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1. Full Text Cilia Organize Ependymal Planar Polarity
by Mirzadeh, Zaman and Han, Young-Goo and Soriano-Navarro, Mario and Garcia-Verdugo, Jose Manuel and Alvarez-Buylla, Arturo
Journal of Neuroscience, ISSN 0270-6474, 02/2010, Volume 30, Issue 7, pp. 2600 - 2610
Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain. Most ependymal cells are born prenatally and are derived from... 
ADULT BRAIN | GENE | HYDROCEPHALUS | BASAL BODIES | ORIENTATION | MICE | CEREBROSPINAL-FLUID | RADIAL GLIA | NEUROSCIENCES | CELL POLARITY | CHLAMYDOMONAS | Cilia - physiology | Nestin | Actins - metabolism | Mice, Transgenic | Green Fluorescent Proteins - genetics | Lateral Ventricles - cytology | Microscopy, Confocal - methods | Nerve Tissue Proteins - genetics | Kinesin - metabolism | Epithelial Cells - physiology | Tubulin - metabolism | Animals | Microscopy, Electron - methods | Ependyma - cytology | Intermediate Filament Proteins - genetics | Cilia - ultrastructure | Cell Polarity - physiology | Mice | In Vitro Techniques | Index Medicus | basal body | ependymal cell | radial glia | planar cell polarity | hydrocephalus | primary cilia
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2. Full Text Osteoarthritis-like changes in Bardet-Biedl syndrome mutant ciliopathy mice (Bbs1M390R/M390R): Evidence for a role of Primary Cilia in cartilage homeostasis and regulation of inflammation
by Sheffield, Isaac D and McGee, Mercedes A and Glenn, Steven J and Baek, Da Young and Coleman, Joshua M and Dorius, Bradley K and Williams, Channing and Rose, Brandon J and Sanchez, Anthony E and Goodman, Michael A and Daines, John M and Eggett, Dennis L and Sheffield, Val C and Suli, Arminda and Kooyman, David L
Frontiers in Physiology, ISSN 1664-042X, 06/2018, Volume 9, pp. 708 - 708
Osteoarthritis (OA) is a debilitating inflammation related disease characterized by joint pain and effusion, loss of mobility, and deformity that may result in... 
Bbs | Bardet-Biedl syndrome | Inflammation | Primary cilia | Osteoarthritis | RHEUMATOID-ARTHRITIS | PHYSIOLOGY | osteoarthritis | primary cilia | PREMATURE OSTEOARTHRITIS | MAJOR ROLE | IDENTIFICATION | inflammation | ARTICULAR-CARTILAGE | DISCOIDIN DOMAIN RECEPTOR | SINGLE CILIA | SERINE-PROTEASE | GENE ACTIVATION | METALLOPROTEINASE 13 EXPRESSION | Health aspects | Risk factors | Bardet–Biedl syndrome
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3. Full Text Cilia-Associated Oxysterols Activate Smoothened
by Raleigh, David R and Sever, Navdar and Choksi, Pervinder K and Sigg, Monika Abedin and Hines, Kelly M and Thompson, Bonne M and Elnatan, Daniel and Jaishankar, Priyadarshini and Bisignano, Paola and Garcia-Gonzalo, Francesc R and Krup, Alexis Leigh and Eberl, Markus and Byrne, Eamon F.X and Siebold, Christian and Wong, Sunny Y and Renslo, Adam R and Grabe, Michael and McDonald, Jeffrey G and Xu, Libin and Beachy, Philip A and Reiter, Jeremy F
Molecular Cell, ISSN 1097-2765, 10/2018, Volume 72, Issue 2, pp. 316 - 327.e5
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely... 
CBP | HSD11β2 | oxysterol | Hedgehog | primary cilium | Smoothened | sterol | medulloblastoma | cilia | lipid | OXIDATION | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | 7-DEHYDROCHOLESTEROL | TRAFFICKING | CYCLOPAMINE | PROTEINS | BINDING | LEMLI-OPITZ SYNDROME | HEDGEHOG | MODULATION | CELL BIOLOGY | Physiological aspects | Medical colleges | Lipids | Gliomas | Index Medicus
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4. Full Text Primary Cilia‐Mediated Mechanotransduction in Human Mesenchymal Stem Cells
by Hoey, David A and Tormey, Shane and Ramcharan, Stacy and O'Brien, Fergal J and Jacobs, Christopher R
STEM CELLS, ISSN 1066-5099, 11/2012, Volume 30, Issue 11, pp. 2561 - 2570
Physical loading is a potent stimulus required to maintain bone homeostasis, partly through the renewal and osteogenic differentiation of mesenchymal stem... 
