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1. Full Text Intravital mucosal imaging of CD8(+) resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
by Beura, LK and Mitchell, JS and Thompson, EA and Schenkel, JM and Mohammed, J and Wijeyesinghe, S and Fonseca, R and Burbach, BJ and Hickman, HD and Vezys, V and Fife, BT and Masopust, D
NATURE IMMUNOLOGY, ISSN 1529-2908, 02/2018, Volume 19, Issue 2, pp. 173 - 173
CD8(+) T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to... 
MIGRATION | PROTECTIVE IMMUNITY | ACTIVATION | PERSISTENCE | RM CELLS | LOCAL ANTIGEN | INFECTION | DIFFERENTIATION | IMMUNOLOGY | PROLIFERATIVE CAPACITY | LYMPHOCYTES | Cell proliferation | Antigens | Memory cells | Immunological memory | CD8 antigen | Mucosa | Immunosurveillance | Activation | Lymphocytes T | Lymphoid tissue | Cell differentiation | Microscopy | Lymphocytes | Rodents | Skin | Recall | Cancer
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2. Full Text Toll‐like receptors – sentries in the B‐cell response
by Bekeredjian‐Ding, Isabelle and Jego, Gaetan
Immunology, ISSN 0019-2805, 11/2009, Volume 128, Issue 3, pp. 311 - 323
Summary Toll‐like receptors (TLR) play a central role in the initiation of the innate immune response to pathogens. Upon recognition of molecular motifs... 
viruses | B cells | bacteria | Toll‐like receptors | antibody responses | Toll-like receptors | Bacteria | Viruses | Antibody responses | PROLIFERATIVE RESPONSES | INDUCED CYTIDINE DEAMINASE | IMMUNOLOGY | CPG DNA | C-H TRANSCRIPTION | BLOOD MONONUCLEAR-CELLS | PLASMACYTOID DENDRITIC CELLS | INFLUENZA-VIRUS INFECTION | CLASS-SWITCH RECOMBINATION | NF-KAPPA-B | BRUTONS-TYROSINE KINASE | Immunomodulation | Humans | Toll-Like Receptors - immunology | Immunity, Innate | Host-Pathogen Interactions | Animals | Toll-Like Receptors - genetics | Antibody Formation | Mice | B-Lymphocytes - pathology | Toll-Like Receptors - metabolism | Immunoglobulin Class Switching | B-Lymphocytes - metabolism | Antigens | Immunoglobulins | Universities and colleges | Review
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3. Full Text Defective immune responses in mice lacking LUBAC‐mediated linear ubiquitination in B cells
by Sasaki, Yoshiteru and Sano, Soichi and Nakahara, Masaki and Murata, Shigeo and Kometani, Kohei and Aiba, Yuichi and Sakamoto, Shinji and Watanabe, Yoshihiro and Tanaka, Keiji and Kurosaki, Tomohiro and Iwai, Kazuhiro
The EMBO Journal, ISSN 0261-4189, 09/2013, Volume 32, Issue 18, pp. 2463 - 2476
The linear ubiquitin chain assembly complex (LUBAC) plays a crucial role in activating the canonical NF‐κB pathway, which is important for B‐cell development... 
