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Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2014, Volume 279, Issue 3, pp. 266 - 274
Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to... 
Oncotic necrosis | Drug-induced liver injury | Mitochondrial dysfunction | c-Jun-N-terminal kinase | Acetaminophen protein adducts | C-Jun-N-terminal kinase | OXIDANT STRESS | HEPATIC-NECROSIS | N-ACETYLCYSTEINE | INDUCED LIVER-INJURY | TERMINAL KINASE | CULTURED MOUSE HEPATOCYTES | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | INDUCED HEPATOTOXICITY | PROTEIN ADDUCTS | Glutathione - metabolism | Humans | Middle Aged | Mitochondrial Diseases - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Necrosis - pathology | Young Adult | Analgesics, Non-Narcotic - toxicity | Mitochondrial Diseases - chemically induced | Adult | Female | Cell Death - drug effects | Hepatocytes - drug effects | Antidotes - pharmacology | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Subcellular Fractions - drug effects | Acetaminophen - toxicity | Acetaminophen - antagonists & inhibitors | Enzyme Activation - drug effects | Subcellular Fractions - metabolism | Mitochondria, Liver - drug effects | Proteins - metabolism | Acetylcysteine - pharmacology | Aged | Primary Cell Culture | Subcellular Fractions - enzymology | Hepatocytes - enzymology | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | INJURIES | NECROSIS | GLUTATHIONE | LIVER | MITOCHONDRIA | LIVER CELLS | ADDUCTS | TIME DEPENDENCE | 60 APPLIED LIFE SCIENCES | acetaminophen protein adducts | mitochondrial dysfunction | oncotic necrosis
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2015, Volume 283, Issue 3, pp. 168 - 177
Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is... 
Biomarkers | Inflammation | Bile acids | HMGB1 | Primary human hepatocytes | Obstructive cholestasis | RAT HEPATOCYTES | ACETAMINOPHEN HEPATOTOXICITY | INDUCED LIVER-INJURY | CELL-DEATH | DUCT-LIGATED MICE | RECEPTOR TGR5 | URSODEOXYCHOLIC ACID | ONCOTIC NECROSIS | PRIMARY BILIARY-CIRRHOSIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PRIMARY SCLEROSING CHOLANGITIS | Bile Acids and Salts - blood | Species Specificity | Bile Acids and Salts - toxicity | Humans | Mice, Inbred C57BL | Cells, Cultured | Hepatocytes - pathology | Biomarkers - blood | Hepatocytes - metabolism | Jaundice, Obstructive - pathology | Necrosis | Dose-Response Relationship, Drug | Animals | Cholestasis, Extrahepatic - blood | Jaundice, Obstructive - blood | Glycochenodeoxycholic Acid - toxicity | Acetylation | Primary Cell Culture | Keratin-18 - blood | Cholestasis, Extrahepatic - pathology | HMGB1 Protein - blood | Hepatocytes - drug effects | Keratin | Care and treatment | Jaundice, Obstructive | Analysis | Cholestasis | Deoxycholic acid | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | GLYCINE | PATIENTS | INJURIES | RODENTS | BILIARY TRACT | TOXICITY | LEVELS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | POLYPEPTIDES | NECROSIS | CHOLIC ACID | INFLAMMATION | LIVER | LIVER CELLS | AMINOTRANSFERASES | BILE | bile acids | primary human hepatocytes | inflammation | biomarkers | obstructive cholestasis | apoptosis
Journal Article
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 06/2015, Volume 145, Issue 2, pp. 307 - 320
Journal Article
EXPERIMENTAL BIOLOGY AND MEDICINE, ISSN 1535-3702, 05/2015, Volume 240, Issue 5, pp. 645 - 656
Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | primary cell isolation | COLLAGEN | primary human hepatocytes | Liver | liver tissue engineering | CULTURE | LIPOCYTES | IN-VITRO | HEPATIC STELLATE CELLS | non-parenchymal liver cells | SINUSOIDAL ENDOTHELIAL-CELLS | DISEASE | KUPFFER CELLS | liver in vitro model | INDUCED HEPATOTOXICITY
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2006, Volume 46, Issue 3, pp. 411 - 419
Background/Aims The direct implication of low-density lipoprotein receptor (LDLR) in hepatitis C virus (HCV) infection of human hepatocyte has not been... 
