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index medicus (56) 56
progesterone metabolite 5-alpha-pregnan-3-alpha-ol-20-one (51) 51
animals (47) 47
neurosciences (35) 35
male (32) 32
pharmacology & pharmacy (32) 32
rats (31) 31
progesterone (27) 27
neurosteroids (25) 25
anxiolytic activity (24) 24
female (24) 24
pregnanolone - pharmacology (24) 24
gaba-a receptor (23) 23
neuroactive steroids (22) 22
rat-brain (19) 19
rats, sprague-dawley (19) 19
allopregnanolone (18) 18
brain (18) 18
humans (15) 15
dose-response relationship, drug (13) 13
gaba (13) 13
neurosteroid (13) 13
psychiatry (13) 13
5-alpha-pregnan-3-alpha-ol-20-one (12) 12
gamma-aminobutyric-acid (12) 12
mice (12) 12
modulation (12) 12
gaba receptor (11) 11
a receptor (10) 10
behavior, animal - drug effects (10) 10
pregnanolone (10) 10
progesterone - pharmacology (10) 10
receptor (10) 10
receptors, gaba-a - drug effects (10) 10
steroids (10) 10
3-alpha-hydroxy-5-alpha-pregnan-20-one (9) 9
anxiety (9) 9
central-nervous-system (9) 9
rat (9) 9
metabolite 5-alpha-pregnan-3-alpha-ol-20-one (8) 8
pregnancy (8) 8
seizures - chemically induced (8) 8
anticonvulsants - pharmacology (7) 7
brain - drug effects (7) 7
clinical neurology (7) 7
endocrinology & metabolism (7) 7
gaba a receptor (7) 7
neuroactive steroid (7) 7
pregnanolone - metabolism (7) 7
progesterone - metabolism (7) 7
alphaxalone (6) 6
anti-anxiety agents - pharmacology (6) 6
behavioral sciences (6) 6
biochemistry & molecular biology (6) 6
epilepsy (6) 6
motor activity - drug effects (6) 6
adult (5) 5
benzodiazepine (5) 5
binding (5) 5
brain - metabolism (5) 5
catamenial epilepsy (5) 5
cerebral-cortex (5) 5
chloride ionophore (5) 5
complex (5) 5
elevated plus-maze (5) 5
estrous-cycle (5) 5
gaba modulators - pharmacology (5) 5
gaba-a-receptor (5) 5
long-term potentiation (5) 5
progesterone - blood (5) 5
rats, wistar (5) 5
receptors, gaba-a - metabolism (5) 5
steroid-hormone metabolites (5) 5
stress (5) 5
substance abuse (5) 5
3α-hydroxy-5α-pregnan-20-one (4) 4
5α-pregnan-3α-ol-20-one (4) 4
anxiety - drug therapy (4) 4
benzodiazepines (4) 4
corticosterone - blood (4) 4
dehydroepiandrosterone (4) 4
depression (4) 4
diazepam (4) 4
estrogen (4) 4
ethanol - pharmacology (4) 4
gaba antagonists - pharmacology (4) 4
hormone metabolites (4) 4
hypnotics and sedatives - pharmacology (4) 4
k tu pharmacology & pharmacy (4) 4
mechanism (4) 4
metabolites (4) 4
methyl-d-aspartate (4) 4
neurosteroid allopregnanolone (4) 4
plus-maze (4) 4
pregnenolone (4) 4
pregnenolone sulfate (4) 4
pregnenolone-sulfate (4) 4
progesterone - therapeutic use (4) 4
receptor complex (4) 4
seizures (4) 4
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European Journal of Pharmacology, ISSN 0014-2999, 1989, Volume 166, Issue 2, pp. 325 - 329
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2003, Volume 23, Issue 37, pp. 11641 - 11652
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 01/2003, Volume 28, Issue 1, pp. 1 - 13
Journal Article
Pediatric Research, ISSN 0031-3998, 06/2003, Volume 53, Issue 6, pp. 956 - 964
Pregnane steroids have sedative and neuroprotective effects on the brain as a result of interactions with the steroid-binding site of the GABA(A) receptor. To... 
FETAL SHEEP | TISSUE DISTRIBUTION | ANXIOLYTIC ACTIVITY | PEDIATRICS | CENTRAL-NERVOUS-SYSTEM | ALLOPREGNANOLONE CONCENTRATIONS | RAT-BRAIN | SOMATOSENSORY-EVOKED POTENTIALS | 5-ALPHA-REDUCTASE ISOZYMES | PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE | CEREBRAL-CORTEX
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/1996, Volume 278, Issue 2, pp. 510 - 517
The anxiolytic and anticonvulsant effects of benzodiazepines, barbiturates, ethanol and neuroactive steroids are mediated by selective Interactions with... 
SUBUNIT MESSENGER-RNAS | GABA-A RECEPTOR | INVERSE AGONIST | ANXIOLYTIC ACTIVITY | CROSS-TOLERANCE | PHARMACOLOGY & PHARMACY | OPERATED CHLORIDE CHANNELS | PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE | HORMONE METABOLITES | CEREBRAL-CORTEX | BRAIN
Journal Article
NEUROENDOCRINOLOGY, ISSN 0028-3835, 02/1996, Volume 63, Issue 2, pp. 166 - 172
The time courses of changes in rat brain neuroactive steroid concentrations and gamma-aminobutyric acid type A (GABA(A)) receptor function elicited by acute... 
cortex | stress | A RECEPTOR | neurosteroids | GABA receptors | ENDOCRINOLOGY & METABOLISM | DECREASE | gonadal steroids | BINDING | NEUROSCIENCES | PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE | CEREBRAL-CORTEX
Journal Article
Pain Medicine, ISSN 1526-2375, 2010, Volume 11, Issue 10, pp. 1469 - 1476
Journal Article
Pediatric Research, ISSN 0031-3998, 12/2003, Volume 54, Issue 6, pp. 840 - 847
Pregnane steroids have sedative and neuroprotective effects on the brain, due to interactions with the steroid-binding site of the GABA(A) receptor. In the... 
5-ALPHA-REDUCTASE | BRAIN ALLOPREGNANOLONE | A RECEPTOR | LATE-GESTATION | ANXIOLYTIC ACTIVITY | PEDIATRICS | ALLOPREGNANOLONE CONCENTRATIONS | INTRAUTERINE GROWTH-RESTRICTION | RAT-BRAIN | PROGESTERONE METABOLITE 5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE | OVINE FETUS
Journal Article
Journal Article
EPILEPSY RESEARCH, ISSN 0920-1211, 01/1993, Volume 14, Issue 1, pp. 17 - 30
The acute effects of progesterone and its brain metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha-OH-DHP) on focal epileptic seizures in the cat's visual... 
5-ALPHA-PREGNAN-3-ALPHA-OL-20-ONE | PROGESTERONE | RELEASE | CEREBRAL-CORTEX | CLINICAL NEUROLOGY | OVARIAN-STEROIDS | INTRACORTICAL AXON COLLATERALS | SEIZURE THRESHOLD | CORTICO-GENICULATE CELLS | AREA 17 | ANTICONVULSANTS | RECEPTOR COMPLEX | GABAA RECEPTOR | EPILEPSY | RAT-BRAIN | MODULATION
Journal Article