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世界胃肠病学杂志:英文版, ISSN 1007-9327, 2017, Volume 23, Issue 42, pp. 7519 - 7530
AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive... 
Drug metabolism | CYP3A | Constitutive androstane receptor | Pregnane X receptor | Cholestasis
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 12/2018, Volume 104, Issue 6, pp. 1191 - 1198
Rifampin demonstrated dose‐dependent relative induction between cytochrome P (CYP)3A and P‐glycoprotein (P‐gp), organic anion transporting polypeptides... 
PHARMACOLOGY & PHARMACY | SINGLE | PHARMACOKINETICS | METABOLISM | PREGNANE-X-RECEPTOR | FELODIPINE | Research
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 07/2019, pp. 112103 - 112103
ETHNOPHARMACOLOGICAL RELEVANCECholestasis is a clinical syndrome caused by toxic bile acid retention that will lead to serious liver diseases. Ursodeoxycholic... 
Index Medicus
Journal Article
by Chen, RH and Jiang, J and Hu, ZS and Ye, WC and Yuan, QQ and Li, MY and Wen, JK and Deng, YQ
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 05/2019, Volume 95, Issue 5, pp. 507 - 518
The cytochrome P450 3A subfamily plays vital roles in the metabolism of endogenous chemicals and xenobiotics. Understanding the basal expression of CYP3A in... 
NF-Y | P450 SUPERFAMILY | DNA-BINDING | SP1 | ALPHA | PHARMACOLOGY & PHARMACY | HUMAN LIVER | PXR | CYP3A4 | PREGNANE-X-RECEPTOR | BASAL EXPRESSION
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 10/2013, Volume 41, Issue 10, pp. 1752 - 1762
Genes that are important for the detoxification of drugs and other xenobiotics show a high degree of interindividual variation attributable to regulation by... 
IN-VITRO | IMPACT | DISEASE | PHARMACOLOGY & PHARMACY | NUCLEAR FACTOR 4-ALPHA | CYP3A4 | IDENTIFICATION | PREGNANE-X-RECEPTOR | TRANSCRIPTIONAL REGULATION | CYTOCHROME-P450 3A4 | COMPREHENSIVE ANALYSIS
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 03/2019, Volume 105, Issue 3, pp. 730 - 737
The pharmacokinetic (PK) and clinical implications of combining metformin with rifampicin are relevant to increasing numbers of patients with diabetic... 
PREGNANE X RECEPTOR | HOMEOSTASIS | HYPERGLYCEMIA | PHARMACOKINETICS | DISEASE | CREATININE | INCREASES | PHARMACOLOGY & PHARMACY | CATION TRANSPORTERS OCT1 | EXPRESSION | Research
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2006, Volume 281, Issue 26, pp. 17882 - 17889
It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. Cytochrome... 
TUMOR-NECROSIS-FACTOR | TRANSCRIPTIONAL ACTIVATION | ARYL-HYDROCARBON RECEPTOR | SIGNALING PATHWAY | CONSTITUTIVE ANDROSTANE RECEPTOR | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AH RECEPTOR | PREGNANE-X-RECEPTOR | NUCLEAR RECEPTOR | DRUG-METABOLISM
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2016, Volume 44, Issue 12, pp. 1940 - 1948
Traditional in vitro human liver cell culture models lose key hepatic functions such as metabolic activity during short-term culture. Advanced... 
PREGNANE-X RECEPTOR | INTERLEUKIN-6 IL-6 | IN-VITRO | HUMAN HEPATOCYTES | GENE-EXPRESSION | KUPFFER CELLS | PHARMACOLOGY & PHARMACY | PRO-INFLAMMATORY ACTIVITIES | NF-KAPPA-B | METABOLIZING-ENZYMES | INDUCED HEPATOTOXICITY | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 2003, Volume 38, Issue 4, pp. 978 - 988
Many drugs that are substrates of CYP3A4, the major human drug-metabolizing cytochrome P450 (CYP), show higher clearance in women than in men. Although this... 
ERYTHROMYCIN BREATH TEST | CYTOCHROME-P450 3A | METABOLISM | PHARMACOKINETICS | DRUG-INTERACTIONS | INTERINDIVIDUAL VARIABILITY | GENDER | GASTROENTEROLOGY & HEPATOLOGY | PREGNANE-X-RECEPTOR | GROWTH-HORMONE SECRETION | P-GLYCOPROTEIN
Journal Article
Immunity, ISSN 1074-7613, 08/2014, Volume 41, Issue 2, pp. 296 - 310
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2006, Volume 116, Issue 8, pp. 2280 - 2289
While it has long been known that inflammation and infection reduce expression of hepatic cytochfome P450 (CYP) genes involved in xenobiotic metabolism and... 
MEDICINE, RESEARCH & EXPERIMENTAL | BLOOD-MONONUCLEAR-CELLS | GLUCOCORTICOID-RECEPTOR | MESSENGER-RNA | HUMAN HEPATOCYTES | CONSTITUTIVE ANDROSTANE RECEPTOR | TUMOR PROMOTER | PREGNANE-X-RECEPTOR | REGULATE EXPRESSION | NUCLEAR RECEPTOR | BOWEL-DISEASE
Journal Article
Chinese Pharmaceutical Journal, ISSN 1001-2494, 05/2018, Volume 53, Issue 10, pp. 783 - 787
Journal Article
Pharmacogenomics, ISSN 1462-2416, 04/2019, Volume 20, Issue 6, pp. 447 - 456
 This study aimed to investigate the effect of and mechanism involved in the SNP on cyclosporine metabolism and outcomes of liver transplantation (LT).  The... 
cyclosporine | single nucleotide polymorphism | liver transplantation | IL-17 | CELLS | PREGNANE X-RECEPTOR | SUSCEPTIBILITY | VARIABILITY | IMPACT | INHIBITION | GENE | PHARMACOLOGY & PHARMACY | TACROLIMUS
Journal Article