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PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7292, pp. 1149 - 1154
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e22261
...) cells is important for understanding both normal and pathological hematopoietic development in vivo... 
PRIMITIVE STREAK | CD34(+) CELLS | DEFINITIVE HEMATOPOIESIS | IN-VITRO | EXTENSIVE CAPABILITY | EMBRYONIC STEM-CELLS | ENDOTHELIAL-CELLS | CORD BLOOD | BIOLOGY | HEMOANGIOGENIC PROGENITORS | COMMON PRECURSOR | Embryonic Stem Cells - metabolism | Antigens, CD34 - metabolism | Embryonic Stem Cells - cytology | Leukocyte Common Antigens - metabolism | Humans | Mesoderm - drug effects | Mesoderm - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Hematopoiesis - drug effects | Blood Cells - cytology | Clone Cells | Culture Media, Serum-Free - pharmacology | Induced Pluripotent Stem Cells - cytology | Blood Cells - drug effects | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Hematopoietic Stem Cells - drug effects | Cell Line | Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - drug effects | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Hematopoietic Stem Cells - metabolism | Pluripotent Stem Cells - metabolism | Animals | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Pluripotent Stem Cells - drug effects | Stromal Cells - cytology | Cytokines | Monomolecular films | Cell culture | Pediatrics | Medical research | Leukemia | Blood cells | Embryos | Blood | Hemopoiesis | Medicine | Studies | Primitive streak | Angiogenesis | Hematopoiesis | Monolayers | Stem cells | In vivo methods and tests | Differentiation | Pluripotency
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 329, Issue 5987, pp. 85 - 89
T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK) lymphocytes constitute an essential component of the innate immune... 
T lymphocytes | Beta cells | Thymocytes | Stromal cells | REPORTS | Cell lines | Stem cells | Natural killer cells | Tissue therapy | Cells | Tumors | SURVIVAL | IN-VITRO | NK CELLS | RECOGNITION | VIVO | PATHWAY | MULTIDISCIPLINARY SCIENCES | H-2-DEFICIENT LYMPHOMA VARIANTS | DIFFERENTIATION | EXPRESSION | T-Lymphocytes - physiology | Oligonucleotide Array Sequence Analysis | Coculture Techniques | Lymphopoiesis - genetics | Gene Expression Profiling | Genes, T-Cell Receptor beta | T-Lymphocytes - transplantation | Melanoma, Experimental - immunology | Gene Expression Regulation, Developmental | Gene Deletion | Tumor Suppressor Proteins - genetics | Killer Cells, Natural - immunology | Precursor Cells, T-Lymphoid - cytology | Repressor Proteins - metabolism | Precursor Cells, T-Lymphoid - physiology | Tumor Suppressor Proteins - metabolism | Signal Transduction | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Cells, Cultured | Repressor Proteins - genetics | Killer Cells, Natural - physiology | Gene Knock-In Techniques | Mice, Knockout | Cell Lineage | Killer Cells, Natural - cytology | Animals | T-Lymphocytes - cytology | Tamoxifen - pharmacology | Cell Line, Tumor | Tamoxifen - analogs & derivatives | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Stromal Cells - physiology | Stromal Cells - cytology | Cytotoxicity, Immunologic | Killer cells | Genetic aspects | T cells | Cancer cells | Cellular biology | Gene expression | Lymphocytes
Journal Article
Cancer cell, ISSN 1535-6108, 2016, Volume 30, Issue 6, pp. 849 - 862
.... To isolate and characterize relapse-inducing cells, we used genetic engineering and proliferation-sensitive dyes in patient-derived xenografts of acute lymphoblastic leukemia... 
