Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (415) 415
Publication (72) 72
Book / eBook (11) 11
Book Chapter (5) 5
Conference Proceeding (4) 4
Newsletter (4) 4
Book Review (2) 2
Dissertation (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (349) 349
humans (321) 321
primates (233) 233
genetics & heredity (228) 228
index medicus (217) 217
evolution, molecular (208) 208
evolution (203) 203
genomics (157) 157
primates - genetics (135) 135
phylogeny (124) 124
research (121) 121
genes (118) 118
genetics (110) 110
genetic aspects (105) 105
evolutionary biology (102) 102
genomes (101) 101
molecular sequence data (100) 100
human genome (99) 99
biochemistry & molecular biology (96) 96
segmental duplications (91) 91
gene duplication (87) 87
research article (86) 86
base sequence (83) 83
genome (79) 79
biotechnology & applied microbiology (74) 74
genome, human (74) 74
biological evolution (70) 70
dna (69) 69
analysis (67) 67
gene expression (66) 66
chromosomes (63) 63
species specificity (60) 60
biology (58) 58
pan troglodytes - genetics (56) 56
genetic variation (55) 55
multidisciplinary sciences (55) 55
sequence analysis, dna (55) 55
sequence (54) 54
genetic research (50) 50
proteins (47) 47
cell biology (45) 45
male (45) 45
models, genetic (44) 44
in situ hybridization, fluorescence (43) 43
monkeys & apes (43) 43
chromosome mapping (42) 42
mice (41) 41
mammals (40) 40
selection, genetic (40) 40
mutation (38) 38
primate evolution (38) 38
sequence alignment (38) 38
article (37) 37
physiological aspects (37) 37
chimpanzee (34) 34
female (34) 34
life sciences (34) 34
chimpanzees (33) 33
computational biology (33) 33
expression (32) 32
human genetics (32) 32
structural variation (32) 32
copy number variation (31) 31
multigene family (31) 31
science (31) 31
deoxyribonucleic acid (30) 30
molecular evolution (30) 30
amino acid sequence (29) 29
comparative genomics (29) 29
medicine (29) 29
mouse (29) 29
positive selection (29) 29
exons (28) 28
rearrangements (28) 28
deoxyribonucleic acid--dna (27) 27
evolutionary genetics (27) 27
gene dosage (27) 27
polymorphism (27) 27
polymorphism, genetic (27) 27
human evolution (26) 26
molecular biology (26) 26
gene (25) 25
identification (25) 25
pseudogenes (25) 25
recombination (25) 25
sequence homology, nucleic acid (25) 25
bioinformatics (24) 24
disease (24) 24
gene conversion (24) 24
origin (24) 24
transposable elements (24) 24
human-genome (23) 23
polymerase chain reaction (23) 23
divergence (22) 22
diversity (22) 22
haplotypes (22) 22
hominidae - genetics (22) 22
centromere - genetics (21) 21
family (21) 21
immunology (21) 21
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
UofT at Scarborough - Stacks (6) 6
Gerstein Science - Stacks (4) 4
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
UofT at Mississauga - Stacks (3) 3
Robarts - Stacks (2) 2
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
UTL at Downsview - May be requested (1) 1
UofT at Scarborough - Withdrawn (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Primate segmental duplications: crucibles of evolution, diversity and disease
by Eichler, Evan E and Bailey, Jeffrey A
Nature Reviews Genetics, ISSN 1471-0056, 07/2006, Volume 7, Issue 7, pp. 552 - 564
Compared with other mammals, the genomes of humans and other primates show an enrichment of large, interspersed segmental duplications (SDs) with high levels... 
MOLECULAR CHARACTERIZATION | GENETICS & HEREDITY | GENE CONVERSION | HOT-SPOTS | PERICENTRIC-INVERSION | TRANSCRIPTIONAL PROFILE | HUMAN-GENOME | RECOMBINATION HOTSPOT | STRUCTURAL VARIATION | COPY-NUMBER VARIATION | HUMAN COLOR-VISION | Gene Duplication | Genetic Variation | Primates - genetics | Animals | Humans | Genetic Diseases, Inborn - genetics | Evolution, Molecular
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text The origins and impact of primate segmental duplications
by Marques-Bonet, Tomas and Girirajan, Santhosh and Eichler, Evan E
Trends in Genetics, ISSN 0168-9525, 2009, Volume 25, Issue 10, pp. 443 - 454
Duplicated sequences are substrates for the emergence of new genes and are an important source of genetic instability associated with rare and common diseases.... 
