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Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 9, p. 1299
The renin-angiotensin receptor AT2R controls systemic blood pressure and is also suggested to modulate metastasis of cancer cells. However, in the latter case,... 
Caveolin-1 | PTP1B | metastasis | AT2 receptor
Journal Article
Molecules, ISSN 1420-3049, 08/2018, Volume 23, Issue 9, p. 2167
Acorn leaves, which possess potential pharmacologic effects, are traditionally consumed as food in China. Phytochemical investigations of acorn leaves yielded... 
MIN6 | Polyphenol | PTP1B inhibitory activities | Α-glucosidase | Acorn leaves | Pancreatic protection | OXIDATIVE STRESS | PHENOLIC-COMPOUNDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha-glucosidase and PTP1B inhibitory activities | polyphenol | CHEMISTRY, MULTIDISCIPLINARY | acorn leaves | SPP | PTP1B | ANTIOXIDANT | AMYLASE | INFUSIONS | pancreatic protection | Plant Extracts - chemistry | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Plant Extracts - pharmacology | Humans | Polyphenols - pharmacology | Insulin-Secreting Cells - metabolism | Enzyme Inhibitors - chemistry | Molecular Structure | Phytochemicals - chemistry | Plant Leaves - chemistry | Cell Survival - drug effects | Magnetic Resonance Spectroscopy | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | alpha-Glucosidases | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Polyphenols - chemistry | Oxidative Stress - drug effects | Phytochemicals - pharmacology | Quercus - chemistry | Index Medicus | α-glucosidase and PTP1B inhibitory activities
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 11/2019, Volume 92, pp. 103221 - 103221
A series of ten -(3-(1 -tetrazole-5-yl)phenyl)acetamide derivatives (NM-07 to NM-16) designed from a lead molecule identified previously in our laboratory were... 
PTP1B | And tetrazoles | Diabetes | Index Medicus
Journal Article
Natural Product Communications, ISSN 1934-578X, 2018, Volume 13, Issue 2, pp. 185 - 188
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 01/2018, Volume 111, pp. 474 - 481
The classical non-transmembrane protein tyrosine phosphatase 1B (PTP1B) has emerged as a key negative regulator of insulin signaling pathways that leads to... 
Flavonoids | Enzymatic inhibition type | Diabetes mellitus | PTP1B inhibition | PTP1B INHIBITORS | TARGET | FOOD SCIENCE & TECHNOLOGY | ANTI-ALZHEIMERS DISEASE | C-GLYCOSYLATION | OBESITY | GLUCOSIDASE | TOXICOLOGY | MODULATION | Type 2 diabetes | Tyrosine | Enzymes | Phosphatases | Phenols | Insulin resistance | Isoflavones | Index Medicus
Journal Article
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 03/2016, Volume 36, Issue 3, pp. 533 - 539
Journal Article
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 12/2016, Volume 36, Issue 12, pp. 2888 - 2894
Journal Article
Marine Drugs, ISSN 1660-3397, 03/2019, Volume 17, Issue 3, p. 166
The marine alga, (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic... 
Bromophenols | PTP1B | Symphyocladia latiuscula | Diabetes | Insulin-resistant HepG2 | insulin-resistant HepG2 | diabetes | bromophenols
Journal Article
Marine Drugs, ISSN 1660-3397, 2019, Volume 17, Issue 5, p. 302
(Harvey) Okamura is an edible marine alga that has been widely used in Korea, China, and Japan as a rich source of dietary fiber and essential minerals. In our... 
Fucosterol epoxide | α-glucosidase | PTP1B | Hizikia fusiformis | Glycyrrhetinic acid | glycyrrhetinic acid | fucosterol epoxide
Journal Article
Cancer Letters, ISSN 0304-3835, 03/2016, Volume 372, Issue 1, pp. 82 - 88
In this study, a synthetic steroidal glycoside SBF-had strong and preferential antitumor effects on the human chronic myeloid leukemia (CML) cell line K562 and... 
Imatinib | PTP1B | Bcr-Abl | Chronic myeloid leukemia | SBF-1
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2010, Volume 30, Issue 2, pp. 200 - 206
OBJECTIVE—To investigate the capacity of the adipokine leptin to promote angiogenesis by modulating the function of circulating angiogenic cells (CACs).... 
