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Biomedicine & Pharmacotherapy, ISSN 0753-3322, 06/2019, Volume 114, p. 108782
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. In our study, we aimed to investigate the effects of alkannin on HCC cells... 
Alkannin | Hepatocellular carcinoma | PTEN/PI3K/AKT | miR-92a
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2018, Volume 22, Issue 21, pp. 7222 - 7232
Journal Article
Journal of Functional Foods, ISSN 1756-4646, 06/2019, Volume 57, pp. 255 - 265
Ginsenosides have been reported to possess pharmacological effects, such as antioxidative, anti-inflammatory and antitumor effects. Nevertheless, little has... 
MCF-7 cells | Ginsenoside Rk1 | PTEN/PI3K/Akt/mTOR pathway | ROS | Apoptosis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 501, Issue 1, pp. 106 - 112
Resveratrol (RSV), an edible polyphenolic phytoalexin, plays an important role in ameliorating inflammation, including skin inflammation after burn injury.... 
miR-17 | mTOR pathway | Skin inflammation | Burn injury | Resveratrol | PTEN/PI3K/AKT pathway | DRUG | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | RATS | PROLIFERATION | CANCER | PROTECTS | BURN | BIOPHYSICS | SIGNALING PATHWAY | INFLAMMATORY RESPONSE | PTEN/P13K/AKT pathway | EXPRESSION
Journal Article
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2019, Volume 23, Issue 11, pp. 4890 - 4897
OBJECTIVE: The aim of this study was to investigate the effect of micro-ribonucleic acid (miR)-130a on neuronal injury in rats with intracerebral hemorrhage... 
Neuronal injury | Intracranial hemorrhage | PTEN/PI3K/AKT | MiR-130a | ACTIVATION | ERYTHROPOIETIN | FOCAL CEREBRAL-ISCHEMIA | PHARMACOLOGY & PHARMACY | AKT | CONTRIBUTES
Journal Article
by Shi, YJ and Xu, W and Han, YF and Li, JX and Niu, LL and Chen, YD
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 11/2019, Volume 23, Issue 11, pp. 4924 - 4931
OBJECTIVE: The aim of this study was to investigate the effects of micro-ribonucleic acid (miR)-21 on hypertensive rats through the phosphatase and tensin... 
Hypertension | MIGRATION | CELLS | MiR-21 | PHOSPHATASE | PTEN/PI3K/Akt/mTOR signaling pathway | PTEN | PHARMACOLOGY & PHARMACY | PROLIFERATION | AKT | EXPRESSION | CANCER
Journal Article
by Dong, J and Dong, J and Zhao, Y and Zhao, Y and He, X.-K and He, X-K
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 09/2018, Volume 22, Issue 18, pp. 6109 - 6118
OBJECTIVE: DJ-1-phosphate and tension homology deleted on chromosome ten/phosphatidylinositol-3-kinase/protein kinase B (PTEN/PI3K/AKT) signaling pathway plays... 
DJ-1 | Cardiomyocyte | MiR-192 | PTEN/PI3K/AKX | Apoptosis | I-R | BIOMARKERS | PHARMACOLOGY & PHARMACY | PTEN/PI3K/AKT | EXPRESSION | MICRORNA
Journal Article
by Chen, Z and Zhou, ZY and He, CC and Zhang, JL and Wang, J and Xiao, ZY
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 11/2018, Volume 22, Issue 21, pp. 7222 - 7232
OBJECTIVE: Hepatocellular Carcinoma (HCC) is a worldwide common and malignant tumor. It is discovered in recent years that long non-coding RNAs (lncRNAs)... 
PTEN/PI3K/AKT signaling | LONG NONCODING RNAS | MECHANISM | PROGNOSIS | GROWTH | LncRNA | Hepatocellular carcinoma | PHARMACOLOGY & PHARMACY | EMT | PROGRESSION
Journal Article
by Wen, DH and Liu, J and Cui, DJ and Wang, XX
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2019, Volume 12, Issue 6, pp. 7278 - 7284
Phosphatase and tensin homologues deleted on chromosome ten (PTEN)-phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT/PKB) signaling pathways widely... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | Leukemia | PTEN-PI3K/AKT | PTEN | DJ-1 | IDENTIFICATION | resistance | CHEMOTHERAPY | ADR
Journal Article
by Li, P and Qin, H and Li, XJ
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2019, Volume 12, Issue 7, pp. 8739 - 8745
The PI3K/AKT signaling pathway plays an important role in tumor occurrence. PTEN can negatively regulate the PTEN/AKT signaling pathway, and DJ-1 is the... 