B cell | linear ubiquitin chain assembly complex | antibody response | canonical NF‐κB pathway | ERK | Canonical NF-κB pathway | Linear ubiquitin chain assembly complex | Antibody response | ACTIVATION | COMPLEX | INDEPENDENT TYPE-2 ANTIGENS | BIOCHEMISTRY & MOLECULAR BIOLOGY | canonical NF-kappa B pathway | RECEPTOR | CELL BIOLOGY | CHRONIC PROLIFERATIVE DERMATITIS | LYMPHOCYTE DEVELOPMENT | SIGNALING PATHWAY | CHAINS | NF-KAPPA-B | NEMO | Immunity, Cellular - genetics | Electrophoresis, Polyacrylamide Gel | Mice, Inbred C57BL | NF-kappa B - immunology | Immunoblotting | Mice, Transgenic | NF-kappa B - metabolism | Ubiquitination - immunology | MAP Kinase Signaling System - immunology | Animals | B-Lymphocytes - immunology | Flow Cytometry | Models, Animal | Mice | Receptors, Tumor Necrosis Factor - immunology | Ubiquitin-Protein Ligases - genetics | Real-Time Polymerase Chain Reaction | B-Lymphocytes - metabolism | Multiprotein Complexes - immunology | Signal transduction | TNF inhibitors | Cellular biology | Immune system | Animal models | canonical NF-κB pathway
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4. Full Text Manipulation of B-cell responses with histone deacetylase inhibitors
by Waibel, Michaela and Christiansen, Ailsa J and Hibbs, Margaret L and Shortt, Jake and Jones, Sarah A and Simpson, Ian and Light, Amanda and O'Donnell, Kristy and Morand, Eric F and Tarlinton, David M and Johnstone, Ricky W and Hawkins, Edwin D
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6838
Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are... 
MULTIPLE-MYELOMA | BURKITT-LYMPHOMA | ANTICANCER ACTIVITIES | EPIGENETIC CONTROL | MULTIDISCIPLINARY SCIENCES | GERMINAL CENTER | PROLIFERATIVE LUPUS NEPHRITIS | AUTOIMMUNE-DISEASE | LYN-DEFICIENT MICE | PRIMARY IMMUNE-RESPONSE | THERAPEUTIC ACTIVITIES | Cell Survival - drug effects | Mice, Inbred C57BL | Cells, Cultured | Male | Germinal Center - drug effects | Immunologic Memory - drug effects | B-Lymphocytes - drug effects | Animals | Cell Differentiation - drug effects | Lupus Erythematosus, Systemic - drug therapy | Female | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Indoles - pharmacology | Indoles - therapeutic use | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Drug Evaluation, Preclinical | Hydroxamic Acids - pharmacology
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5. Full Text Differential expression, modulation and bioactivity of distinct fish IL‐12 isoforms: Implication towards the evolution of Th1‐like immune responses
by Wang, Tiehui and Husain, Mansourah and Hong, Suhee and Holland, Jason W
European Journal of Immunology, ISSN 0014-2980, 05/2014, Volume 44, Issue 5, pp. 1541 - 1551
IL‐12 is a heterodimeric cytokine composed of an α‐chain (p35) and a β‐chain (p40). Primarily produced by APCs, IL‐12 induces IFN‐γ production in T, B and NK... 
Infection | IL‐12 | Bioactivity | Th1 immune responses | Rainbow trout | IL-12 | RAINBOW-TROUT | IFN-GAMMA | PROLIFERATIVE-KIDNEY-DISEASE | FUNCTIONAL-CHARACTERIZATION | IMMUNOLOGY | ADAPTIVE IMMUNITY | REGULATORY MECHANISMS | GENE-EXPRESSION | TELEOST FISH | CYTOKINE FAMILY | TROUT ONCORHYNCHUS-MYKISS | Oncorhynchus mykiss - metabolism | Th1 Cells - pathology | Fish Proteins - biosynthesis | Fish Proteins - immunology | Gene Expression Regulation - immunology | Male | Th1 Cells - immunology | Fish Diseases - pathology | Th1 Cells - metabolism | Animals | Interleukin-12 Subunit p35 - immunology | Interferon-gamma - immunology | Interleukin-12 Subunit p35 - biosynthesis | Fish Diseases - immunology | Female | Interleukin-12 Subunit p40 - immunology | Oncorhynchus mykiss - immunology | Immunity, Cellular | Interleukin-12 Subunit p40 - biosynthesis | Interferon-gamma - biosynthesis | Fish Diseases - metabolism | Immune response | Gene expression | Trout | Analysis | Fishes | Pathogens
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6. Full Text Retinal pigment epithelial cells display specific transcriptional responses upon TNF-α stimulation
by Korthagen, Nicoline M and van Bilsen, Kiki and Swagemakers, Sigrid M A and van de Peppel, Jeroen and Bastiaans, Jeroen and van der Spek, Peter J and van Hagen, P Martin and Dik, Willem A
British Journal of Ophthalmology, ISSN 0007-1161, 05/2015, Volume 99, Issue 5, pp. 700 - 704
Background/aims Tumour necrosis factor-α (TNF-α) is a key mediator of ocular inflammation and its interaction with the retinal pigment epithelium (RPE) may be... 
