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Medicinal Research Reviews, ISSN 0198-6325, 01/2009, Volume 29, Issue 1, pp. 29 - 64
Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic effectiveness and decrease systemic side effects in the treatment... 
prodrug | bioreductive activation | hypoxia | N‐oxide | nitroreduction | target‐specific activation | gene‐directed enzyme prodrug therapy (GDEPT) | metal complex | nitroaromatic | quinone | Gene-directed enzyme prodrug therapy (GDEPT) | Nitroreduction | N-oxide | Quinone | Target-specific activation | Metal complex | Nitroaromatic | Hypoxia | Prodrug | Bioreductive activation | target-specific activation | CHEMISTRY, MEDICINAL | SELECTIVE ANTITUMOR AGENTS | MMP INHIBITOR MARIMASTAT | BENZOQUINONE ALKYLATING-AGENTS | ESCHERICHIA-COLI NITROREDUCTASE | POTENTIAL HYPOXIC CYTOTOXINS | CYTOTOXICITY IN-VITRO | HUMAN NAD(P)H-QUINONE OXIDOREDUCTASE | PHARMACOLOGY & PHARMACY | INDOLEQUINONE PHOSPHORAMIDATE PRODRUGS | gene-directed enzyme prodrug therapy (GDEPT) | ANTIBODY-DIRECTED ENZYME | N-OXIDE DERIVATIVES | Quinones - pharmacokinetics | Quinones - chemistry | Hydrocarbons, Aromatic - pharmacology | Oxidation-Reduction | Humans | Organometallic Compounds - pharmacokinetics | Prodrugs - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Cyclic N-Oxides - pharmacokinetics | Cell Hypoxia | Hydrocarbons, Aromatic - chemistry | Cyclic N-Oxides - chemistry | Animals | Prodrugs - pharmacokinetics | Cyclic N-Oxides - pharmacology | Hydrocarbons, Aromatic - pharmacokinetics | Drug Design | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Prodrugs - pharmacology | Organometallic Compounds - pharmacology | Quinones - pharmacology
Journal Article
2015, ISBN 9780128035191, 84
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that... 
Industrial chemistry & manufacturing technologies | Prodrugs | Medicine | Drug development | Pharmaceutical chemistry
eBook