Catalogue
Articles
RSS feedX
Search Filters
Format
Subjects
Library Location
Language
Publication Date2016, Advances in experimental medicine and biology, ISBN 3319350722, Volume 922, x, 184
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein...
Structure | Membrane proteins | Biochemistry | Life Sciences | Protein Science | Protein Structure
Structure | Membrane proteins | Biochemistry | Life Sciences | Protein Science | Protein Structure
Book
Details 
2010, Methods in molecular biology, ISBN 1607617617, Volume 654., xii, 459
Book
Details
Science, ISSN 0036-8075, 01/2017, Volume 355, Issue 6322, pp. 294 - 298
Despite decades of work by structural biologists, there are still similar to 5200 protein families with unknown structure outside the range of comparative...
FOLD | CRYSTAL-STRUCTURE | FAMILIES | MULTIDISCIPLINARY SCIENCES | DOMAINS | STRUCTURE PREDICTION | REVEALS | Amino Acid Sequence | Computational Biology - methods | Models, Molecular | Crystallography, X-Ray | Protein Folding | Proteins - genetics | Sequence Analysis, Protein | Algorithms | Databases, Protein | Protein Conformation | Software | Proteins - chemistry | Metagenome | Evolution, Molecular | Amino acid sequence | Protein structure prediction | Methods | Sequences | Genomes | Data | Sequence | Biologists | Membrane proteins | Proteins | Model matching | Predictions | Evolution | Models | Modelling | Mathematical models | Protein structure | Alignment | Contact
FOLD | CRYSTAL-STRUCTURE | FAMILIES | MULTIDISCIPLINARY SCIENCES | DOMAINS | STRUCTURE PREDICTION | REVEALS | Amino Acid Sequence | Computational Biology - methods | Models, Molecular | Crystallography, X-Ray | Protein Folding | Proteins - genetics | Sequence Analysis, Protein | Algorithms | Databases, Protein | Protein Conformation | Software | Proteins - chemistry | Metagenome | Evolution, Molecular | Amino acid sequence | Protein structure prediction | Methods | Sequences | Genomes | Data | Sequence | Biologists | Membrane proteins | Proteins | Model matching | Predictions | Evolution | Models | Modelling | Mathematical models | Protein structure | Alignment | Contact
Journal Article
Details
Digital rights
Loading RightsNature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7288, pp. 619 - 623
The worldwide epidemic of obesity has increased the urgency to develop a deeper understanding of physiological systems related to energy balance and energy...
ADIPOCYTE LINEAGE | OLIGONUCLEOTIDE ARRAYS | CELLS | ADIPOSE CONVERSION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | PPAR-GAMMA | CEREBELLAR DEVELOPMENT | DIFFERENTIATION | ADIPOGENESIS | Protein Structure, Tertiary | NIH 3T3 Cells | Mice, Inbred C57BL | Adipose Tissue - cytology | PPAR gamma - metabolism | Mice, Knockout | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Female | Cell Differentiation | Mice | Smad Proteins - metabolism | Obesity | Care and treatment | Fat cells | Physiological aspects | Fibroblasts | Genetic aspects | Research | DNA binding proteins | Proteins | Tissue | Gene expression | Methods | adipogenesis | brown adipose tissue | white adipose tissue | SMAD signaling | Zfp423 | preadipocytes | cell fate determination | BMP signaling | PPARγ
ADIPOCYTE LINEAGE | OLIGONUCLEOTIDE ARRAYS | CELLS | ADIPOSE CONVERSION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | PPAR-GAMMA | CEREBELLAR DEVELOPMENT | DIFFERENTIATION | ADIPOGENESIS | Protein Structure, Tertiary | NIH 3T3 Cells | Mice, Inbred C57BL | Adipose Tissue - cytology | PPAR gamma - metabolism | Mice, Knockout | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Gene Expression Regulation, Developmental | Female | Cell Differentiation | Mice | Smad Proteins - metabolism | Obesity | Care and treatment | Fat cells | Physiological aspects | Fibroblasts | Genetic aspects | Research | DNA binding proteins | Proteins | Tissue | Gene expression | Methods | adipogenesis | brown adipose tissue | white adipose tissue | SMAD signaling | Zfp423 | preadipocytes | cell fate determination | BMP signaling | PPARγ
Journal Article
Details
Digital rights
Loading RightsAngewandte Chemie International Edition, ISSN 1433-7851, 11/2014, Volume 53, Issue 45, pp. 12253 - 12256
Solid‐state NMR spectroscopy is an emerging tool for structural studies of crystalline, membrane‐associated, sedimented, and fibrillar proteins. A major...
