Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
pten-induced putative kinase (313) 313
mitochondria (264) 264
index medicus (223) 223
parkin protein (176) 176
parkinson's disease (175) 175
movement disorders (155) 155
neurodegenerative diseases (153) 153
humans (149) 149
autophagy (136) 136
proteins (124) 124
oxidative stress (120) 120
mutation (118) 118
animals (113) 113
mitophagy (104) 104
apoptosis (100) 100
pink1 (100) 100
kinases (98) 98
cell biology (93) 93
parkin (86) 86
biochemistry & molecular biology (77) 77
phagocytosis (77) 77
ubiquitin (77) 77
mitochondria - metabolism (74) 74
pten protein (74) 74
mice (72) 72
protein kinases - genetics (71) 71
protein kinases - metabolism (71) 71
neurons (69) 69
neurosciences (69) 69
dopamine (66) 66
phosphorylation (65) 65
multidisciplinary sciences (64) 64
neurodegeneration (61) 61
medicine (59) 59
parkinsons disease (58) 58
ubiquitin-protein ligases - metabolism (57) 57
rodents (54) 54
mutations (53) 53
mitochondrial dna (52) 52
science (52) 52
activation (51) 51
article (49) 49
male (49) 49
disease (47) 47
parkinson disease - genetics (46) 46
nervous system diseases (45) 45
ubiquitin-protein ligase (45) 45
gene expression (44) 44
genetic aspects (44) 44
parkinsons-disease (44) 44
research article (44) 44
ubiquitin-protein ligases - genetics (44) 44
cell death (43) 43
quality control (43) 43
biology (42) 42
homeostasis (42) 42
signal transduction (42) 42
parkinson disease (41) 41
reactive oxygen species (40) 40
dopamine receptors (39) 39
membrane potential (39) 39
pten-induced putative kinase 1 (39) 39
animal models (38) 38
pathogenesis (38) 38
parkinson’s disease (36) 36
genes (35) 35
neurology (34) 34
park7 protein (33) 33
age (32) 32
research (32) 32
substantia nigra (32) 32
female (31) 31
synuclein (31) 31
ubiquitination (31) 31
analysis (30) 30
degradation (30) 30
mitochondrial dysfunction (30) 30
protein (30) 30
genetics (29) 29
basal ganglia (28) 28
brain (28) 28
damaged mitochondria (28) 28
lrrk2 protein (28) 28
metabolism (28) 28
mitochondria - genetics (27) 27
physiological aspects (27) 27
alpha-synuclein (26) 26
cells (26) 26
central nervous system diseases (26) 26
inflammation (26) 26
neuroscience (26) 26
mechanisms (25) 25
mitochondrial degradation (25) 25
cancer (24) 24
cell survival (24) 24
insects (24) 24
recruitment (24) 24
aging (23) 23
degeneration (23) 23
dysfunction (23) 23
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text GW29-e0367 PTEN Induced Putative Kinase 1 (PINK1) Regulates Mitophagy to Alleviate Angiotensin II-Induced Cardiac Injury
by Xiong, Wenjun and Li, Jiaying and Peng, Zhengliang and Ma, Zhuang and Xie, Xiangkun and Li, Hanlin and Se, Zhen and Lai, Wenyan and Zhan, Qiong and Zeng, Qingchun and Ren, Hao and Xu, Dingli
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2018, Volume 72, Issue 16, p. C14
Mitochondria | Microscopy | PTEN-induced putative kinase | Angiotensin | Cardiomyocytes | Angiotensin II | Autophagy | PTEN protein | Apoptosis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Nitric oxide induction of parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: Functional role of neuronal nitric oxide synthase during mitophagy
by Han, Ji-Young and Kang, Min-Ji and Kim, Kyung-Hee and Han, Pyung-Lim and Kim, Hyun-Seok and Ha, Ji-Young and Son, Jin H
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 16, pp. 10325 - 10335
The failure to trigger mitophagy is implicated in the pathogenesis of familial Parkinson disease that is caused by PINK1 or Parkin mutations. According to the... 
