X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (77664) 77664
Book Chapter (271) 271
Dissertation (266) 266
Publication (73) 73
Web Resource (68) 68
Book / eBook (41) 41
Reference (36) 36
Magazine Article (34) 34
Newsletter (28) 28
Streaming Video (23) 23
Conference Proceeding (17) 17
Newspaper Article (17) 17
Government Document (12) 12
Book Review (5) 5
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (45987) 45987
animals (39112) 39112
phosphorylation (21553) 21553
protein-tyrosine kinases - metabolism (18997) 18997
mice (18881) 18881
biochemistry & molecular biology (16394) 16394
signal transduction (16185) 16185
male (13549) 13549
female (13319) 13319
cell biology (12780) 12780
oncology (11856) 11856
tyrosine (11340) 11340
protein-tyrosine kinase (11101) 11101
expression (9919) 9919
protein-tyrosine kinases - antagonists & inhibitors (9739) 9739
activation (9334) 9334
molecular sequence data (8558) 8558
rats (8504) 8504
protein-tyrosine kinases - genetics (8315) 8315
cell line (8239) 8239
mutation (8213) 8213
cells, cultured (7761) 7761
receptor protein-tyrosine kinases - metabolism (7521) 7521
kinases (7499) 7499
cancer (7313) 7313
receptor protein-tyrosine kinases - genetics (7260) 7260
proteins (7089) 7089
amino acid sequence (7060) 7060
research (6431) 6431
immunology (5928) 5928
middle aged (5593) 5593
adult (5503) 5503
cell line, tumor (5365) 5365
apoptosis (5199) 5199
tyrosine kinase (5154) 5154
gene expression (4991) 4991
proto-oncogene proteins - genetics (4946) 4946
cells (4928) 4928
base sequence (4862) 4862
enzyme activation (4858) 4858
enzyme inhibitors - pharmacology (4847) 4847
research article (4794) 4794
tyrosine - metabolism (4612) 4612
transfection (4606) 4606
hematology (4549) 4549
proto-oncogene proteins - metabolism (4523) 4523
multidisciplinary sciences (4452) 4452
receptor (4335) 4335
signal transduction - physiology (4329) 4329
tumor cells, cultured (4315) 4315
aged (4301) 4301
analysis (4169) 4169
signal-transduction (4128) 4128
gene (4020) 4020
protein (3936) 3936
signal transduction - drug effects (3913) 3913
protein tyrosine phosphatases - metabolism (3877) 3877
protein binding (3741) 3741
genetic aspects (3656) 3656
physiological aspects (3643) 3643
tumors (3496) 3496
immunohistochemistry (3489) 3489
genetics & heredity (3410) 3410
blotting, western (3396) 3396
protein-tyrosine kinases - physiology (3384) 3384
neurosciences (3320) 3320
kinetics (3232) 3232
protein-tyrosine kinases (3232) 3232
identification (3228) 3228
kinase (3107) 3107
tyrosine phosphorylation (3103) 3103
protein kinase inhibitors - pharmacology (2964) 2964
mice, inbred c57bl (2914) 2914
pharmacology & pharmacy (2880) 2880
receptors (2861) 2861
binding sites (2838) 2838
protein-serine-threonine kinases - metabolism (2820) 2820
antineoplastic agents - therapeutic use (2818) 2818
cell proliferation (2794) 2794
ligands (2748) 2748
protein tyrosine kinase (2748) 2748
inhibition (2725) 2725
growth (2715) 2715
protein-tyrosine-phosphatase (2686) 2686
protein kinase inhibitors - therapeutic use (2670) 2670
binding (2605) 2605
time factors (2602) 2602
antineoplastic agents - pharmacology (2585) 2585
phosphorylation - drug effects (2564) 2564
gene-expression (2550) 2550
phosphoproteins - metabolism (2526) 2526
genes (2515) 2515
mice, knockout (2509) 2509
medicine (2500) 2500
in-vivo (2489) 2489
biology (2452) 2452
metastasis (2424) 2424
dose-response relationship, drug (2418) 2418
medicine, research & experimental (2348) 2348
biophysics (2342) 2342
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (77145) 77145
Japanese (883) 883
Chinese (670) 670
French (305) 305
German (231) 231
Russian (112) 112
Spanish (75) 75
Portuguese (61) 61
Hungarian (47) 47
Polish (44) 44
Korean (25) 25
Czech (21) 21
Dutch (20) 20
Italian (20) 20
Norwegian (16) 16
Finnish (9) 9
Swedish (9) 9
Danish (8) 8
Serbian (4) 4
Ukrainian (4) 4
Bulgarian (3) 3
Croatian (2) 2
Turkish (2) 2
Persian (1) 1
Romanian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2017, Volume 17, Issue 2, pp. 93 - 115
.... Proliferation depends on progression through four distinct phases of the cell cycle G0/G1, S, G2 and M which is regulated by several cyclin-dependent kinases (CDKs... 