protein structures | magic‐angle spinning | proton detection | solid‐state NMR spectroscopy | Magic-angle spinning | Solid-state NMR spectroscopy | Protein structures | Proton detection | solid-state NMR spectroscopy | DEUTERATED PROTEINS | UBIQUITIN | ULTRA-FAST MAS | RESOLUTION | METHYL-GROUPS | CHEMISTRY, MULTIDISCIPLINARY | magic-angle spinning | RESONANCE ASSIGNMENT | AMYLOID FIBRILS | DYNAMICS | BACKBONE | SPECTRA | Nuclear Magnetic Resonance, Biomolecular - methods | Protein Conformation | Proteins - chemistry
protein structures | magic‐angle spinning | proton detection | solid‐state NMR spectroscopy | Magic-angle spinning | Solid-state NMR spectroscopy | Protein structures | Proton detection | solid-state NMR spectroscopy | DEUTERATED PROTEINS | UBIQUITIN | ULTRA-FAST MAS | RESOLUTION | METHYL-GROUPS | CHEMISTRY, MULTIDISCIPLINARY | magic-angle spinning | RESONANCE ASSIGNMENT | AMYLOID FIBRILS | DYNAMICS | BACKBONE | SPECTRA | Nuclear Magnetic Resonance, Biomolecular - methods | Protein Conformation | Proteins - chemistry
Journal Article
Details
Digital rights
Loading RightsNature Biotechnology, ISSN 1087-0156, 04/2011, Volume 29, Issue 4, pp. 335 - 340
After decades of slow progress, the pace of research on membrane protein structures is beginning to quicken thanks to various improvements in technology,...
CYTOCHROME-C-OXIDASE | ANGSTROM RESOLUTION | X-RAY CRYSTALLOGRAPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRYSTAL-STRUCTURE | COUPLED RECEPTOR | ESCHERICHIA-COLI | SIZE-EXCLUSION CHROMATOGRAPHY | HYDANTOIN TRANSPORTER MHP1 | MOLECULAR-BASIS | LACTOCOCCUS-LACTIS | Protein Structure, Tertiary | Membrane Proteins - chemistry | Protein Unfolding | X-Ray Diffraction | Databases, Protein | Crystallization | Protein Engineering | Protein Stability | Recombinant Proteins - biosynthesis | Proteins | Usage | Diffraction | X-rays | Research | Structure | Membrane proteins | chemistry | Tertiary | Protein Structure | Recombinant Proteins | Chemical Sciences | Protein | Membrane Proteins | Databases | Kemi | biosynthesis
CYTOCHROME-C-OXIDASE | ANGSTROM RESOLUTION | X-RAY CRYSTALLOGRAPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRYSTAL-STRUCTURE | COUPLED RECEPTOR | ESCHERICHIA-COLI | SIZE-EXCLUSION CHROMATOGRAPHY | HYDANTOIN TRANSPORTER MHP1 | MOLECULAR-BASIS | LACTOCOCCUS-LACTIS | Protein Structure, Tertiary | Membrane Proteins - chemistry | Protein Unfolding | X-Ray Diffraction | Databases, Protein | Crystallization | Protein Engineering | Protein Stability | Recombinant Proteins - biosynthesis | Proteins | Usage | Diffraction | X-rays | Research | Structure | Membrane proteins | chemistry | Tertiary | Protein Structure | Recombinant Proteins | Chemical Sciences | Protein | Membrane Proteins | Databases | Kemi | biosynthesis
Journal Article
Details
Digital rights
Loading Rights1991, ISBN 9780471513261, Volume 35., ix, 310 p., [2] leaves of plates.
Book
Details
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 04/2014, Volume 82, Issue 4, pp. 587 - 595
When experimental protein NMR data are too sparse to apply traditional structure determination techniques, de novo protein structure prediction methods can be...
RDC | sparse data | NOE | protein structure prediction | topology prediction | Topology prediction | Sparse data | Protein structure prediction | RESIDUAL DIPOLAR COUPLINGS | FOLD DETERMINATION | ROSETTA | BIOPHYSICS | CHEMICAL-SHIFTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOGY | Algorithms | Proteins - metabolism | Models, Chemical | Protein Structure, Secondary | Nuclear Magnetic Resonance, Biomolecular - methods | Models, Molecular | Protein Conformation | Proteins - chemistry | Monte Carlo Method | Protein Folding | Proteins - ultrastructure | Nuclear magnetic resonance | Analysis | Membrane proteins
RDC | sparse data | NOE | protein structure prediction | topology prediction | Topology prediction | Sparse data | Protein structure prediction | RESIDUAL DIPOLAR COUPLINGS | FOLD DETERMINATION | ROSETTA | BIOPHYSICS | CHEMICAL-SHIFTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOGY | Algorithms | Proteins - metabolism | Models, Chemical | Protein Structure, Secondary | Nuclear Magnetic Resonance, Biomolecular - methods | Models, Molecular | Protein Conformation | Proteins - chemistry | Monte Carlo Method | Protein Folding | Proteins - ultrastructure | Nuclear magnetic resonance | Analysis | Membrane proteins
Journal Article
Details
Digital rights
Loading RightsProgress in Nuclear Magnetic Resonance Spectroscopy, ISSN 0079-6565, 2006, Volume 48, Issue 1, pp. 47 - 62
Xplor-NIH [1] is a generalized package for biomolecular structure determination from experimental NMR data combined with known geometric data. This is achieved...