Medical Education | LINEAGE-SPECIFIC AMPLIFICATION | CHROMOSOME | GENE DUPLICATION | MOUSE | GENETICS & HEREDITY | REARRANGEMENTS | HUMAN-GENOME | STRUCTURAL VARIATION | COPY-NUMBER VARIATION | HOMINOID EVOLUTION | CHIMPANZEE | Gene Duplication | Genetic Variation | Interspersed Repetitive Sequences - genetics | Primates - genetics | Animals | Humans | Genome - genetics | Models, Genetic | Phylogeny | Evolution, Molecular | Genètica | Evolució molecular | Primats
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication
by Dennis, Megan Y and Nuttle, Xander and Sudmant, Peter H and Antonacci, Francesca and Graves, Tina A and Nefedov, Mikhail and Rosenfeld, Jill A and Sajjadian, Saba and Malig, Maika and Kotkiewicz, Holland and Curry, Cynthia J and Shafer, Susan and Shaffer, Lisa G and de Jong, Pieter J and Wilson, Richard K and Eichler, Evan E
Cell, ISSN 0092-8674, 05/2012, Volume 149, Issue 4, pp. 912 - 922
Gene duplication is an important source of phenotypic change and adaptive evolution. We leverage a haploid hydatidiform mole to identify highly identical... 
MIGRATION | ORIGIN | DNA-SEQUENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONSTRUCTION | HOMINID | POLYMORPHISM | UPPER MIOCENE | GENOME | COPY-NUMBER VARIATION | RESOURCE | CELL BIOLOGY | Mammals - genetics | Humans | Molecular Sequence Data | In Situ Hybridization, Fluorescence | Segmental Duplications, Genomic | DNA Copy Number Variations | Hydatidiform Mole - genetics | Pregnancy | Primates - genetics | Animals | Genetics, Medical | Female | GTPase-Activating Proteins - genetics | Evolution, Molecular | Birth
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text A burst of segmental duplications in the genome of the African great ape ancestor
by Ventura, Mario and Hillier, LaDeana W and Mardis, Elaine R and Fulton, Lucinda A and Aksay, Gozde and Cardone, Maria Francesca and Marques-Bonet, Tomas and Malfavon-Borja, Ray and Alkan, Can and Girirajan, Santhosh and Jiang, Zhaoshi and Graves, Tina A and Eichler, Evan E and Chen, Lin and Kidd, Jeffrey M and Siswara, Priscillia and Cheng, Ze and Navarro, Arcadi and Wilson, Richard K and Baker, Carl
Nature, ISSN 0028-0836, 02/2009, Volume 457, Issue 7231, pp. 877 - 881
It is generally accepted that the extent of phenotypic change between human and great apes is dissonant with the rate of molecular change. Between these two... 
MULTIDISCIPLINARY SCIENCES | PRIMATE EVOLUTION | HUMANS | ARCHITECTURE | DISORDERS | COPY NUMBER VARIATION | RHESUS MACAQUE GENOME | STRUCTURAL VARIATION | CHIMPANZEE | Gene Duplication | Reproducibility of Results | Animals | Catarrhini - classification | Humans | Africa | Genome - genetics | Chromosome Mapping | Catarrhini - genetics | Evolution, Molecular | Polymorphism, Genetic | Apes | Usage | DNA microarrays | Nucleotide sequence | Physiological aspects | Genetic aspects | Research | Comparative analysis | Methods | Signal transduction | Genetic testing | Monkeys & apes | Fluorescence in situ hybridization | Genètica | Evolució molecular | Genòmica | Primats
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Accelerated exon evolution within primate segmental duplications
by Lorente-Galdos, Belen and Bleyhl, Jonathan and Santpere, Gabriel and Vives, Laura and Ramírez, Oscar and Hernandez, Jessica and Anglada, Roger and Cooper, Gregory M and Navarro, Arcadi and Eichler, Evan E and Marques-Bonet, Tomas
Genome Biology, ISSN 1474-7596, 01/2013, Volume 14, Issue 1, pp. R9 - R9
Background: The identification of signatures of natural selection has long been used as an approach to understanding the unique features of any given species.... 