Human mesenchymal stem cell | Primary cilium | Mechanotransduction | Proliferation | Osteogenic Differentiation | Fluid flow | Osteogenic differentiation | FLOW PERFUSION CULTURE | OSTEOBLAST DIFFERENTIATION | FLUID SHEAR-STRESS | BONE-MARROW | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | INDUCED PROLIFERATION | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | NITRIC-OXIDE | HEMATOLOGY | MARROW STROMAL CELLS | Cilia - physiology | RNA, Small Interfering - genetics | Tumor Suppressor Proteins - metabolism | Cell Proliferation | Humans | Cells, Cultured | Stress, Physiological | Hedgehog Proteins - metabolism | Bone Regeneration | Gene Knockdown Techniques | Mechanotransduction, Cellular | Biomechanical Phenomena | Microtubules - metabolism | Mesenchymal Stromal Cells - ultrastructure | Tumor Suppressor Proteins - genetics | Centrioles - metabolism | Mesenchymal Stromal Cells - physiology | Osteogenesis - genetics | Medical societies | Genes | Information management | Gene expression | Mechanical engineering | Financial disclosure | Stem cell research | Osteoporosis | Analysis | Stem cells | Research institutes | Kidney diseases | Biomedical engineering | Index Medicus | Tissue-Specific Stem Cells
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5. Full Text The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality
by Boskovski, Marko T and Yuan, Shiaulou and Pedersen, Nis Borbye and Goth, Christoffer Knak and Makova, Svetlana and Clausen, Henrik and Brueckner, Martina and Khokha, Mustafa K
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 456 - 459
Heterotaxy is a disorder of left-right body patterning, or laterality, that is associated with major congenital heart disease(1). The aetiology and mechanisms... 
PROTEIN | FLUID-FLOW | NODE | MULTIDISCIPLINARY SCIENCES | CONGENITAL HEART-DISEASE | O-GLYCOSYLATION | MOUSE | LEFT-RIGHT AXIS | XENOPUS EMBRYOS | LEFT-RIGHT ASYMMETRY | LEFTWARD FLOW | ADAM17 Protein | Cilia - physiology | Heterotaxy Syndrome - genetics | Xenopus Proteins - genetics | Xenopus - genetics | Humans | Embryo, Nonmammalian - metabolism | Receptor, Notch1 - chemistry | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Xenopus - embryology | Receptor, Notch1 - deficiency | N-Acetylgalactosaminyltransferases - genetics | Body Patterning | N-Acetylgalactosaminyltransferases - metabolism | Amino Acid Sequence | N-Acetylgalactosaminyltransferases - deficiency | Peptide Fragments - metabolism | Signal Transduction | Glycosylation | Receptor, Notch1 - metabolism | Cilia - metabolism | ADAM Proteins - metabolism | Peptide Fragments - chemistry | Animals | Xenopus Proteins - deficiency | Xenopus Proteins - metabolism | Mice | Receptor, Notch1 - genetics | Genotype & phenotype | Fourier transforms | Peptides | Microscopy | Ligands | Gene expression | Defects | Index Medicus | live imaging | primary cilium | left-right patterning | gastrocoel roof plate | congenital heart disease | O-glycosylation | motility | mouse node | mechanosensation | GalNAcT11 | Xenopus tropicalis
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6. Full Text Phosphorylation‐dependent Akt–Inversin interaction at the basal body of primary cilia
by Suizu, Futoshi and Hirata, Noriyuki and Kimura, Kohki and Edamura, Tatsuma and Tanaka, Tsutomu and Ishigaki, Satoko and Donia, Thoria and Noguchi, Hiroko and Iwanaga, Toshihiko and Noguchi, Masayuki
The EMBO Journal, ISSN 0261-4189, 06/2016, Volume 35, Issue 12, pp. 1346 - 1363
A primary cilium is a microtubule‐based sensory organelle that plays an important role in human development and disease. However, regulation of Akt in cilia... 
Inversin | Akt | signal transduction | primary cilia | INVS | INFANTILE NEPHRONOPHTHISIS | SIGNALING PATHWAYS | RENAL CYSTS | PROTEIN | CILIOPATHIES | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL POLARITY | CELL BIOLOGY | GENE | RIGHT DETERMINANT INVERSIN | Cell Line | Phosphorylation | Humans | Transcription Factors - genetics | Basal Bodies - metabolism | Cilia - metabolism | Protein Interaction Mapping | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | DNA Mutational Analysis | Mice | Protein Processing, Post-Translational | Proto-Oncogene Proteins c-akt - metabolism | Cell division | Amino acids | Cell growth | Kinases | Index Medicus | Cell Adhesion, Polarity & Cytoskeleton | Molecular Biology of Disease
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7. Full Text In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations
by Shimada, Hiroko and Lu, Quanlong and Insinna-Kettenhofen, Christine and Nagashima, Kunio and English, Milton A and Semler, Elizabeth M and Mahgerefteh, Jacklyn and Cideciyan, Artur V and Li, Tiansen and Brooks, Brian P and Gunay-Aygun, Meral and Jacobson, Samuel G and Cogliati, Tiziana and Westlake, Christopher J and Swaroop, Anand
Cell Reports, ISSN 2211-1247, 07/2017, Volume 20, Issue 2, pp. 384 - 396
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome... 
