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International Journal of Molecular Sciences, ISSN 1661-6596, 02/2017, Volume 18, Issue 2, pp. 337 - 337
Bone fracture healing is a complicated physiological regenerative process initiated in response to injury and is similar to bone development. To demonstrate... 
Exogenous | Endogenous | Bone fracture healing | Parathyroid hormone-related protein (PTHrP) | PTHrP+/− mice | Callus tissue | Bony Callus - drug effects | Fractures, Bone | Fracture Healing - drug effects | Time Factors | Bone Resorption - genetics | Cartilage - cytology | Bone Resorption - metabolism | Models, Animal | Cell Differentiation | Osteogenesis - genetics | Gene Expression | Bone Density | Osteoblasts - drug effects | Osteogenesis - drug effects | Parathyroid Hormone-Related Protein - genetics | Cartilage - metabolism | Osteoclasts - metabolism | Mice, Knockout | Parathyroid Hormone-Related Protein - pharmacology | Animals | Mice | Bone Development - genetics | Fracture Healing - genetics | Bony Callus - metabolism | Osteoblasts - metabolism | Osteoclasts - drug effects | Alkaline phosphatase | Femur | Callus | Collagen (type I) | RNA-directed DNA polymerase | Insulin-like growth factor I | Bone healing | Bone turnover | Phosphatase | Osteoblasts | Insulin | Western blotting | Parathyroid hormone-related protein | Polymerase chain reaction | Proteins | Bone growth | Fractures | Parathyroid hormone | Rodents | Collagen | Acid phosphatase (tartrate-resistant) | Parathyroid | Bone (endochondral) | Osteogenesis | parathyroid hormone-related protein (PTHrP) | endogenous | bone fracture healing | callus tissue | exogenous
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4655 - 4669
Parathyroid hormone-related protein (PTHrP) is a secreted factor expressed in almost all normal fetal and adult tissues. It is involved in a wide range of... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | HORMONE-RELATED PROTEIN | MAMMARY-GLAND DEVELOPMENT | CANCER METASTASIS | PROSTATE-CANCER | MOUSE MODEL | PARATHYROID-HORMONE | BONE METASTASIS | MONOCLONAL-ANTIBODY | TRANSGENIC MICE | Angiogenic Proteins - genetics | Cell Adhesion Molecules - genetics | Epithelial Cells - metabolism | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - immunology | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - therapy | Mammary Glands, Animal - growth & development | Antibodies, Neutralizing - immunology | Antibodies, Neutralizing - therapeutic use | Mammary Neoplasms, Experimental - pathology | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Female | Receptors, CXCR4 - genetics | Parathyroid Hormone-Related Protein - deficiency | Neoplasm Proteins - genetics | Angiogenic Proteins - biosynthesis | Apoptosis Regulatory Proteins - biosynthesis | Cell Adhesion Molecules - biosynthesis | Neoplasm Proteins - biosynthesis | Parathyroid Hormone-Related Protein - genetics | Cell Cycle Proteins - biosynthesis | Disease Progression | Mice, Knockout | Parathyroid Hormone-Related Protein - immunology | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Receptors, CXCR4 - physiology | Animals | Mammary Glands, Animal - metabolism | Receptors, CXCR4 - biosynthesis | Breast Neoplasms - pathology | Parathyroid Hormone-Related Protein - physiology | Mice | Cellular proteins | Breast tumors | Parathyroid hormone | Development and progression | Metastasis | Research | Properties
Journal Article
ONCOGENE, ISSN 0950-9232, 08/2017, Volume 36, Issue 31, pp. 4498 - 4507
Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that... 
SIGNALING PATHWAYS | PTH/PTHRP-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIPEPTIDE ANTIBODIES | MASS-SPECTROMETRY | CELL BIOLOGY | OSTEOBLAST-DERIVED PTHRP | HORMONE-RELATED PROTEIN | ONCOLOGY | PROSTATE-CANCER | GENETICS & HEREDITY | PARATHYROID-HORMONE | BONE METASTASIS | STABLE-ISOTOPE STANDARDS
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 11/2019, Volume 30, Issue 11, pp. 860 - 874
The parathyroid hormone (PTH) type 1 receptor (PTHR) is the canonical G protein-coupled receptor (GPCR) for PTH and PTH-related protein (PTHrP) and the key... 
G protein-coupled receptor | parathyroid hormone | endosomes | cAMP | cryo-EM structure | allostery | ACTIVATION | PARATHYROID-HORMONE RECEPTOR | BONE-MINERAL DENSITY | PTH | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | BACKBONE MODIFICATION | POSTMENOPAUSAL WOMEN | CRYO-EM STRUCTURE | PEPTIDE | CAMP
Journal Article