RESPIRATORY-CHAIN | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Nitric Oxide | Mitophagy | PTEN-induced Putative Kinase 1 (PINK1) | UBIQUITIN LIGASE ACTIVITY | MITOCHONDRIAL QUALITY-CONTROL | Parkinson Disease | ACTIVATE PARKIN | S-NITROSYLATION | PINK1/PARKIN-MEDIATED MITOPHAGY | nNOS | DISEASE | COMPLEX I ACTIVITY | Parkin | Electron Transport | Protein Kinases - genetics | Dopaminergic Neurons - pathology | Humans | Mitochondrial Degradation - genetics | Dopaminergic Neurons - metabolism | HEK293 Cells | Parkinson Disease - metabolism | Protein Kinases - deficiency | Disease Models, Animal | Fibroblasts - metabolism | Nitric Oxide - biosynthesis | Parkinson Disease - pathology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Parkinson Disease - genetics | Fibroblasts - pathology | Mice, Knockout | Nitric Oxide Synthase Type I - deficiency | Protein Transport | Animals | Protein Binding | Mice | Nitric Oxide Synthase Type I - genetics | Primary Cell Culture | Ubiquitin-Protein Ligases - genetics | Index Medicus | Molecular Bases of Disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Cytosolic PTEN-induced putative kinase 1 Is stabilized by the NF- κ B pathway and promotes non-selective mitophagy
by Lim, Grace G.Y and Chua, Doreen S.K and Basil, Adeline H and Chan, Hui-Ying and Chai, Chou and Arumugam, Thiruma and Lim, Kah-Leong
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 27, pp. 16882 - 16893
The potential cellular function of the 53-kDa cytosolic form of PINK1 (PINK1-53) is often overlooked because of its rapid degradation by the proteasome upon... 
ACTIVATE PARKIN | UBIQUITINATION | RECRUITMENT | LOCALIZATION | TRANSLOCATION | PINK1 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAMAGED MITOCHONDRIA | MUTATIONS | PARKINSONS-DISEASE | Protein Kinases - metabolism | Mitochondria - enzymology | Protein Kinases - genetics | Humans | Mice, Inbred C57BL | Protein Kinases - chemistry | NF-kappa B - metabolism | Mitochondria - metabolism | Amino Acid Motifs | Mitochondrial Degradation | Cytosol - enzymology | Ubiquitination | Animals | Mitochondria - genetics | NF-kappa B - genetics | Neurons - enzymology | TNF Receptor-Associated Factor 6 - metabolism | Cytosol - metabolism | Mice | Neurons - metabolism | Protein Stability | TNF Receptor-Associated Factor 6 - genetics | Parkinson disease | ubiquitylation (ubiquitination) | mitophagy | PTEN-induced putative kinase 1 (PINK1) | parkin | Cell Biology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy
by Zhang, Juan and Chen, Ke and Wang, Linghao and Wan, Xinxin and Shrestha, Chandrama and Zhou, Jingsong and Mo, Zhaohui
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2016, Volume 476, Issue 4, pp. 299 - 305
Chronic elevated glucose is harmful to pancreatic β-cells, resulting in pancreatic β-cells dysfunction and apoptosis. Understanding the molecular mechanisms... 
β-cells | Autophagy | Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 | Apoptosis | High glucose | NETWORK | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOPHAGY | SELECTIVE AUTOPHAGY | PARKIN | PINK1 | BIOPHYSICS | INCREASE | MASS | beta-cells | EXPRESSION | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Protein Kinases - genetics | Rats, Wistar | PTEN Phosphohydrolase - metabolism | Male | Insulin-Secreting Cells - metabolism | Animals | RNA Interference | Glucose - metabolism | Insulin-Secreting Cells - cytology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress
by Yuan, Xiang-li and Guo, Ji-feng and Shi, Zhen-hua and Xiao, Zhi-qian and Yan, Xin-xiang and Zhao, Bao-lu and Tang, Bei-sha
Brain Research, ISSN 0006-8993, 2010, Volume 1351, pp. 229 - 237
Abstract The identification of rare monogenic forms of Parkinson's disease (PD) has provided tremendous insights into the molecular pathogenesis of the... 
Neurology | PTEN-induced putative kinase 1 ( PINK1) | Mitochondria | Reactive oxidative species (ROS) | Parkinson's disease (PD) | PTEN-induced putative kinase 1 (PINK1) | APOPTOSIS | SH-SY5Y | PROTEIN | ONSET PARKINSONS-DISEASE | NEURODEGENERATION | DJ-1 | RECESSIVE PARKINSONISM | NEUROSCIENCES | PATHOGENESIS | PINK1 | COMPLEX-I | Mitochondria - enzymology | Protein Kinases - genetics | Reactive Oxygen Species - metabolism | Humans | Oxidative Stress - physiology | Oxidative Stress - genetics | Cell Membrane - genetics | Parkinson Disease - genetics | Mutation - genetics | Cell Membrane - enzymology | Mitochondria - genetics | Parkinson Disease - enzymology | Protein Kinases - physiology | 1-Methyl-4-phenylpyridinium - toxicity | Cell Line, Tumor | Membrane Potential, Mitochondrial - physiology | Fetus | Cytochrome c | Oxidative stress | Parkinson's disease | Medical genetics | Dimethyl sulfoxide | Fluorescein | Genetic research | Development and progression | Genetic aspects | Mitochondrial DNA | Flat panel displays | Cell culture
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Phosphatase and tensin homolog‐induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy
by Tang, Ying and Liu, Jiankang and Long, Jiangang
Journal of Diabetes Investigation, ISSN 2040-1116, 05/2015, Volume 6, Issue 3, pp. 250 - 255
Diabetes is an independent risk factor for cardiovascular morbidity and mortality. Diabetes‐associated cardiac pathophysiology is recognized to be due to... 
