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Biochemical Journal, ISSN 0264-6021, 06/2009, Volume 420, Issue 3, pp. 391 - 402
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role ill the progression of human carcinoma. Overexpression promotes tumour-cell... 
Presenilin (PS)/γ-secretase activity | Raft | Nuclear translocation | Signalling | L1 cell-adhesion molecule (L1-CAM) | A disintegrin and metalloprotease 10 (ADAM10) | MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | raft | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | presenilin (PS)/gamma-secretase activity | nuclear translocation | a disintegrin and metalloprotease 10 (ADAM10) | COLORECTAL-CANCER | LIPID RAFTS | GENE-EXPRESSION | L1 ADHESION MOLECULE | GAMMA-SECRETASE | BINDING | signalling | INTRACELLULAR DOMAIN | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Cricetulus | Membrane Microdomains - metabolism | Humans | Neural Cell Adhesion Molecule L1 - genetics | Ovarian Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Ovarian Neoplasms - genetics | Cell Nucleus - metabolism | Flow Cytometry | Transfection | Presenilins - metabolism | Presenilins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Active Transport, Cell Nucleus | Neural Cell Adhesion Molecule L1 - metabolism | CHO Cells | Cell Line | Cricetinae | Lysosome-Associated Membrane Glycoproteins - metabolism | Signal Transduction | Membrane Proteins - genetics | ADAM10 Protein | Binding Sites - genetics | Reverse Transcriptase Polymerase Chain Reaction | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell Line, Tumor | ADAM Proteins - genetics | Microscopy, Fluorescence | Index Medicus | mAb, monoclonal antibody | CRABPII, cellular retinoic acid-binding protein II | LAMP-1, lysosomal-associated membrane protein 1 | pAb, polyclonal antibody | MT1-MMP, membrane type-1 matrix metalloproteinase | hL1, human L1 | TAPI-0, N-(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide | DRM, detergent-resistant membrane | ECL®, enhanced chemiluminescence | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | L1cyt, the cytoplasmic part of L1 | L1, L1 cell-adhesion molecule | qRT-PCR, quantitative real-time PCR | FNIII, fibronectin III | MDK, midkine or neurite growth-promoting factor 2 | ADAM, a disintegrin and metalloprotease | TACE, tumour-necrosis factor-α converting enzyme | FCS, fetal-calf serum | DAPT, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester (also known as presenilin inhibitor IX) | presenilin (PS) | ICD, intracellular domain | γ-secretase activity | siRNA, small interfering RNA | CTF, C-terminal fragment | CHO, Chinese-hamster ovary | HEK-293, human embryonic kidney-293 | PS, presenilin(-1) | APP, amyloid precursor protein | RIP, regulated intramembrane proteolysis
Journal Article
Journal Article
Journal Article
Journal Article
Genetics, ISSN 0016-6731, 07/2017, Volume 206, Issue 3, pp. 1479 - 1493
Mutations in the Presenilin genes are the major genetic cause of Alzheimer's disease. Presenilin and Nicastrin are essential components of gamma-secretase, a... 
Conditional knockdown | Brain | Alzheimer’s disease | γ-secretase | shRNA | CALCIUM HOMEOSTASIS | gamma-secretase | NICASTRIN | NOTCH | NEURODEGENERATION | brain | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | TRANSGENIC DROSOPHILA | conditional knockdown | GENETICS & HEREDITY | FAMILIAL ALZHEIMERS-DISEASE | GAMMA-SECRETASE ACTIVITY | MUTATIONS | Alzheimer's disease | Amyloid Precursor Protein Secretases - genetics | Brain - cytology | Membrane Glycoproteins - metabolism | Neurons - cytology | Brain - growth & development | Codon, Nonsense | Drosophila Proteins - metabolism | Membrane Glycoproteins - genetics | Brain - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Aging - genetics | Presenilins - metabolism | Presenilins - genetics | Drosophila - growth & development | Neurons - metabolism | Drosophila - metabolism | Drosophila Proteins - genetics | Apoptosis | Drosophila - genetics | Evolution, Molecular | Genetic aspects | Research | Presenilins | Drosophila | Climbing | Forebrain | Presenilin | Lethality | mRNA | Inactivation | Defects | Eye | Proteins | Signal transduction | Tubulin | Neurodegeneration | Rodents | Aging | Age | Cell survival | Deactivation | Neurodegenerative diseases | Neurons | Mortality | Mutants | Membrane proteins | Studies | Nicastrin | Life span | Insects | Mutation | Alzheimers disease | Secretase | Parasympathetic nervous system | Index Medicus | Investigations
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 25, pp. 8566 - 8580
Journal Article
Cell, ISSN 0092-8674, 06/2016, Volume 166, Issue 1, pp. 193 - 208
Journal Article
Genetics, ISSN 0016-6731, 02/2018, Volume 208, Issue 2, pp. 745 - 762
Journal Article
Journal Article