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1. Full Text IGFBP3 Suppresses Retinopathy through Suppression of Oxygen-Induced Vessel Loss and Promotion of Vascular Regrowth
by Chatarina Lofqvist and Jing Chen and Kip M. Connor and Alexandra C. H. Smith and Christopher M. Aderman and Nan Liu and John E. Pintar and Thomas Ludwig and Ann Hellstrom and Lois E. H. Smith and Institute of Clinical Sciences, Section for the Health of Women and Children and Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation and Sahlgrenska akademin and Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 25, pp. 10589 - 10594
Vessel loss precipitates many diseases. In particular, vessel loss resulting in hypoxia induces retinal neovascularization in diabetic retinopathy and in... 
Diabetic angiopathies | Diabetic retinopathy | Oxygen | Messenger RNA | Blood vessels | Retina | Regrowth | Hypoxia | Mice | Infants | Angiogenesis | Retinopathy of prematurity | Insulin-like growth factor | Binding protein-3 | Insulin-like growth factor 1 | Stem cells | SURVIVAL | stem cells | FACTOR-BINDING PROTEIN-3 | angiogenesis | MULTIDISCIPLINARY SCIENCES | MOUSE | binding protein-3 | DNA-SYNTHESIS | retinopathy of prematurity | BREAST-CANCER | ENDOTHELIAL-CELLS | DISEASE | LINE | insulin-like growth factor | insulin-like growth factor 1 | PREMATURITY | GROWTH-FACTOR-I | Insulin-Like Growth Factor Binding Protein 3 - genetics | Retinopathy of Prematurity - classification | Humans | Insulin-Like Growth Factor Binding Protein 3 - blood | Insulin-Like Growth Factor Binding Protein 3 - deficiency | Insulin-Like Growth Factor Binding Protein 3 - pharmacology | Retinal Neovascularization - metabolism | RNA, Messenger - metabolism | Retinopathy of Prematurity - physiopathology | Dose-Response Relationship, Drug | Retina - cytology | Hyperoxia - complications | Infant, Newborn | Disease Models, Animal | Retinopathy of Prematurity - etiology | Gene Expression Regulation | Mice, Transgenic | Gestational Age | Mice, Knockout | Animals | Infant, Premature | Retinal Neovascularization - chemically induced | Insulin-Like Growth Factor Binding Protein 1 - blood | Retinopathy of Prematurity - metabolism | Retinopathy of Prematurity - pathology | Angiogenesis inhibitors | Research | Retrolental fibroplasia | Binding proteins | Biological Sciences | like growth factor 1 | insulin | like growth factor binding protein | Premature | Disease Models | RNA | Transgenic | Retinal Neovascularization/chemically induced/metabolism | Infant | MEDICIN OCH HÄLSOVETENSKAP | Insulin-Like Growth Factor Binding Protein 1/blood | Prematurity/classification/etiology/metabolism/pathology/physiopathology | Hyperoxia/complications | MEDICAL AND HEALTH SCIENCES | Drug | Insulin-Like Growth Factor Binding Protein | Retinopathy of | Knockout | Messenger/metabolism | Retina/cytology | 3/blood/deficiency/genetics/pharmacology | Newborn | Animal | Dose-Response Relationship
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2. Full Text Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants
by Schmidt, Barbara, MD and Roberts, Robin S., MSc and Davis, Peter G., MD and Doyle, Lex W., MD and Asztalos, Elizabeth V., MD and Opie, Gillian, MD and Bairam, Aida, PhD and Solimano, Alfonso, MD and Arnon, Shmuel, MD and Sauve, Reginald S., MD and Caffeine Apnea Prematurity CAP Tr and Caffeine for Apnea of Prematurity CAP Trial Investigators and Caffeine for Apnea of Prematurity (CAP) Trial Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2015, Volume 167, Issue 5, pp. 982 - 986.e2
Objective To evaluate bronchopulmonary dysplasia (BPD), serious brain injury, and severe retinopathy of prematurity (ROP) as predictors of poor long-term... 
