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BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 02/2015, Volume 1851, Issue 2, pp. 220 - 230
Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. We previously observed that the levels of... 
Phosphatidylcholine | Heavy isotope labeling | Lipidomics | Prostaglandin | Arachidonic acid | Eicosanoid | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER FIBROSIS | TRIACYLGLYCEROL | IDENTIFICATION | DROPLETS | CELL BIOLOGY | BIOPHYSICS | ASSOCIATION | Unsaturated fatty acids | Ligases | Liver diseases
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e15540
The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma. ACSL4 mainly esterifies arachidonic acid (AA) into... 
ARACHIDONIC-ACID RELEASE | RAT-LIVER | CYCLIC-AMP | TUMOR PROGRESSION | LEYDIG-CELLS | BENZODIAZEPINE-RECEPTOR PBR | CHOLESTEROL TRANSPORT | EPIDERMAL-GROWTH-FACTOR | BIOLOGY | HUMAN HEPATOCELLULAR-CARCINOMA | STEROIDOGENIC CELLS | Arachidonic Acid - metabolism | Cell Proliferation | Arachidonate 12-Lipoxygenase - metabolism | Coenzyme A Ligases - genetics | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Coenzyme A Ligases - metabolism | Breast Neoplasms - enzymology | RNA Interference | Cyclooxygenase 2 - genetics | Lipoxygenases - metabolism | Fatty Acids - metabolism | Arachidonate 12-Lipoxygenase - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Expression Regulation, Enzymologic | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Lipoxygenases - genetics | Cell Movement | Prostaglandins - metabolism | COX-2 inhibitors | Metabolites | Ligases | Cancer cells | Physiological aspects | Breast cancer | Genetic aspects | Arachidonic acid | Drugs | Phosphorylation | Motility | Hepatocellular carcinoma | Biosynthesis | Biochemistry | Metastasis | Kinases | Prostaglandin endoperoxide synthase | Metastases | Proteins | Liver cancer | Genotype & phenotype | Mitochondria | Cell growth | Colon cancer | Rodents | Cell cycle | Tumorigenesis | Colon | Trends | Enzymes | Aggressive behavior | Intracellular levels | Metabolism | Fatty acids | Esterification | Medicine | Side effects | Breast | Regulation | Cyclooxygenase-2 | Cancer | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40794
The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The... 
GAMMA AGONISTS | MURINE MODEL | RAT | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | COX-2 INHIBITORS | 5-LIPOXYGENASE | CANCER | EXPRESSION | BREAST | Immunohistochemistry | Arachidonate 5-Lipoxygenase - metabolism | Humans | Tetracycline - pharmacology | Enzyme Inhibitors - pharmacology | Injections, Intraperitoneal | Coenzyme A Ligases - antagonists & inhibitors | Molecular Targeted Therapy | Coenzyme A Ligases - metabolism | Receptors, Progesterone - metabolism | Enzyme Inhibitors - administration & dosage | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Breast Neoplasms - enzymology | Animals | Analysis of Variance | MCF-7 Cells | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Estrogen Receptor alpha - metabolism | Female | Cell Proliferation - drug effects | Mice | COX-2 inhibitors | Growth | Ligases | Analysis | Physiological aspects | Development and progression | Progesterone | Cancer | Cell proliferation | Phosphorylation | Motility | Laboratories | Estrogens | Xenotransplantation | Clinical trials | Oncology | Hepatocellular carcinoma | Biochemistry | Arachidonic acid | Kinases | Cancer therapies | Prostaglandin endoperoxide synthase | Metastases | Transfection | Xenografts | Cell cycle | Tumorigenesis | Inhibition | Colon | Trends | Enzymes | Phenotypes | Therapeutic applications | Breast cancer | Metabolism | Esterification | Medicine | Inhibitors | Liquid oxygen | Doxycycline | Breast | In vivo methods and tests | Cyclooxygenase-2 | Synergistic effect | Prostate cancer | Combinatorial analysis | Tumors | Polymorphism
Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 01/2014, Volume 1841, Issue 1, pp. 44 - 53
Acyl coenzyme A synthetase long-chain family members (ACSLs) are a family of enzymes that convert long-chain free fatty acids into their acyl-CoAs and play an... 
Prostaglandins | Cyclooxygenase | acyl-CoA synthetase long-chain family member | Phospholipase A2 | Arachidonic acid | Glycerophospholipid | Phospholipase A
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 01/2014, Volume 1841, Issue 1, pp. 44 - 53
Acyl coenzyme A synthetase long-chain family members (ACSLs) are a family of enzymes that convert long-chain free fatty acids into their acyl-CoAs and play an... 
CELLS | CYTOSOLIC PHOSPHOLIPASE A | BIOCHEMISTRY & MOLECULAR BIOLOGY | acyl-CoA synthetase long-chain family member | RELEASE | Arachidonic acid | IDENTIFICATION | Phospholipase A | REDUCED FERTILITY | COA SYNTHETASE | CELL BIOLOGY | Prostaglandins | Cyclooxygenase | NOMENCLATURE | BIOPHYSICS | Glycerophospholipid | TRIACSIN-C | MICE | EXPRESSION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2002, Volume 290, Issue 5, pp. 1427 - 1433
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been demonstrated to suppress colorectal tumorigenesis. NSAIDs have also been used to treat inflammatory... 
OVEREXPRESSION | APOPTOSIS | OXIDATIVE STRESS | TRANSPORT | BIOPHYSICS | GLUTATHIONE | MRP/GS-X PUMP | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | ASPIRIN | ANTIINFLAMMATORY DRUGS | Prostaglandin-Endoperoxide Synthases - biosynthesis | Gene Expression Regulation, Enzymologic - drug effects | Colonic Neoplasms - genetics | Reactive Oxygen Species - metabolism | HT29 Cells - metabolism | Glutamate-Cysteine Ligase - biosynthesis | Cyclooxygenase 2 | Humans | Multidrug Resistance-Associated Proteins - biosynthesis | Colonic Neoplasms - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Transfection | ATP-Binding Cassette Transporters - genetics | Enzyme Induction - drug effects | Multidrug Resistance-Associated Proteins - genetics | Multigene Family - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Prostaglandin-Endoperoxide Synthases - genetics | HT29 Cells - drug effects | Isoenzymes - genetics | ATP-Binding Cassette Transporters - biosynthesis | Membrane Proteins | Enzyme Induction - genetics | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | HT29 Cells - enzymology | Glutamate-Cysteine Ligase - genetics | Colonic Neoplasms - enzymology | Isoenzymes - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - genetics | g-GCSh gene | sulindac | MRP1 gene | g-Glutamylcysteine synthase | MRP3 gene
Journal Article