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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cancer Research, ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 07/2006, Volume 145, Issue 1, pp. 162 - 172
The Th2 cytokines interleukin (IL)‐4 and IL‐13 and chemokine monocyte chemoattractant protein‐1 (MCP‐1) are significantly involved in bronchial hyperreactivity... 
chemokines/monokines | allergy | epithelial cells | cytokines/interleukins | signalling/signal transduction | Allergy | Cytokines/interleukins | Epithelial cells | Chemokines/monokines | Signalling/signal transduction | ALLERGIC INFLAMMATION | CYTOKINES | CHEMOKINES | KAPPA-B | RELEASE | IMMUNOLOGY | HUMAN EOSINOPHILS | EOTAXIN-2 | ASTHMA PATHOGENESIS | ALVEOLAR MACROPHAGES | AIRWAY HYPERRESPONSIVENESS | Up-Regulation | Epithelial Cells - metabolism | Gene Expression - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - metabolism | Interleukins - metabolism | MAP Kinase Signaling System | Dose-Response Relationship, Drug | Janus Kinase 2 | Bronchi - metabolism | Chemokine CCL2 - metabolism | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-4 - metabolism | Imidazoles - pharmacology | Tyrphostins - pharmacology | Interleukin-13 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Pyridines - pharmacology | Enzyme Activation | Cell Line, Transformed | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Mutual fund industry | Protein kinases | Index Medicus | signal transduction | monokines | cytokines | Basic Immunology | chemokines | signalling | interleukins
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 2042 - 2047
Mice homozygous for the Tyr208Asn amino acid substitution in the carboxy terminus of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1)... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GENE | TAK1 | AUTOIMMUNITY | INNATE | ACTIVATED PROTEIN-KINASES | STRESS | Inflammation - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Neutrophil Infiltration | Sweet Syndrome - genetics | Signal Transduction - immunology | MAP Kinase Kinase Kinase 5 - metabolism | Disease Models, Animal | Neutrophils - pathology | Sweet Syndrome - immunology | MAP Kinase Kinase Kinase 5 - genetics | Neutrophils - enzymology | MAP Kinase Kinase Kinases - genetics | Neutrophils - immunology | Sweet Syndrome - pathology | Inflammation - immunology | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | Sweet Syndrome - enzymology | Inflammation - genetics | Mice | Inflammation - enzymology | MAP Kinase Kinase Kinase 5 - immunology | Neutrophils | Physiological aspects | Development and progression | Models | Inflammation | Skin | Autoimmune diseases | Dermatitis | Health aspects | Mitogen-activated protein kinases | Splenomegaly | SHP-1 protein | TAK1 protein | MAP kinase | Homology | Leukocytes (neutrophilic) | Interleukin 1 receptors | Kinases | Amino acid substitution | Clonal deletion | Interleukin 1 | Skin diseases | Syk protein | Mutation | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, deletion and activation of results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and... 
CELLCYCLE | SIGNALING | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOGENIC K-RAS | CANCER-CELLS | SUPPRESSOR | GENE | ONCOLOGY | SRC | KINASE INHIBITOR | EXPRESSION PROFILES | MUTATIONS | TUMORIGENESIS | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2012, Volume 36, Issue 1, pp. 32 - 42
C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense.... 
CELLS | RESPONSES | ACTIVATION | CANDIDA-ALBICANS | PATTERN-RECOGNITION RECEPTOR | TYROSINE KINASE | HOST-DEFENSE | DECTIN-2 | IMMUNOLOGY | T-LYMPHOCYTES | FUNGAL-INFECTIONS | Cytokines
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 38, pp. 33335 - 33344
Journal Article
Science, ISSN 0036-8075, 9/2002, Volume 297, Issue 5589, pp. 2048 - 2051
The bacterium Bacillus anthracis causes the death of macrophages, which may allow it to avoid detection by the innate immune system. We found that B. anthracis... 
Bacteriophages | Myeloid cells | Anthrax | Cell death | Genes | Innate immunity | Reports | Infections | Macrophages | Apoptosis | Necrosis | CELLS | ACTIVATED PROTEIN-KINASE | TOXIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | TRANSCRIPTION | BACILLUS-ANTHRACIS | MICE | Mitogen-Activated Protein Kinase Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Bacterial Toxins - toxicity | Transcription Factor RelA | NF-kappa B - metabolism | MAP Kinase Kinase 3 | MAP Kinase Signaling System | MAP Kinase Kinase 6 | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein-Tyrosine Kinases - genetics | Teichoic Acids - pharmacology | p38 Mitogen-Activated Protein Kinases | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Macrophages - physiology | Carrier Proteins - toxicity | Cell Line | Gene Expression | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Antigens, Bacterial | Imidazoles - pharmacology | I-kappa B Kinase | Macrophage Activation | Macrophages - enzymology | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | NF-kappa B - genetics | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Enzyme Activation | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinases - metabolism | Bacillus anthracis | Research | Proteins | Enzymes | Pharmacology | Bacteriology | Index Medicus
Journal Article