RNA single-cell sequencing | minimal residual disease (MRD) | acute lymphoblastic leukemia | patient-derived xenograft (PDX) cells | Cancer stem cells | primary patients' ALL MRD cells | dormant tumor cells | treatment resistance | INITIATING CELLS | STEM-CELLS | ONCOLOGY | MYELOID-LEUKEMIA | PROPAGATING CELLS | MINIMAL RESIDUAL DISEASE | CANCER | CHILDHOOD | CHEMOTHERAPY | DISCOVERY | XENOGRAFTS | CELL BIOLOGY | Neoplasm, Residual - pathology | Neoplasm Transplantation | Cell Proliferation | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Neoplasm Recurrence, Local - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Neoplastic Stem Cells - pathology | Adult | Tumor Cells, Cultured | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Single-Cell Analysis | Child | Antineoplastic Combined Chemotherapy Protocols - metabolism | Gene Expression Profiling - methods | Neoplasm, Residual - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Sequence Analysis, RNA - methods | Disease-Free Survival | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasm Recurrence, Local - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Medical colleges | Genetic vectors | Genetically modified organisms | Genetic engineering | Research institutes | Acute lymphocytic leukemia | Health aspects | Index Medicus
Journal Article
Cancer cell, ISSN 1535-6108, 2008, Volume 13, Issue 6, pp. 483 - 495
Faithful modeling of mixed-lineage leukemia in murine cells has been difficult to achieve... 
STEMCELL | CELLCYCLE | HEMATOPOIETIC-CELLS | B-CELLS | STEM-CELLS | ONCOLOGY | MLL REARRANGEMENTS | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MYELOGENOUS LEUKEMIA | THERAPEUTIC TARGET | GENE-EXPRESSION PROFILES | ACUTE MYELOID-LEUKEMIA | FLT3 MUTATIONS | Translocation, Genetic | Antigens, CD34 - analysis | Myeloid-Lymphoid Leukemia Protein - metabolism | Cell Proliferation | Fetal Stem Cells - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Multipotent Stem Cells - metabolism | rac GTP-Binding Proteins - metabolism | Aneuploidy | Gene Expression Profiling | Stem Cell Transplantation | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | rac GTP-Binding Proteins - genetics | Neoplastic Stem Cells - pathology | Cell Culture Techniques | Fetal Blood - immunology | Transduction, Genetic | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Genotype | Cell Lineage | Multipotent Stem Cells - pathology | Phenotype | Environment | Mice, Inbred NOD | Mice | Fetal Stem Cells - pathology | Oncogene Proteins, Fusion - metabolism | Species Specificity | Gene Expression Regulation, Neoplastic | Neoplastic Stem Cells - immunology | Multipotent Stem Cells - immunology | Fetal Stem Cells - immunology | Intercellular Signaling Peptides and Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Leukemia, Experimental - pathology | Fetal Blood - metabolism | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Chromosomes, Human, Pair 11 | Cell Transformation, Neoplastic - pathology | Cell Line, Transformed | Leukemia, Experimental - metabolism | Apoptosis | Leukemia, Myeloid, Acute - genetics | Cytogenetics | Models | Growth factors | Analysis | Leukemia | Stem cells
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 329, Issue 5987, pp. 89 - 93
.... The last stage of T lineage commitment in vivo involves mechanisms to suppress natural killer cell potential, to suppress myeloid and dendritic cell potential, and to silence the stem cell... 
Beta cells | Transcription factors | Stromal cells | Genes | REPORTS | Stem cells | Cultured cells | Natural killer cells | Cellular differentiation | Progenitor cells | Cells | SURVIVAL | DECISION | NOTCH1 | DENDRITIC CELLS | GENE | PATHWAY | ALPHA-BETA | MULTIDISCIPLINARY SCIENCES | DIFFERENTIATION | EXPRESSION | GATA-3 | T-Lymphocytes - physiology | Receptors, Notch - metabolism | Genes, T-Cell Receptor delta | Lymphopoiesis - genetics | Gene Expression Profiling | Repressor Proteins - deficiency | T-Lymphocytes - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Precursor Cells, T-Lymphoid - cytology | Cell Differentiation | Repressor Proteins - metabolism | Genes, T-Cell Receptor gamma | Precursor Cells, T-Lymphoid - physiology | Tumor Suppressor Proteins - metabolism | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Repressor Proteins - genetics | Transcription Factors - genetics | Killer Cells, Natural - physiology | Mice, Knockout | Transcription Factors - metabolism | Cell Lineage | Killer Cells, Natural - cytology | Animals | T-Lymphocytes - cytology | Mice | Precursor Cells, T-Lymphoid - immunology | T cells | Genetic aspects | Cell lines | Proteins | Cellular biology | Gene expression | Lymphocytes
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e14698
The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and modulation of immune responses but its role in stem cell biology is unknown... 
