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Prostaglandins, leukotrienes and essential fatty acids, ISSN 0952-3278, 04/2015, Volume 95, p. 19
In this study, the inhibitory profiles of the prostacyclin analogues treprostinil and naxaprostene on several isolated smooth muscle preparations have been... 
Prostacyclin
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 07/2012, Volume 84, Issue 1, pp. 68 - 75
The prostacyclin analogues, iloprost and treprostinil are extensively used in treating pulmonary hypertension. Their binding profile and corresponding... 
Cyclic AMP | Prostacyclin analogues | Prostanoid receptors | Radioligand binding | Calcium influx
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2003, Volume 285, Issue 1, pp. 241 - 250
We have previously shown that estrogen treatment increases cerebrovascular cyclooxygenase-1, prostacyclin synthase, and production of prostacyclin. Therefore,... 
Prostaglandin endoperoxide | Cyclooxygenase | Prostacyclin
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 04/2010, Volume 298, Issue 4, pp. 1260 - 1266
Phospholipase A2 (PLA2), a regulatory enzyme found in most mammalian cells, catalyzes the breakdown of membrane phospholipids to arachidonic acid. There are... 
Endothelium-derived contracting factor | Thromboxane A | Prostacyclin
Journal Article
The New England journal of medicine, ISSN 1533-4406, 12/2015, Volume 373, Issue 26, pp. 2522 - 2533
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2017, Volume 39, Issue 8, pp. e23 - e23
The aim of this study was to compare the pharmacokinetics (PK) of selexipag and its active metabolite ACT-333679 following single oral administration of one... 
Internal Medicine | Medical Education | Pediatrics | Prostacyclin | Pharmacology | Tablets | Pharmacokinetics
Journal Article
Diseases, ISSN 2079-9721, 05/2018, Volume 6, Issue 2, p. 38
Journal Article
Tetrahedron letters, ISSN 0040-4039, 01/2020, Volume 61, Issue 5, p. 151428
[Display omitted] •Prostacyclin mimetics such as treprostinil are used to treat pulmonary aterial hypertension.•Dose limiting toxicities of treprostinil limit... 
Treprostinil | Prostacyclin | Prodrug | Acylsulfonamide
Journal Article
Chest, ISSN 0012-3692, 07/2008, Volume 134, Issue 1, pp. 139 - 145
Background: Treprostinil, a long-acting prostacyclin analog, diminished the symptoms of pulmonary arterial hypertension (PAH) in controlled 12-week clinical... 
Treprostinil sodium | Prostacyclin | Bosentan | Pulmonary hypertension | Combination drug therapy
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2011, Volume 437, Issue 2, pp. 185 - 197
Inflammation when unchecked is associated with many prevalent disorders such as the classic inflammatory diseases arthritis and periodontal disease, as well as... 
Platelet | MicroRNA | Lipid mediator | Omega-3 fatty acid | Resolution | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Macrophages - physiology | Autacoids - physiology | Eicosapentaenoic Acid - analogs & derivatives | Humans | Lipoxins - physiology | Rats | MicroRNAs - metabolism | Blood Platelets - physiology | Animals | Docosahexaenoic Acids - physiology | Inflammation - drug therapy | Inflammation Mediators - pharmacology | Macrophages - drug effects | Eicosapentaenoic Acid - physiology | Inflammation - prevention & control | Mice | Homeostasis - drug effects | Blood Platelets - drug effects | Inflammation Mediators - physiology | Inflammation - physiopathology | Index Medicus | PGLYRP, peptidoglycan recognition protein | TNF, tumour necrosis factor | lipid mediator | GPR32, G-protein-coupled receptor for RvD1 | resolution | ALX | TX, thromboxane | RvE1, resolvin E1 | PGI3, Δ17-prostacyclin | PUFA, polyunsaturated fatty acid | FPR2, G-protein-coupled receptor for lipoxin A4 | PMN, polymorphonuclear cell | COX, cyclo-oxygenase | NF-κB, nuclear factor κB | VMSC, vascular smooth muscle cell | miRNA, microRNA | DHA, docosahexaenoic acid | LTB4, leukotriene B4 | p70S6K, ribosomal protein S6 kinase | IL, interleukin | CRP, C-reactive protein | PDGF, platelet-derived growth factor | MS, liquid chromatography-tandem MS | MAPK, mitogen-activated protein kinase | TLR, Toll-like receptor | PI3K, phosphoinositide 3-kinase | LOX, lipoxygenase | HETE, hydroxyeicosatetraenoic acid | TF, transcription factor | Review | neutrophil | PDGFR, PDGF receptor | omega-3 fatty acid | CD, cluster of differentiation | ChemR23, G-protein-coupled receptor for RvE1 | apoE, apolipoprotein E | LX, lipoxin | PGI2, prostacyclin | LDL, low-density lipoprotein | EPA, eicosapentaenoic acid | IFN, interferon | rS6, ribosomal protein S6 | ERK, extracellular-signal-regulated | RvD1, resolvin D1 | 7-TM, G-protein-coupled seven-transmembrane receptor | LC-MS | AA, arachidonic acid | microRNA | platelet | IκB, inhibitory κB | SPM, specialized proresolving mediator
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 05/2018, Volume 20, Issue 1, pp. 77 - 77
Journal Article