Pediatrics | PMA Postmenstrual age | ROP Retinopathy of prematurity | BPD Bronchopulmonary dysplasia | CAP Caffeine for Apnea of Prematurity | BRONCHOPULMONARY DYSPLASIA | IMPACT | APNEA | SEVERE RETINOPATHY | CAFFEINE THERAPY | PEDIATRICS | OUTCOMES | PREMATURITY | CHILDREN | Prognosis | Follow-Up Studies | Infant, Very Low Birth Weight | Oxygen - therapeutic use | Humans | Leukomalacia, Periventricular - mortality | Child, Preschool | Brain Injuries - complications | Male | Brain Injuries - mortality | Leukomalacia, Periventricular - complications | Echoencephalography | Retinopathy of Prematurity - complications | Female | Child Behavior Disorders - complications | Infant, Newborn | Treatment Outcome | Morbidity | Bronchopulmonary Dysplasia - complications | Cysts - complications | Bronchopulmonary Dysplasia - mortality | Cognition Disorders - complications | Retinopathy of Prematurity - mortality | Blindness - complications | Cerebral Ventricles - abnormalities | Deafness - complications | Infant, Premature | Cysts - mortality | Health Status | Disabled Persons | Brain | Infants | Injuries
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3. Retinopathy of Prematurity-Incidence Today
by Zin, Andrea and Gole, Glen A
Clinics in Perinatology, ISSN 0095-5108, 06/2013, Volume 40, Issue 2, pp. 185 - 200
Retinopathy of prematurity (ROP) in high-income countries now occurs, mostly in extreme low birth weight infants. In those countries, the incidence of ROP... 
Childhood blindness | Retinopathy of prematurity detection | Retinopathy of prematurity | Retinopathy of prematurity incidence | MORTALITY | RISK-FACTORS | LOW-BIRTH-WEIGHT | VISUAL IMPAIRMENT | OBSTETRICS & GYNECOLOGY | MORBIDITY | EXTREMELY PRETERM INFANTS | WEEKS GESTATION | PEDIATRICS | SCREENING CRITERIA | INDIA | Humans | Child, Preschool | Infant | Neonatal Screening - methods | Blindness - epidemiology | Retinopathy of Prematurity - epidemiology | Incidence | Pregnancy | Retinopathy of Prematurity - diagnosis | Infant, Low Birth Weight - physiology | Infant, Very Low Birth Weight - physiology | Infant, Premature | Retinopathy of Prematurity - complications | Female | Blindness - etiology | Child | Infant Mortality - trends | Infant, Newborn
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4. Full Text Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010
by Blencowe, Hannah and Lawn, Joy E and Vazquez, Thomas and Fielder, Alistair and Gilbert, Clare
Pediatric Research, ISSN 0031-3998, 12/2013, Volume 74, Issue 1, pp. 35 - 49
BACKGROUND: Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. We estimated ROP burden at the global... 
SYSTEMATIC ANALYSIS | MIDDLE-INCOME COUNTRIES | MULTICENTER TRIAL | AGE 6 YEARS | IMAGE-ANALYSIS | BIRTH-WEIGHT | RANDOMIZED-TRIAL | FOLLOW-UP | PEDIATRICS | NATURAL-HISTORY | SCREENING CRITERIA | History, 21st Century | Humans | Models, Statistical | Retinopathy of Prematurity - epidemiology | Premature Birth - epidemiology | Animals | Vision Disorders - history | Vision Disorders - prevention & control | Retinopathy of Prematurity - history | Retinopathy of Prematurity - complications | Global Health - statistics & numerical data | Retinopathy of Prematurity - prevention & control | Premature Birth - history | Vision Disorders - epidemiology | Infant, Newborn | Vision Disorders - etiology | Population Study
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5. Full Text Mechanisms and Management of Retinopathy of Prematurity
by Hartnett, M. Elizabeth and Penn, John S
The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 26, pp. 2515 - 2526
This article reviews retinopathy of prematurity, particularly regarding oxygen use, and describes current and potential therapies based on mechanistic studies... 
