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biochemistry & molecular biology (5) 5
prk (5) 5
humans (4) 4
pkn (4) 4
rho (4) 4
phosphorylation (3) 3
rat-liver (3) 3
small gtpase-rho (3) 3
zipper-like sequences (3) 3
activation (2) 2
amino-terminal region (2) 2
animals (2) 2
catalytic domain (2) 2
kinases (2) 2
life sciences (2) 2
pkc, protein kinase c (2) 2
prk, protein kinase c-related kinase (2) 2
protein kinase c - chemistry (2) 2
protein kinase c - metabolism (2) 2
protein kinase c-related kinase (2) 2
rhoa (2) 2
abl, abelson murine leukemia viral oncogene (1) 1
acoh, acetic acid (1) 1
agc kinase (1) 1
agc, protein kinase a (1) 1
aicar, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (1) 1
amino acid motifs (1) 1
amino acid sequence (1) 1
ampk, amp-activated protein kinase (1) 1
anti-cancer drugs (1) 1
apoptosis (1) 1
atf2, activating transcription factor 2 (1) 1
atm, ataxia telangiectasia mutated (1) 1
atp, adenosine triphosphate (1) 1
aurora-a (1) 1
axonal-transport (1) 1
benzimidazole (1) 1
binding-sites (1) 1
biochemistry (1) 1
biophysics (1) 1
brsk, brain-specific kinase (1) 1
c families (1) 1
c-related kinase (1) 1
c-related kinase-2 (1) 1
cak, cyclin-dependent kinase-activating kinase (1) 1
camk, calmodulin-dependent kinase (1) 1
camkk, camk kinase (1) 1
cancer (1) 1
cdc25 phosphatases - metabolism (1) 1
cdc25b (1) 1
cdc25b phosphatase (1) 1
cdi, 1,1′-carbonyldiimidazole (1) 1
cdk, cyclin-dependent protein kinase (1) 1
cdk1 (1) 1
cell adhesion (1) 1
cell biology (1) 1
cell cycle (1) 1
cell cycle proteins - metabolism (1) 1
cell line (1) 1
cell-cycle (1) 1
cell-proliferation (1) 1
cerebellar granule neurons (1) 1
cerebral-ischemia (1) 1
chembl, european molecular biology laboratory chemical database (1) 1
chemical probe (1) 1
chemical tool (1) 1
chemistry, medicinal (1) 1
chemistry, organic (1) 1
chk, checkpoint kinase (1) 1
chromosome mapping (1) 1
citron-kinase (1) 1
ck, casein kinase (1) 1
cleavage furrow (1) 1
clk, cdc2-like kinase (1) 1
csk, c-terminal src kinase (1) 1
cv, column volumes (1) 1
cyclin-dependent kinases (1) 1
cytokines (1) 1
cytokinesis - physiology (1) 1
cytoplasmic domain (1) 1
cytoplasmic linker protein of 170 kda (1) 1
cytoskeleton - metabolism (1) 1
cytoskeleton function (1) 1
dcm, dichloromethane (1) 1
dipea, n,n-diisopropylethylamine (1) 1
discovery (1) 1
dmf, n,n-dimethyl-formamide (1) 1
dmso, dimethyl sulfoxide (1) 1
dna, deoxyribonucleic acid (1) 1
drug design (1) 1
drug discovery (1) 1
dyrk, dual-specificity tyrosine-phosphorylated and -regulated kinase (1) 1
edta, ethylenediaminetetraacetic acid (1) 1
ef2k, elongation-factor-2 kinase (1) 1
egf, epidermal growth factor (1) 1
egta, egtazic acid (1) 1
enzyme activation (1) 1
eph-a2, ephrin a2 receptor (1) 1
epidermal growth factor receptor (1) 1
erk, extracellular-signal-regulated kinase (1) 1
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
2019
.... To mediate their effects, they interact with downstream effectors. The protein kinase C-related kinase (PRK... 
HR1 | PRK | PRK1 | RhoA | PKN | Rho | HR1b | HR1a | Interactions | Structure | GTPase | HR1c | G protein
Dissertation
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2020, Volume 30, Issue 8, p. 127040
[Display omitted] Kinases are signalling proteins which have proven to be successful targets for the treatment of a variety of diseases, predominantly in cancers... 
Heart failure | Chemical probe | Benzimidazole | Inflammation | PKN2 | Chemical tool | Kinases | PRK2 | AGC kinase | Protein kinase N2 | Cancer | ACTIVATION | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | PROTEIN-KINASES | DISCOVERY | RHOA | INHIBITORS | EDTA, ethylenediaminetetraacetic acid | HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid | IC50, half maximal inhibitory concentration | C families | PRO2, glutamate 5-kinase Pro2 | KD, dissociation constant | ChEMBL, European Molecular Biology Laboratory Chemical database | threonine kinase | PDB, protein databank | DIPEA, N,N-diisopropylethylamine | DMF, N,N-dimethyl-formamide | TR-FRET, time resolved fluorescence resonance energy transfer | GST, glutathione S-transferase | EtOH, ethanol | TCEP, tris(2-carboxyethyl)phosphine | CDI, 1,1′-carbonyldiimidazole | SFM, scanning force microscopy | PAK2, p21 activated kinase 2 | STK, serine | PKN, protein kinase N | PARP, poly(ADP-ribose) polymerase | Ki, inhibitor constant | THF, tetrahydrofuran | G | DCM, dichloromethane | SDS, sodium dodecyl sulfate | PAGE, polyacrylamide gel electrophoresis | NMR, nuclear magnetic resonance | HATU, hexafluorophosphate azabenzotriazole tetramethyl uronium | SAR, structure activity relationship | AcOH, acetic acid | MeOH, methanol | DNA, deoxyribonucleic acid | ATP, adenosine triphosphate | Abl, Abelson murine leukemia viral oncogene | CLK, CDC2-like kinase | PKC, protein kinase C | AGC, protein kinase A | EGTA, egtazic acid | CV, column volumes | DMSO, dimethyl sulfoxide | PRK, protein kinase C-related kinase
Journal Article
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2004, Volume 314, Issue 3, pp. 688 - 694
PKN1 is a fatty acid and Rho-activated serine/threonine protein kinase whose catalytic domain is highly homologous to protein kinase C (PKC) family... 
NF-κB | PKN | RNA interference | TRAF | Kinase | Luciferase | PRK | Rho | PKC | TNF | CYTOPLASMIC DOMAIN | NECROSIS-FACTOR RECEPTOR | ZIPPER-LIKE SEQUENCES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMALL GTPASE-RHO | CATALYTIC DOMAIN | C-RELATED KINASE | TERMINAL KINASE | kinase | NF-kappa B | BIOPHYSICS | luciferase | BINDING-SITES | NF-KAPPA-B | TRANSCRIPTION FACTOR
Journal Article
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