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Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
... (protein kinase A/protein kinase G/protein kinase Q family kinases such as Akt (protein kinase 13), S6K (p70 ribosomal S6 kinase... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | kinase inhibitor | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | cancer | serum and glucocorticoid protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
Current neurovascular research, ISSN 1567-2026, 2017, Volume 14, Issue 2, pp. 141 - 148
Background: Transient receptor potential (TRP) channels are a superfamily of ion channels termed after the trp gene in Drosophila that are diverse in structure... 
Oxidative stress | Erythropoietin | Nicotinamide adenine dinucleotide (NAD+) | Thermoregulation | Cardiovascular disease | Nerve growth factor | Aging-related disorders | Autophagy | AMP activated protein kinase (AMPK) | Angiogenesis | Hamartin (tuberous sclerosis 1)/tuberin (tuberous sclerosis 2) (TSC1/TSC2) | Epidermal growth factor | Pain | Aging | Programmed cell death | Phosphoinositide 3 –kinase (PI 3-K) | Mechanistic target of rapamycin (mTOR) | MTOR Complex 2 (mTORC2) | Proline rich Akt substrate 40 kDa (PRAS40) | Alzheimer’s disease | MTOR Complex 1 (mTORC1) | Diabetes mellitus | Silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) | Akt | TRPV1 | Metabolism | Sirtuin | Endothelial cells | Transient receptor potential | Vanilloid receptor 1 | Stem cells | Nicotinamide | Hyperthermia | Apoptosis | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Protein Kinases - metabolism | TRPV Cation Channels - metabolism | Animals | TOR Serine-Threonine Kinases - metabolism | Calcium - metabolism | Humans | Signal Transduction - physiology | Erythropoietin - metabolism | Neurodegenerative Diseases - metabolism | TOR protein | Capsaicin | Capsaicin receptors | AKT protein | Kinases | Calcium signalling | Transient receptor potential proteins | Signal transduction | Neurodegeneration | Ion channels | Growth factors | Trophic factors | Cell survival | Neurodegenerative diseases | AMP | Rapamycin | External stimuli | Camphor | Phagocytosis | Metabolic disorders
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 05/2013, Volume 452, Issue 3, pp. 499 - 508
...]}. Mutations that trigger activation of Akt would also stimulate SGK. Moreover, Akt and SGK possess analogous substrate specificities and are likely to phosphorylate overlapping substrates to promote proliferation... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene 1 (NDRG1) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Predictive Value of Tests | Cell Proliferation | Humans | Immediate-Early Proteins - biosynthesis | Molecular Sequence Data | Proto-Oncogene Proteins c-akt - physiology | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Growth Inhibitors - therapeutic use | Breast Neoplasms - enzymology | Drug Resistance, Neoplasm - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | HEK293 Cells | Cell Line, Tumor | Female | Sheep | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | SGK, serum- and glucocorticoid-regulated kinase | HEK, human embryonic kidney | MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium | mTORC, mTOR complex | phosphoinositide 3-kinase (PI3K) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | mTOR, mammalian target of rapamycin | FOXO, forkhead box O | GI50, growth inhibition by 50 | FBS, fetal bovine serum | qRT-PCR, quantitative reverse transcription–PCR | mammalian target of rapamycin (mTOR) | GSK3, glycogen synthase kinase 3 | PRAS40, proline-rich Akt substrate of 40 kDa | N-Myc, neuroblastoma-derived Myc | NDRG1, N-Myc downstream-regulated gene 1 | PH, pleckstrin homology | TBST, Tris-buffered saline-Tween | protein kinase inhibitor | shRNA, short hairpin RNA
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 10/2014, Volume 463, Issue 3, pp. 413 - 427
We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article