retinal degeneration | ciliopathies | ciliogenesis | Joubert syndrome | primary cilia | iPSC | ciliary transition zone | Hedgehog signaling | LCA | organoid | PLURIPOTENT STEM-CELLS | JOUBERT-SYNDROME | RETINAL DEGENERATION | LEBER CONGENITAL AMAUROSIS | VERTEBRATE DEVELOPMENT | TRANSITION ZONE | DISEASE | CHEMICALLY-DEFINED CULTURE | CENTROSOMAL PROTEIN | SENSORY NEURONS | CELL BIOLOGY | Antigens, Neoplasm - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Hedgehog Proteins - metabolism | Adenylyl Cyclases - metabolism | Smoothened Receptor - metabolism | Mutation - genetics | Neoplasm Proteins - metabolism | Smoothened Receptor - genetics | Mice, Knockout | Homozygote | Animals | Hedgehog Proteins - genetics | Alleles | Antigens, Neoplasm - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | ADP-Ribosylation Factors - metabolism | Adenylyl Cyclases - genetics | Neoplasm Proteins - genetics | ADP-Ribosylation Factors - genetics | Cilia | Fibroblasts - metabolism | Index Medicus | Ciliopathies | Retinal degeneration | Organoid
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8. Full Text Three-dimensional architecture of epithelial primary cilia
by Sun, SF and Fisher, RL and Bowser, SS and Pentecost, BT and Sui, HX
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2019, Volume 116, Issue 19, pp. 9370 - 9379
We report a complete 3D structural model of typical epithelial primary cilia based on structural maps of full-length primary cilia obtained by serial section... 
MULTIDISCIPLINARY SCIENCES | FREEZE-SUBSTITUTION | 3D structure | SENSORY CILIA | MICROTUBULE DOUBLETS | primary cilium | IMAGE | MOLECULAR ARCHITECTURE | SECRETORY-CELLS | electron microscopy | CRYOELECTRON TOMOGRAPHY | BASAL BODY | INTRAFLAGELLAR TRANSPORT | REVEALS | Architecture | Analysis | Proteins | Vesicles | Computational fluid dynamics | Tubules | Crosslinking | Liquid flow | Transport processes | Cell interactions | Budding | Three dimensional models | Cilia
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9. Full Text Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/β‐Catenin in Primary Cilia of Osteoblasts
by Zhou, Jian and Gao, Yu‐Hai and Zhu, Bao‐Ying and Shao, Jia‐Le and Ma, Hui‐Ping and Xian, Cory J and Chen, Ke‐Ming
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2019, Volume 34, Issue 7, pp. 1336 - 1351
Extremely low-frequency electromagnetic fields have been considered a potential candidate for the prevention and treatment of osteoporosis; however, their... 
WNT10B | SINUSOIDAL ELECTROMAGNETIC FIELDS | PRIMARY CILIUM | OSTEOBLASTS | WNT/β‐CATENIN | OSTEOGENIC DIFFERENTIATION | RISK | STRENGTH | PROLIFERATION | MATURATION | THERAPY | beta-CATENIN | SIGNALING PATHWAY | MICROARCHITECTURE | MINERALIZATION | ENDOCRINOLOGY & METABOLISM | WNT | EXPOSURE | Femur | Electromagnetism | Wnt protein | RNA-mediated interference | siRNA | Electromagnetic fields | Osteoblasts | Osteoporosis | Signal transduction | Bone growth | Bone mass | Osteoblastogenesis | Collagen | Catenin | Osteogenesis | Cilia | Index Medicus
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10. Full Text The ciliary membrane‐associated proteome reveals actin‐binding proteins as key components of cilia
by Kohli, Priyanka and Höhne, Martin and Jüngst, Christian and Bertsch, Sabine and Ebert, Lena K and Schauss, Astrid C and Benzing, Thomas and Rinschen, Markus M and Schermer, Bernhard
EMBO reports, ISSN 1469-221X, 09/2017, Volume 18, Issue 9, pp. 1521 - 1535
Primary cilia are sensory, antennae‐like organelles present on the surface of many cell types. They have been involved in a variety of diseases collectively... 
Myo5a | proximity labeling | actin‐binding proteins | primary cilia | STED | actin-binding proteins | LOCALIZATION | VERTEBRATE PRIMARY CILIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | IDENTIFICATION | NEGATIVE REGULATOR | CELL BIOLOGY | TRANSPORT | PURIFICATION | ENRICHMENT | CELL-CYCLE | CILIOGENESIS | Microfilament Proteins - chemistry | Signal Transduction | Humans | Actins - metabolism | Computational Biology | Gene Expression Regulation | Gene Knockout Techniques | Myosins - genetics | Cilia - metabolism | Myosins - deficiency | Membranes - metabolism | Animals | Proteomics | Actins - chemistry | Myosins - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Proteome - metabolism | Binding | Regulators | Biotinylation | Protein purification | Polymerization | Antennae | Organelles | Cell surface | Mammalian cells | Proteins | Depolymerization | Dynamic tests | Actin | Myosin | Genetic engineering | Immunofluorescence | Dismantling | Cilia | Index Medicus | Methods & Resources | Scientific Reports | Cell Adhesion, Polarity & Cytoskeleton | Membrane & Intracellular Transport | Scientific Report
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