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JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 09/2013, Volume 78, Issue 18, pp. 9488 - 9493
We report herein for the first time the enantioselective synthesis of 8-aza-PGE(1). The synthesis used the cross olefin metathesis reaction to connect the... 
POTENT | ASYMMETRIC-SYNTHESIS | ANALOGS | INTERMOLECULAR ADDITION-REACTIONS | RECEPTOR AGONISTS | CONSTRUCTION | EP4 | CHEMISTRY, ORGANIC | PROSTAGLANDIN | DISCOVERY | METHYL-ESTER
Journal Article
JOURNAL OF ENDOCRINOLOGY, ISSN 0022-0795, 06/2016, Volume 229, Issue 3, pp. 287 - 294
Prostaglandins inhibit insulin secretion in a manner similar to that of norepinephrine (NE) and somatostatin. As NE inhibits endocytosis as well as exocytosis,... 
VESICLE FUSION | GRANULE EXOCYTOSIS | PGE2 INHIBITION | INSULIN-SECRETION | prostaglandin E-1 | PERTUSSIS TOXIN | MEDIATE PRESYNAPTIC INHIBITION | ENDOCRINOLOGY & METABOLISM | K-ATP CHANNEL | GAMMA SUBUNIT | endocytosis | EXO-ENDOCYTOSIS | heterotrimeric G-protein Gz | beta-cells | KISS-AND-RUN
Journal Article
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, ISSN 0002-9378, 03/2015, Volume 212, Issue 3
OBJECTIVE: Prostaglandin E-1 (PGE(1)) is commonly used in obstetric practice for labor induction and cervical ripening and in treating postpartum hemorrhage;... 
cervical ripening | postpartum hemorrhage | RANDOMIZED-CONTROLLED-TRIAL | EXACERBATIONS | asthma in pregnancy | MISOPROSTOL | prostaglandin E-1 | ASPIRIN-SENSITIVE ASTHMA | OBSTETRICS & GYNECOLOGY
Journal Article
JOURNAL OF WOUND CARE, ISSN 0969-0700, 07/2015, Volume 24, Issue 7, pp. 293 - 293
Objective: Lipo-prostaglandin E-1 (lipo-PGE(1)) is a well-known potent vasodilator that increases peripheral blood flow. However, the effects of this agent on... 
lipo-prostaglandin E-1 | ULCERS | wound healing | OCCLUSIVE DISEASE | MICROSPHERES | EFFICACY | SECONDARY | prostaglandin E-1 | PATTERN FLAPS | microcirculation | DERMATOLOGY | DOUBLE-BLIND | animal model | blood flow
Journal Article
ZEITSCHRIFT FUR RHEUMATOLOGIE, ISSN 0340-1855, 09/2018, Volume 77, Issue 7, pp. 633 - 636
ZusammenfassungDas chronische infantile neurokutaneoartikulare Syndrom (CINCA) ist eine Erkrankung mit Defekt im CIAS1 (NLRP3)-Gen, welches uber das veranderte... 
Angiogenesis | CELLS | Wound healing | INHIBITION | CINCA | Skin ulcer | GROWTH | RHEUMATOLOGY | ProstaglandinE
Journal Article
JOURNAL OF PHARMACEUTICAL SCIENCES, ISSN 0022-3549, 04/2010, Volume 99, Issue 4, pp. 1774 - 1789
This study was designed to test the feasibility of polymeric microspheres as an inhalable carrier for prostaglandin E-1 (PGE(1)) for treatment of pulmonary... 
LARGE POROUS PARTICLES | CHEMISTRY, MEDICINAL | DRUG-DELIVERY | SIZE | FORMULATION | prostaglandin E-1 (PGE) | CHEMISTRY, MULTIDISCIPLINARY | HEMODYNAMICS | NANOPARTICLES | pulmonary delivery | IN-VITRO | polyvinyl alcohol (PVA) | GROWTH | PHARMACOLOGY & PHARMACY | PLGA microspheres | VASODILATOR | SUSTAINED-RELEASE | pulmonary arterial hypertension (PAH)
Journal Article
Biology of Reproduction, ISSN 0006-3363, 04/2018, Volume 98, Issue 4, pp. 465 - 479
In ruminants, uterine pulses of prostaglandin (PG) F-2 alpha characterize luteolysis, while increased PGE(2)/PGE(1) distinguish early pregnancy. This study... 
