X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
prmt5 (260) 260
index medicus (194) 194
methylation (193) 193
humans (152) 152
animals (110) 110
biochemistry & molecular biology (101) 101
protein-arginine n-methyltransferases - metabolism (99) 99
cell biology (89) 89
protein-arginine n-methyltransferases - genetics (80) 80
expression (78) 78
arginine (74) 74
cancer (70) 70
proteins (61) 61
arginine methylation (58) 58
mice (55) 55
cell line, tumor (52) 52
transcription (52) 52
growth (51) 51
oncology (50) 50
gene expression (49) 49
complex (45) 45
arginine - metabolism (43) 43
transferases (41) 41
article (39) 39
protein binding (39) 39
histones - metabolism (37) 37
protein arginine methyltransferase (37) 37
sm proteins (37) 37
histone (34) 34
protein methyltransferases - metabolism (34) 34
activation (33) 33
dna methylation (33) 33
female (33) 33
gene (33) 33
gene-expression (33) 33
signal transduction (33) 33
methyltransferases (32) 32
research (32) 32
apoptosis (31) 31
epigenetics (31) 31
protein-arginine n-methyltransferases (31) 31
histones (30) 30
analysis (29) 29
chromatin (29) 29
binding (28) 28
protein (28) 28
cell proliferation (27) 27
gene expression regulation, neoplastic (27) 27
phosphorylation (27) 27
protein-arginine n-methyltransferases - antagonists & inhibitors (26) 26
arginine methyltransferase prmt5 (25) 25
male (25) 25
rna (25) 25
cells (24) 24
biology (22) 22
multidisciplinary sciences (22) 22
methyltransferase (21) 21
splicing (21) 21
epigenetic inheritance (20) 20
genetic aspects (20) 20
identification (20) 20
arginine methyltransferase 5 (19) 19
biophysics (19) 19
cell differentiation (19) 19
in-vivo (19) 19
pre-messenger-rna (19) 19
amino acid sequence (18) 18
development and progression (18) 18
molecular sequence data (18) 18
mutation (18) 18
protein methylation (18) 18
breast cancer (17) 17
epigenesis, genetic (17) 17
health aspects (17) 17
hek293 cells (17) 17
hela cells (17) 17
lymphoma (17) 17
physiological aspects (17) 17
protein methyltransferases - genetics (17) 17
research article (17) 17
gene knockdown techniques (16) 16
genes (16) 16
in-vitro (16) 16
kinases (16) 16
care and treatment (15) 15
cell line (15) 15
developmental biology (15) 15
differentiation (15) 15
enzymes (15) 15
genetics & heredity (15) 15
histone methylation (15) 15
post-translational modification (15) 15
proliferation (15) 15
protein arginine methyltransferase 5 (15) 15
protein-arginine n-methyltransferases - chemistry (15) 15
spinal muscular-atrophy (15) 15
cell cycle (14) 14
middle aged (14) 14
nuclear proteins - metabolism (14) 14
transcription factors - metabolism (14) 14
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Experimental and Clinical Cancer Research, 02/2019, Volume 38, Issue 1, p. 64
CFLAR , also known as c-FLIP , is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that... 
PRMT5 | ITCH | CFLAR | PRMT1 | Apoptosis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 317 - 333
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
PRMT5 inhibitors | N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives | Anti-tumor | SM PROTEINS | PRMT5 | METHYLATION | COMPLEX | CHEMISTRY, MEDICINAL | PICLN | GROWTH | IDENTIFICATION
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 06/2019, Volume 114, p. 108790
Protein arginine methyltransferases (PRMTs) play important roles in protein methylation. PRMT5 is the major type II arginine methyltransferase that catalyzes... 
PRMT5 | Biomarker | Oncogene | Cancer
Journal Article
Gene, ISSN 0378-1119, 12/2019, Volume 720, p. 144099
Emerging evidence demonstrates that circular RNA (circRNA) is a novel class of non-coding RNA that plays a pivotal role in cancer. Recently, circ-PRMT5 was... 
Circular RNA | circ-PRMT5 | Proliferation | NSCLC | EZH2
Journal Article
Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 94, p. 36646
Journal Article
Oncotarget, ISSN 1949-2553, 06/2018, Volume 9, Issue 47, pp. 28625 - 28637
Genotype specific vulnerabilities of cancer cells constitute a promising strategy for the development of new therapeutics. Deletions of non-essential genes in... 
PRMT5 | MTAP | Target | RIOK1 | Cancer
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2017, Volume 114, Issue 34, pp. E7092 - E7100
Ion channels are proteins that span the cell’s membrane and affect the rapid transfer of ions. Kinases are proteins that transfer a phosphate from ATP to... 
PRMT5 | TRPM7 | Ion channel | Kinase | TRPM6 | Biological Sciences | kinase | PNAS Plus | ion channel
Journal Article
Methods (San Diego, Calif.), ISSN 1046-2023, 09/2019
Arginine methylation is now recognized as a major contributor to proteome diversity and is, as such, involved in a large range of cellular processes. There is... 
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2016, Volume 7, Issue 2, pp. 162 - 166
The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool... 
PRMT5 | structure guided design | property based optimization | Methyltransferase
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7692 - 7710
Journal Article
Oncotarget, ISSN 1949-2553, 05/2019, Volume 10, Issue 34, p. 3151
Protein arginine methyltransferases (PRMTs) catalyze the methylation of arginine residues on both histones and non-histone proteins. PRMT5, a member of the... 
Journal Article
Journal Article
Developmental biology, ISSN 0012-1606, 08/2019
During skeletal development, limb progenitors become specified as chondrocytes and subsequently differentiate into specialized cartilage compartments. We... 
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2633 - 2643
Purpose: Little is known about the function of histone arginine methylation in acute lymphoblastic leukemia (ALL). The objective was to evaluate whether... 
PRMT5 | COMPLEX | PROTEIN | METHYLTRANSFERASE | ONCOLOGY | E2A ACTIVITY | SUPPRESSES | EXPRESSION | HISTONE ARGININE METHYLATION
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 05/2017, Volume 15, Issue 17, pp. 3648 - 3661
Protein arginine methyltransferase 5 (PRMT5) is a type II PRMT enzyme critical for diverse cellular processes and different types of cancers. Many efforts have... 
Journal Article