Angiogenesis | Obesity | Src kinase | Circulating angiogenic cells | PTP1B | Leptin | circulating angiogenic cells | leptin | angiogenesis | obesity
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2012, Volume 165, Issue 8, pp. 2497 - 2511
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2016, Volume 57, Issue 7, pp. 732 - 735
A new unusual bis-tetrahydroxanthone connected through an ether bond, named asperdichrome ( ), was isolated from a culture broth of sp. TPU1343 together with... 
PTP1B inhibitor | Secalonic acid | Aspergillus sp. TPU1343 | Asperdichrome | TARGET | IRIOMOTE ISLAND | METABOLITES | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | SPONGE EURYSPONGIA SP | SECALONIC ACID D | Aspergillus sp TPU1343 | FAMILY | PTP1B | Tyrosine | Phosphatases | Protein binding
Journal Article
by Sun J and Fu X and Liu Y and Wang Y and Huo B and Guo Y and Gao X and Li W and Hu X
Drug Design, Development and Therapy, ISSN 1177-8881, 12/2015, Volume 2015, Issue Issue 1, pp. 6327 - 6342
Jing Sun,1 Xueqi Fu,1-3 Ye Liu,1 Yongsen Wang,1 Bo Huo,1 Yidi Guo,1 Xuefeng Gao,1 Wannan Li,1-3,* Xin Hu1-3,* 1School of Life Sciences, 2Key Laboratory for... 
T2DM | PTP1B | Honokiol | Insulin sensitizer
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2019, Volume 141, Issue 32, pp. 12634 - 12647
Active-site loops are integral to the function of numerous enzymes. They enable substrate and product binding and release, sequester reaction intermediates,... 
SYSTEM | DOMAIN | ENZYME CATALYSIS | PTP1B | ENERGETICS | STATE | INTERMEDIATE | MOLPROBITY | CYSTEINE | MOTIONS | CHEMISTRY, MULTIDISCIPLINARY | Index Medicus
Journal Article
Journal of Functional Foods, ISSN 1756-4646, 02/2018, Volume 41, pp. 232 - 239
Acorn has been used as a functional food with numerous nutritional and active ingredients. In this study, 3 new triterpenoids, together with 22 known compounds... 
Hypoglycaemic | Acorn | α-Glucosidase and PTP1B inhibitory activities | Quercus liaotungensis | Triterpenoids | alpha-Glucosidase and PTP1B inhibitory activities | CHINENSIS | FOOD SCIENCE & TECHNOLOGY | CONSTITUENTS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11298 - 11308
A series of novel marine phidianidine derivatives were designed, synthesized, and evaluated for their immunosuppressive activities during our search of... 
PTP1B INHIBITORS | 1,2,4-OXADIAZOLES | IN-VITRO | CHEMISTRY, MEDICINAL | ACID | ANALOGS | BIOLOGICAL EVALUATION | DISCOVERY
Journal Article
BBA - General Subjects, ISSN 0304-4165, 05/2019, Volume 1863, Issue 5, pp. 941 - 949
Elevated homocysteine is epidemiologically related to insulin resistance. Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling.... 
PTP1B | Thioredoxin system | Homocysteine | Insulin signaling | S-homocysteinylation | SYSTEM | MAMMALIAN THIOREDOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | INSULIN SENSITIVITY | BIOPHYSICS | OXIDIZED PTP1B | RESISTANCE | THIOREDOXIN REDUCTASE | PLASMA HOMOCYSTEINE | ASSOCIATION | BINDING | Tyrosine | Glucose metabolism | Phosphatases | Phenols | Insulin resistance | Glucose | Insulin | Dextrose
Journal Article
Biochemistry, ISSN 0006-2960, 11/2018, Volume 57, Issue 45, pp. 6443 - 6451
Protein tyrosine phosphatases (PTPs) are an important class of regulatory enzymes that exhibit aberrant activities in a wide range of diseases. A detailed... 
SYSTEM | NETWORKS | INHIBITION | PTP1B | MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 1, pp. 306 - 316
Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic function and plasticity by modulation of... 
CHEMISTRY, MEDICINAL | INHIBITION | PTP1B | REDUCTION | ALZHEIMERS-DISEASE | SUBSTRATE | IDENTIFICATION | DEFICITS | EXPRESSION
Journal Article
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