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PLoS biology, ISSN 1545-7885, 2009, Volume 7, Issue 6, p. e1000121
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 461, Issue 7267, pp. 1084 - 1091
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
BOX PROTEIN SKP2 | COMPLEX | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | PTEN | RESTORATION | ACCUMULATION | ONCOGENE-INDUCED SENESCENCE | INHIBITOR | EXPRESSION | P53 | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis
Journal Article
Journal Article
Cellular physiology and biochemistry, ISSN 1421-9778, 2015, Volume 36, Issue 3, pp. 956 - 965
Background: Berberine, a well-known component of the Chinese herbal medicine Huanglian, has wide range of biochemical and pharmacological effects, including... 
Original Paper | Berberine | miR-93 | Ovarian cancer cells | Cisplatin | APOPTOSIS | PHYSIOLOGY | INVOLVEMENT | CYCLE ARREST | MICRORNAS | mir-93 | CHEMOTHERAPY | CELL BIOLOGY | LEUKEMIA-CELLS | RESISTANCE | CHEMORESISTANCE | CARCINOMA | EXPRESSION | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Luciferases - metabolism | MicroRNAs - antagonists & inhibitors | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Proto-Oncogene Proteins c-akt - genetics | Luciferases - genetics | PTEN Phosphohydrolase - antagonists & inhibitors | Ribonucleosides - pharmacology | Female | Ovary - drug effects | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Genes, Reporter | Ovary - metabolism | PTEN Phosphohydrolase - agonists | PTEN Phosphohydrolase - genetics | Ovary - pathology | Signal Transduction | PTEN Phosphohydrolase - metabolism | Epithelial Cells - pathology | Cisplatin - pharmacology | Drug Synergism | Berberine - pharmacology | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | MicroRNAs - genetics | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 3/2010, Volume 107, Issue 12, pp. 5471 - 5476
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is deregulated in many human diseases including cancer, diabetes, obesity, and autoimmunity. PI3K... 
Proteins | Phosphatases | HeLa cells | Lipids | Insulin resistance | Gene expression regulation | Physiological regulation | Insulin | Phosphatidylinositols | Cancer | Explains mouse phenotypes | Lipid phosphatase | Protein:protein interactions | PTEN tumor suppressor | Insulin signaling | CATALYTIC SUBUNIT | MULTIDISCIPLINARY SCIENCES | P85-ALPHA SUBUNIT | PHOSPHOINOSITIDE 3-KINASE | CANCER | MICE LACKING | 3'-KINASE | insulin signaling | GENE | PI3K | NEOPLASIA | lipid phosphatase | protein:protein interactions | explains mouse phenotypes | INCREASED INSULIN SENSITIVITY | Protein Subunits | Sequence Deletion | Humans | Cercopithecus aethiops | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Phosphatidylinositol 3-Kinases - deficiency | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Peptide Fragments - metabolism | Signal Transduction | Phosphatidylinositol 3-Kinases - chemistry | PTEN Phosphohydrolase - metabolism | Epidermal Growth Factor - metabolism | Recombinant Fusion Proteins - chemistry | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Insulin - metabolism | Peptide Fragments - chemistry | Phenotype | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | HeLa Cells | COS Cells | PTEN Phosphohydrolase - chemistry | Phosphatidylinositol | Chemical properties | Research | Phosphotransferases | Protein-protein interactions | Tumors | Biological Sciences
Journal Article
Cell Cycle, ISSN 1551-4005, 2014, Volume 8, Issue 14, pp. 2198 - 2210
Journal Article