APES | POSITIVE SELECTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NATURAL-SELECTION | GENETICS & HEREDITY | HUMANS | COPY NUMBER VARIATION | MOLECULAR CLOCKS | REARRANGEMENTS | HUMAN-GENOME | STRUCTURAL VARIATION | CHIMPANZEE | Gene Duplication | Primates - genetics | Animals | Exons | Humans | Genome, Human | Evolution, Molecular | Evolució molecular | Genoma humà | Research
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Signals of Historical Interlocus Gene Conversion in Human Segmental Duplications
by Dumont, Beth L and Eichler, Evan E
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e75949
Standard methods of DNA sequence analysis assume that sequences evolve independently, yet this assumption may not be appropriate for segmental duplications... 
DNA-SEQUENCES | DISEASE RISK | HUMAN GENOME | POSITIVE SELECTION | MULTIDISCIPLINARY SCIENCES | PRIMATE EVOLUTION | RECOMBINATION RATES | HOT-SPOTS | COPY NUMBER VARIATION | RAPID EVOLUTION | FAMILY | Segmental Duplications, Genomic - genetics | Mutation | Sequence Analysis, DNA - methods | Humans | Genome, Human - genetics | Genomes | Nucleotide sequencing | Analysis | Genes | Genomics | DNA sequencing | Nucleotide sequence | Gene families | Biological evolution | Palindromes | Glycoproteins | Y chromosomes | Neuroblastoma | Conversion | Gene sequencing | Pregnancy | Hypotheses | Reproduction (copying) | Evolution | Gene conversion | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans
by Bekpen, Cemalettin and Künzel, Sven and Xie, Chen and Eaaswarkhanth, Muthukrishnan and Lin, Yen-Lung and Gokcumen, Omer and Akdis, Cezmi A and Tautz, Diethard
BMC Genomics, ISSN 1471-2164, 03/2017, Volume 18, Issue 1, p. 222
Background: Segmental duplications are an abundant source for novel gene functions and evolutionary adaptations. This mechanism of generating novelty was very... 
UV response | SPATA31 gene family | Copy number variation | Core duplicons | Segmental Duplications | Comparative Genomics | RAS | RELEASE | MULTIPLE SEQUENCE ALIGNMENT | CRYPTOCHROME | GENOME SEQUENCE | TBC1D3 | CYTO-TOXICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COPY NUMBER | GENETICS & HEREDITY | DIVERSITY | DNA-REPAIR | Gene Duplication | Multigene Family | Humans | Segmental Duplications, Genomic | Chromosome Mapping | Phylogeny | Protein Domains - genetics | DNA Copy Number Variations | Primates - genetics | Animals | Ultraviolet Rays | DNA Damage - radiation effects | Evolution, Molecular | Adaptations | Biotechnology | Copy number | Spermatogenesis | Positive selection | Genomics | Genes | Antibodies | Cytotoxicity | Homology | Genomes | Tissues | Nuclei | DNA repair | Proteins | Nucleoli | Reproduction (copying) | Phylogenetics | Primates | Evolution | Tumor necrosis factor-TNF | Localization | Bioinformatics | Chromosomes | Deoxyribonucleic acid--DNA | Novelty | CRISPR | U.V. radiation | Gene families | Mammals | Gene expression | Monkeys & apes | Immunological tolerance | Diurnal | Polymerase chain reaction | Mutagenesis | Cell lines | Irradiation | Sensitivity enhancement | Radiation damage
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
by Williams, Eleanor M and Friedman, Cynthia and Trask, Barbara J and Linardopoulou, Elena V and Young, Janet M and Fan, Yuxin
Nature, ISSN 0028-0836, 09/2005, Volume 437, Issue 7055, pp. 94 - 100
Human subtelomeres are polymorphic patchworks of interchromosomal segmental duplications at the ends of chromosomes. Here we provide evidence that these... 