Heart | Phosphatase and tensin homolog‐induced putative kinase 1/Parkin | Diabetes | Phosphatase and tensin homolog-induced putative kinase 1/Parkin | OXIDATIVE STRESS | CARDIAC INJURY | MYOCARDIAL-INFARCTION | MITOCHONDRIAL | CARDIOMYOCYTES | Phosphatase and tensin homolog-induced putative kinase 1 | PROTECTS | PINK1 | INDUCED AUTOPHAGY | ENDOCRINOLOGY & METABOLISM | DYSFUNCTION | MUTATIONS | Parkin | Phosphatases | Tensin | Parkinson's disease | Neurodegenerative diseases | Diabetes mellitus | Cardiomyocytes | Mitochondrial DNA | Kinases | Morbidity | Risk factors | Mitochondria | PTEN-induced putative kinase | Myocardium | Parkin protein | Cardiovascular diseases | ATP | PTEN protein | Movement disorders | Adenosine triphosphate | Apoptosis | Mini Review
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text MITOCHONDRIA The needless PINK1
by Baumann, K
NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 02/2018, Volume 19, Issue 2, p. 76
CELL BIOLOGY | Parkinson's disease | Mitochondria | PTEN-induced putative kinase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Correction: Loss of PINK1 increases the heart's vulnerability to ischemia- reperfusion injury (PLoS ONE)
by Siddall, Hilary K and Yellon, Derek M and Ong, Sang-Bing and Mukherjee, Uma A and Burke, Niall and Hall, Andrew R and Angelova, Plamena R and Ludtmann, Marthe H. R and Deas, Emma and Davidson, Sean M and Mocanu, Mihaela M and Hausenloy, Derek J
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6
[...]the labels and legends for Figures 7 and 8 were incorrectly switched. (2013) Correction: Loss of PINK1 Increases the Heart's Vulnerability to... 
Ischemia | PTEN-induced putative kinase | Reperfusion
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization
by Ha, Byung Hak and Boggon, Titus J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 5, pp. 1642 - 1650
The pseudokinase group encompasses some 10% of protein kinases, but pseudokinases diverge from canonical kinases in key motifs. The two members of the small... 
COMPLEX | PROTEIN | RECOGNITION | signal transduction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SGK269/PEAK1 | dimerization | MECHANISMS | protein kinase | LIVE | SIGNALING NETWORK | crystal structure | PTEN-induced putative kinase (PINK1) | Protein Kinases - metabolism | Protein Kinases - genetics | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Protein Multimerization | Protein-Tyrosine Kinases - chemistry | Protein Domains | Protein Kinases - chemistry | Crystallography, X-Ray | Protein Folding | Protein Structure and Folding
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
by Yang, Weili and Liu, Yunbo and Tu, Zhuchi and Xiao, Chong and Yan, Sen and Ma, Xishan and Guo, Xiangyu and Chen, Xiusheng and Yin, Peng and Yang, Zhengyi and Yang, Su and Jiang, Tianzi and Li, Shihua and Qin, Chuan and Li, Xiao-Jiang
Cell Research, ISSN 1001-0602, 04/2019, Volume 29, Issue 4, pp. 334 - 336
PARKIN | CELL BIOLOGY | Deletion | CRISPR | Monkeys | Clonal deletion | Neurodegeneration | PTEN-induced putative kinase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text In search of early neuroradiological biomarkers for Parkinson’s Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 −/− rats
by Cai, Xuezhu and Qiao, Ju and Knox, Tatiana and Iriah, Sade and Kulkarni, Praveen and Madularu, Dan and Morrison, Tom and Waszczak, Barbara and Hartner, Jochen C and Ferris, Craig F
Brain Research, ISSN 0006-8993, 03/2019, Volume 1706, pp. 58 - 67
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, with 60,000 new cases diagnosed each year in the US. There are multiple animal... 
