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Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8202 - 8211
BET proteins are key epigenetic regulators that regulate transcription through binding to acetylated lysine (AcLys) residues of histones and transcription... 
PROTEIN-DEGRADATION | CHEMISTRY, MEDICINAL | BRD4
Journal Article
Autophagy, ISSN 1554-8627, 2013, Volume 9, Issue 10, pp. 1500 - 1508
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 09/2019, Volume 83, Issue 9, pp. 1740 - 1746
Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol... 
Chrysin | protein degradation | SREBP | Index Medicus
Journal Article
11/2012
The flow of ruminal undegradable protein (RUP) to the small intestine can be increased if ruminal degradation of dietary protein is reduced. The objective of... 
soybean meal | Extrusion | cattle | protein supplements | protein degradation
Web Resource
Biochimica et Biophysica Acta - General Subjects, ISSN 0304-4165, 01/2016, Volume 1860, Issue 1, pp. 192 - 198
Background It is probable that the great majority of human cataract results from the spontaneous decomposition of long-lived macromolecules in the human lens.... 
Human aging | Protein degradation | Crystallins | Lens | Lifespan
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 41, pp. E9717 - E9726
Journal Article
Metabolism, ISSN 0026-0495, 05/2019, Volume 94, pp. 88 - 95
Low-density lipoprotein cholesterol (LDL-C) is the hallmark of atherosclerotic cardiovascular diseases. The hepatic LDL receptor (LDLR) plays an important role... 
PCSK9 | Protein degradation | LDLR | Endosome | Low-density lipoprotein cholesterol
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 03/2019, Volume 14, Issue 3, pp. 361 - 368
Bifunctional degrader molecules, known as proteolysis-targeting chimeras (PROTACs), function by recruiting a target to an E3 ligase, forming a... 
DESIGN | RECOGNITION | PROTEIN-DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Letters
Journal Article
06/2013
Seed formation consists of two major stages: embryo pattern formation and maturation. During seed maturation, the embryo accumulates storage material, acquires... 
Phosphorylation | Protein degradation | Plant hormone | Protein-protein interaction | Development | 0309 | Phase transition
Dissertation
Autophagy, ISSN 1554-8627, 2007, Volume 3, Issue 2, pp. 160 - 162
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 02/2019, Volume 56, Issue 2, pp. 1293 - 1309
The G protein-coupled GABA receptors, constituted from GABA and GABA subunits, are important regulators of neuronal excitability by mediating long-lasting... 
GABA receptor | Protein degradation | Ubiquitination | E3 ubiquitin ligase | CaMKII | Lysosome
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 448 - 466
Human murine double minute 2 (MDM2) protein is a primary endogenous cellular inhibitor of the tumor suppressor p53 and has been pursued as an attractive cancer... 
CHEMISTRY, MEDICINAL | PROTEIN-DEGRADATION | MDM2 INHIBITOR | CLINICAL-TRIALS | CANCER | E3 UBIQUITIN LIGASE | P53
Journal Article
International Review of Cell and Molecular Biology, ISSN 1937-6448, 01/2019, Volume 343, pp. 37 - 63
Plants rely on a sophisticated innate immune system to recognize pathogens and defend against pathogen attacks. The immune system must be precisely regulated... 
NLR receptor | Protein degradation | Ubiquitination | Plant immunity | Proteasome
Conference Proceeding
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 12, pp. 18623 - 18623
Journal Article
Cancer Research, ISSN 0008-5472, 01/2019, Volume 79, Issue 1, pp. 251 - 262
Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number of E3 ligases successfully... 
BET | UBIQUITINATION | DESIGN | ACTIVATION | CHIMERIC MOLECULES | INHIBITION | ONCOLOGY | INDUCE DEGRADATION | TARGETED PROTEIN-DEGRADATION | KNOCKDOWN | BROMODOMAIN
Journal Article
Journal of Dairy Science, ISSN 0022-0302, 07/2010, Volume 93, Issue 7, pp. 3216 - 3230
Mixed model analysis of data from 32 studies (122 diets) was used to evaluate the precision and accuracy of the omasal sampling technique for quantifying... 
microbial protein synthesis | omasal sampling | protein degradation | milk protein | Milk protein | Protein degradation | Omasal sampling | Microbial protein synthesis
Journal Article
Genes and Development, ISSN 0890-9369, 09/2002, Volume 16, Issue 18, pp. 2403 - 2414
Journal Article
Neuron, ISSN 0896-6273, 2004, Volume 43, Issue 3, pp. 321 - 332
Amyloid-β (Aβ) plaques and neurofibrillary tangles are the hallmark neuropathological lesions of Alzheimer's disease (AD). Using a triple transgenic model... 
ANTIBODIES | IMMUNIZATION | AMYLOID DEPOSITION | INHIBITION | PROTEIN-DEGRADATION | ALZHEIMERS-DISEASE | MOUSE MODEL | TRIPLE-TRANSGENIC MODEL | MICE | PATHOLOGY | NEUROSCIENCES
Journal Article
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