L-TRYPTOPHAN TRANSPORT | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | 2,3-DIOXYGENASE ACTIVITY | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | MULTIDISCIPLINARY SCIENCES | CD4(+) T-CELLS | CEREBROSPINAL-FLUID | NEURAL PRECURSOR CELLS | MARROW STROMAL CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Mesenchymal Stromal Cells - enzymology | Gene Expression Regulation, Enzymologic - drug effects | Humans | Male | Interferon-beta - physiology | RNA - genetics | Cell Differentiation - genetics | Adult | Kynurenine - metabolism | Mesenchymal Stromal Cells - physiology | RNA - metabolism | Mesenchymal Stromal Cells - drug effects | Mice, Inbred C57BL | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Enzyme Activation - drug effects | Metabolic Networks and Pathways - genetics | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mice | Metabolic Networks and Pathways - drug effects | Interferon-gamma - pharmacology | Cell proliferation | Multiple sclerosis | Senescence | Antimicrobial activity | Transcription | Mesenchyme | Stem cell transplantation | Infections | Activation | Neurogenesis | Biomedical materials | Cell growth | Allografts | Metabolites | Modulation | Bone marrow | Biocompatibility | Physiology | Dioxygenase | Medical research | Enzymes | Immune response | Hematology | Tryptophan | Cell division | Metabolism | Brain research | Hospitals | γ-Interferon | Stem cells | Neural stem cells | Interferon | Differentiation
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0177962
Adult neural crest stem-derived cells (NCSC) are of extraordinary high plasticity and promising candidates for use in regenerative medicine... 
PROGENITOR CELLS | MESENCHYMAL STROMAL CELLS | STEM-CELLS | TRUNK | MULTIDISCIPLINARY SCIENCES | PERIODONTAL-LIGAMENT | ONTOGENY | GENERATION | SKIN-DERIVED PRECURSORS | DIFFERENTIATION | MELANOCYTES | RNA-Binding Proteins - genetics | Humans | Adipose Tissue - cytology | Melanocytes - metabolism | Neurons - cytology | Receptors, Nerve Growth Factor - metabolism | Neural Stem Cells - cytology | Schwann Cells - cytology | Neural Crest - metabolism | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Snail Family Transcription Factors - genetics | Melanocytes - cytology | Nestin - genetics | Adult | Female | Cell Differentiation | Neurons - metabolism | Dermis - cytology | Nuclear Proteins - genetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Gene Expression | Neural Crest - cytology | Dermis - metabolism | Snail Family Transcription Factors - metabolism | Microinjections | Bone Marrow Cells - cytology | Neural Crest - growth & development | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Schwann Cells - metabolism | Transcription Factor Brn-3A - metabolism | Chick Embryo | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Animals | Transcription Factor Brn-3A - genetics | Twist-Related Protein 1 - genetics | Twist-Related Protein 1 - metabolism | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Bone Marrow Cells - metabolism | Mesenchymal Stem Cell Transplantation | RNA-Binding Proteins - metabolism | Adipose tissues | Comparative analysis | Skin | Neurosciences | Nestin | Adipose tissue | Leukocyte migration | Laboratories | Sox9 protein | Dermis | Melanocytes | Nervous system | Human tissues | Regeneration (physiology) | Cell adhesion & migration | Msi1 protein | Plasticity (neural) | Ethics | Immunology | Pathways | Surgery | Bone marrow | Hair | Hematology | Neurons | Tissue engineering | Schwann cells | Brn-3 protein | Gene expression | Embryos | Neural crest | Medicine | Regeneration | Human performance | Stromal cells | Stem cells | Cell migration | Dental pulp
Journal Article