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Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2009, Volume 13, Issue 9 B, pp. 3358 - 3369
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2000, Volume 97, Issue 4, pp. 1456 - 1460
The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced. The deduced amino acid sequences... 
Proteins | Hydrolysis | Enzymes | Biological Sciences | Transfection | Complementary DNA | Presenilins | Antibodies | HeLa cells | Protein precursors | Kinetics | Alzheimer's disease | Membrane aspartic proteases | ENDOPROTEOLYSIS | membrane aspartic proteases | GENE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | RELEASE | HUMAN-IMMUNODEFICIENCY-VIRUS
Journal Article
Autophagy, ISSN 1554-8627, 2019
PSEN2 (presenilin 2) is one of the 3 proteins that, when mutated, causes early onset familial Alzheimer disease (FAD) cases. In addition to its well-known role... 
RAB7 | calcium | Alzheimer disease | presenilin | ER-mitochondria tethering | ATP2A/SERCA | autophagosome-lysosome fusion
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2006, Volume 96, Issue 5, pp. 1423 - 1440
γ‐Secretase cleavage, mediated by a complex of presenilin, presenilin enhancer (Pen‐2), nicastrin, and Aph‐1, is the final proteolytic step in generating... 
γ‐secretase | Pen‐2 | zebrafish | Alzheimer's disease | presenilin | Pen-2 | Presenilin | Zebrafish | γ-secretase | BETA-PRECURSOR PROTEIN | APH-1 INTERACTS | GAMMA-SECRETASE COMPLEX | INTRAMEMBRANE PROTEOLYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | gamma-secretase | ROHON-BEARD NEURONS | TRANSMEMBRANE DOMAIN | TERMINAL FRAGMENT | GLYCOSYLATED NICASTRIN | NEUROSCIENCES | CELL-DEATH | IN-VIVO | Body Patterning - drug effects | Presenilin-2 | Receptors, Notch - metabolism | Gene Expression Regulation, Developmental - genetics | Apoptosis - genetics | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Membrane Proteins - deficiency | Membrane Proteins - physiology | Fish Proteins - physiology | Reverse Transcriptase Polymerase Chain Reaction - methods | Membrane Proteins - metabolism | Neurons - metabolism | Indoles | In Situ Hybridization - methods | Disease Models, Animal | Blotting, Western - methods | Oligonucleotides, Antisense - pharmacology | Fish Proteins - chemistry | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Gene Expression Regulation, Developmental - drug effects | Tumor Suppressor Protein p53 - metabolism | In Situ Nick-End Labeling - methods | Alzheimer Disease | Immunohistochemistry - methods | Blotting, Northern | Fish Proteins - deficiency | Zebrafish Proteins - deficiency | Animals | Cell Count - methods | Membrane Proteins - chemistry | Embryo, Nonmammalian | Tumor Suppressor Protein p53 - chemistry | Body Patterning - genetics | Neurons | Apoptosis | Proteins | Neurology | Fish | Alzheimers disease | Developmental | Immunohistochemistry | Disease Models | Embryo | RNA | methods | Cell Count | Oligonucleotides | Antisense | Blotting | Western | Receptors | genetics | In Situ Hybridization | Genetically Modified | Nonmammalian | Northern | Body Patterning | diagnostic use | pharmacology | Psykiatri | Drug | chemistry | In Situ Nick-End Labeling | Gene Expression Regulation | Notch | Zebrafish Proteins | physiology | drug effects | Fish Proteins | Messenger | Reverse Transcriptase Polymerase Chain Reaction | Membrane Proteins | Tumor Suppressor Protein p53 | deficiency | Animal | Dose-Response Relationship | metabolism | Psychiatry
Journal Article
Journal Article
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 12/2018, Volume 66, Issue 4, pp. 1323 - 1339
PRESENILIN 1 (PSEN1) and PRESENILIN 2 (PSEN2) genes are loci for mutations causing familial Alzheimer’s disease (fAD). However, the function of these genes and... 
Pathogenesis | Genes | Innate immunity | Immunity | Autophagy | Loci | Proteins | Mitochondria | Presenilin 2 | Presenilin 1 | Physiology | Mutation | Alzheimer's disease | Secretase | Phagocytosis
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2016, Volume 20, Issue 9, pp. 1686 - 1695
Journal Article
Journal Article