Computational Toolbox | Proteins | Nucleic acids | Structure determination | NMR restraints | Optimization | RESIDUAL DIPOLAR COUPLINGS | STRUCTURE REFINEMENT | CHEMICAL-SHIFTS | MEAN-FORCE | NUCLEAR-MAGNETIC-RESONANCE | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | PROTEIN-STRUCTURE DETERMINATION | structure determination | nucleic acids | PROTON DISTANCE CONSTRAINTS | MACROMOLECULAR STRUCTURE DETERMINATION | SPECTROSCOPY | optimization | proteins | X-RAY | computational toolbox | COMPLETE CROSS-VALIDATION
Computational Toolbox | Proteins | Nucleic acids | Structure determination | NMR restraints | Optimization | RESIDUAL DIPOLAR COUPLINGS | STRUCTURE REFINEMENT | CHEMICAL-SHIFTS | MEAN-FORCE | NUCLEAR-MAGNETIC-RESONANCE | PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | CHEMISTRY, PHYSICAL | PROTEIN-STRUCTURE DETERMINATION | structure determination | nucleic acids | PROTON DISTANCE CONSTRAINTS | MACROMOLECULAR STRUCTURE DETERMINATION | SPECTROSCOPY | optimization | proteins | X-RAY | computational toolbox | COMPLETE CROSS-VALIDATION
Journal Article
Details
Digital rights
Loading RightsNATURE GENETICS, ISSN 1061-4036, 07/2019, Volume 51, Issue 7, pp. 1072 - 1073
Genetics has played a key role in understanding the relationship between the DNA sequence encoding a protein and the protein’s three-dimensional structure. Two...
GENETICS & HEREDITY | Proteins | Datasets | Mutagenesis | Nucleotide sequence | Amino acid sequence | Genetics | Mutation | Protein structure | Deoxyribonucleic acid--DNA
GENETICS & HEREDITY | Proteins | Datasets | Mutagenesis | Nucleotide sequence | Amino acid sequence | Genetics | Mutation | Protein structure | Deoxyribonucleic acid--DNA
Journal Article
Details
Digital rights
Loading RightsMethods, ISSN 1046-2023, 09/2011, Volume 55, Issue 1, pp. 94 - 106
► X-ray crystallography is a critical tool in the study of biological systems. ► Significant time and effort are required to determine and optimize many...
Macromolecular crystallography | Automation | Diffraction | X-ray | Phenix | Python | MAXIMUM-LIKELIHOOD | DENSITY MODIFICATION | PROTEIN-STRUCTURE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | CRYSTALLOGRAPHY | MODEL | REFINEMENT | MOLECULAR-REPLACEMENT | STRUCTURE VALIDATION | Crystallography, X-Ray - methods | Algorithms | Automation, Laboratory - instrumentation | High-Throughput Screening Assays | Crystallography, X-Ray - instrumentation | Molecular Structure | Proteins - analysis | Software | Proteins - chemistry | Proteomics - methods | Data Collection - methods | Automation, Laboratory - methods | Mechanization | Macromolecular Crystallography
Macromolecular crystallography | Automation | Diffraction | X-ray | Phenix | Python | MAXIMUM-LIKELIHOOD | DENSITY MODIFICATION | PROTEIN-STRUCTURE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | CRYSTALLOGRAPHY | MODEL | REFINEMENT | MOLECULAR-REPLACEMENT | STRUCTURE VALIDATION | Crystallography, X-Ray - methods | Algorithms | Automation, Laboratory - instrumentation | High-Throughput Screening Assays | Crystallography, X-Ray - instrumentation | Molecular Structure | Proteins - analysis | Software | Proteins - chemistry | Proteomics - methods | Data Collection - methods | Automation, Laboratory - methods | Mechanization | Macromolecular Crystallography
Journal Article
Details
Digital rights
Loading RightsNature, ISSN 0028-0836, 01/2005, Volume 433, Issue 7022, pp. 128 - 132
We present a protocol for the experimental determination of ensembles of protein conformations that represent simultaneously the native structure and its...
