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Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 05/2019, Volume 10, Issue 5, pp. 726 - 731
Nonsense mutations introduce a premature termination codon (PTC) and are the underlying cause of multiple rare genetic diseases and cancers. Although certain... 
Premature termination codon (PTC) readthrough | CHEMISTRY, MEDICINAL | INHIBITION | DISEASES | 2-aminothiazole-4-carboxamides | cell-based assay | nonsense mutations | library screening
Journal Article
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 11/2011, Volume 89, Issue 11, pp. 1149 - 1161
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 19, pp. 5842 - 5848
A structure–activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature... 
Organic synthesis | Thiazolidinones | Readthrough compounds | Premature termination codons | CHEMISTRY, MEDICINAL | PHENOTYPE | CHEMISTRY, ORGANIC | READ-THROUGH | SUPPRESSION | GENTAMICIN | AMINOGLYCOSIDE | NONSENSE | DISEASE | CYSTIC-FIBROSIS | STOP MUTATIONS | ATAXIA-TELANGIECTASIA | Codon, Terminator - genetics | Furans - pharmacology | Open Reading Frames | Transcriptional Activation | Ribosomes - metabolism | Codon, Nonsense - chemistry | Structure-Activity Relationship | Molecular Targeted Therapy | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Furans - chemistry | Tumor Suppressor Proteins - genetics | Drug Design | Cell Cycle Proteins - genetics | Ataxia Telangiectasia - drug therapy | Molecular Structure | Protein Biosynthesis - genetics | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ataxia Telangiectasia - metabolism | Cell Cycle Proteins - biosynthesis | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Codon, Terminator - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | High-Throughput Screening Assays | Thiazoles - chemical synthesis | Codon, Nonsense - metabolism | Ataxia Telangiectasia - genetics | Peptide Chain Termination, Translational - genetics | Thiazoles - chemistry | Thiazoles - pharmacology | Furans - chemical synthesis | Mutation | Tumor Suppressor Proteins - biosynthesis | DNA-Binding Proteins - biosynthesis | Codon, Nonsense - genetics | Analysis | Codon | Hybrids
Journal Article
Neurotherapeutics, ISSN 1933-7213, 10/2015, Volume 12, Issue 4, pp. 874 - 886
Journal Article