines: 750 | Medical disciplines: 700
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 03/2014, Volume 15, Issue 3, pp. 4878 - 4902
The mitogen-activated protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4... 
MK5 | Molecular mechanisms | PRAK | MAPKAPK5 | Molecular dynamics simulations | Homology modelling | Protein-ligand complexes | Protein-protein interactions | Electrostatic potential surfaces | p38α | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Protein Structure, Tertiary | Amino Acid Sequence | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Humans | Substrate Specificity | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Static Electricity | Molecular Dynamics Simulation | Mitogen-Activated Protein Kinase Kinases - chemistry | Mitogen-Activated Protein Kinase Kinases - metabolism | Thermodynamics | Mitogen-Activated Protein Kinase 14 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Enzyme Inhibitors - chemistry | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 14 - chemistry | Protein-Serine-Threonine Kinases - metabolism | Proteins | Cell culture | Phosphorylation | Kinases | Electrostatics | Index Medicus | 730 | 728 | VDP | homology modelling | molecular dynamics simulations | molecular mechanisms | electrostatic potential surfaces | protein-ligand complexes | protein-protein interactions
Journal Article