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Journal Article
Neuroscience, ISSN 0306-4522, 2011, Volume 193, pp. 440 - 451
Abstract Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that... 
Neurology | mast cell tryptase | paclitaxel-induced pain | TRPV1 | TRPA1 | proteinase-activated receptor 2 | TRPV4 | Proteinase-activated receptor 2 | Mast cell tryptase | Paclitaxel-induced pain | NEUROSCIENCES | SENSORY NEURONS | CAPSAICIN RECEPTOR | MECHANICAL HYPERALGESIA | IN-VIVO | KINASE-C-EPSILON | ION-CHANNEL | PERIPHERAL NEUROPATHY | INFLAMMATORY PAIN | PROTEASE-ACTIVATED-RECEPTOR-2 SENSITIZES | IRRITABLE-BOWEL-SYNDROME | Tryptases - metabolism | Central Nervous System - metabolism | Capsaicin - pharmacology | Receptor, PAR-2 - metabolism | Type C Phospholipases - metabolism | Male | Neuralgia - pathology | Dose-Response Relationship, Drug | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Drug Interactions | Paclitaxel - toxicity | Time Factors | Protein Kinase C - metabolism | TRPV Cation Channels - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Neuralgia - chemically induced | Neuralgia - physiopathology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mice, Inbred ICR | Hyperalgesia - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Gene Expression Regulation - drug effects | Pain Measurement - methods | Pyrroles - pharmacology | Animals | Analysis of Variance | Ankyrins - antagonists & inhibitors | Anilides - pharmacology | Ankyrins - metabolism | Central Nervous System - drug effects | Mice | Physical Stimulation - adverse effects | Carbazoles - pharmacology | Oligopeptides - pharmacology | Protein Kinase C - pharmacology | Enzymes | Care and treatment | Neurosciences | Paclitaxel | Phospholipases | Protein kinases | Cancer
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2007, Volume 117, Issue 7, pp. 1979 - 1987
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24314 - 24325
Proteinase-activated receptor 2 (PAR(2)), a seven-transmembrane G protein-coupled receptor, is activated at inflammatory sites by proteolytic cleavage of its... 
IMMUNE-RESPONSE | PROTEINASE-ACTIVATED RECEPTORS | INFLAMMATORY RESPONSES | LUNG EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | TOLL-LIKE RECEPTORS | MAJOR ROLE | NF-KAPPA-B | ENDOGENOUS LIGANDS | INNATE IMMUNITY | Humans | Adaptor Proteins, Vesicular Transport - genetics | Immunity, Innate - genetics | NF-kappa B - immunology | Signal Transduction - immunology | Receptor, PAR-2 - immunology | Myeloid Differentiation Factor 88 - immunology | Adaptor Proteins, Signal Transducing - immunology | Toll-Like Receptor 4 - agonists | Cytokines - genetics | Cytokines - immunology | Receptor, PAR-2 - genetics | Cell Line | Immunity, Innate - drug effects | Receptors, Interleukin - immunology | Oligopeptides - immunology | Myeloid Differentiation Factor 88 - genetics | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Inflammation - immunology | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Adaptor Proteins, Vesicular Transport - immunology | Receptors, Interleukin - genetics | Mice, Knockout | Animals | NF-kappa B - genetics | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Lipopolysaccharides - pharmacology | Receptor, PAR-2 - agonists | Inflammation - genetics | Mice | Oligopeptides - pharmacology | Genes, Dominant - genetics | Genes, Dominant - immunology
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 04/2017, Volume 15, Issue 4, pp. 597 - 607
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2012, Volume 366, Issue 1, pp. 20 - 33
In this trial, vorapaxar, a protease-activated–receptor 1 antagonist that inhibits thrombin-induced platelet activation, was not effective in reducing the... 
MEDICINE, GENERAL & INTERNAL | PLACEBO | GLYCOPROTEIN IIB/IIIA INHIBITORS | CLOPIDOGREL | TASK-FORCE | SAFETY | DOUBLE-BLIND | ANTIPLATELET THERAPY | Follow-Up Studies | Angioplasty | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Combined Modality Therapy | Lactones - adverse effects | Lactones - therapeutic use | Acute Coronary Syndrome - drug therapy | Intracranial Hemorrhages - chemically induced | Coronary Artery Bypass | Acute Coronary Syndrome - therapy | Aged | Hemorrhage - chemically induced | Antagonists (Biochemistry) | Drugs | Dose-response relationship (Biochemistry) | Dosage and administration | Product/Service Evaluations | Drug therapy | Coronary heart disease | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Cardiovascular disease | Hemorrhage | Bleeding | Investigations | Manuscripts | Ischemia | Blood platelets | Acute coronary syndromes | Research centers | Malalties cardiovasculars | Bypass cardiopulmonar | Medicaments | Bypass cardiopulmonary | Plaquetes sanguínies | Cardiovascular diseases | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 12/2011, Volume 17, Issue 6, pp. 742 - 749
Targets for antipruritic therapies are now expanding from the skin to the central nervous system. Recent studies demonstrate that various neuronal receptors in... 
Histamine | Itch | Spinal cord | Neurokinin‐1 receptor | Gastrin‐releasing peptide | Opioid | Skin | Pruritus | Neurokinin-1 receptor | Gastrin-releasing peptide | DORSAL-HORN NEURONS | PROTEINASE-ACTIVATED RECEPTOR-2 | GENE-RELATED PEPTIDE | KAPPA-OPIOID RECEPTORS | VASOACTIVE-INTESTINAL-PEPTIDE | INTRATHECAL MORPHINE | HISTAMINE H-1 RECEPTORS | NEUROSCIENCES | PHARMACOLOGY & PHARMACY | MORPHINE-INDUCED ITCH | INDUCED SCRATCHING BEHAVIOR | SUBSTANCE-P RECEPTOR | Receptors, Histamine - physiology | Receptors, Serotonin - physiology | Gastrin-Secreting Cells - physiology | Receptors, Bradykinin - physiology | Humans | Receptors, Serotonin - drug effects | Receptors, Histamine - drug effects | Receptors, Bradykinin - drug effects | Receptors, Neurokinin-1 - physiology | Receptors, Glutamate - drug effects | Pruritus - physiopathology | Receptors, Opioid - physiology | Receptors, Neurokinin-1 - drug effects | Animals | Pruritus - drug therapy | Spinal Cord - physiology | Drug Design | Neurotransmitter Agents - physiology | Receptors, Opioid - drug effects | Receptors, Glutamate - physiology | Gastrin-Secreting Cells - drug effects | Antihistamines | Methyl aspartate | Gabapentin | Dermatology | Sulfonamides | Bradykinin | Formulae, receipts, prescriptions | Gastrin | Dermatologic agents | Glutamate | Drugs | pruritus | Opioid receptors | Glutamic acid receptors (ionotropic) | Substance P | Central nervous system | Opioid receptors (type mu) | N-Methyl-D-aspartic acid receptors | Antagonists | Glutamic acid receptors | Drug development | Side effects | gabapentin | Neurotransmission | Dorsal horn
Journal Article