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phosphatases (185) 185
blotting, western (181) 181
phosphatidylinositol 3-kinases - genetics (179) 179
cells (178) 178
analysis (176) 176
genetic aspects (171) 171
protein kinase inhibitors - pharmacology (171) 171
gene expression regulation, neoplastic (170) 170
pten phosphohydrolase - physiology (169) 169
middle aged (165) 165
proto-oncogene proteins c-akt - antagonists & inhibitors (162) 162
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phosphoric monoester hydrolases - metabolism (143) 143
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mice, inbred c57bl (140) 140
in-vivo (139) 139
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phosphorylation - drug effects (137) 137
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immunohistochemistry (117) 117
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metastasis (111) 111
prostate cancer (111) 111
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Cell Metabolism, ISSN 1550-4131, 03/2014, Volume 19, Issue 3, pp. 393 - 406
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 06/2010, Volume 411, Issue 11-12, pp. 846 - 852
Journal Article
Cancer Research, ISSN 0008-5472, 11/2008, Volume 68, Issue 22, pp. 9221 - 9230
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8736 - 8747
The majority of melanomas show constitutive activation of the RAS-RAF-MAP/ERK kinase (MEK)-mitogen-activated protein kinase (MAPK) pathway. AZD6244 is a... 
BREAST-CANCER | KINASE KINASE-1/2 INHIBITOR | PIK3CA | ONCOLOGY | PROTEIN-KINASE | IN-VIVO | GROWTH | PTEN | MUTATIONS | EXPRESSION | HUMAN CANCER | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | PTEN Phosphohydrolase - genetics | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | PTEN Phosphohydrolase - metabolism | Melanoma - pathology | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Skin Neoplasms - metabolism | Phosphatidylinositol 3-Kinase - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | AZD8055 | MEK | AZD6244 | melanoma | BRAF | AKT | MAPK
Journal Article
Cancer Research, ISSN 0008-5472, 09/2013, Volume 73, Issue 17, pp. 5402 - 5415
AKT signaling is constitutively activated in various cancers, due in large part to loss-of-function in the PTEN and PHLPP phosphatases that act as tumor... 
BREAST-CANCER | SURVIVAL | OVEREXPRESSION | ACTIVATION | ONCOLOGY | GROWTH | KINASE | RESISTANCE | NF-KAPPA-B | EXPRESSION | MTOR | Adenocarcinoma - pathology | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | 3' Untranslated Regions - genetics | Lung Neoplasms - pathology | MicroRNAs - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Immunoenzyme Techniques | Carcinoma, Adenosquamous - blood supply | PTEN Phosphohydrolase - antagonists & inhibitors | Forkhead Transcription Factors - metabolism | Female | Adenocarcinoma - genetics | Lung - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Lung Neoplasms - blood supply | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Lung - pathology | Carcinoma, Adenosquamous - pathology | Signal Transduction | Carcinoma, Non-Small-Cell Lung - blood supply | Carcinoma, Non-Small-Cell Lung - genetics | PTEN Phosphohydrolase - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | Carcinoma, Adenosquamous - genetics | Blotting, Western | Adenocarcinoma - blood supply | Animals | Phosphoprotein Phosphatases - genetics | Mice, Nude | Mice | Mice, Inbred BALB C | MicroRNAs - genetics | Forkhead Box Protein O3 | Apoptosis | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 06/2015, Volume 36, Issue 3, pp. 956 - 965
Background: Berberine, a well-known component of the Chinese herbal medicine Huanglian, has wide range of biochemical and pharmacological effects, including... 
Original Paper | Berberine | miR-93 | Ovarian cancer cells | Cisplatin | APOPTOSIS | PHYSIOLOGY | INVOLVEMENT | CYCLE ARREST | MICRORNAS | mir-93 | CHEMOTHERAPY | CELL BIOLOGY | LEUKEMIA-CELLS | RESISTANCE | CHEMORESISTANCE | CARCINOMA | EXPRESSION | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Luciferases - metabolism | MicroRNAs - antagonists & inhibitors | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Luciferases - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Ribonucleosides - pharmacology | Female | Ovary - drug effects | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Genes, Reporter | Ovary - metabolism | PTEN Phosphohydrolase - agonists | PTEN Phosphohydrolase - genetics | Ovary - pathology | Signal Transduction | PTEN Phosphohydrolase - metabolism | Epithelial Cells - pathology | Cisplatin - pharmacology | Drug Synergism | Berberine - pharmacology | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | MicroRNAs - genetics | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2010, Volume 30, Issue 27, pp. 9306 - 9315
Journal Article
Science, ISSN 0036-8075, 9/2009, Volume 325, Issue 5945, pp. 1261 - 1265
Journal Article
Carcinogenesis, ISSN 0143-3334, 02/2013, Volume 34, Issue 2, pp. 454 - 463
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2016, Volume 19, Issue 3, pp. 443 - 453
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8715 - 8725
Journal Article
Journal Article