PROLIFERATIVE RETINOPATHY | CELL-DIVISION | MEDICINE, GENERAL & INTERNAL | NEONATAL-RAT | OXYGEN-INDUCED RETINOPATHY | MOUSE MODEL | EXTREMELY PRETERM INFANTS | PATHOLOGICAL RETINAL ANGIOGENESIS | PROLYL HYDROXYLASE INHIBITION | RAT MODEL | ENDOTHELIAL GROWTH-FACTOR | Retinopathy of Prematurity - etiology | Erythropoietin - therapeutic use | Infant, Very Low Birth Weight | Humans | Oxygen - adverse effects | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Retinopathy of Prematurity - physiopathology | Retinal Vessels - pathology | Retinopathy of Prematurity - diagnosis | Antioxidants - therapeutic use | Animals | Retinal Vessels - growth & development | Retinopathy of Prematurity - therapy | Infant, Premature | Models, Animal | Infant, Newborn | Infants (Newborn) | Care and treatment | Medical examination | Medical case management | Retrolental fibroplasia | Infants (Premature) | Causes of | Diagnosis | Health aspects | Methods | Index Medicus | Abridged Index Medicus
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6. Full Text Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP), A Randomized, Controlled Trial. I: Primary Outcomes
by The STOP-ROP Multicenter Study Group and STOP-ROP Multicenter Study Grp and The STOP-ROP Multicenter Study Group
Pediatrics, ISSN 0031-4005, 02/2000, Volume 105, Issue 2, pp. 295 - 310
Objective. To determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (ROP) to reduce the... 
Retinopathy of prematurity | Oxygen therapy | Prematurity | Neonatal outcomes | Oxygen toxicity | Bronchopulmonary dysplasia | Visual loss | prematurity | oxygen toxicity | neonatal outcomes | HYPOXEMIA | MODEL | bronchopulmonary dysplasia | visual loss | retinopathy of prematurity | oxygen therapy | RETROLENTAL FIBROPLASIA | INFANTS | PEDIATRICS | SEVERITY | ENDOTHELIAL GROWTH-FACTOR | Retinopathy of Prematurity - blood | Humans | Oximetry | Infant | Male | Disease Progression | Oxygen - blood | Oxygen Inhalation Therapy - adverse effects | Retinopathy of Prematurity - therapy | Retinopathy of Prematurity - complications | Female | Oxygen Inhalation Therapy - methods | Infant, Newborn | Fluorescein Angiography | Retinopathy of Prematurity - pathology | Evaluation | Care and treatment | Retrolental fibroplasia | Infants (Premature) | Babies | Pediatrics | Oxygen | Eyes & eyesight
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7. Full Text A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity
by Di Fiore, Juliann M., BSEE and Bloom, Jeffrey N., MD and Orge, Faruk, MD and Schutt, Alison, MD and Schluchter, Mark, PhD and Cheruvu, Vinay K., MSc, MS and Walsh, Michele, MD and Finer, Neil, MD and Martin, Richard J., MD
Journal of Pediatrics, The, ISSN 0022-3476, 2010, Volume 157, Issue 1, pp. 69 - 73
Objective Retinopathy of prematurity (ROP), a vasoproliferative disorder of the retina in preterm infants, is associated with multiple factors, including... 
Pediatrics | APNEA | BIRTH-WEIGHT INFANTS | CAFFEINE THERAPY | FLUCTUATIONS | PEDIATRICS | PRETERM INFANTS | ILLNESS SEVERITY | HYPEROXIA | CARBON-DIOXIDE | PULSE OXIMETER | RAT MODEL | Age Factors | Humans | Laser Therapy | Infant | Male | Retinopathy of Prematurity - epidemiology | Oxygen - metabolism | Retinopathy of Prematurity - physiopathology | Hypoxia - metabolism | Incidence | Hypoxia - epidemiology | Female | Ohio - epidemiology | Infant, Newborn | Severity of Illness Index | Risk Factors | Linear Models | Hypoxia - complications | Gestational Age | Retinopathy of Prematurity - diagnosis | Oxygen - administration & dosage | Infant, Premature | Sex Factors | Hypoxia - physiopathology | Retinopathy of Prematurity - surgery | Retrolental fibroplasia | Infants (Premature) | Physiological aspects | Ophthalmology | Universities and colleges | Vascular endothelial growth factor | Endothelium | Intermittent hypoxia | oxygen saturation | infant | retinopathy of prematurity
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8. Predicting the risk of preterm labor by second trimester measurement and a risk factor scoring system
by Tanha, Fatemeh Davari and Sardari, Fariba and Eftekhar, Zahra and Mahbod, Kaveh and Mood, Nargess Izady
Predicting the risk of preterm labor by second trimester measurement and a risk factor scoring system, 12/2005
Background: Preterm labor (delivery after 20 weeks and before 37 weeks of gestation) is the leading cause of prenatal mortality in developed countries. Many... 
