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Biochimie, ISSN 0300-9084, 2019
Porphyromonas gingivalis uses a type IX secretion system (T9SS) to deliver more than 30 proteins to the bacterial surface using a conserved C-terminal domain... 
Posttranslational modification | Prodomain | Periodontal disease | Secretion | Limited proteolysis | Inhibition | Sortase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 5, pp. E866 - E875
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal... 
myostatin prodomain | myostatin activation | latent activation | GDF8 | GDF8 prodomain | CELLS | MULTIDISCIPLINARY SCIENCES | MUSCLE MASS | IDENTIFICATION | MYOSTATIN ACTIVITY | GROWTH-FACTOR-BETA | ACTIVIN-A | TGF | PROTEIN-1 | BINDING | PROPEPTIDE | Medicine, Experimental | Medical research | Myostatin | Gene expression | Health aspects | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Development, ISSN 0950-1991, 09/2009, Volume 136, Issue 22, pp. 3691 - 3697
Advances in our understanding of the many levels of regulation of TGF beta and BMP signaling were reported at the recent FASEB Summer Conference entitled 'The... 
RECEPTOR COMPLEXES | CELLS | ACTIVATION | GROWTH | PRODOMAIN | REQUIRES | DEVELOPMENTAL BIOLOGY | DORSOVENTRAL AXIS | PROTEINS | SMAD1/5 PHOSPHORYLATION | DROSOPHILA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 47, pp. 19160 - 19178
Journal Article
Journal of Experimental Botany, ISSN 0022-0957, 04/2019, Volume 70, Issue 7, pp. 1997 - 2002
Proteolytic cascades are hierarchical sets of proteases that activate each other by proteolytic cleavage. Textbook examples are Ser proteases regulating blood... 
ACTIVATION | Peptidase | FURIN | prodomain cleavage | MATURATION | proteolytic cascade | CYSTEINE PROTEINASE | protease activation | PLANT SCIENCES | MATRIX METALLOPROTEINASES | proteinase | ENZYMES | ALEURAIN | processing | INHIBITORS | signalling | PROTEASE | PROPEPTIDE | Viewpoints
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 10/2009, Volume 18, Issue 20, pp. 3987 - 3996
ADAM10, a member of a disintegrin and metalloprotease family, is an α-secretase capable of anti-amyloidogenic proteolysis of the amyloid precursor protein.... 
CONVERTING-ENZYME TACE | BETA-SECRETASE | CYSTEINE SWITCH | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRODOMAIN | GENETICS & HEREDITY | KINASE-C | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | DISINTEGRIN METALLOPROTEASE | FAMILY | Association Studies
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2019, Volume 27, Issue 7, pp. 1437 - 1443
Myostatin is a negative regulator of skeletal muscle growth and myostatin inhibitors are promising lead compounds against muscle atrophic disorders such as... 
Myostatin | Inhibitor | Cyclization | Peptide | Structure-activity relationship | CACHEXIA | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRODOMAIN | MUSCLE | CHEMISTRY, ORGANIC | IDENTIFICATION | MICE | Muscles | Lead compounds | Peptides | Pharmacy
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2019, Volume 10, Issue 6, pp. 985 - 990
Inhibition of myostatin is a promising strategy for treatment of muscle atrophic disorders. We had already identified a 23mer peptide (1) as a synthetic... 
peptide | Inhibitor | structure-activity relationship | muscle atrophic disorder | myostatin | CHEMISTRY, MEDICINAL | SKELETAL-MUSCLE MASS | PRODOMAIN | IDENTIFICATION | FOLLISTATIN
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 08/2012, Volume 19, Issue 8, pp. 1288 - 1298
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2010, Volume 285, Issue 22, pp. 17029 - 17037
Transforming growth factor-β1 (TGF-β1) is secreted as part of an inactive complex consisting of the mature dimer, the TGF-β1 propeptide (latency-associated... 
Protein Structure and Folding | Transforming Growth Factor Beta (TGFbeta) | Prodomain | Signal Transduction | Extracellular Matrix Proteins | Latency-associated Peptide | Camurati-Engelmann Disease | Latent TGF-β | TGF-β | Binding Protein | Protein Folding | Protein-Protein Interactions
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 08/2019, Volume 55, Issue 62, pp. 9108 - 9111
Journal Article
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 07/2018, Volume 218, Issue 3, pp. 434 - 442
Background. Falcipain-2a ([FP2a] PF3D7_1115700) is a Plasmodium falciparum cysteine protease and hemoglobinase. Functional FP2a is required for potent activity... 
artemisinin resistance | Plasmodium falciparum | ACT | malaria | falcipain 2a | CYSTEINE PROTEASE FALCIPAIN-2 | PARASITES | INFECTIOUS DISEASES | DIHYDROARTEMISININ-PIPERAQUINE FAILURE | PRODOMAIN | MICROBIOLOGY | IMMUNOLOGY | HEMOGLOBIN DEGRADATION | CAMBODIA | IN-VITRO | CHINA-MYANMAR BORDER | PROTEINASE | Major and Brief Reports
Journal Article