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01/2013
Nitric oxide synthase (NOS) is regulated by protein-protein interactions. We had earlier shown that PKG inhibits activated NOS in endothelial cells and... 
Protein kinase G | Nitric oxide synthase
Web Resource
03/2012
Background: Nitric oxide synthase (NOS) is negatively regulated by protein-protein interactions with caveolin-1 before extracellular activating signals release... 
caveolin-1 | protein kinase G | nitric oxide synthase
Web Resource
Circulation Research, ISSN 0009-7330, 08/2007, Volume 101, Issue 5, pp. 465 - 474
Voltage-dependent Ca channel function (Cav1.2, L-type Ca channel) is required for cardiac excitation-contraction (E-C) coupling. Cav1.2 plays a key role in... 
Phosphorylation | 1.2 | Calcium channel | Protein kinase G
Journal Article
Bioorganic & medicinal chemistry letters, 08/2019, pp. 126610 - 126610
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 04/2012, Volume 302, Issue 8, pp. C1162 - C1173
Journal Article
Journal Article
Revista Espanola de Cardiologia, ISSN 0300-8932, 2014, Volume 67, Issue 5, pp. 394 - 404
Even when reperfusion therapy is applied as early as possible, survival and quality of life are compromised in a considerable number of patients with... 
Myocardial infarction | Remote ischemic conditioning | Protein kinase G | Reperfusion injury
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2018, Volume 201, Issue 5, pp. 1421 - 1433
Phagosome maturation is an important innate defense mechanism of macrophages against bacterial infections. The mycobacterial secretory protein kinase G (PknG),... 
TUBERCULOSIS PHAGOSOME | ENDOSOME FUSION | RAB5 EFFECTORS | ARREST | PROTEIN-KINASE-G | MACROPHAGES | PATHOGENIC MYCOBACTERIA | TRANS-GOLGI NETWORK | COMPARTMENTS | IMMUNOLOGY | MATURATION
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 10/2019, Volume 118, pp. 109216 - 109216
The osseointegration process of implant is seriously impaired in type 2 diabetes mellitus (T2DM) that causes high failure rate, and insufficiency exists in... 
Osseointegration | Protein kinase G II (PKG II) | Type 2 diabetes mellitus | Cyclic guanosine monophosphate (cGMP) | Insulin | Cinaciguat | Index Medicus
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2017, Volume 41, Issue 11, pp. 4273 - 4276
An unusual alkaloid, talaramide A (1), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by... 
METABOLITES | SESTERTERPENOIDS | ERA | PROTEIN-KINASE-G | NATURAL-PRODUCTS | TUBERCULOSIS | DRUGS | ASPERGILLUS SP 085242 | ISOCOUMARINS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 1, pp. 146 - 151
In heart failure, the expression of cardiac β -adrenergic receptors (β -ARs) increases. However, the precise role of β -AR signaling within cardiomyocytes... 
c-Jun | c-Jun N-Terminal kinase | β3-adrenergic receptor | Transforming growth factor β1 | Protein kinase G | Cardiomyocyte | adrenergic receptor | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 509 - 514
Development of a class of bicyclic inhibitors of the cyclic GMP-dependent protein kinase ( PKG), starting from known compounds with activity against a related... 
Plasmodium falciparum | Imidazopyridine | Malaria | SAR | Protein kinase G | PARASITES | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Proteins | Imidazopyridines | Analysis | Protein kinases | Cyclic guanylic acid | Hygiene
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 02/2010, Volume 298, Issue 2, pp. E222 - E228
Journal Article
by Xu, ZC and Wu, JM and Xin, JZ and Feng, YN and Hu, GM and Shen, J and Li, MZ and Zhang, YY and Xiao, H and Wang, L
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 09/2018, Volume 503, Issue 1, pp. 146 - 151
In heart failure, the expression of cardiac beta(3)-adrenergic receptors (beta(3)-ARs) increases. However, the precise role of beta(3)-AR signaling within... 
FIBROSIS | STIMULATION | Protein kinase G | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | CARDIOMYOPATHY | BETA-3-ADRENERGIC RECEPTORS | beta-adrenergic receptor | c-Jun | c-Jun N-Terminal kinase | BIOPHYSICS | Transforming growth factor beta 1 | Cardiomyocyte | NITRIC-OXIDE | PROTEINS | UP-REGULATION
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7005 - 13
Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein... 
DABRAFENIB | SELECTIVE INHIBITOR | DESIGN | RING-STAGE | ARTEMISININ RESISTANCE | MULTIDISCIPLINARY SCIENCES | MALARIA | FAMILY | Protein kinase G | Erythrocytes | High-throughput screening | Cytotoxicity | Parasites | Drug resistance | Kinases | Proteins | Disease transmission | Developmental stages | Protein kinase | Antimalarial agents | Cyclic GMP | Thiazoles | Life cycles
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 01/2016, Volume 137, Issue 1, pp. 289 - 298
Background: Although arachidonic acid metabolites, cysteinyl leukotrienes (cys-LTs; leukotriene [LT] C-4, LTD4, and LTE4), and prostaglandin (PG) E-2 are... 
SUBTYPE | GAMMA | GPR17 | extracellular signal-regulated kinase | ACTIVATION | macrophage inflammatory protein 1 beta | c-fos | EP3 | INDUCTION | IMMUNOLOGY | prostaglandin D-2 | prostaglandin E-2 | IMMUNE | RESPONSES | ALLERGY | CYSLT RECEPTORS | E-prostanoid receptor 3 | ASTHMA | Mast cells | protein kinase G | leukotriene D-4 | CysLTR
Journal Article
CANCER PREVENTION RESEARCH, ISSN 1940-6207, 02/2018, Volume 11, Issue 2, pp. 81 - 91
The cGMP signaling axis has been implicated in the suppression of intestinal cancers, but the inhibitory mechanism and the extent to which this pathway can be... 
TRANSCRIPTIONAL ACTIVITY | TUMOR CELL-GROWTH | INHIBITION | ONCOLOGY | PROTEIN-KINASE-G | COLORECTAL-CANCER | INTESTINAL ADENOMAS | COLON | PROLIFERATION | BETA-CATENIN | GUANYLYL CYCLASE-C
Journal Article
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