TRANSITION | NATIVE PROTEINS | BACKBONE MOTION | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | NMR RELAXATION | X-RAY | ORDER PARAMETERS | STATE | SIMULATIONS | COUPLING-CONSTANTS | Reproducibility of Results | Magnetic Resonance Spectroscopy | Computer Simulation | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Models, Molecular | Protein Conformation | Solutions - chemistry | Proteins | NMR | Nuclear magnetic resonance | Molecular biology | Spectrum analysis
TRANSITION | NATIVE PROTEINS | BACKBONE MOTION | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | NMR RELAXATION | X-RAY | ORDER PARAMETERS | STATE | SIMULATIONS | COUPLING-CONSTANTS | Reproducibility of Results | Magnetic Resonance Spectroscopy | Computer Simulation | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Models, Molecular | Protein Conformation | Solutions - chemistry | Proteins | NMR | Nuclear magnetic resonance | Molecular biology | Spectrum analysis
Journal Article
Details
Digital rights
Loading RightsProtein Science, ISSN 0961-8368, 11/2007, Volume 16, Issue 11, pp. 2472 - 2482
The process of experimental determination of protein structure is marred with a high ratio of failures at many stages. With availability of large quantities of...
structural genomics | target selection | protein structure initiative | protein crystallization | X‐ray crystallography | X-ray crystallography | Protein crystallization | Target selection | Structural genomics | Protein structure initiative | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREDICTION | SEQUENCE | COMPLEXITY | DISORDER | PIPELINE | THERMOTOGA-MARITIMA | PROTEOMICS | Computational Biology - methods | Magnetic Resonance Spectroscopy - methods | Protein Structure, Secondary | Isoelectric Focusing | Crystallization | Probability | Crystallography, X-Ray - methods | Sequence Analysis, Protein | Databases, Protein | Protein Conformation | Proteins - chemistry | Proteomics - methods | Genomics - methods
structural genomics | target selection | protein structure initiative | protein crystallization | X‐ray crystallography | X-ray crystallography | Protein crystallization | Target selection | Structural genomics | Protein structure initiative | BIOCHEMISTRY & MOLECULAR BIOLOGY | PREDICTION | SEQUENCE | COMPLEXITY | DISORDER | PIPELINE | THERMOTOGA-MARITIMA | PROTEOMICS | Computational Biology - methods | Magnetic Resonance Spectroscopy - methods | Protein Structure, Secondary | Isoelectric Focusing | Crystallization | Probability | Crystallography, X-Ray - methods | Sequence Analysis, Protein | Databases, Protein | Protein Conformation | Proteins - chemistry | Proteomics - methods | Genomics - methods
Journal Article
Details
Digital rights
Loading RightsJournal of Physical Chemistry B, ISSN 1520-6106, 06/2014, Volume 118, Issue 24, pp. 6405 - 6416
Intrinsically disordered proteins (IDPs) represent a new frontier in structural biology since the primary characteristic of IDPs is that structures need to be...
RESIDUAL DIPOLAR COUPLINGS | UNSTRUCTURED PROTEINS | CONFORMATIONAL ENSEMBLES | STATE ENSEMBLES | UNFOLDED STATE | FREE-ENERGY LANDSCAPE | CHEMICAL-SHIFTS | CHEMISTRY, PHYSICAL | PROTEIN-STRUCTURE DETERMINATION | MOLECULAR-DYNAMICS SIMULATIONS | SH3 DOMAIN | Nuclear Magnetic Resonance, Biomolecular | Peptide Fragments - chemistry | Amyloid beta-Peptides - chemistry | Protein Structure, Secondary | Intrinsically Disordered Proteins - chemistry | Molecular Dynamics Simulation | Peptides | Physical chemistry | Molecular dynamics | Knowledge base | Biology | Nuclear magnetic resonance | NMR spectroscopy | Alzheimer's disease
RESIDUAL DIPOLAR COUPLINGS | UNSTRUCTURED PROTEINS | CONFORMATIONAL ENSEMBLES | STATE ENSEMBLES | UNFOLDED STATE | FREE-ENERGY LANDSCAPE | CHEMICAL-SHIFTS | CHEMISTRY, PHYSICAL | PROTEIN-STRUCTURE DETERMINATION | MOLECULAR-DYNAMICS SIMULATIONS | SH3 DOMAIN | Nuclear Magnetic Resonance, Biomolecular | Peptide Fragments - chemistry | Amyloid beta-Peptides - chemistry | Protein Structure, Secondary | Intrinsically Disordered Proteins - chemistry | Molecular Dynamics Simulation | Peptides | Physical chemistry | Molecular dynamics | Knowledge base | Biology | Nuclear magnetic resonance | NMR spectroscopy | Alzheimer's disease
Journal Article
Details
Digital rights
Loading Rights