GENE-EXPRESSION | OPHTHALMOLOGY | NEOVASCULARIZATION | BARRIER | Cell Line | Retinal Pigment Epithelium - metabolism | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Gene Expression Regulation - physiology | Gene Expression Profiling | Transcription Factors - genetics | Blotting, Western | HT29 Cells | Tumor Necrosis Factor-alpha - pharmacology | Real-Time Polymerase Chain Reaction | Retinal Pigment Epithelium - drug effects | Macular degeneration | Diabetic retinopathy | Tumor necrosis factor | Research | Gene expression | Risk factors | Proliferative vitreoretinopathy
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7. Full Text Spatially and Genetically Distinct African Trypanosome Virulence Variants Defined by Host Interferon-γ Response
by Lorna MacLean and Martin Odiit and Annette MacLeod and Liam Morrison and Lindsay Sweeney and Anneli Cooper and Peter G. E. Kennedy and Jeremy M. Sternberg
The Journal of Infectious Diseases, ISSN 0022-1899, 12/2007, Volume 196, Issue 11, pp. 1620 - 1628
We describe 2 spatially distinct foci of human African trypansomiasis in eastern Uganda. The Tororo and Soroti foci of Trypanosoma brucei rhodesiense infection... 
Cytokines | Parasitic diseases | Virulence | Medical genetics | Infections | Glasgow coma scale | Parasites | Genotypes | Trypanosome | Blood plasma | INFECTIOUS DISEASES | INFECTIONS | CELL PROLIFERATIVE RESPONSES | NITRIC-OXIDE | RESISTANCE | SLEEPING SICKNESS | CNS | MICROBIOLOGY | IMMUNOLOGY | BRUCEI-BRUCEI | SUPPRESSION | IL-10 | Humans | Host-Parasite Interactions - genetics | Virulence - genetics | Glasgow Coma Scale | Polymerase Chain Reaction | Trypanosoma brucei rhodesiense - genetics | Blood-Brain Barrier - parasitology | Severity of Illness Index | Blood-Brain Barrier - immunology | Interferon-gamma - cerebrospinal fluid | Interleukins - blood | Malaria, Cerebral - parasitology | Antiviral Agents - blood | Malaria, Cerebral - immunology | Genotype | Host-Parasite Interactions - immunology | Coma - parasitology | Coma - immunology | Disease Progression | Trypanosomiasis, African - immunology | Phenotype | Animals | Trypanosoma brucei rhodesiense - pathogenicity | Uganda | Interferon-gamma - blood | virulence | interferon-gamma | African trypanosomiasis
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8. Full Text Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex [Review]
by Tokunaga, Fuminori and Iwai, Kazuhiro
Endocrine Journal, ISSN 0918-8959, 2012, Volume 59, Issue 8, pp. 641 - 652
The NF-κB pathway is a central signaling pathway for inflammatory and immune responses, and aberrant NF-κB signaling is implicated multiple disorders, such as... 
Ubiquitin | NF-κB | Inflammation | Immunity | PROTEIN-KINASE-C | ACTIVATION | GENOTOXIC STRESS | CHAIN ASSEMBLY COMPLEX | RIG-I | NF-kappa B | CHRONIC PROLIFERATIVE DERMATITIS | SHARPIN | INTERACTING PROTEIN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | POLYUBIQUITIN CHAINS | Polyubiquitin - metabolism | Osteogenesis - physiology | Neoplasms - etiology | Polyubiquitin - biosynthesis | Apoptosis - drug effects | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | NF-kappa B - metabolism | Inflammation - etiology | Ubiquitination | Animals | CD40 Antigens - metabolism | Carrier Proteins - metabolism | Immunity, Innate - physiology | Mice | Transcription Factors | Ubiquitins - metabolism
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9. Full Text Phytochemical regulation of the tumor suppressive microRNA, miR‐34a, by p53‐dependent and independent responses in human breast cancer cells
by Hargraves, Kris G and He, Lin and Firestone, Gary L
Molecular Carcinogenesis, ISSN 0899-1987, 05/2016, Volume 55, Issue 5, pp. 486 - 498
The tumor suppressive microRNA miR‐34a is transcriptionally regulated by p53 and shown to inhibit breast cancer cell proliferation as well as being a marker of... 
artemisinin | Indole‐3‐carbinol | anti‐proliferative response | artesunate | CDK4 | Indole-3-carbinol | Anti-proliferative response | Artesunate | Artemisinin | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-proliferative response | CYCLE ARREST | KAPPA-B | P53 | ANTICANCER ACTIVITY | MESSENGER-RNAS | IN-VITRO | ONCOLOGY | UP-REGULATION | EXPRESSION | Cyclin-Dependent Kinase 4 - genetics | Humans | Cyclin-Dependent Kinase 4 - metabolism | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Breast Neoplasms - genetics | MCF-7 Cells | Cell Line, Tumor | Female | Indoles - pharmacology | Cell Proliferation - drug effects | MicroRNAs - genetics | Gene Expression Regulation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Breast cancer | MicroRNA | Tumor proteins | Cancer cells | Genetic markers | Phytochemicals | Cancer therapies | MicroRNAs | Flow cytometry | p53 Protein | Gene expression | Ribonucleic acid--RNA | Ablation | Signal transduction | 3' Untranslated regions | Cell cycle | Breast | Tumor suppressor genes | Human behavior | Binding sites | Cancer | Tumors
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10. Full Text Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma
by Rychak, Emily and Mendy, Derek and Shi, Tao and Ning, Yuhong and Leisten, Jim and Lu, Ling and Miller, Karen and Narla, Rama K and Orlowski, Robert Z and Raymon, Heather K and Bjorklund, Chad C and Thakurta, Anjan and Gandhi, Anita K and Cathers, Brian E and Chopra, Rajesh and Daniel, Thomas O and Lopez‐Girona, Antonia
British Journal of Haematology, ISSN 0007-1048, 03/2016, Volume 172, Issue 6, pp. 889 - 901
Summary Pomalidomide is an IMiD® immunomodulatory agent, which has shown clinically significant benefits in relapsed and/or refractory multiple myeloma (rrMM)... 
dexamethasone | apoptosis | myeloma | anti‐proliferative | pomalidomide | resistance | Resistance | Pomalidomide | Anti-proliferative | Dexamethasone | Myeloma | Apoptosis | SURVIVAL | CELLS | BIM | THALIDOMIDE | CEREBLON EXPRESSION | anti-proliferative | GLUCOCORTICOID-RECEPTOR | THERAPY | PLUS DEXAMETHASONE | HEMATOLOGY | LOW-DOSE DEXAMETHASONE | Immunomodulation - drug effects | Dexamethasone - administration & dosage | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Multiple Myeloma - immunology | Thalidomide - administration & dosage | Mice, SCID | Xenograft Model Antitumor Assays - methods | Drug Synergism | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Female | Cell Proliferation - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Thalidomide - therapeutic use | Tumor Cells, Cultured | Multiple Myeloma - genetics | Multiple myeloma | Models | Interferon | Biological response modifiers | Gene expression | Steroids
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