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1. Full Text How I treat common variable immune deficiency
by Cunningham-Rundles, Charlotte
Blood, ISSN 0006-4971, 07/2010, Volume 116, Issue 1, pp. 7 - 15
Common variable immunodeficiency is a rare immune deficiency, characterized by low levels of serum immunoglobulin G, A, and/or M with loss of antibody... 
PRIMARY IMMUNODEFICIENCY DISEASES | GRANULOMATOUS-DISEASE | MEMORY B-CELLS | NODULAR REGENERATIVE HYPERPLASIA | PRIMARY HYPOGAMMAGLOBULINEMIA | INTRAVENOUS IMMUNOGLOBULIN | ANTIBODY-DEFICIENCY | IGA DEFICIENCY | OF-THE-LITERATURE | HEMATOLOGY | INTERNET-BASED PATIENT | Common Variable Immunodeficiency - immunology | Humans | Common Variable Immunodeficiency - blood | Hematologic Diseases - immunology | Hematologic Diseases - therapy | Neoplasms - therapy | Bacterial Infections - therapy | Neoplasms - blood | Immunoglobulins, Intravenous - therapeutic use | Bacterial Infections - immunology | Common Variable Immunodeficiency - therapy | Hematologic Diseases - blood | Neoplasms - immunology | Survival Analysis | Bacterial Infections - blood | How I Treat | Immunobiology
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2. Full Text Primary immune deficiencies with aberrant IgE production
by Ozcan, Esra, MD and Notarangelo, Luigi D., MD and Geha, Raif S., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2008, Volume 122, Issue 6, pp. 1054 - 1062
IgE antibodies play a central role in the pathogenesis of atopic diseases and in host immunity against parasitic infections. IgE has potent activities on mast... 
Allergy and Immunology | WAS | IPEX | Omenn syndrome | IgE | primary immune deficiency | HIES | WISKOTT-ALDRICH-SYNDROME | RECURRENT-INFECTION SYNDROME | IMMUNOLOGY | VERSUS-HOST-DISEASE | THYMIC STROMAL LYMPHOPOIETIN | INTERFERON-GAMMA | ALLERGY | HYPERIMMUNOGLOBULIN-E SYNDROME | REGULATORY T-CELLS | CLASS-SWITCH RECOMBINATION | X-LINKED THROMBOCYTOPENIA | IMMUNOGLOBULIN-E | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - immunology | Hypersensitivity, Immediate - genetics | Th2 Cells - immunology | Th1 Cells - immunology | Promoter Regions, Genetic - genetics | T-Lymphocytes, Regulatory - immunology | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Hypersensitivity, Immediate - immunology | Immunologic Deficiency Syndromes - genetics | Parasitic Diseases - immunology | Parasitic Diseases - genetics | Promoter Regions, Genetic - immunology | STAT3 Transcription Factor - immunology | Immunologic Deficiency Syndromes - immunology | Cytokines - genetics | Antibody Formation - genetics | STAT3 Transcription Factor - genetics | Cytokines - immunology | Tyrosine | Adenosine | Immunoglobulin E | Transplantation | Lymphomas | DNA binding proteins | T cells | Hematopoietic stem cells | Medical research | Mutation | Rodents | Allergies | Immune system
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3. Full Text Toll‐like receptor signaling in primary immune deficiencies
by Maglione, Paul J and Simchoni, Noa and Cunningham‐Rundles, Charlotte
Annals of the New York Academy of Sciences, ISSN 0077-8923, 11/2015, Volume 1356, Issue 1, pp. 1 - 21
Toll‐like receptors (TLRs) recognize common microbial or host‐derived macromolecules and have important roles in early activation of the immune system.... 