lung cancer | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | proliferation | PTEN | apoptosis | Curcumin | DJ-1 | PTEN/PI3K/AKT | PROGRESSION
Journal Article
by Li, MZ and Wang, CR and Lin, CL
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2019, Volume 12, Issue 7, pp. 8992 - 8998
Enhanced activity of the PI3K/AKT signal pathway is correlated with tumorigenesis. As a negative regulator of PTEN, DJ-1 over-expression is associated with the... 
MEDICINE, RESEARCH & EXPERIMENTAL | cell proliferation | apoptosis | breast cancer | Curcumin | DJ-1 | PTEN/PI3K/AKT | PROGRESSION
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2019, Volume 23, Issue 8, pp. 3461 - 3470
OBJECTIVE: To study the correlations of micro ribonucleic acid (miR)-126 expression with pathogenesis and prognosis of glioma, and to screen potential... 
MDM2-p53 pathway | Prognosis | PTEN/PI3K/Akt pathway | MiR-126 | Glioma | MIGRATION | CELLS | miR-126 | INVASION | PHARMACOLOGY & PHARMACY | PROLIFERATION | MIRNAS | CANCER
Journal Article
by Shang, H and Wang, T and Shang, F and Li, M and Luo, Y and Huang, KM
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 04/2019, Volume 23, Issue 7, pp. 3080 - 3087
OBJECTIVE: The phosphatase and tensin homologue deleted on chromosome ten (PTEN) acts as a tumor suppressor gene by inhibiting the phosphatidylinositol... 
Colorectal cancer | PTEN | DJ-1 | Proliferation | SUPPRESSION | 5-FLUOROURACIL | INVASION | PATHWAY | GROWTH | PHARMACOLOGY & PHARMACY | Curcumin | PTEN/PI3K/AKT | PROMOTES
Journal Article
International Journal of Oncology, ISSN 1019-6439, 7/2014, Volume 45, Issue 1, pp. 104 - 112
Colon cancer is one of the most common malignancies and the treatments for colon cancer have been developed substantially in the last decades, but there is... 
PTEN/PI3K | Akt | resveratrol | colon cancer | Wnt/β-catenin | anti-proliferation | Anti-proliferation | PTEN/PI3K/Akt | Colon cancer | Resveratrol | NATURAL-PRODUCT | APOPTOSIS | GRAPES | KINASE | PTEN | TUMOR | CHEMOPREVENTION | ONCOLOGY | Wnt/beta-catenin | GROWTH | CYTOTOXICITY | EXPRESSION | Proteins | Phosphorylation | Cell growth | Adenoviruses | Colorectal cancer | Cell cycle | Mutation | Gene expression | Phosphatase | Kinases | Cancer therapies | Apoptosis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 1, pp. 1 - 7
For colorectal cancer (CRC) patients, local and systemic inflammatory responses have been extensively reported to closely associate with patient survival.... 
COX and LOX metabolic pathways | Enzyme inhibitors | Proliferation | Colorectal cancer | PTEN/PI3K/AKT pathway | Apoptosis | CELLS | ANGIOGENESIS | STATISTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMORS | DELETION | OVEREXPRESSION | BIOPHYSICS | GROWTH | TARGETS | 5-LIPOXYGENASE | EXPRESSION | Enzymes | Phosphatases | Development and progression | Arachidonic acid | Health aspects | Index Medicus
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 01/2019, Volume 109, pp. 1032 - 1040
Glioma is a common brain tumor, which is a serious threat to the life and health of human with high mortality rate. Recently, neferine (NEF) has been reported... 
Neferine | microRNA-10b | PTEN/PI3K/AKT | Proliferation | Glioma | p38MAPK | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INDUCED APOPTOSIS | PTEN | GROWTH | PHARMACOLOGY & PHARMACY | MicroRNA | Tumor proteins | Gliomas | Health aspects | Brain tumors | Mortality
Journal Article