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International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 06/2011, Volume 43, Issue 6, pp. 877 - 885
Amyloid-β (Aβ) is believed to play a crucial role in the ethiopathogenesis of Alzheimer's Disease (AD). In particular, its interactions with biologically... 
Oligomers | Tau | Alzheimer's disease | Amyloid precursor protein | Metal ions
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 06/2016, Volume 8, Issue 6, pp. 595 - 608
Despite continuing debate about the amyloid -protein (or A hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that... 
MEDICINE, RESEARCH & EXPERIMENTAL | treatment | NEURITIC DEGENERATION | TAU PATHOLOGY | Alzheimer | APOLIPOPROTEIN-E | genetics | cell biology | IN-VIVO | BETA-SECRETASE BACE1 | A-BETA | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | GAMMA-SECRETASE | GENOME-WIDE ASSOCIATION
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 06/2019, Volume 294, Issue 24, pp. 9366 - 9366
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 13
An early pathological hallmark of Alzheimer’s disease (AD) is amyloid-β (Aβ) deposits in the brain, which largely consist of up to 43 amino acids long Aβ... 
Cerebrospinal fluid | Peptides | Glycopeptides | Alzheimer's disease | Amyloid precursor protein
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 11/2018, Volume 119, pp. 190 - 198
Metabotropic glutamate receptor 5 (mGluR ) is a drug target for central nervous system disorders such as fragile X syndrome that involve excessive... 
Amyloid-beta precursor protein | AFQ-056 | MPEP | mGluR5 | Fmr1 | MRZ-8456 | mGluR
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2010, Volume 30, Issue 36, pp. 11938 - 11950
Aggregation of amyloid-beta (A beta) and Tau protein are hallmarks of Alzheimer's disease (AD), and according to the A beta-cascade hypothesis, A beta is... 
AMYLOID-INDUCED NEURODEGENERATION | OXIDATIVE STRESS | PROTEIN OLIGOMERS | NEURITE OUTGROWTH | MECHANISM | ALZHEIMERS-DISEASE | AXONAL-TRANSPORT | PRECURSOR PROTEIN | NEUROTOXICITY | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 11/2009, Volume 29, Issue 45, pp. 14271 - 14286
M-1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a... 
ACTIVATION | MEMORY | CORTEX | XANOMELINE | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | MODULATION | DISCOVERY | AGONIST | BETA
Journal Article
Neuron, ISSN 0896-6273, 03/2005, Volume 45, Issue 5, pp. 675 - 688
Progressive memory loss and cognitive dysfunction are the hallmark clinical features of Alzheimer's disease (AD). Identifying the molecular triggers for the... 
HUMAN NEURONS | MEMORY CONSOLIDATION | DEMENTIA | A-BETA-42 ACCUMULATION | DOWN-SYNDROME | AMYGDALA MODULATION | AMYLOID PRECURSOR PROTEIN | PLAQUES | NEUROSCIENCES | BRAIN | IMPAIRMENT
Journal Article
Respiratory Physiology & Neurobiology, ISSN 1569-9048, 07/2019, Volume 265, pp. 55 - 67
Alzheimer’s disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of... 
Neuroinflammation | Presenilin-1 | Pulmonary chemoreflex | Respiratory behaviour | Amyloid precursor protein
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2007, Volume 26, Issue 6, pp. 1702 - 1712
Processing of the amyloid precursor protein (APP) by β‐ and γ‐secretases leads to the generation of amyloid‐β (Aβ) peptides with varying lengths. Particularly... 
dimerization | secretase | amyloid Aβ | amyloid precursor protein (APP) | GxxxG | Amyloid Aβ | Dimerization | Amyloid precursor protein (APP) | Secretase
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 166 - 170
The gamma-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important... 
PRESENILIN | COMPLEX | PARTICLE ELECTRON CRYOMICROSCOPY | TRANSMEMBRANE DOMAIN-4 | MEMBRANE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NICASTRIN | CRYO-EM | FAMILY INTRAMEMBRANE PROTEASE | BINDING | Cryoelectron Microscopy | Protein Structure, Tertiary | Models, Molecular | Crystallography, X-Ray | Amyloid Precursor Protein Secretases - chemistry | Humans | Index Medicus
Journal Article
NATURE, ISSN 0028-0836, 11/2001, Volume 414, Issue 6860, pp. 212 - 216
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory drugs (NSAIDs)(1-5). It has... 
DOMAIN | INHIBITION | PATHWAY | ALZHEIMERS-DISEASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BETA-PROTEIN | PRECURSOR PROTEIN | BRAIN | PRESENILIN-1
Journal Article
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