infection | human immunology | Toll‐like receptors | primary immune deficiency | Infection | Human immunology | Toll-like receptors | Primary immune deficiency | ANHIDROTIC ECTODERMAL DYSPLASIA | X-LINKED AGAMMAGLOBULINEMIA | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | GENE POLYMORPHISMS | ESSENTIAL MODULATOR MUTATION | BRUTONS TYROSINE KINASE | TUMOR-NECROSIS-FACTOR | PYOGENIC BACTERIAL-INFECTIONS | NF-KAPPA-B | HERPES-SIMPLEX ENCEPHALITIS | Job Syndrome - immunology | Agammaglobulinemia - immunology | Job Syndrome - genetics | Agammaglobulinemia - genetics | Humans | Granulomatous Disease, Chronic - genetics | Granulomatous Disease, Chronic - immunology | Signal Transduction - immunology | Bacterial Infections - genetics | Bacterial Infections - immunology | Myeloid Differentiation Factor 88 - immunology | Genetic Diseases, X-Linked - genetics | Adenosine Deaminase - deficiency | Adenosine Deaminase - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Severe Combined Immunodeficiency - immunology | Signal Transduction - genetics | I-kappa B Kinase - genetics | Genetic Diseases, X-Linked - immunology | Severe Combined Immunodeficiency - genetics | Animals | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Adenosine Deaminase - immunology | Proteins | B cells | Dendritic cells | Health aspects | Rodents | Immune system | Defects | Immune systems | Adenosines | Macromolecules | Bacteria | Viruses | Activation
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4. Full Text Autoimmune manifestations in primary immune deficiencies
by Bussone, Guillaume and Mouthon, Luc
Autoimmunity Reviews, ISSN 1568-9972, 2008, Volume 8, Issue 4, pp. 332 - 336
Abstract Autoimmune manifestations have long been perceived as paradoxical in patients with primary immune deficiencies (PID). However, a defect in the... 
Allergy and Immunology | Autoimmunity | Complement | Primary immune deficiency | Common variable immune deficiency | APECED | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | HYPER-IGM SYNDROME | WISKOTT-ALDRICH-SYNDROME | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | GENE | DISEASE | LYMPHOPROLIFERATIVE SYNDROME | MUTATIONS | AUTOSOMAL RECESSIVE FORM | Lupus | Systemic lupus erythematosus | T cells | Type 1 diabetes | Thyroid diseases
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5. Full Text Immune deficiency and autoimmunity
by Atkinson, Thomas Prescott
Current Opinion in Rheumatology, ISSN 1040-8711, 09/2012, Volume 24, Issue 5, pp. 515 - 521
PURPOSE OF REVIEWTo provide an overview of the mechanisms of autoimmunity associated with primary immunodeficiencies. RECENT FINDINGSOver the past several... 
immunologic deficiency syndromes | primary immune deficiency | WISKOTT-ALDRICH-SYNDROME | SYNDROME PROTEIN | OMENN-SYNDROME | PRIMARY-IMMUNODEFICIENCY | RHEUMATOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | INBORN-ERRORS | autoimmunity | MUTATIONS | autoantibodies | T-CELLS | STAT5B DEFICIENCY | Autoantibodies - metabolism | Interleukin-2 Receptor alpha Subunit - deficiency | Wiskott-Aldrich Syndrome - immunology | Humans | Autoimmunity - genetics | Syndrome | DiGeorge Syndrome - immunology | T-Lymphocytes, Regulatory - immunology | Immunologic Deficiency Syndromes - genetics | T-Lymphocytes - immunology | Cytokines - antagonists & inhibitors | Mutation | STAT5 Transcription Factor - deficiency | Immunologic Deficiency Syndromes - immunology | Forkhead Transcription Factors - deficiency | Cytokines - immunology | Interleukin-2 Receptor alpha Subunit - immunology
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6. Full Text Unravelling fungal immunity through primary immune deficiencies
by Lilic, Desa
Current Opinion in Microbiology, ISSN 1369-5274, 2012, Volume 15, Issue 4, pp. 420 - 426
Highlights ► Patients with primary immune deficiencies have contributed enormously to our understanding of immunological pathways mediating immunity to fungi.... 
