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1. Full Text Prodrugs-from serendipity to rational design
by Huttunen, Kristiina M and Raunio, Hannu and Rautio, Jarkko
Pharmacological Reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 750 - 771
The prodrug concept has been used to improve undesirable properties of drugs since the late 19th century, although it was only at the end of the 1950s that the... 
PHYSICOCHEMICAL PROPERTIES | DIRECT THROMBIN INHIBITOR | VALYL ESTER PRODRUG | 3-AMINO-1,2,4-BENZOTRIAZINE 1,4-DIOXIDE | ORAL-DRUG DELIVERY | PROTON PUMP INHIBITORS | DIPIVALYL EPINEPHRINE | PHARMACOLOGY & PHARMACY | HYPOXIA-ACTIVATED PRODRUGS | CLINICAL PHARMACOKINETICS | LIVER-TARGETED PRODRUG | Technology, Pharmaceutical - trends | Prodrugs - adverse effects | Animals | Drug-Related Side Effects and Adverse Reactions - prevention & control | Prodrugs - pharmacokinetics | Biotransformation | Humans | Drug Design | Prodrugs - therapeutic use | Drug Discovery | Prodrugs - pharmacology | Index Medicus
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2. Full Text Prodrugs: Design and clinical applications
by Rautio, Jarkko and Kumpulainen, Hanna and Heimbach, Tycho and Oliyai, Reza and Oh, Dooman and Järvinen, Tomi and Savolainen, Jouko
Nature Reviews Drug Discovery, ISSN 1474-1776, 03/2008, Volume 7, Issue 3, pp. 255 - 270
Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/ or chemical transformation in vivo to release the active parent drug,... 
TENOFOVIR DISOPROXIL FUMARATE | DIRECT THROMBIN INHIBITOR | COA REDUCTASE INHIBITORS | MEDIATED CELLULAR EFFLUX | AMINOMETHYL)-1-CYCLOHEXANE ACETIC-ACID | DRUG-DELIVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ESTRAMUSTINE PHOSPHATE | PHARMACOLOGY & PHARMACY | PHARMACOKINETIC PROPERTIES | IN-VIVO EVALUATION | WATER-SOLUBLE PRODRUGS | Prodrugs - administration & dosage | Absorption | Animals | Humans | Drug Design | Biological Availability | Prodrugs - chemistry | Parenteral Nutrition | Administration, Topical | Drug Delivery Systems
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3. Prodrug design
: perspectives, approaches and applications in medicinal chemistry
by Redasani, Vivekkumar K and Bari, Sanjay B
2015, ISBN 0128035196
Drugs | Design | Prodrugs | Drug Design | Pharmaceutical chemistry
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4. Design of prodrugs
by Bundgaard, Hans
1985, ISBN 9780444806758, vii, 360
Drugs | Prodrugs | Biotransformation | Metabolism | Biopharmaceutics | Chemistry, Pharmaceutical | Pharmaceutical chemistry
Book
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5. Full Text Design of anticancer prodrugs for reductive activation
by Chen, Yu and Hu, Longqin
Medicinal Research Reviews, ISSN 0198-6325, 01/2009, Volume 29, Issue 1, pp. 29 - 64
Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic effectiveness and decrease systemic side effects in the treatment... 
prodrug | bioreductive activation | hypoxia | N‐oxide | nitroreduction | target‐specific activation | gene‐directed enzyme prodrug therapy (GDEPT) | metal complex | nitroaromatic | quinone | Gene-directed enzyme prodrug therapy (GDEPT) | Nitroreduction | N-oxide | Quinone | Target-specific activation | Metal complex | Nitroaromatic | Hypoxia | Prodrug | Bioreductive activation | target-specific activation | CHEMISTRY, MEDICINAL | SELECTIVE ANTITUMOR AGENTS | MMP INHIBITOR MARIMASTAT | BENZOQUINONE ALKYLATING-AGENTS | ESCHERICHIA-COLI NITROREDUCTASE | POTENTIAL HYPOXIC CYTOTOXINS | CYTOTOXICITY IN-VITRO | HUMAN NAD(P)H-QUINONE OXIDOREDUCTASE | PHARMACOLOGY & PHARMACY | INDOLEQUINONE PHOSPHORAMIDATE PRODRUGS | gene-directed enzyme prodrug therapy (GDEPT) | ANTIBODY-DIRECTED ENZYME | N-OXIDE DERIVATIVES | Quinones - pharmacokinetics | Quinones - chemistry | Hydrocarbons, Aromatic - pharmacology | Oxidation-Reduction | Humans | Organometallic Compounds - pharmacokinetics | Prodrugs - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Cyclic N-Oxides - pharmacokinetics | Cell Hypoxia | Hydrocarbons, Aromatic - chemistry | Cyclic N-Oxides - chemistry | Animals | Prodrugs - pharmacokinetics | Cyclic N-Oxides - pharmacology | Hydrocarbons, Aromatic - pharmacokinetics | Drug Design | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Prodrugs - pharmacology | Organometallic Compounds - pharmacology | Quinones - pharmacology
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6. Bioreversible carriers in drug design
: theory and applications
by Roche, Edward B
1987, ISBN 0080346812, viii, 292
Prodrugs | Drug carriers (Pharmacy)
Book
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7. Full Text Prodrug Design
: Perspectives, Approaches and Applications in Medicinal Chemistry
by Vivekkumar Redasani and Sanjay Bari
2015, ISBN 9780128035191, 84
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that... 
