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2002, Current topics in microbiology and immunology, ISBN 3540430962, Volume 268., 213
Book
Journal of Biological Chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 39, pp. 30019 - 30025
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2010, Volume 285, Issue 39, pp. 30026 - 30033
In the yeast Saccharomyces cerevisiae, a precursor form of aminopeptidase I (prApe1) and alpha-mannosidase (Ams1) are selectively transported to the vacuole... 
YEAST | DOMAIN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOPLASM | COMPONENTS | DYNAMICS | VACUOLE TARGETING PATHWAY | ATG8/LC3 | SACCHAROMYCES-CEREVISIAE | BINDING-PROTEINS | Microtubule-Associated Proteins - chemistry | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | alpha-Mannosidase - chemistry | alpha-Mannosidase - metabolism | Protein Transport - physiology | Autophagy - physiology | Saccharomyces cerevisiae - metabolism | Aminopeptidases - chemistry | Nuclear Magnetic Resonance, Biomolecular | Vacuoles - chemistry | Receptors, Cell Surface - chemistry | Aminopeptidases - metabolism | Protein Structure, Tertiary | Aminopeptidases - genetics | Vacuoles - genetics | Protein Structure, Secondary | Vesicular Transport Proteins - genetics | Receptors, Cell Surface - metabolism | Vesicular Transport Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Saccharomyces cerevisiae - chemistry | Autophagy-Related Protein 8 Family | Saccharomyces cerevisiae Proteins - metabolism | Vacuoles - metabolism | alpha-Mannosidase - genetics | Receptors, Cell Surface - genetics | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | NMR | Yeast | Trafficking | Protein Synthesis and Degradation | Protein Structure | Protein Degradation | Autophagy | Cell Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 41, pp. 17004 - 17009
α-Synuclein is an abundant brain protein that binds to lipid membranes and is involved in the recycling of presynaptic vesicles. In Parkinson disease,... 
Proteins | Yeasts | Brain | Pathology | Neurons | Ubiquitins | Cell lines | Parkinson disease | Antibodies | Lewy bodies | Neurodegeneration | Protein misfolding | CELLS | MULTIDISCIPLINARY SCIENCES | neurodegeneration | TOXICITY | AUTOPHAGY | PROTEIN-DEGRADATION | protein misfolding | IN-VIVO | PROTEASOME | EXPRESSION | DOMAINS | AGGREGATION | PARKINSONS-DISEASE | Saccharomyces cerevisiae - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Molecular Sequence Data | Substrate Specificity | Ubiquitin-Protein Ligase Complexes - genetics | Substantia Nigra - metabolism | Endosomes - metabolism | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Ubiquitination | Lysosomes - metabolism | HEK293 Cells | Nedd4 Ubiquitin Protein Ligases | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Lewy Bodies - metabolism | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | alpha-Synuclein - chemistry | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Mice | In Vitro Techniques | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | alpha-Synuclein - metabolism | Locus Coeruleus - metabolism | Parkinson Disease - etiology | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 48, pp. 37159 - 37169
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway,... 
EPITHELIAL-MESENCHYMAL TRANSITION | SUPPRESSOR | APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GROWTH | TRANSCRIPTION | PROLIFERATION | DROSOPHILA | STEM-CELL DIFFERENTIATION | Transcription Coactivators | E3 Ubiquitin Ligase | Signal Transduction | Protein Phosphorylation | Protein Degradation | Hippo Pathway | TAZ | Breast Cancer
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2011, Volume 186, Issue 4, pp. 2065 - 2072
To understand better the endogenous sources of MHC class I peptide ligands, we generated an antigenic reporter protein whose degradation is rapidly and... 
I ANTIGEN PRESENTATION | PROTEIN-DEGRADATION | MAJOR SOURCE | HYPOTHESIS | EEYARESTATIN | IMMUNOLOGY | TRANSLATION | MAMMALIAN-CELLS | MOLECULES | Ovalbumin - immunology | Ribosomal Proteins - biosynthesis | Green Fluorescent Proteins - genetics | Peptide Biosynthesis - immunology | Recombinant Fusion Proteins - metabolism | Cell Membrane Permeability - genetics | Ovalbumin - metabolism | Ribosomal Proteins - deficiency | Signal Transduction - immunology | H-2 Antigens - genetics | Peptide Fragments - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Recombinant Fusion Proteins - biosynthesis | H-2 Antigens - biosynthesis | Peptide Fragments - metabolism | Ribosomal Proteins - genetics | Mice, Inbred C57BL | Morpholines - pharmacology | Antigen Presentation - genetics | Signal Transduction - genetics | Immunologic Surveillance - drug effects | Antigen Presentation - immunology | Immunologic Surveillance - genetics | Peptide Biosynthesis - genetics | Cell Membrane Permeability - immunology | Animals | Signal Transduction - drug effects | Green Fluorescent Proteins - biosynthesis | CD8-Positive T-Lymphocytes - drug effects | Cell Membrane Permeability - drug effects | Protein Stability - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Peptide Biosynthesis - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2011, Volume 31, Issue 41, pp. 14508 - 14520
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2004, Volume 24, Issue 8, pp. 1888 - 1896
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1529 - 1537
In this study, the coordinated activation of ubiquitin-proteasome pathway (UPP), autophagy-lysosomal pathway (ALP), and mitochondrial remodeling including... 