Pathology | HYPER-IGE SYNDROME | IDIOPATHIC CD4 LYMPHOCYTOPENIA | INFECTIONS | AUTOIMMUNITY | CHRONIC GRANULOMATOUS-DISEASE | SUSCEPTIBILITY | INNATE | PRIMARY IMMUNODEFICIENCIES | STAT1 MUTATIONS | MICROBIOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | Adaptive Immunity | Fungi - immunology | Animals | Humans | Th17 Cells - immunology | Immunity, Innate | Immunologic Deficiency Syndromes - immunology | Immunologic Deficiency Syndromes - microbiology | Mycoses - immunology | Th17 Cells - microbiology | Cytokines - immunology | Immunodeficiency | Chronic mucocutaneous candidiasis | Stat3 protein | Antibodies | Chronic infection | Immunity | Interleukin 17 | Fungi | Phagocytes | Reviews | Interleukin 1 | Stat1 protein | Immune system | Neutropenia
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7. Full Text Immune deficiency: changing spectrum of pathogens
by Duraisingham, S. S and Manson, A and Grigoriadou, S and Buckland, M and Tong, C. Y. W and Longhurst, H. J
Clinical & Experimental Immunology, ISSN 0009-9104, 08/2015, Volume 181, Issue 2, pp. 267 - 274
Summary Current UK national standards recommend routine bacteriology surveillance in severe antibody‐deficient patients, but less guidance exists on virology... 
antibody deficiency | IgA | infection | viral | norovirus | Infection | Norovirus | Antibody deficiency | Viral | PRIMARY ANTIBODY DEFICIENCIES | DIAGNOSIS | VIRUS | MANAGEMENT | IMMUNOGLOBULIN | COMMON VARIABLE IMMUNODEFICIENCY | PHENOTYPES | IMMUNOLOGY | CHILDREN | PRIMARY HYPOGAMMAGLOBULINEMIA | RHINOVIRUS INFECTION | Immunologic Deficiency Syndromes - pathology | Staphylococcal Infections - pathology | Humans | Rhinovirus - isolation & purification | Antibodies, Viral - blood | Picornaviridae Infections - virology | Bronchoalveolar Lavage Fluid - microbiology | Feces - microbiology | Feces - virology | Pseudomonas - immunology | Retrospective Studies | Staphylococcal Infections - microbiology | Haemophilus Infections - pathology | Rhinovirus - immunology | Immunologic Deficiency Syndromes - immunology | Antibodies, Bacterial - blood | Picornaviridae Infections - pathology | Picornaviridae Infections - immunology | Bronchoalveolar Lavage Fluid - virology | Staphylococcal Infections - immunology | Staphylococcus aureus - isolation & purification | Immunologic Deficiency Syndromes - virology | Immunologic Deficiency Syndromes - microbiology | Pseudomonas Infections - microbiology | Haemophilus influenzae - isolation & purification | Pseudomonas Infections - immunology | Pseudomonas - isolation & purification | Haemophilus Infections - microbiology | Haemophilus influenzae - immunology | Pseudomonas Infections - pathology | Immunoglobulin A - blood | Staphylococcus aureus - immunology | Haemophilus Infections - immunology | Virus diseases | Pathogenic microorganisms | Immunoglobulin A | Immunoglobulin G | Immunodeficiency | Translational
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8. Full Text Norovirus infection in primary immune deficiency
by Brown, Li‐An K and Clark, Ian and Brown, Julianne R and Breuer, Judith and Lowe, David M
Reviews in Medical Virology, ISSN 1052-9276, 05/2017, Volume 27, Issue 3, pp. e1926 - n/a
Summary Norovirus is acknowledged to be a leading cause of acute gastroenteritis worldwide, and its importance as a cause of chronic infection in immune... 
norovirus | primary immune deficiency | immunodeficiency | MURINE NOROVIRUS | HEMATOPOIETIC STEM-CELL | COMMON VARIABLE IMMUNODEFICIENCY | P2 DOMAIN | TRANSPLANT RECIPIENTS | VIRAL POLYMERASE INHIBITOR | NORWALK VIRUS-REPLICATION | VIROLOGY | CALICIVIRUS ENTERITIS | MONOCLONAL-ANTIBODIES | FAVIPIRAVIR T-705 | Disease susceptibility | Health aspects | Gastroenteritis | Immunodeficiency | Immunoglobulins | Nutrient deficiency | Intravenous administration | Immune response | Nutrition | CD8 antigen | Mucosa | Immune clearance | Clinical trials | Chronic infection | Diarrhea | Cytotoxicity | Parenteral nutrition | Infections | Ribavirin | Immune response (humoral) | Immunosuppressive agents | CD4 antigen | Atrophy | Diet | Health risk assessment | Breast milk
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