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Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3747 - 3757
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). It acquires phenotypic drug resistance inside macrophages, and this resistance mainly... 
PREGNANE X RECEPTOR | SURVIVAL | RESISTANT TUBERCULOSIS | EXTRAHEPATIC TISSUES | TRANSPORTERS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | METABOLIZING-ENZYMES | EXPRESSION | CYTOCHROME-P-450 | CHEMOTHERAPY | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Humans | Mycobacterium tuberculosis - immunology | Pregnane X Receptor - agonists | Male | Pregnane X Receptor - metabolism | Tuberculosis, Pulmonary - drug therapy | Host-Pathogen Interactions - drug effects | Mycobacterium tuberculosis - drug effects | Ketoconazole - pharmacology | ATP-Binding Cassette Transporters - agonists | ATP-Binding Cassette Transporters - genetics | RNA Interference | Mycobacterium tuberculosis - physiology | ATP-Binding Cassette Transporters - metabolism | Pregnane X Receptor - genetics | Rifampin - therapeutic use | Lung - metabolism | Drug Resistance, Bacterial - drug effects | Macrophages - immunology | Macrophages - microbiology | Recombinant Proteins - metabolism | Gene Transfer Techniques | Microbial Viability - drug effects | Mice, Inbred C57BL | Cells, Cultured | Recombinant Proteins - chemistry | Macrophages - cytology | Antibiotics, Antitubercular - pharmacology | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Pregnane X Receptor - antagonists & inhibitors | Lung - drug effects | Antibiotics, Antitubercular - therapeutic use | Genes, Reporter - drug effects | Rifampin - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Mycobacterium tuberculosis - growth & development | Mycobacterium tuberculosis | Drug nonresponsiveness | tuberculosis | drug transport | nuclear receptor | drug resistance | PXR | Cell Biology
Journal Article
Critical Reviews in Toxicology, ISSN 1040-8444, 1/2014, Volume 44, Issue 1, pp. 64 - 82
Journal Article
World journal of gastroenterology : WJG, ISSN 1007-9327, 2017, Volume 23, Issue 42, pp. 7519 - 7530
AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive... 
Drug metabolism | CYP3A | Constitutive androstane receptor | Pregnane X receptor | Cholestasis
Journal Article
Journal Article
Journal of pharmacological sciences, ISSN 1347-8648, 2014, Volume 126, Issue 2, pp. 146 - 154
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2019, Volume 20, Issue 18, p. 4562
Sesquiterpenes, the main components of plant essential oils, are bioactive compounds with numerous health-beneficial activities. Sesquiterpenes can interact... 
gene reporter assay | VITRO | ALPHA-HUMULENE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | pregnane X receptor | PRECISION-CUT LIVER | sesquiterpene | cytochrome P450 3A4 | CHEMISTRY, MULTIDISCIPLINARY | mRNA expression | SLICES | INHIBITION | BETA-CARYOPHYLLENE OXIDE | ARYL-HYDROCARBON RECEPTOR | CYTOCHROME-P450 ENZYMES | GENE-EXPRESSION | protein expression | precision-cut liver slices | Monocyclic Sesquiterpenes - pharmacology | Liver - enzymology | Carbonyl Reductase (NADPH) - metabolism | Farnesol - pharmacology | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Pregnane X Receptor - agonists | Male | Metabolic Clearance Rate | Pregnane X Receptor - metabolism | Polycyclic Sesquiterpenes - pharmacology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Hep G2 Cells | Receptors, Aryl Hydrocarbon - agonists | Cytochrome P450 Family 2 - metabolism | Cytochrome P-450 CYP3A - metabolism | Aldo-Keto Reductases - metabolism | Aged, 80 and over | Receptors, Aryl Hydrocarbon - metabolism | Female | Aged | Sesquiterpenes - pharmacology | Cytochrome | Alkaline phosphatase | Physiological effects | CYP1A protein | Liver | Bilirubin | Proteins | Receptors | Aromatic compounds | Sesquiterpenes | Physiology | Drug dosages | Nutraceuticals | Cytochromes P450 | Functional foods & nutraceuticals | Enzymes | Alanine | Cytochrome P450 | Remedies | Nuclear receptors | Patients | Herbal medicine | Prescription drugs | Alanine transaminase | Protein expression | Plasma levels | Aspartate aminotransferase
Journal Article