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Nature Chemical Biology, ISSN 1552-4450, 02/2018, Volume 14, Issue 3, pp. 201 - 202
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 342a - 342a
Journal Article
NATURE, ISSN 0028-0836, 06/2011, Volume 474, Issue 7352, pp. 521 - U154
Adenosine receptors and beta-adrenoceptors are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins on binding the agonists adenosine(1)... 
CRYSTALLIZATION | ADRENOCEPTOR | COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | THERMOSTABILIZATION | STABILITY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | PROTEIN-COUPLED RECEPTORS | BINDING
Journal Article
by Zhou, J and Wild, C
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2019, Volume 19, Issue 16, pp. 1363 - 1364
Journal Article
NATURE, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 317 - 317
In response to adenosine 59-diphosphate, the P2Y(1) receptor (P2Y(1)R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug... 
COMPLEX | NUCLEOTIDE RECEPTORS | RECOGNITION | SMALL-MOLECULE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | PURINERGIC RECEPTORS | ANTAGONISTS | DISCOVERY | AGONIST
Journal Article
03/2012
A large number of G-protein-coupled receptors (GPCRs) show varying degrees of basal or constitutive activity. This constitutive activity is usually minimal in... 
Constitutive activity | inverse agonists | inverse agonism | G-protein-coupled receptors
Web Resource
Nature communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 554 - 1
The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: 'J.D.B. is a... 
Engineering | G protein-coupled receptors | Human communication
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2017, Volume 174, Issue S1, pp. S272 - S359
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective... 
PHARMACOLOGY & PHARMACY | Databases, Pharmaceutical | Knowledge Bases | Animals | Humans | Enzymes - drug effects | Ligands | Enzymes - metabolism | Enzymes | Pharmacology | G protein-coupled receptors | Nomenclature | Ion channels (ligand-gated) | Ions | Ion channels | Nuclear receptors | The Concise Guide to Pharmacology 2017
Journal Article
SCIENCE, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1266 - 1273
The beta(2)-adrenergic receptor (beta(2)AR) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein ( G protein)-coupled receptors... 
BETA ADRENERGIC-RECEPTOR | LIGAND-BINDING SPECIFICITY | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED-RECEPTORS | CONSERVED ASPARTIC-ACID | RESONANCE ENERGY-TRANSFER | BETA-2-ADRENERGIC RECEPTORS | IDENTIFICATION | AGONISTS | INDUCED CONFORMATIONAL-CHANGES
Journal Article
Developmental & Comparative Immunology, ISSN 0145-305X, 10/2019, p. 103512
Journal Article
NATURE REVIEWS DRUG DISCOVERY, ISSN 1474-1776, 03/2013, Volume 12, Issue 3, pp. 205 - 216
Agonists of seven-transmembrane receptors, also known as G protein-coupled receptors (GPCRs), do not uniformly activate all cellular signalling pathways linked... 
BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HEART-FAILURE | IN-VIVO | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | ALLOSTERIC MODULATION | MU-OPIOID RECEPTOR | ACTIVE STATE | PHARMACOLOGICAL AGONISM
Journal Article
American Journal of Physiology, ISSN 0193-1857, 07/2018, Volume 315, Issue 1, p. 6
Extracellular adenosine nucleoside is a potent, endogenous mediator that signals through specific G protein-coupled receptors, and exerts pleiotropic effects... 
Adenosine | Liver diseases | G protein-coupled receptors | Disease | Fibrosis | Physiology
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2013, Volume 56, Issue 9, pp. 3446 - 3455
Biophysical fragment screening of a thermostabilized beta(1)-adrenergic receptor (beta(1)AR) using surface plasmon resonance (SPR) enabled the identification... 
COMPLEX | CHEMISTRY, MEDICINAL | RESOLUTION CRYSTAL-STRUCTURE | OPIOID RECEPTOR | THERMOSTABILIZATION | PROGRESS | DOPAMINE | PROTEIN-COUPLED RECEPTORS | INHIBITOR | AGONISTS | DISCOVERY
Journal Article
Molecular Nutrition and Food Research, ISSN 1613-4125, 11/2018, Volume 62, Issue 22, p. e1800530
Modulating β -adrenergic receptor (β -AR) expression and activation is important for maintaining skeletal muscle function. In this study, two food factors,... 
G protein-coupled receptors | genistein | resveratrol | adrenergic receptors | skeletal muscles
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2009, Volume 106, Issue 37, pp. 15950 - 15955
The forebrain cholinergic system promotes higher brain function in part by signaling through the M-1 muscarinic acetylcholine receptor (mAChR). During... 
SIGNAL-TRANSDUCTION | HIPPOCAMPUS | FEAR | GENE | SUBTYPES | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | MICE | EXPRESSION | SEIZURE ACTIVITY
Journal Article