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PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74225
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine and human... 
II MICE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | C57BL/6 MICE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | T-CELL | INDUCTION | IL-23 | IL-12 | TH17 CELLS | Autoimmunity | Liver - pathology | Humans | Th1-Th2 Balance | Interleukin-17 - immunology | Cholangitis - immunology | Liver Cirrhosis, Biliary - chemically induced | Mitochondria - immunology | Autoantibodies - biosynthesis | Immunoconjugates - administration & dosage | Fatty Acids, Monounsaturated - immunology | Immunoconjugates - immunology | Interleukins - genetics | Signal Transduction - immunology | Liver - immunology | Liver Cirrhosis, Biliary - immunology | Interleukin-23 Subunit p19 - genetics | Interleukins - immunology | Fatty Acids, Monounsaturated - chemistry | Serum Albumin, Bovine - chemistry | Interleukin-12 Subunit p35 - deficiency | Interferon-gamma - genetics | Interferon-gamma - deficiency | Cholangitis - pathology | Disease Models, Animal | Interleukin-23 Subunit p19 - deficiency | Cholangitis - chemically induced | Cholangitis - genetics | Serum Albumin, Bovine - immunology | Liver - metabolism | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-12 Subunit p35 - genetics | Interleukin-17 - deficiency | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Biliary - genetics | Mice, Knockout | Animals | Interleukin-12 Subunit p35 - immunology | Interferon-gamma - immunology | Interleukins - deficiency | Mice | Interleukin-23 Subunit p19 - immunology | Autoantibodies | Cytokines | Analysis | Biliary cirrhosis | B cells | T cells | Health aspects | Primary biliary cirrhosis | Pathogenesis | Liver | Helper cells | Interleukin 22 | Interleukin 23 | Lymphocytes T | Arthritis | Structure-activity relationships | Signal transduction | Mitochondria | Immunology | Pathways | Clonal deletion | Lymphocytes | Rodents | Deletion | Immunization | Rheumatology | Cholangitis | Interleukin 12 | Inflammation | Medicine | Cirrhosis | Signaling | Tuberculosis | Hepatocytes | γ-Interferon | Interferon | Autoimmune diseases
Journal Article
Journal Article
Journal Article
Expert Review of Clinical Pharmacology, ISSN 1751-2433, 01/2016, Volume 9, Issue 1, pp. 13 - 26
Primary biliary cirrhosis (PBC) is characterized by progressive nonsuppurative destruction of small bile ducts, resulting in intrahepatic cholestasis, fibrosis... 
obeticholic acid | ursodeoxycholic acid | autoimmune disease | cholangitis | primary biliary cirrhosis | AUTOIMMUNE LIVER-DISEASE | BILE-ACID | SALT EXPORT PUMP | BIOCHEMICAL RESPONSE | URSODEOXYCHOLIC-ACID | HEPATIC STELLATE CELLS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR 15 | SPONTANEOUS HEPATOCARCINOGENESIS | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2008, Volume 49, Issue 6, pp. 1038 - 1045
Background/Aims In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the... 
Gastroenterology and Hepatology | Primary biliary cirrhosis (PBC) | Ursodeoxycholic acid (UDCA) | Tumor necrosis factor α (TNFα) | Cytotoxic T-lymphocyte antigen 4 (CTLA-4) | Anion exchanger 2 (AE2)/SLC4A2 | Multidrug resistance 1 (MDR1)/ABCB1 | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ANION-EXCHANGER | ALLELES | Tumor necrosis factor alpha (TNF alpha); Anion exchanger 2 (AE2)/SLC4A2 | LIVER-DISEASE | P-GLYCOPROTEIN | AUTOIMMUNITY | CTLA-4 | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | SINGLE NUCLEOTIDE POLYMORPHISMS | PRIMARY SCLEROSING CHOLANGITIS | Genetic Testing | Prognosis | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Male | Antigens, CD - genetics | SLC4A Proteins | Case-Control Studies | Liver Cirrhosis, Biliary - immunology | Liver X Receptors | Antiporters - genetics | Chloride-Bicarbonate Antiporters | Adult | Female | Orphan Nuclear Receptors | France | Severity of Illness Index | Genetic Predisposition to Disease | Kaplan-Meier Estimate | Proportional Hazards Models | Receptors, Cytoplasmic and Nuclear - genetics | DNA-Binding Proteins - genetics | Liver Cirrhosis, Biliary - genetics | CTLA-4 Antigen | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | ATP Binding Cassette Transporter, Sub-Family B | Aged | Polymorphism, Single Nucleotide | Anion Transport Proteins - genetics | Antigens | Anion exchangers (Biology) | Genetic research | Ursodiol | Cystic fibrosis | Genetic aspects | Disease susceptibility | Biliary cirrhosis | Universities and colleges | Tumors
Journal Article
by K Belk and CW Craver
Value in Health : The Journal of the International Society for Pharmacoeconomics and Outcomes Research, ISSN 1098-3015, 05/2017, Volume 20, Issue 5, p. A378
Journal Article
World Journal of Hepatology, ISSN 1948-5182, 2015, Volume 7, Issue 7, pp. 926 - 941
Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver disease characterized by a triad of chronic cholestasis, circulating... 
Cirrhosis | Primary biliary cirrhosis | Cholestatic liver disease | Liver transplantation | Ursodeoxycholic acid | Review
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 1, pp. 133 - 140
Background & Aims Ursodeoxycholic acid (UDCA) exerts anticholestatic, antifibrotic and antiproliferative effects in primary biliary cirrhosis (PBC) via... 
Gastroenterology and Hepatology | Drug transport | Clinical trial | Biotransformation | Cholestasis | Bile | ULCERATIVE-COLITIS | HUMANS | HCO3-UMBRELLA | BIOCHEMICAL RESPONSE | P-GLYCOPROTEIN | CYTOCHROME-P450 3A | METABOLISM | LIVER | GASTROENTEROLOGY & HEPATOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Ursodeoxycholic Acid - administration & dosage | Intestinal Mucosa - metabolism | Bile Acids and Salts - blood | Cholestasis - metabolism | Humans | Middle Aged | Gene Expression Profiling | Ursodeoxycholic Acid - blood | Cytochrome P-450 CYP3A - genetics | Biliary Tract - metabolism | Duodenum - metabolism | Adult | Female | Cholestasis - drug therapy | Glycine - blood | Ursodeoxycholic Acid - pharmacokinetics | Cholagogues and Choleretics - administration & dosage | Inactivation, Metabolic - physiology | Liver Cirrhosis, Biliary - drug therapy | Cholagogues and Choleretics - blood | Taurine - blood | Carrier Proteins - genetics | Cholagogues and Choleretics - pharmacokinetics | Carrier Proteins - metabolism | Cytochrome P-450 CYP3A - metabolism | Biliary Tract - drug effects | Liver Cirrhosis, Biliary - metabolism | Duodenum - drug effects | Drug resistance in microorganisms | Medical colleges | Bile acids | Detoxification (Substance abuse treatment) | Cytochrome P-450 | Ursodiol | Cystic fibrosis | Calcifediol | Biliary cirrhosis | Sulfates | Drug resistance | Machinery | Deoxycholic acid | Magneto-electric machines | Vitamin D | Alfacalcidol
Journal Article