INVESTIGATIONAL AURORA KINASE | PHASE-II TRIAL | POLO-LIKE-KINASE | EARLY EMBRYONIC-DEVELOPMENT | DINACICLIB SCH 727965 | ADVANCED SOLID TUMORS | ONCOLOGY | PREVENTS TUMOR-GROWTH | VOLASERTIB BI 6727 | DEPENDENT KINASE INHIBITOR | SMALL-MOLECULE INHIBITOR | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Humans | Checkpoint Kinase 1 - physiology | Aurora Kinase A - antagonists & inhibitors | Cyclin-Dependent Kinase 2 - physiology | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - physiology | Aurora Kinase A - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Checkpoint Kinase 1 - antagonists & inhibitors | Clinical Trials as Topic | Neoplasms - drug therapy | Animals | Cyclin-Dependent Kinase 4 - physiology | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - physiology | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Care and treatment | Usage | MicroRNA | Cell cycle | Research | Cancer
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2004, Volume 64, Issue 19, pp. 7099 - 7109
.... In addition, BAY 43-9006 demonstrated significant activity against several receptor tyrosine kinases involved in neovascularization and tumor progression, including vascular endothelial growth factor receptor (VEGFR... 
CELLS | ACTIVATION | GENE | ONCOLOGY | SIGNALING PATHWAY | PROTEIN-KINASE | MAP KINASE | B-RAF | INHIBITORS | CANCER | ENDOTHELIAL GROWTH-FACTOR | Niacinamide - analogs & derivatives | Humans | Phenylurea Compounds | Neovascularization, Pathologic - enzymology | Benzenesulfonates - pharmacology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | MAP Kinase Kinase Kinases - antagonists & inhibitors | Administration, Oral | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Neoplasms - enzymology | Neoplasms - blood supply | MAP Kinase Kinase Kinases - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Disease Progression | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice, Nude | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | Pyridines - pharmacology | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 1995, Volume 270, Issue 5240, pp. 1326 - 1331
...) kinase family members, including ERK (extracellular signal-regulated kinase), JNK (c-JUN NH$_2$-terminal protein kinase... 
T lymphocytes | Cell growth | Genetic vectors | Neurons | Cell death | Cell nucleus | Antibodies | Cultured cells | Cellular differentiation | Research Article | Apoptosis | PROGRAMMED CELL-DEATH | SIGNAL-TRANSDUCTION | PHEOCHROMOCYTOMA CELLS | PROTO-ONCOGENE | FACTOR DEPRIVATION | FACTOR WITHDRAWAL | MULTIDISCIPLINARY SCIENCES | MICROTUBULE-ASSOCIATED PROTEIN-2 | SYMPATHETIC NEURONS | PC12 CELLS | NERVE GROWTH-FACTOR | Protein Kinases - metabolism | MAP Kinase Kinase Kinases | Protein-Tyrosine Kinases - metabolism | Staurosporine | Neurons - cytology | MAP Kinase Kinase 3 | PC12 Cells | MAP Kinase Kinase 1 | Nerve Growth Factors - pharmacology | Protein-Tyrosine Kinases - genetics | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase Kinases | JNK Mitogen-Activated Protein Kinases | Cell Differentiation | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Genes, jun | Mitogen-Activated Protein Kinases | Alkaloids - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Signal Transduction | Sympathetic Nervous System - cytology | Protein-Serine-Threonine Kinases - genetics | Rats | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Animals | Neurons - enzymology | Enzyme Activation | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 | Protein-Tyrosine Kinases - antagonists & inhibitors | Protein kinases | Research | Proteins | Neurology | Rodents | Genes
Journal Article