YEAST | HUMAN-CHROMOSOMES | STRAND BREAK REPAIR | EVOLUTION | DNA | MULTIDISCIPLINARY SCIENCES | SEQUENCE | POLYMORPHISM | OLFACTORY RECEPTOR GENE | HUMAN-GENOME | TELOMERES | Gene Duplication | Chromosome Breakage - genetics | Chromosomes, Human - genetics | Genomics | Humans | Computational Biology | Sequence Homology, Nucleic Acid | Primates - genetics | Animals | Time Factors | Base Sequence | DNA Repair | Recombination, Genetic - genetics | Polymorphism, Genetic - genetics | Models, Genetic | Genome, Human | Telomere - genetics | Translocation, Genetic - genetics | Genetic recombination | Chromosomes | DNA repair | Human Genome Project
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications
by She, Xinwei and Liu, Ge and Ventura, Mario and Zhao, Shaying and Misceo, Doriana and Roberto, Roberta and Cardone, Maria Francesca and Rocchi, Mariano and Green, Eric D and Archidiacano, Nicoletta and Eichler, Evan E and NISC Comparative Sequencing Progr and NISC Comparative Sequencing Program
Genome Research, ISSN 1088-9051, 05/2006, Volume 16, Issue 5, pp. 576 - 583
Compared with other sequenced animal genomes, human segmental duplications appear larger, more interspersed, and disproportionately represented as... 
INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | HUMANS | IMPACT | EVOLUTION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SEQUENCE | REGIONS | GENETICS & HEREDITY | SELECTION | HUMAN-GENOME | Gene Duplication | Humans | Pan troglodytes - genetics | Molecular Sequence Data | In Situ Hybridization, Fluorescence | Base Pair Mismatch | Hominidae - genetics | Sequence Analysis, DNA | Sequence Homology, Nucleic Acid | Animals | Papio - genetics | Base Pairing | Base Sequence | Genome, Human | Chromosomes | Databases, Factual | Evolution, Molecular | Analysis | Old-World monkeys | Primates | New-World monkeys | Genetic aspects | In situ hybridization | Comparative analysis | Letter
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Serial segmental duplications during primate evolution result in complex human genome architecture
by Stankiewicz, Paweł and Shaw, Christine J and Withers, Marjorie and Inoue, Ken and Lupski, James R
Genome Research, ISSN 1088-9051, 11/2004, Volume 14, Issue 11, pp. 2209 - 2220
The human genome is particularly rich in low-copy repeats (LCRs) or segmental duplications (5%-10%), and this characteristic likely distinguishes us from lower... 
LOW-COPY REPEATS | TRANSPOSABLE-ELEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRAND EXCHANGE | CHROMOSOMAL REARRANGEMENTS | Y-CHROMOSOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COX10 GENE | GENETICS & HEREDITY | HOMOLOGOUS RECOMBINATION | PERICENTRIC-INVERSION | HNPP DELETION | MOLECULAR-MECHANISMS | Cell Line | Repetitive Sequences, Nucleic Acid - genetics | Humans | Mutagenesis - genetics | Databases, Genetic | Molecular Sequence Data | In Situ Hybridization, Fluorescence | Sequence Analysis, DNA | Chromosomes, Human, Pair 17 - genetics | Primates - genetics | Animals | Recombination, Genetic - genetics | Genome, Human | Evolution, Molecular | Primates | Genetic research | Research | Human genome | Natural history
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text DupMasker: A tool for annotating primate segmental duplications
by Jiang, Zhaoshi and Hubley, Robert and Smit, Arian and Eichler, Evan E
Genome Research, ISSN 1088-9051, 08/2008, Volume 18, Issue 8, pp. 1362 - 1368
Segmental duplications (SDs) play an important role in genome rearrangement, evolution, and the copy-number variation (CNV) of primate genomes. Such sequences... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | DISORDERS | REARRANGEMENTS | SYNTENY | EVOLUTION | COPY-NUMBER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | SEQUENCE | DISEASE | REGIONS | GENETICS & HEREDITY | HUMAN-GENOME | Consensus Sequence | Primates - genetics | Animals | Base Sequence | Humans | Chromosome Aberrations | Genetic Diseases, Inborn - genetics | Macaca mulatta - genetics | Software | Genome, Human | Genomics - methods | Gene amplification | Nucleotide sequence | Genomics | Analysis | Resource
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights