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index medicus (496) 496
biochemistry & molecular biology (390) 390
presequence (252) 252
mitochondria - metabolism (223) 223
molecular sequence data (218) 218
amino acid sequence (217) 217
mitochondria (211) 211
cell biology (189) 189
animals (169) 169
proteins (148) 148
presequence translocase (142) 142
protein import (128) 128
protein transport (126) 126
humans (122) 122
inner membrane (121) 121
yeast mitochondria (102) 102
biophysics (101) 101
import (95) 95
protein precursors - metabolism (95) 95
saccharomyces cerevisiae - metabolism (88) 88
saccharomyces-cerevisiae (88) 88
translocation (85) 85
mitochondrial proteins - metabolism (83) 83
outer-membrane (83) 83
saccharomyces cerevisiae proteins - metabolism (83) 83
intermembrane space (78) 78
plant sciences (75) 75
base sequence (71) 71
biological transport (71) 71
membrane proteins - metabolism (70) 70
protein binding (70) 70
mitochondrial dna (69) 69
precursor proteins (67) 67
membrane transport proteins - metabolism (66) 66
preprotein translocase (65) 65
complex (63) 63
mitochondrial membrane transport proteins - metabolism (63) 63
mitochondrial membranes - metabolism (63) 63
physiological aspects (56) 56
peptides (55) 55
mitochondria - enzymology (54) 54
sequence homology, amino acid (51) 51
intracellular membranes - metabolism (50) 50
saccharomyces cerevisiae - genetics (49) 49
protein conformation (47) 47
rats (47) 47
research (47) 47
saccharomyces cerevisiae proteins - genetics (47) 47
models, molecular (46) 46
cloning, molecular (45) 45
recombinant fusion proteins - metabolism (45) 45
presequences (43) 43
protein processing, post-translational (43) 43
carrier proteins - metabolism (42) 42
mitochondrial presequence (42) 42
models, biological (42) 42
mutation (41) 41
protein structure, secondary (41) 41
protein translocation (41) 41
yeast (41) 41
precursor (40) 40
transport (40) 40
analysis (39) 39
membranes (39) 39
molecular biology (39) 39
saccharomyces cerevisiae proteins - chemistry (39) 39
identification (38) 38
kinetics (38) 38
sequence alignment (38) 38
mitochondrial membrane transport proteins (37) 37
mitochondrial membrane transport proteins - chemistry (37) 37
mitochondrial protein import (36) 36
saccharomyces cerevisiae (36) 36
protein structure, tertiary (35) 35
recognition (35) 35
protein folding (34) 34
tim50 (34) 34
protein precursors - genetics (33) 33
protein transport - physiology (33) 33
cytosol - metabolism (32) 32
escherichia-coli (32) 32
membrane proteins - genetics (32) 32
processing peptidase (32) 32
article (31) 31
binding (31) 31
life sciences (31) 31
protein precursors - chemistry (31) 31
chloroplasts (30) 30
genes (30) 30
genetics & heredity (30) 30
membrane (30) 30
plant proteins - metabolism (30) 30
channel (29) 29
hsp70 (29) 29
mice (29) 29
mitochondrial proteins - chemistry (29) 29
mitochondrial proteins - genetics (29) 29
protein (29) 29
receptor (29) 29
amino acids (28) 28
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Journal Article
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 08/2016, Volume 214, Issue 4, pp. 417 - 431
Tim17 is a central, membrane-embedded subunit of the mitochondrial protein import machinery. In this study, we show that Tim17 contains a pair of highly... 
CYTOCHROME-C | INNER MEMBRANE | PRESEQUENCE TRANSLOCASE | CHANNEL | BIOGENESIS | MACHINERY | IDENTIFICATION | INTERMEMBRANE SPACE | MIA40 | PREPROTEINS | CELL BIOLOGY
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2004, Volume 336, Issue 5, pp. 1129 - 1140
We have isolated, characterized and determined the three-dimensional NMR solution structure of the presequence of ATPsynthase F β subunit from Nicotiana... 