Muscle protein degradation | Mitochondrial remodelling | Mitophagy | LC3b | MuRF1 | MAMMALIAN TARGET | mitochondrial remodelling | SPORT SCIENCES | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | muscle protein degradation | EXERCISE-INDUCED MUSCLE | COORDINATE ACTIVATION | FOXO TRANSCRIPTION FACTORS | HUMAN SKELETAL-MUSCLE | MITOCHONDRIAL FISSION | mitophagy | RESISTANCE EXERCISE | GENE-EXPRESSION | C2C12 MYOTUBES | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Serine | Ubiquitin - metabolism | Male | Physical Endurance | Insulin - blood | Phosphoproteins - metabolism | Autophagy | Tripartite Motif Proteins | Quadriceps Muscle - enzymology | Time Factors | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle Proteins - metabolism | Adult | Proto-Oncogene Proteins c-akt - metabolism | Quadriceps Muscle - pathology | Autophagy-Related Protein 12 | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Muscle - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Small Ubiquitin-Related Modifier Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Energy Intake | GTP Phosphohydrolases - metabolism | Autophagy-Related Protein 5 | Energy Metabolism | Biopsy | Running | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Blood Glucose - metabolism | Forkhead Box Protein O3 | Proteins | Musculoskeletal system | Signal transduction | Physiology | Athletes | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3239 - 3253
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2017, Volume 232, Issue 3, pp. 650 - 664
Heat stress attenuated increases in REDD1 and KLF15, two genes directly targeted by glucocorticoids that decrease protein synthesis by inhibiting mTORC1. Heat... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | SKELETAL-MUSCLE | PHYSIOLOGY | UBIQUITIN-PROTEASOME SYSTEM | GLUCOCORTICOID-INDUCED MYOPATHY | E3 LIGASE MURF1 | PROTEIN-DEGRADATION | FOXO TRANSCRIPTION FACTORS | NF-KAPPA-B | GROWTH-FACTOR-I | MOLECULAR-MECHANISMS | CELL BIOLOGY | Heat-Shock Response - drug effects | Dexamethasone - adverse effects | Glycogen Synthase Kinase 3 beta | Phosphatidylinositol 3-Kinases - metabolism | Muscle Fibers, Skeletal - drug effects | Muscular Atrophy - chemically induced | RNA, Messenger - metabolism | Time Factors | Muscle Proteins - metabolism | Muscular Atrophy - prevention & control | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | Muscular Atrophy - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Muscular Atrophy - pathology | RNA, Messenger - genetics | HSP72 Heat-Shock Proteins - metabolism | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Muscle Fibers, Skeletal - pathology | Mice | Dexamethasone | Central nervous system depressants | Physiological aspects | Muscles | Protein biosynthesis | Stress (Physiology) | Steroids | Myotubes | Glucocorticoids | DNA damage | AKT protein | Skeletal muscle | Stress | 1-Phosphatidylinositol 3-kinase | Degradation | Atrophy | Signal transduction | Heat | Pathways | Protein synthesis | Heat tolerance | Heat stress | Chemical synthesis | In vitro methods and tests | Deoxyribonucleic acid--DNA | Kruppel protein | Index Medicus | Original | Original s
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2011, Volume 25, Issue 1, pp. 99 - 110
Cachectic muscle wasting is a frequent complication of many inflammatory conditions, due primarily to excessive muscle catabolism. However, the pathogenesis... 
Autophagosomes | Lactacystin | Atrogin-1/MAFbx | p38 MAPK | 3-Methyladenine | RAT SKELETAL-MUSCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | FOXO TRANSCRIPTION FACTORS | lactacystin | CELL BIOLOGY | MESSENGER-RNAS | autophagosomes | PROTEIN-DEGRADATION | SIGNALING PATHWAY | AMINO-ACIDS | IN-VIVO | BIOLOGY | atrogin-1/MAFbx | 3-methyladenine | INNATE IMMUNITY | C2C12 MYOTUBES | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Autophagy - drug effects | Lysosomes - metabolism | RNA Interference | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Muscles - metabolism | Phagosomes - drug effects | Cell Line | Muscular Atrophy - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Enzyme Inhibitors - pharmacology | Toll-Like Receptor 4 - genetics | Muscular Atrophy - genetics | Imidazoles - pharmacology | SKP Cullin F-Box Protein Ligases - metabolism | Toll-Like Receptor 4 - metabolism | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Animals | Signal Transduction - drug effects | Muscles - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | Index Medicus | Research Communications | atrogin-1 | MAFbx
Journal Article