PTEN-induced putative kinase 1 | Biomarkers | Parkinson’s Disease | Quantitative anisotropy | Diffusion weighted imaging | Substantia nigra
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
by Xiao, Bin and Deng, Xiao and Lim, Grace Gy and Xie, Shaoping and Zhou, Zhi Dong and Lim, Kah-Leong and Tan, Eng-King
Cell death & disease, ISSN 2041-4889, 07/2018, Volume 9, Issue 8, pp. 794 - 1
The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. 
Mitochondria | Superoxide | Parkin protein | PTEN-induced putative kinase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
by Shiba-Fukushima, Kahori and Imai, Yuzuru and Yoshida, Shigeharu and Ishihama, Yasushi and Kanao, Tomoko and Sato, Shigeto and Hattori, Nobutaka
Scientific Reports, ISSN 2045-2322, 2012, Volume 2, Issue 1, p. 1002
Parkinson's disease genes PINK1 and parkin encode kinase and ubiquitin ligase, respectively. The gene products PINK1 and Parkin are implicated in mitochondrial... 
LOCALIZATION | RECRUITMENT | PINK1 | MULTIDISCIPLINARY SCIENCES | DAMAGED MITOCHONDRIA | P62/SQSTM1 | DEGRADATION | PROTEIN LIGASE | MUTATIONS | RECESSIVE PARKINSONISM | PARL | Phosphorylation - physiology | Protein Kinases - metabolism | Protein Structure, Tertiary | Protein Kinases - genetics | Humans | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Male | Protein Transport - physiology | Mitochondria - metabolism | Mitochondrial Degradation - physiology | Mice, Knockout | Animals | Mitochondria - genetics | Membrane Potential, Mitochondrial - physiology | Female | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Phosphorylation | Mitochondria | Parkinson's disease | Neurodegenerative diseases | PTEN-induced putative kinase | Parkin protein | Membrane potential | Kinases | Phagocytosis | Ubiquitin-protein ligase | Movement disorders
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Variation in the PTEN-induced putative kinase 1 gene associated with the increase risk of type 2 diabetes in northern Chinese
by QU, YANCHUN and SUN, LIANG and YANG, ZE and HAN, RUIFA
Journal of Genetics, ISSN 0022-1333, 4/2011, Volume 90, Issue 1, pp. 125 - 128
PTEN-induced putative kinase 1 (PINK1) gene encodes a serine/threonine protein kinase that localizes to mitochondria and protects cells from... 
Life Sciences | PTEN-induced putative kinase 1 | human genetics | Life Sciences, general | case–control studies | Microbial Genetics and Genomics | polymerase chain reaction-restriction fragments length polymorphism | type 2 diabetes mellitus | Evolutionary Biology | Plant Genetics & Genomics | Animal Genetics and Genomics | case-control studies | POLYMORPHISMS | GENETICS & HEREDITY | MUTATIONS | PARKINSONS-DISEASE | Body Mass Index | Protein Kinases - metabolism | Protein Kinases - genetics | Body Weight | Genetic Association Studies | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Genotype | Male | Case-Control Studies | Genetic Variation | Point Mutation - genetics | Female | Type 2 diabetes | Genetic research | Genetic aspects | Risk factors | Genetics | Genetic diversity | Diabetes | Kinases | Chromosomes | Indexing in process
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402
by Aerts, Liesbeth and Craessaerts, Katleen and De Strooper, Bart and Morais, Vanessa A
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 5, pp. 2798 - 2811
Background: PINK1 mutations affect mitochondrial homeostasis and cause Parkinson disease. Results: PINK1 is phosphorylated on the outer mitochondrial membrane.... 
LOSS-OF-FUNCTION | OXIDATIVE STRESS | Serine | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAMAGED MITOCHONDRIA | PINK1-DEPENDENT PHOSPHORYLATION | Protein Phosphorylation | PTEN-induced Putative Kinase 1 (PINK1) | RECESSIVE PARKINSONISM | MITOCHONDRIAL MORPHOLOGY | Parkinson Disease | ACTIVATE PARKIN | Mitochondria | Neurodegenerative Disease | PROTEASE PARL | COMPLEX I ACTIVITY | Threonine Protein Kinase | PARKIN RECRUITMENT | Posttranslational Modification (PTM) | Protein Kinases - metabolism | Phosphorylation | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Protein Kinases - chemistry | Mitochondria - metabolism | Serine - chemistry | Serine - metabolism | Mitochondrial Membranes - metabolism | Molecular Bases of Disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
16. Full Text TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy
by Yang, Rui Meng and Tao, Jiong and Zhan, Ming and Yuan, Hao and Wang, Hai Hong and Chen, Sai Juan and Zhu, Chen and de Thé, Hugues and Zhou, Jun and Guo, Yin and Zhu, Jun
Cell death and differentiation, ISSN 1350-9047, 03/2019, Volume 26, Issue 11, pp. 2430 - 2446
TAMM41, located within the congenital heart diseases (CHD) sensitive region of 3p25 deletion syndrome, is a mitochondrial membrane maintenance protein critical... 