corpus luteum | prostaglandin E 1 | prostaglandin F 2α | luteolysis | GRAVID UTERINE HORN | LIFE-SPAN | PROGESTERONE | RECEPTOR | CORPORA-LUTEA | prostaglandin E-1 | MAINTENANCE | IN-VITRO | REPRODUCTIVE BIOLOGY | prostaglandin F-2 alpha | OVINE EMBRYOS | ESTROUS-CYCLE
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 05/2013, Volume 10, Issue 5, pp. 1655 - 1667
Journal Article
Shock, ISSN 1073-2322, 09/2017, Volume 48, Issue 3, pp. 333 - 339
Objective: Nonocclusive mesenteric ischemia (NOMI) is accompanied by mesenteric artery spasms that are at least in part due to endothelin system activation.... 
Blood vessels | prostaglandins | vasospasm | Rho kinase | human | papaverine | SURGERY | ACTIVATION | RESISTANCE ARTERIES | KINASE | ISCHEMIA | MECHANISMS | BLOOD-FLOW | RESPONSES | VASOPRESSIN | PERIPHERAL VASCULAR DISEASE | ENDOTHELIN-1 | HEMATOLOGY | VASOCONSTRICTION | CRITICAL CARE MEDICINE
Journal Article
by Li, WH and Li, DY and Qian, WH and Liu, JL and Xu, TD and Zhu, H and He, HY
INTERNATIONAL UROLOGY AND NEPHROLOGY, ISSN 0301-1623, 04/2014, Volume 46, Issue 4, pp. 781 - 786
Purpose Contrast-induced nephropathy (CIN) is an important complication in the use of iodinated contrast media. The present study aimed to assess the safety... 
METAANALYSIS | ALPROSTADIL | CIN | Percutaneous coronary intervention | Prostaglandin E-1 | TRIAL | IMPACT | Primary prevention | UROLOGY & NEPHROLOGY | MEDIA | CHRONIC KIDNEY-DISEASE | Contrast-induced nephropathy | PENTOXIFYLLINE | EPIDEMIOLOGY | NEPHROTOXICITY
Journal Article
INTERNATIONAL IMMUNOPHARMACOLOGY, ISSN 1567-5769, 07/2016, Volume 36, pp. 142 - 150
Gastrointestinal complications are frequent in renal transplant recipients. In this regard, renal ischemia/reperfusion injury (IRI)-induced gastric damage... 
Oxidative stress | ACUTE KIDNEY INJURY | APOPTOSIS | CYTOKINES | E-1 | Inflammation | Prostaglandin-E-1 | IMMUNOLOGY | REACTIVE OXYGEN | Renal ischemia/reperfusion injury | ATTENUATION | Gastric damage | PHARMACOLOGY & PHARMACY | MISOPROSTOL | ISCHEMIA-REPERFUSION | NF-KAPPA-B | TRANSCRIPTION FACTOR
Journal Article
PAIN PRACTICE, ISSN 1530-7085, 02/2016, Volume 16, Issue 2, pp. 245 - 256
BackgroundThe important pathophysiologic factor of neurogenic intermittent claudication (NIC) in lumbar spinal canal stenosis (LSCS) has been reported to be... 
treatment | VELOCITY | LIMAPROST | INTERMITTENT CLAUDICATION MODEL | lumbar spinal canal stenosis | NERVE ROOT | neurogenic intermittent claudication | BLOOD-FLOW | DERIVATE | PORCINE CAUDA-EQUINA | CLINICAL NEUROLOGY | prostaglandin E1 | clinical outcome | WALKING DYSFUNCTION | ANESTHESIOLOGY | GRADED COMPRESSION | OP-1206 ALPHA-CD
Journal Article
by Kang, SW and Ahn, HJ and Seo, B and Kim, OK and Lee, YJ and Shin, JH and Lee, GJ and Park, HK
SENSORS AND ACTUATORS B-CHEMICAL, ISSN 0925-4005, 11/2014, Volume 203, pp. 245 - 251
Prostagladin E1 (Alprostadil (R), PGE1) is often used for patients with critical limb ischemia due to its vasodilator and anti-platelet effects. Although PGE1... 
ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | Oxygen | REAL-TIME MEASUREMENT | ISCHEMIA/REPERFUSION INJURY | SUPEROXIDE | ACTIVATION | Myocardial ischemia-reperfusion | PROTECTION | PEROXYNITRITE | HEARTS | CARDIAC MYOCYTES | Prostaglandin E1 | INSTRUMENTS & INSTRUMENTATION | Nitric oxide | IN-VIVO | L-ARGININE | Simultaneous monitoring | Sol-gel-modified microsensors
Journal Article
Journal Article
PHARMACEUTICAL RESEARCH, ISSN 0724-8741, 07/2008, Volume 25, Issue 7, pp. 1686 - 1695
Purpose. Prostaglandins have potent and diverse biologic activities, but their clinical application is severely restricted, mainly due to rapid inactivation in... 
LIPID MICROSPHERES | ACID | DRUG-DELIVERY | HYDROLYSIS | nanoparticle | vascular disorder | RELEASE | prostaglandin E-1 | CHEMISTRY, MULTIDISCIPLINARY | PHOSPHATE | THERAPY | PRODRUG | MODELS | iron | PHARMACOLOGY & PHARMACY | ARTERIAL OCCLUSIVE DISEASE | poly(lactic acid)
Journal Article
MOLECULAR MEDICINE REPORTS, ISSN 1791-2997, 10/2015, Volume 12, Issue 4, pp. 5723 - 5729
Mesenchymal stem cells (MSCs) have become a recent focus of experimental and clinical research regarding myocardial regeneration. However, the therapeutic... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | KAPPA-B ACTIVATION | MYOCARDIAL-INFARCTION | INJURY | apoptosis | ISCHEMIC-HEART | DEATH | MITOCHONDRIAL-MEMBRANE | prostaglandin E-1 | HYPOXIA | serum deprivation | ONCOLOGY | mesenchymal stem cells | IN-VIVO | BCL-2 FAMILY-MEMBERS
Journal Article
by Zhang, YH and Sun, YT and Li, GQ and Yin, L and Wang, TT and Yang, Y and Gu, JK
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, ISSN 1570-0232, 10/2013, Volume 937, pp. 97 - 102
The determination of Prostaglandin (PG) E-1 in plasma is challenged by its low concentration (pg/mL) and endogenous interference. An LC-MS/MS method for the... 
Plasma | CHEMISTRY, ANALYTICAL | OCCLUSIVE DISEASE | ALPROSTADIL | BIOCHEMICAL RESEARCH METHODS | MECHANISMS | Prostaglandin E-1 | ARTERIAL-DISEASE | INTRAVENOUS-INFUSION | LC-MS/MS | Beagle dog | METABOLISM | Pharmacokinetics | PERIPHERAL VASCULAR-DISEASE
Journal Article
Journal Article
by Dong, MF and Ma, ZS and Ma, SJ and Chai, SD and Tang, PZ and Yao, DK and Wang, LX
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, ISSN 1074-2484, 09/2012, Volume 17, Issue 3, pp. 303 - 307
Objective: To evaluate the therapeutic effects of prostaglandin E-1 (PGE(1)) on residual pulmonary arterial hypertension (PAH) after corrective surgery for... 
DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | METAANALYSIS | ventricular function | EISENMENGER-SYNDROME | GUIDELINES | ADULTS | prostaglandin E-1 | residual pulmonary hypertension | THERAPY | congenital heart disease | mortality | PHARMACOLOGY & PHARMACY
Journal Article
PHARMACEUTICAL RESEARCH, ISSN 0724-8741, 07/2009, Volume 26, Issue 7, pp. 1792 - 1800
Prostaglandin E-1 (PGE(1)) is an effective treatment for peripheral vascular diseases. The encapsulation of PGE(1) in nanoparticles for its sustained-release... 
encapsulation | LIPID MICROSPHERES | ALKALINE-PHOSPHATASE | LEUPRORELIN ACETATE | biodegradable nanoparticles | INJECTABLE MICROSPHERES | RELEASE | INDUCTION | prostaglandin E-1 | CHEMISTRY, MULTIDISCIPLINARY | PRODRUG | DOUBLE-BLIND | NANOSPHERES | PHARMACOLOGY & PHARMACY | PERIPHERAL VASCULAR-DISEASE | zinc
Journal Article
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