Presequence | Mitochondria | NMR | SDS | Structure
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 2012 - 10
Maintenance of the mitochondrial proteome depends on import of newly made proteins from the cytosol. More than half of mitochondrial proteins are made as... 
IMPORT | DOMAIN | OUTER-MEMBRANE PROTEIN | CHANNEL | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL PRESEQUENCE TRANSLOCASE | Proteins | Mitochondria | Mutagenesis | Protein transport | Cytosol | Random mutagenesis
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2011, Volume 30, Issue 13, pp. 2545 - 2556
m ‐AAA proteases exert dual functions in the mitochondrial inner membrane: they mediate the processing of specific regulatory proteins and ensure protein... 
AAA protease | presequence‐assisted folding | mitochondria | oxidative stress | ribosome biogenesis | presequence-assisted folding | COMPLEX | INNER MEMBRANE | HEREDITARY SPASTIC PARAPLEGIA | RIBOSOMAL-PROTEINS MRPS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | STATIONARY-PHASE | YEAST MITOCHONDRIA | DEGRADATION | SUBUNIT | Metalloendopeptidases - genetics | Ribosomal Proteins - chemistry | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Metalloendopeptidases - metabolism | Protein Transport - physiology | Deinococcus - metabolism | Ribosomal Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Sequence Analysis, Protein | Deinococcus - enzymology | Organisms, Genetically Modified | Ribosomal Proteins - genetics | Catalytic Domain - genetics | Models, Molecular | Amino Acid Sequence - physiology | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | Protein Transport - genetics | Sequence Homology, Amino Acid | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Metalloendopeptidases - physiology | Protein Processing, Post-Translational | Mitochondria - physiology | Protein Binding - physiology | Saccharomyces cerevisiae Proteins - chemistry | Oxidative stress | Mitochondria | Membranes | Cellular biology | Molecular biology | Proteases | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2018, Volume 29, Issue 7, pp. 776 - 785
Mitochondria are the powerhouses of eukaryotic cells. The activity of the respiratory chain complexes generates a proton gradient across the inner membrane,... 
CYTOCHROME-C-OXIDASE | YEAST MITOCHONDRIA | FRATAXIN | TRANSLATIONAL REGULATION | PRESEQUENCE TRANSLOCASE | INNER MEMBRANE | BIOGENESIS | SACCHAROMYCES-CEREVISIAE | PROTEIN-SYNTHESIS | SCAFFOLD | CELL BIOLOGY
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 03/2015, Volume 427, Issue 5, pp. 1075 - 1084
Translocation of the majority of mitochondrial proteins from the cytosol into mitochondria requires the cooperation of TOM and TIM23 complexes in the outer and... 
OUTER-MEMBRANE | DOMAIN | PRESEQUENCE TRANSLOCASE | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLOCATION CONTACT SITES | protein sorting | protein translocation | IMPORT | TIM50 | ELEMENTS | MOTOR | TIM23 | PREPROTEIN TRANSLOCASE | INNER
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 03/2012, Volume 37, Issue 3, pp. 85 - 91
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 11, pp. 4000 - 4011
Mitochondria are attractive therapeutic targets for developing agents to delay age-related frailty and diseases. However, few promising leads have been... 
TRANSLOCATION | PRESEQUENCE | ANTIOXIDANTS | MECHANISM | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN IMPORT | peptides | NEUTROPHIL ELASTASE | ALPHA-AMYLASE INHIBITORS | LIVER ALDEHYDE DEHYDROGENASE | CYCLOTIDES | bioenergetics | peptide chemical synthesis | peptide interaction | cell-penetrating peptide (CPP) | PENETRATING PEPTIDES | Index Medicus
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2018, Volume 9, Issue 1, pp. 4028 - 4028
The presequence translocase of the mitochondrial inner membrane (TIM23 complex) facilitates anterograde precursor transport into the matrix and lateral release... 
MATRIX | COMPLEX | INSERTION | PRESEQUENCE TRANSLOCASE | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL PROTEIN IMPORT | CHLOROPLASTS | COMPONENTS | RECEPTOR | MECHANISMS | PREPROTEINS | Yeasts | Membrane Transport Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mitochondrial Membranes - metabolism | Index Medicus
Journal Article