Industrial chemistry & manufacturing technologies | Prodrugs | Medicine | Drug development | Pharmaceutical chemistry
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8. Full Text Organic Carbamates in Drug Design and Medicinal Chemistry
by Ghosh, Arun K and Brindisi, Margherita
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 2895 - 2940
The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many... 
ENZYME PRODRUG THERAPY | NS3 SERINE-PROTEASE | HIV-1 PROTEASE INHIBITORS | CHEMISTRY, MEDICINAL | ACID AMIDE HYDROLASE | SOLID-PHASE SYNTHESIS | 2 BETA-SECRETASE | HEPATITIS-C-VIRUS | HUMAN-LEUKOCYTE ELASTASE | GAMMA-SECRETASE INHIBITORS | ACUTE RESPIRATORY SYNDROME | Antiviral Agents - pharmacology | Chemistry Techniques, Synthetic | Chemistry, Pharmaceutical - methods | Hepatitis C - drug therapy | Drug Stability | Humans | HIV Protease | HIV Protease Inhibitors - chemistry | Carbamates - chemistry | HIV Protease Inhibitors - pharmacology | Carbamates - chemical synthesis | Serine Proteinase Inhibitors - chemistry | Antiviral Agents - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Drug Design | Prodrugs - chemical synthesis | Cysteine Proteinase Inhibitors - chemistry | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Viral Nonstructural Proteins - antagonists & inhibitors | Serine Proteinase Inhibitors - pharmacology | Carbamates - pharmacology
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9. Full Text Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy
by Hu, Xu and Tian, Hailong and Jiang, Wei and Song, Aixin and Li, Zhonghao and Luan, Yuxia
Small, ISSN 1613-6810, 12/2018, Volume 14, Issue 52, pp. e1802994 - n/a
Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single‐wavelength near‐infrared (NIR)... 
combined phototherapy | micelles | Ce6 | IR820 | single‐wavelength NIR light | single-wavelength NIR light | DRUG-DELIVERY-SYSTEM | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | PHOTODYNAMIC THERAPY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | MAGNETIC NANOPARTICLES | ANTITUMOR-ACTIVITY | CANCER | CHEMISTRY, MULTIDISCIPLINARY | CHLORIN E6 | CO-DELIVERY | PRODRUG | MULTIDRUG-RESISTANCE | NEAR-INFRARED DYE | Conjugates | Medical imaging | Photodynamic therapy | Toxicity | Fluorescence | Light therapy | Photothermal conversion | Anticancer properties | Singlet oxygen | Lasers | Polyethylene glycol | Micelles | Infrared radiation | Biocompatibility | Diagnostic systems | Index Medicus
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10. Full Text Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
by Kratz, Felix
Journal of Controlled Release, ISSN 0168-3659, 2008, Volume 132, Issue 3, pp. 171 - 183
Albumin is playing an increasing role as a drug carrier in the clinical setting. Principally, three drug delivery technologies can be distinguished: coupling... 
Albumin nanoparticles | Human serum albumin | Drug delivery | Prodrugs | Drug conjugates | RHEUMATOID-ARTHRITIS | PROSTATE-SPECIFIC ANTIGEN | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | BINDING PRODRUG | BREAST-CANCER | HUMAN-SERUM-ALBUMIN | PHASE-II TRIAL | IN-VIVO | PHARMACOLOGY & PHARMACY | MTX-HSA | ANTITUMOR EFFICACY | Drug Stability | Humans | Half-Life | Models, Molecular | Prodrugs - chemistry | Chemistry, Pharmaceutical | Prodrugs - metabolism | Drug Carriers | Nanoparticles | Animals | Biological Transport | Drug Design | Drug Compounding | Protein Conformation | Serum Albumin - chemistry | Binding Sites | Serum Albumin - metabolism | Drugs | Antiviral agents | Drug delivery systems | Anthracyclines | Peptides | Albumin | Biological response modifiers | Insulin | Vehicles | Diabetes | Methotrexate | Hepatitis C | Saturated fatty acids | Protein binding | Tumors
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11. Full Text Chalcone derivatives: Promising starting points for drug design
by Gomes, Marcelo N and Muratov, Eugene N and Pereira, Maristela and Peixoto, Josana C and Rosseto, Lucimar P and Cravo, Pedro V. L and Andrade, Carolina H and Neves, Bruno J
Molecules, ISSN 1420-3049, 08/2017, Volume 22, Issue 8, p. 1210
Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward... 
Chalcone derivatives | Molecular modification strategies | Chalcone synthesis | Natural products | Computer-assisted drug design | molecular modification strategies | chalcone derivatives | CHEMISTRY, ORGANIC | BIOISOSTERIC REPLACEMENT | STRUCTURE-BASED PHARMACOPHORES | MOLECULAR DOCKING | chalcone synthesis | FINGERPRINT SIMILARITY SEARCH | FREE-ENERGY SIMULATIONS | MEDICINAL CHEMISTRY | natural products | computer-assisted drug design | VENOUS LYMPHATIC INSUFFICIENCY | PROTEIN-LIGAND DOCKING | BIOLOGICAL EVALUATION | ASSAY INTERFERENCE COMPOUNDS | Prodrugs - chemical synthesis | Prodrugs - chemistry | Chalcone - chemistry | Chalcone - analogs & derivatives | Chalcone - chemical synthesis | Drug Design | Design | Drugs | Chemists | Derivatives | Hybridization | Drug discovery | Drug development | Chemical synthesis | Design optimization
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