Gastroenterology and Hepatology | Virus receptor | Genome replication | Virus entry | LDL RECEPTOR | CULTURED HUMAN HEPATOCYTES | IN-VITRO INFECTION | virus receptor | genome replication | CANDIDATE RECEPTOR | SCAVENGER RECEPTOR | HUMAN HEPATOMA-CELLS | STRUCTURAL PROTEINS | virus entry | TERM PRIMARY CULTURES | BINDING-SITE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | CD18 Antigens - physiology | Humans | Middle Aged | Hepacivirus - genetics | Lipoproteins, LDL - physiology | Hepacivirus - pathogenicity | Hepatocytes - pathology | Male | Antibodies - physiology | Scavenger Receptors, Class B - physiology | Viral Load | RNA, Viral - genetics | Virion | Adult | Female | Hepacivirus - physiology | RNA, Viral - metabolism | Receptors, LDL - genetics | Tricarboxylic Acids - pharmacology | Cells, Cultured | Receptors, LDL - immunology | Hydroxycholesterols - pharmacology | Lipoproteins, HDL - physiology | Gene Expression Regulation - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Adolescent | Hepatocytes - virology | Hepatitis C - physiopathology | Aged | Hepatitis C - pathology | Receptors, LDL - physiology | Anticholesteremic Agents - pharmacology | Hepatitis C | Health aspects | Index Medicus | Scavenger Receptors, Class B | Receptors, LDL | Antibodies | Bicyclo Compounds, Heterocyclic | Life Sciences | Tricarboxylic Acids | Anticholesteremic Agents | Hépatology and Gastroenterology | Gene Expression Regulation | Human health and pathology | Hepatocytes | Hydroxycholesterols | RNA, Viral | Antigens, CD18 | Lipoproteins, HDL | Hepacivirus | Lipoproteins, LDL
Journal Article
Experimental Biology and Medicine, ISSN 1535-3702, 5/2015, Volume 240, Issue 5, pp. 645 - 656
Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH... 
liver in vitro model | primary cell isolation | primary human hepatocytes | Liver | liver tissue engineering | non-parenchymal liver cells | Hepatocytes - cytology | Microscopy, Electron, Scanning | Humans | Cells, Cultured | Liver - cytology | Cell Adhesion | Phagocytosis | Index Medicus | Original Research
Journal Article
Cell Biology and Toxicology, ISSN 0742-2091, 4/2012, Volume 28, Issue 2, pp. 69 - 87
In the pharmaceutical industry, improving the early detection of drug-induced hepatotoxicity is essential as it is one of the most important reasons for... 
Life Sciences | Biochemistry, general | CYP450 activities | Real-time cell analyzer | Cytotoxicity | HepG2 cells | Pharmacology/Toxicology | Gene expression | Primary human hepatocytes | HepaRG cells | Cell Biology | HUMAN HEPATOMA-CELL | CYTOCHROMES P450 | TOXICITY | INDUCTION | MODEL | CELL BIOLOGY | XENOBIOTICS | ENZYMES | TOXICOLOGY | PHASE-I | EXPRESSION | DRUG-METABOLISM | Predictive Value of Tests | Gene Expression - drug effects | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Male | Gene Expression Profiling | Hepatocytes - metabolism | Drug-Related Side Effects and Adverse Reactions | Toxicogenetics | Inhibitory Concentration 50 | Adult | Female | Toxicity Tests - methods | Child | Principal Component Analysis | Chemical and Drug Induced Liver Injury - enzymology | Chemical and Drug Induced Liver Injury - etiology | Hepatocytes - drug effects | RNA, Messenger - genetics | Enzyme Induction | Chemical and Drug Induced Liver Injury - genetics | Lethal Dose 50 | Hep G2 Cells | Models, Biological | Cytochrome P-450 Enzyme System - biosynthesis | Aged | Hepatocytes - enzymology | Liver diseases | Cytochrome P-450 | Physiological aspects | Genetic aspects | Research | Liver cells | Risk factors | Toxicology | Pharmacology | Cellular biology | Ribonucleic acid--RNA | Liver | Index Medicus | Original Research
Journal Article