α-fetoprotein, prematurity, preterm delivery
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9. Early Aggressive Parenteral Nutrition Induced High Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) Levels Can Prevent Risk of Retinopathy of Prematurity
by Can, Emrah and Bülbül, Ali and Uslu, Sinan and Bolat, Fatih and Cömert, Serdar and Nuhoğlu, Asiye
02/2014
Objective: To evaluate early aggressive vs. conservative nutrition and its effect on Retinopathy of Prematurity (ROP) in <32 weeks of gestation neonates.... 
Retinopathy of prematurity | Prematurity | IGFBP3 | Parenteral nutrition | IGF-1
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10. Full Text Neonatal Intensive Care Unit-based screening program for retinopathy of prematurity and its treatment in an Indian population
by Goyal, Anubhav and Giridhar, Ananthraman and Gopalakrishnan, Mahesh and Thachil, Thomas
Indian Journal of Ophthalmology, ISSN 0301-4738, 06/2019, Volume 67, Issue 6, pp. 828 - 833
The purpose was to study the incidence, risk factors, and anatomical outcomes after laser treatment in retinopathy of prematurity (ROP). A retrospective... 
low-risk prethreshold or type 2 retinopathy of prematurity | high-risk prethreshold or type 1 retinopathy of prematurity | Early treatment of retinopathy of prematurity | Neonatal Intensive Care Unit | International Classification of Retinopathy of Prematurity | Humans | Risk Factors | India - epidemiology | Male | Treatment Outcome | Neonatal Screening - methods | Retinopathy of Prematurity - epidemiology | Visual Acuity | Gestational Age | Incidence | Retinopathy of Prematurity - diagnosis | Intensive Care Units, Neonatal | Laser Coagulation - methods | Female | Retrospective Studies | Ophthalmoscopy - methods | Retinopathy of Prematurity - surgery | Infant, Newborn | Neonatal intensive care | Care and treatment | Diagnosis | Retrolental fibroplasia | Patient outcomes | Blood transfusions | Neonates | Multiple births | Intensive care | Oxygen | Retinopathy | Oxygen therapy | Risk groups | Septicemia | Retina | Infants | Risk factors | Gestational age | Developing countries--LDCs | Hospitals | Respiratory distress syndrome | Newborn babies | Lasers | Hemoglobin | Sepsis | Birth weight | Supplementation | Ophthalmology | Age | Original
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11. Full Text Refractive Outcomes Following Bevacizumab Monotherapy Compared With Conventional Laser Treatment: A Randomized Clinical Trial
by Geloneck, Megan M and Chuang, Alice Z and Clark, W. Lloyd and Hunt, Michael G and Norman, Alan A and Packwood, Eric A and Tawansy, Khaled A and Mintz-Hittner, Helen A and BEAT-ROP Cooperative Grp and BEAT-ROP Cooperative Group
JAMA Ophthalmology, ISSN 2168-6165, 11/2014, Volume 132, Issue 11, pp. 1327 - 1333
IMPORTANCE: Children born prematurely who develop retinopathy of prematurity (ROP) often develop myopia, and those who require laser treatment may develop very... 
