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Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7538, pp. 240 - 244
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7576, pp. 100 - 104
Journal Article
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7525, pp. 134 - 137
Journal Article
Nature Neuroscience, ISSN 1097-6256, 09/2010, Volume 13, Issue 9, pp. 1075 - 1081
Journal Article
Journal Article
Nature, ISSN 0028-0836, 10/2009, Volume 461, Issue 7267, pp. 1084 - 1091
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 484 - 488
Synthetic lethality and collateral lethality are two well-validated conceptual strategies for identifying therapeutic targets in cancers with tumour-suppressor... 
VULNERABILITIES | BETA-TRCP | PHOSPHORYLATION | MUTANT-CELLS | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DELETION | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Prostatic Neoplasms - metabolism | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Chromatin Assembly and Disassembly - genetics | Male | NF-kappa B - metabolism | Molecular Targeted Therapy | DNA-Binding Proteins - deficiency | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Ubiquitination | beta-Transducin Repeat-Containing Proteins - metabolism | Prostatic Neoplasms - genetics | Neoplasms - genetics | Proteolysis | Female | Lysine - metabolism | Protein Stability | DNA Helicases - genetics | Genes, Essential - genetics | DNA Helicases - chemistry | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | PTEN Phosphohydrolase - deficiency | PTEN Phosphohydrolase - metabolism | DNA Helicases - deficiency | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Glycogen Synthase Kinase 3 beta - metabolism | DNA Helicases - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Methylation | Neoplasms - pathology | Physiological aspects | Chromatin | Genetic aspects | Research | Oncology, Experimental | Cancer | Cell growth | Genes | Breast cancer | Genomes | Mutation | Kinases | Prostate cancer | Data bases | Tumors | Cell adhesion & migration | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7377, pp. 372 - 375
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
BOX PROTEIN SKP2 | TUMOR SUPPRESSION | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PTEN | ACCUMULATION | ONCOGENE-INDUCED SENESCENCE | EXPRESSION | CANCER | P53 | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis | Index Medicus
Journal Article