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Journal of Experimental Medicine, ISSN 0022-1007, 11/2008, Volume 205, Issue 12, pp. 2781 - 2789
Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid beta-protein (A beta), the central component of... 
BACE1 | MEDICINE, RESEARCH & EXPERIMENTAL | NOTCH LIGANDS | GLYCOGEN-SYNTHASE KINASE-3 | PRESENILIN/GAMMA-SECRETASE | GAMMA-SECRETASE CLEAVAGE | GENERATION | PRECURSOR PROTEIN | RELEASE | IMMUNOLOGY | MISSENSE MUTATIONS | INTRACELLULAR DOMAIN
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 10/2017, Volume 177, Issue 4, pp. 895 - 896
Linked Article: Frew et al. Br J Dermatol 2017; 177:987–998. 
GENE-MUTATIONS | PRESENILIN/GAMMA-SECRETASE | NICASTRIN | ASSOCIATION | ACNE INVERSA | DERMATOLOGY | Hidradenitis Suppurativa | Humans
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 5, pp. E509 - E518
Journal Article
Biophysical Journal, ISSN 0006-3495, 03/2015, Volume 108, Issue 5, pp. 1229 - 1237
Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases... 
LIPIDOMICS | CELLS | COMPLEX | BIOPHYSICS | PATHWAY | MEMBRANE | MODULATORS | PRESENILIN/GAMMA-SECRETASE | FAMILIAL ALZHEIMERS-DISEASE | MUTATIONS | INHIBITOR | Amyloid Precursor Protein Secretases - metabolism | Proteolysis | Amyloid beta-Protein Precursor - chemistry | Humans | HEK293 Cells | Kinetics | Intracellular Membranes - chemistry | Proteins and Nucleic Acids
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 37, pp. 13349 - 13354
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 09/2019, Volume 20, Issue 17, p. 4180
L1 cell adhesion molecule (L1CAM) is a glycoprotein involved in cancer development and is associated with metastases and poor prognosis. Cellular processing of... 
IMMUNOGLOBULIN SUPERFAMILY | OVARIAN-CARCINOMA CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESENILIN/GAMMA-SECRETASE | tumor biology | HUMAN L1CAM | L1CAM | systematic review | biomarker | CHEMISTRY, MULTIDISCIPLINARY | oncogenic signaling | SOLUBLE FORM | cell adhesion | MOUSE MODEL | GENE-EXPRESSION | TUMOR-GROWTH | BINDING | L1-CAM
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2019, Volume 856, p. 172415
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 4, pp. 2762 - 2773
Neurexins (NRXNs) are synaptic cell adhesion molecules having essential roles in the assembly and maturation of synapses into fully functional units.... 
BACE1 | NEUROLIGIN | NEURITE OUTGROWTH | SYNAPSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRESENILIN/GAMMA-SECRETASE | RECEPTOR | NECROSIS-FACTOR-ALPHA | MEDIATED CLEAVAGE | AMYLOID PRECURSOR PROTEIN | MUTATIONS | Membrane Proteins | ADAM ADAMTS | Neurexin | Membrane Enzymes | Secretases | Alzheimer disease | Neurobiology | Metalloprotease | TACE | Microsomes | Synapses
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 3716 - 14
Normal brain development depends on tight temporal and spatial regulation of connections between cells. Mutations in L1cam, a member of the immunoglobulin (Ig)... 
ECTODOMAIN CLEAVAGE | DOMAIN | MOLECULE | AXON INTERACTIONS | MULTIDISCIPLINARY SCIENCES | GROWTH | PRESENILIN/GAMMA-SECRETASE | NEURAL-CELL-ADHESION | MEDIATED RELEASE | CRASH SYNDROME | Immunoglobulins | b-Site APP cleaving enzyme 1 | Hydrocephalus | Axonogenesis | Proteinase | Spasticity | Nervous system | Cell surface | Corpus callosum | Fibronectin | Myelination | Aplasia | Proteolysis | Ventricle
Journal Article