THRESHOLD RETINOPATHY | EYE SIZE | CRYOTHERAPY | OPHTHALMOLOGY | HIGH MYOPIA | PRETERM INFANTS | INTRAVITREAL BEVACIZUMAB | OPTICAL-COMPONENTS | DIODE-LASER | PREMATURITY | CHILDREN | Prospective Studies | Follow-Up Studies | Intravitreal Injections | Humans | Child, Preschool | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Retinoscopy | Bevacizumab | Laser Coagulation - methods | Angiogenesis Inhibitors - therapeutic use | Myopia, Degenerative - etiology | Laser Coagulation - adverse effects | Refraction, Ocular - physiology | Angiogenesis Inhibitors - adverse effects | Visual Acuity - physiology | Infant, Extremely Low Birth Weight | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Gestational Age | Retinopathy of Prematurity - drug therapy | Retinopathy of Prematurity - therapy | Infant, Premature | Retinopathy of Prematurity - surgery | Myopia, Degenerative - diagnosis
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12. Full Text Untitled
by Mayor, R and Dave, P and Venkatesh, R and Singh, S and Agarwal, M and Paul, L and Gurav, P
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, ISSN 0275-004X, 12/2015, Volume 35, Issue 12, pp. E76 - E76
OPHTHALMOLOGY | PREMATURITY
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13. Full Text Propranolol increases vascular permeability through pericyte apoptosis and exacerbates oxygen-induced retinopathy
by Yun, Jang-Hyuk and Koh, Young Jun and Jeong, Han-Seok and Lee, Eun Hui and Lee, Da-Hye and Cho, Chung-Hyun
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 4, pp. 2792 - 2799
Retinopathy of prematurity (ROP) is an eye disease that causes blindness due to delayed vascular growth, retinal ischemia, and resulting abnormal angiogenesis.... 
Oxygen-induced ROP | Pericyte | Retinopathy of prematurity | Propranolol | Vascular permeability | DIABETIC-RETINOPATHY | CELLS | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | VEGF-A | INHIBITION | BIOPHYSICS | BLOCKADE | EXPRESSION | PREMATURITY | ENDOTHELIAL GROWTH-FACTOR | Human Umbilical Vein Endothelial Cells - metabolism | Pericytes - drug effects | Apoptosis - drug effects | Coculture Techniques | Humans | Pericytes - cytology | Capillary Permeability - drug effects | Apoptosis - genetics | Retinal Neovascularization - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Retinopathy of Prematurity - genetics | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Retinal Vessels - pathology | Propranolol - pharmacology | Human Umbilical Vein Endothelial Cells - cytology | Hyperoxia - metabolism | Retinal Neovascularization - genetics | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Tight Junctions - drug effects | Animals, Newborn | Tight Junctions - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Vasodilator Agents - pharmacology | Retinal Vessels - metabolism | Signal Transduction | Mice, Inbred C57BL | Pericytes - metabolism | Retinopathy of Prematurity - chemically induced | Gene Expression Regulation | Retinal Vessels - drug effects | Hyperoxia - chemically induced | Hyperoxia - pathology | Tight Junctions - ultrastructure | Oxygen - administration & dosage | Animals | Hyperoxia - genetics | Retinal Neovascularization - chemically induced | Mice | Retinopathy of Prematurity - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Retinal Neovascularization - pathology | Retinopathy of Prematurity - pathology | Medical colleges | Endothelial growth factors | Analysis | Blindness | Permeability | Apoptosis | Endothelium
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14. Full Text Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants
by Askie, Lisa M and Darlow, Brian A and Davis, Peter G and Finer, Neil and Stenson, Ben and Vento, Maximo and Whyte, Robin
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 04/2017, Volume 2017, Issue 4, p. CD011190
Background The use of supplemental oxygen in the care of extremely preterm infants has been common practice since the 1940s. Despite this, there is little... 
MEDICINE, GENERAL & INTERNAL | RETROLENTAL FIBROPLASIA | THERAPY | METAANALYSIS | SEVERE RETINOPATHY | LOW-BIRTH-WEIGHT | PREMATURE-INFANTS | BORN | PULSE OXIMETRY | OUTCOMES | RESUSCITATION | Retinopathy of Prematurity - etiology | Age Factors | Infant Mortality | Cerebral Palsy - epidemiology | Humans | Oximetry | Infant | Oxygen - adverse effects | Blindness - epidemiology | Retinopathy of Prematurity - epidemiology | Arteries | Oxygen - blood | Incidence | Randomized Controlled Trials as Topic | Enterocolitis, Necrotizing - epidemiology | Oxygen - administration & dosage | Enterocolitis, Necrotizing - etiology | Publication Bias | Selection Bias | Infant, Extremely Premature | Retinopathy of Prematurity - prevention & control | Software | Blindness - etiology | Infant, Newborn
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