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Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 02/2012, Volume 53, Issue 2, pp. 215 - 226
The compartmentation of neutral lipids in plants is mostly associated with seed tissues, where triacylglycerols (TAGs) stored within lipid droplets (LDs) serve... 
HYDROXYSTEROID DEHYDROGENASES | lipids | ARABIDOPSIS-THALIANA | SUNFLOWER OLEOSIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FATTY-ACIDS | phospholipids | lipid storage | SACCHAROMYCES-CEREVISIAE | membranes | STORAGE OIL MOBILIZATION | plant | CENTRAL HYDROPHOBIC DOMAIN | ENDOPLASMIC-RETICULUM | BRASSICA-NAPUS L | endoplasmic reticulum | PRE-RECEPTOR REGULATION
Journal Article
Steroids, ISSN 0039-128X, 03/2019, Volume 143, pp. 73 - 79
Human aldo-keto reductase AKR1C3 (type 2 3α-hydroxysteroid dehydrogenase/type 5 17β-hydroxysteroid dehydrogenase) is involved in testosterone and estrogen... 
AKR | AKR1C3 | Specificity | Monoclonal antibody | 10B10 | Aldo-keto reductase | HUMAN PROSTATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGESTERONE ACTION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | PR-104 | ENDOCRINOLOGY & METABOLISM | REVEALS ROLES | MOLECULAR-CLONING | ALPHA-HYDROXYSTEROID DEHYDROGENASE | INHIBITORS | EXPRESSION | PRE-RECEPTOR REGULATION
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 02/2012, Volume 349, Issue 2, pp. 202 - 213
Journal Article
TRANSLATIONAL PSYCHIATRY, ISSN 2158-3188, 03/2016, Volume 6
The identification of new and more effective treatments for alcohol abuse remains a priority. Alcohol intake activates glucocorticoids, which have a key role... 
SOCIAL-ISOLATION | SOLITARY TRACT | CORTICOTROPIN-RELEASING-FACTOR | ETHANOL DRINKING | PSYCHIATRY | DEPENDENT RATS | STRESS HORMONES | PITUITARY-ADRENAL AXIS | ALDOSTERONE-SENSITIVE NEURONS | PRE-RECEPTOR REGULATION | PEPTIC-ULCER DISEASE
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 218 - 225
► Genes encoding P4 metabolizing enzymes are expressed in Z-12 endometriotic cells. ► Treatments with progesterone and dydrogesterone decrease expression. ►... 
Dydrogesterone | Peritoneal endometriosis | Medroxyprogesterone acetate | Pre-receptor metabolism | Progesterone resistance | Dienogest | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Epithelial Cells - metabolism | Endometriosis - genetics | Epithelial Cells - drug effects | Humans | Endometrium - drug effects | Medroxyprogesterone Acetate - pharmacology | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - metabolism | Membrane Proteins - metabolism | Progesterone - pharmacology | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | Nandrolone - analogs & derivatives | Progestins - pharmacology | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Membrane Proteins - biosynthesis | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Nandrolone - pharmacology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Dydrogesterone - pharmacology | Endometriosis - metabolism | Estradiol Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Receptors, Progesterone - biosynthesis | Medroxyprogesterone | Physiological aspects | Progesterone | RNA | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2007, Volume 282, Issue 46, pp. 33484 - 33493
Hydroxysteroid dehydrogenases (HSDs) are essential for the biosynthesis and mechanism of action of all steroid hormones. We report the complete kinetic... 
11-BETA-HYDROXYSTEROID DEHYDROGENASE | REDOX STATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-SITE | SUPERFAMILY | NICOTINAMIDE-ADENINE DINUCLEOTIDE | HORMONE ACTION | ALDO-KETO REDUCTASE | PRE-RECEPTOR REGULATION | 3-ALPHA-HYDROXYSTEROID DIHYDRODIOL DEHYDROGENASE
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e43965 - e43965
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The... 
POTENT INHIBITOR | CYCLOOXYGENASE INHIBITION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROSTAGLANDIN-F-SYNTHASE | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | MACROMOLECULAR CRYSTALLOGRAPHY | PRE-RECEPTOR REGULATION | CANCER CELL-MIGRATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Meclofenamic Acid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Tolmetin - analogs & derivatives | Indomethacin - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Mefenamic Acid - chemistry | Naproxen - metabolism | Sulindac - metabolism | Ibuprofen - chemistry | Mefenamic Acid - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hydroxyprostaglandin Dehydrogenases - chemistry | Tolmetin - metabolism | Sulindac - chemistry | Flurbiprofen - chemistry | Meclofenamic Acid - chemistry | Ibuprofen - metabolism | Naproxen - chemistry | Tolmetin - chemistry | Flufenamic Acid - metabolism | Aldo-Keto Reductase Family 1 Member C3 | Flufenamic Acid - chemistry | Indomethacin - chemistry | 3-Hydroxysteroid Dehydrogenases - chemistry | Flurbiprofen - metabolism | Oxidoreductases | Research | Nonsteroidal anti-inflammatory drugs | Structure | Properties | Drugs | Dehydrogenases | Drug development | Cancer therapies | Crystallography | Cell adhesion & migration | Proteins | Signal transduction | Distributed control systems | Naproxen | Sulindac | Ibuprofen | Inhibition | Catalysis | NADP | Flurbiprofen | Crystal structure | Carbonyls | Medical research | Enzymes | Antiinflammatory agents | Breast cancer | Inflammation | Aldo-keto reductase | Nonsteroidal antiinflammatory drugs | Carbonyl groups | Testosterone | Signaling | Acids | Mefenamic acid | Ligands | Indomethacin | Drug discovery | Prostate cancer | Prostate | Tumors | Cancer | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | QUINONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | CARCINOGENESIS | OVARIAN ENDOMETRIOSIS | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 2008, Volume 108, Issue 4, pp. 480 - 486
[Abstract.] Antihistamines are effective for treatment of seasonal nasal allergy. Recently, prophylactic treatment with antihistamines in patients with... 
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROID 5-ALPHA-REDUCTASE | RECEPTOR-A | 5 alpha-Reductase | ER-ALPHA | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ESTROGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | YOUNG-WOMEN | TYPE-2 | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 11, pp. 5309 - 5317
Journal Article
POLISH JOURNAL OF VETERINARY SCIENCES, ISSN 1505-1773, 2013, Volume 16, Issue 1, pp. 55 - 62
Companion animals, including bitches, are exposed to intoxication with zearalenone (ZEN) present in feed, and the above may lead to reproductive disorders... 
bitches | HYDROXYSTEROID DEHYDROGENASES | zearalenone | BETA-ZEARALENOL | GRANULOSA-CELLS | PROGESTERONE | immunocytochemistry | ALPHA-ZEARALENOL | ovary | BIOTRANSFORMATION | 17 beta-HSD | MESSENGER-RNA | VETERINARY SCIENCES | RISK-ASSESSMENT | PRE-RECEPTOR REGULATION | 3 beta-HSD | MYCOTOXINS
Journal Article