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NATURE, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 298 - 298
U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of Saccharomyces cerevisiae... 
GROUP-II INTRON | SPLICEOSOME ACTIVATION | ELECTRON CRYOMICROSCOPY | CONFORMATIONAL-CHANGES | ACTIVE-SITE | U5 SNRNP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | SPLICING FACTOR | PRE-MESSENGER-RNA
Journal Article
by Wen, J and Lv, RT and Ma, HH and Shen, HJ and He, CX and Wang, JH and Jiao, FF and Liu, H and Yang, PY and Tan, L and Lan, F and Shi, YJGN and He, C and Shi, Y and Diao, JB
MOLECULAR CELL, ISSN 1097-2765, 03/2018, Volume 69, Issue 6, pp. 1028 - 1028
N-6-methyladenosine (m(6)A) is an abundant modification in eukaryotic mRNA, regulating mRNA dynamics by influencing mRNA stability, splicing, export, and... 
TRANSITION | N-6-METHYLADENOSINE | NUCLEOTIDES | N6-METHYLADENOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEX DETERMINATION | IDENTIFICATION | TRANSLATION | DROSOPHILA | PRE-MESSENGER-RNA | REVEALS | CELL BIOLOGY
Journal Article
by Wan, RX and Yan, CY and Bai, R and Wang, L and Huang, M and Wong, CCL and Shi, YG
SCIENCE, ISSN 0036-8075, 01/2016, Volume 351, Issue 6272, pp. 466 - 475
Splicing of precursor messenger RNA is accomplished by a dynamic megacomplex known as the spliceosome. Assembly of a functional spliceosome requires a... 
METAL-ION CATALYSIS | 3-DIMENSIONAL STRUCTURE | SMALL NUCLEAR-RNA | EM STRUCTURE | ACTIVE-SITE | CRYSTAL-STRUCTURE | EXON-LIGATION | MULTIDISCIPLINARY SCIENCES | ELECTRON-MICROSCOPY | YEAST SPLICEOSOME | PRE-MESSENGER-RNA
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 06/2017, Volume 45, Issue 10, pp. 6051 - 6063
N-6-methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life... 
MA RNA | CELL-FREE FORMATION | N6-METHYLADENOSINE | PAR-CLIP | BIOCHEMISTRY & MOLECULAR BIOLOGY | YTH DOMAIN | SEX DETERMINATION | SPLICE-SITE | NUCLEAR-RNA | RBMX GENE | PRE-MESSENGER-RNA | RNA
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 10/2017, Volume 68, Issue 2, pp. 374 - 374
N-6-methyladenosine (m(6)A) is an essential internal RNA modification that is critical for gene expression control in most organisms. Proteins with a YTH... 
N-6-METHYLADENOSINE | METHYLATION | DOMAIN | RECOGNITION | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-RNA | READER | BINDING | PRE-MESSENGER-RNA | REVEALS | CELL BIOLOGY
Journal Article
by Yu, SS and Jiang, T and Jia, DN and Han, YD and Liu, F and Huang, YW and Qu, Z and Zhao, YT and Tu, JY and Lv, YX and Li, JZ and Hu, XB and Lu, ZJ and Han, SS and Qin, YY and Liu, XL and Xie, SL and Wang, QK and Tang, ZH and Luo, DJ and Liu, MG
BLOOD, ISSN 0006-4971, 02/2019, Volume 133, Issue 8, pp. 805 - 815
Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium via the endothelial-to-hematopoietic transition, are self-renewing,... 
GENE-MUTATIONS | ACTIVATION | COMPLEX | IMPACT | PROTEIN | MDMX | SRSF2 | LINKS | HEMATOLOGY | PRE-MESSENGER-RNA | P53
Journal Article
PLOS GENETICS, ISSN 1553-7390, 04/2015, Volume 11, Issue 4
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3' untranslated regions (3' UTRs) and/or coding sequences. How... 
U1 SNRNP | DIVERGENT TRANSCRIPTION | UNTRANSLATED REGIONS | BINDING PROTEINS | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | PROMOTER DIRECTIONALITY | ACTIVE PROMOTERS | FACTOR-I | UTR LENGTH | PRE-MESSENGER-RNA
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14060 - 14060
Somatic mutations in spliceosome genes are detectable in similar to 50% of patients with myelo-dysplastic syndromes (MDS). We hypothesize that cells harbouring... 
TARGET | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SRSF2 | U2AF1 | MUTATIONS | LEUKEMIA | SELECTION | CANCER | MYELODYSPLASTIC SYNDROMES | PRE-MESSENGER-RNA | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2012, Volume 44, Issue 1, pp. 47 - 52
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 172 - 177
Journal Article
Journal Article
by Wei, JB and Liu, FG and Lu, ZK and Fei, QL and Ai, YX and He, PC and Shi, HL and Cui, XL and Su, R and Klungland, A and Jia, GF and Chen, JJ and He, C
MOLECULAR CELL, ISSN 1097-2765, 09/2018, Volume 71, Issue 6, pp. 973 - 973
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N-6-methyladenosine (m(6)A) and N-6, 2-O-dimethyladenosine (m(6)A(m)) at the... 
OBESITY-ASSOCIATED FTO | SUBSTRATE-SPECIFICITY | METHYLATION | N6-METHYLADENOSINE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | TRANSLATION | ALKB | PRE-MESSENGER-RNA | REVEALS | CELL BIOLOGY
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2012, Volume 4, Issue 145, pp. 145ra104 - 145ra104
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7367, pp. 64 - 69
Journal Article