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Journal Article
by Guo, ZW and Shi, L and Wang, B and He, G and Wang, YM and Chen, G
SCIENCE CHINA-CHEMISTRY, ISSN 1674-7291, 05/2019, Volume 62, Issue 5, pp. 592 - 596
PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C-H arylation reaction of... 
AZOLES | TARGET | PALLADIUM | LIGAND-FREE | PEPTIDYLARGININE DEIMINASE | C-H arylation | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN-ARGININE-DEIMINASE-4 | PAD4 inhibitor | copper catalysis | HETEROARENES | PROTEIN ARGININE DEIMINASE | RADICAL PROCESS | ARYL | benzimidazoles | Inhibitors | Iodides | Aromatic compounds | Pharmacology | Copper | Coordination compounds | Rings (mathematics)
Journal Article
BMC bioinformatics, ISSN 1471-2105, 2012, Volume 13, Issue Suppl 17, pp. S4 - S4
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 03/2019, Volume 52, Issue 3, pp. 818 - 832
Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is... 
IN-VITRO | DESIGN | INHIBITION | PROTEIN-ARGININE-DEIMINASE-4 PAD4 | SCREEN | HALOACETAMIDINE | CALCIUM | CL-AMIDINE | INACTIVATORS | SUFFICIENT | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2015, Volume 58, Issue 3, pp. 1337 - 1344
Protein arginine deiminases (PADs) catalyze the post-translational hydrolysis of arginine residues to form citrulline. This once obscure modification is now... 
NEUTROPHIL EXTRACELLULAR TRAPS | IN-VITRO | IDENTIFY | CHEMISTRY, MEDICINAL | CITRULLINATED PROTEINS | PROTEIN-ARGININE-DEIMINASE-4 PAD4 | MECHANISM | PEPTIDYLARGININE DEIMINASE | CL-AMIDINE | TETRACYCLINE | MURINE MODELS
Journal Article
Current Opinion in Drug Discovery and Development, ISSN 1367-6733, 09/2009, Volume 12, Issue 5, pp. 616 - 627
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2011, Volume 68, Issue 4, pp. 709 - 720
The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that... 
Life Sciences | Biochemistry, general | Life Sciences, general | Epigenetics | Haloacetamidine | HL-60 | Inhibition | Citrulline | Protein arginine deiminase | Biomedicine general | Cell Biology | HISTONE DEACETYLASE INHIBITOR | PROTEIN-ARGININE-DEIMINASE-4 PAD4 | SUBEROYLANILIDE HYDROXAMIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDYLARGININE DEIMINASE | HL-60 CELLS | TUMOR-CELLS | ANTITUMOR-ACTIVITY | CELL BIOLOGY | IN-VITRO | DIFFERENTIATION | EXPRESSION | Hydrolases - metabolism | Cell Survival - drug effects | Hydrolases - genetics | Epigenomics | ADP-ribosyl Cyclase 1 - genetics | Antibiotics, Antineoplastic - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Amidines - chemistry | Neoplasms - drug therapy | Drug Synergism | Animals | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Neoplasms - genetics | Cell Differentiation - drug effects | Enzyme Inhibitors - chemistry | Cell Line, Tumor | Amidines - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Doxorubicin - pharmacology | Protein-Arginine Deiminases | Anthracyclines | Care and treatment | Arginine | Methyltransferases | Gene expression | Health aspects | Cancer | Proteins | Cellular biology | Gene therapy | Index Medicus | inhibition | citrulline | epigenetics | Protein Arginine Deiminase | haloacetamidine
Journal Article
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 05/2016, Volume 227, pp. 43 - 47
Journal Article