Heart | Mitochondria | Embryogenesis | Congenital diseases | Clonal deletion | Etiology | PTEN-induced putative kinase | Heart diseases | Coronary artery disease | Membrane proteins
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
17. Full Text Parkin and PINK1 mitigate STING-induced inflammation
by Sliter, Danielle A and Martinez, Jennifer and Hao, Ling and Chen, Xi and Sun, Nuo and Fischer, Tara D and Burman, Jonathon L and Li, Yan and Zhang, Zhe and Narendra, Derek P and Cai, Huaibin and Borsche, Max and Klein, Christine and Youle, Richard J
Nature, ISSN 0028-0836, 09/2018, Volume 561, Issue 7722, pp. 258 - 262
Although serum from patients with Parkinson's disease contains elevated levels of numerous pro-inflammatory cytokines including IL-6, TNF, IL-1 beta, and IFN... 
OXIDATIVE STRESS | ACTIVATION | MUTANTS | MULTIDISCIPLINARY SCIENCES | IN-VIVO MITOPHAGY | DISEASE | NEURONS | DEFICIENT MICE | MUTATIONS | MITOCHONDRIAL-DNA | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Stress, Physiological | Receptor, Interferon alpha-beta - antagonists & inhibitors | Membrane Proteins - deficiency | Inflammation - metabolism | DNA, Mitochondrial - genetics | Membrane Proteins - metabolism | Parkinson Disease - metabolism | Protein Kinases - deficiency | Physical Conditioning, Animal | Membrane Proteins - genetics | Mice, Inbred C57BL | Alarmins - metabolism | Ubiquitin-Protein Ligases - metabolism | Immunity, Innate | DNA, Mitochondrial - blood | Mitochondrial Degradation | Animals | Receptor, Interferon alpha-beta - immunology | Inflammation - genetics | Ubiquitin-Protein Ligases - deficiency | Inflammation - prevention & control | Mice | Ubiquitin-Protein Ligases - genetics | Inflammation | Genetic aspects | Research | Gene mutations | Risk factors | Ubiquitin | Heart | Cell culture | Oxidative stress | Animal models | Parkinson's disease | Substantia nigra | Parkinsons disease | Innate immunity | Mitochondrial DNA | Kinases | Immunity | Interleukin 6 | Mitochondria | Movement disorders | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Dopamine receptors | Enzymes | Phenotypes | Dopamine | Cytokines | Neurodegenerative diseases | Body temperature | Damage patterns | Insects | Tumor necrosis factor | PTEN-induced putative kinase | Proteomics | Interferon | Parkin protein | Mutation | Methods
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
18. Full Text Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: A mutation update
by Nuytemans, Karen and Theuns, Jessie and Cruts, Marc and Van Broeckhoven, Christine
Human Mutation, ISSN 1059-7794, 2010, Volume 31, Issue 7, pp. 763 - 780
To date, molecular genetic analyses have identified over 500 distinct DNA variants in five disease genes associated with familial Parkinson disease;... 
PINK1 | LRRK2 | Database | Genetic etiology | Parkinson disease | PARK7 | PARK2 | SNCA | INDUCED CELL-DEATH | KINASE-ACTIVITY | AUTOSOMAL-DOMINANT PARKINSONISM | UBIQUITIN-PROTEIN LIGASE | G2019S MUTATION | FRONTOTEMPORAL LOBAR DEGENERATION | RECESSIVE JUVENILE PARKINSONISM | database | genetic etiology | RESTLESS LEGS SYNDROME | GENETICS & HEREDITY | ALPHA-SYNUCLEIN GENE | EARLY-ONSET PARKINSONISM | Oncogene Proteins - genetics | Genetic Predisposition to Disease | Protein Kinases - genetics | Genetic Testing | Humans | Protein-Serine-Threonine Kinases - genetics | Databases, Genetic | Parkinson Disease - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Protein Deglycase DJ-1 | Parkinson Disease - diagnosis | alpha-Synuclein - genetics | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Parkinson's disease | Neurodegenerative diseases | Lewy body disease | Data processing | Genetic screening | PARK7 protein | Databases | Reviews | Etiology | DNA | PTEN-induced putative kinase | Genetic analysis | Parkin protein | LRRK2 protein | copy number | Movement disorders | Mutation Update
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights