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1. Full Text Methimazole-induced liver injury overshadowed by methylprednisolone pulse therapy: Case report
by Abramavicius, Silvijus and Velickiene, Dzilda and Kadusevicius, Edmundas
Medicine (United States), ISSN 0025-7974, 09/2017, Volume 96, Issue 39, p. e8159
Rationale: Treatment choices are limited, when deciding how to manage thyrotoxicosis and moderate to severe Graves ophthalmopathy (GO) with suspected optic... 
Graves ophthalmopathy, intravenous methylprednisolone pulse therapy, methimazole | DIAGNOSIS | MANAGEMENT | intravenous methylprednisolone pulse therapy | Graves ophthalmopathy | ANTITHYROID DRUGS | GUIDELINES | PHARMACODYNAMICS | methimazole | PREDNISOLONE | MEDICINE, GENERAL & INTERNAL | PHARMACOKINETICS | HEPATITIS | STEROID-THERAPY | HEPATOTOXICITY | Methimazole - administration & dosage | Glucocorticoids - administration & dosage | Thyrotoxicosis - complications | Humans | Optic Nerve Diseases - diagnosis | Medication Therapy Management | Methylprednisolone - adverse effects | Symptom Assessment - methods | Dose-Response Relationship, Drug | Optic Nerve Diseases - complications | Methimazole - adverse effects | Female | Thyrotoxicosis - physiopathology | Graves Ophthalmopathy - drug therapy | Glucocorticoids - adverse effects | Liver Function Tests | Antithyroid Agents - adverse effects | Optic Nerve Diseases - physiopathology | Treatment Outcome | Antithyroid Agents - administration & dosage | Chemical and Drug Induced Liver Injury - physiopathology | Thyrotoxicosis - diagnosis | Chemical and Drug Induced Liver Injury - diagnosis | Graves Ophthalmopathy - diagnosis | Administration, Intravenous | Chemical and Drug Induced Liver Injury - therapy | Aged | Pulse Therapy, Drug - methods | Graves Ophthalmopathy - physiopathology | Methylprednisolone - administration & dosage
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2. Full Text Prolonged methylprednisolone therapy after the pulse treatment for patients with moderate-to-severe paraquat poisoning A retrospective analysis
by Gao, J and Feng, SY and Wang, J and Yang, SY and Li, Y
MEDICINE, ISSN 0025-7974, 06/2017, Volume 96, Issue 25, p. e7244
This retrospective study aims to evaluate the effect of prolonged methylprednisolone (MP) therapy on the mortality of patients with moderate-to-severe paraquat... 
DEXAMETHASONE THERAPY | MEDICINE, GENERAL & INTERNAL | paraquat | PLASMA | lung injury | EFFICACY | CYCLOPHOSPHAMIDE | methylprednisolone | mortality | HEMOPERFUSION | MODEL | Severity of Illness Index | Multivariate Analysis | Humans | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Risk | Treatment Outcome | Antidotes - administration & dosage | Pulse Therapy, Drug | Paraquat - poisoning | Creatinine - blood | Adult | Female | Retrospective Studies | Methylprednisolone - administration & dosage | Usage | Care and treatment | Poisoning | Methylprednisolone | Risk factors
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3. Full Text Comparison of intravenous methylprednisolone therapy vs. oral methylprednisolone therapy in patients with Graves’ ophthalmopathy
by Aktaran, Ş and Akarsu, E and Erbağci, İ and Araz, M and Okumuş, S and Kartal, M
International Journal of Clinical Practice, ISSN 1368-5031, 01/2007, Volume 61, Issue 1, pp. 45 - 51
A prospective, randomised and single blind clinical trial was designed to compare intravenous methylprednisolone pulse (IVGC) with oral methylprednisolone... 
SINGLE-BLIND | MEDICINE, GENERAL & INTERNAL | THYROID-ASSOCIATED OPHTHALMOPATHY | MANAGEMENT | SMOKING | QUALITY-OF-LIFE | ORBITAL RADIOTHERAPY | ORBITOPATHY | STEROID PULSE THERAPY | Glucocorticoids - administration & dosage | Prospective Studies | Administration, Oral | Humans | Male | Methylprednisolone - adverse effects | Treatment Outcome | Quality of Life | Adult | Female | Infusions, Intravenous | Graves Ophthalmopathy - drug therapy | Glucocorticoids - adverse effects | Methylprednisolone - administration & dosage | Methylprednisolone | Analysis
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4. Full Text Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial
by Grootscholten, C and Ligtenberg, G and Hagen, E.C and van den Wall Bake, A.W.L and de Glas-Vos, J.W and Bijl, M and Assmann, K.J and Bruijn, J.A and Weening, J.J and van Houwelingen, H.C and Derksen, R.H.W.M and Berden, J.H.M and for the Dutch Working Party on Systemic Lupus Erythematosus and Dutch Working Party Systemic Lupus and Dutch Working Party on Systemic Lupus Erythematosus and for the Dutch Working Party on Systemic Lupus Erythematosus
Kidney International, ISSN 0085-2538, 08/2006, Volume 70, Issue 4, pp. 732 - 742
Until recently, intravenous cyclophosphamide pulses with oral corticosteroids were regarded standard therapy for proliferative lupus nephritis (LN).... 
clinical trial | lupus nephritis | immunosuppression | clinical nephrology | randomized controlled trial | Clinical nephrology | Clinical trial | Immunosuppression | Lupus nephritis | Randomized controlled trial | LONG-TERM | PULSE CYCLOPHOSPHAMIDE | SUSTAINED AMENORRHEA | OVARIAN FAILURE | IMMUNOSUPPRESSIVE THERAPY | RENAL FLARES | HERPES-ZOSTER | INTRAVENOUS CYCLOPHOSPHAMIDE | UROLOGY & NEPHROLOGY | TERM-FOLLOW-UP | MYCOPHENOLATE-MOFETIL | Azathioprine - administration & dosage | Azathioprine - therapeutic use | Cyclophosphamide - administration & dosage | Injections, Intravenous | Prednisolone - administration & dosage | Methylprednisolone - therapeutic use | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Lupus Nephritis - drug therapy | Male | Cyclophosphamide - therapeutic use | Lupus Nephritis - blood | Anti-Inflammatory Agents - therapeutic use | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Prednisolone - therapeutic use | Drug Therapy, Combination | Immunosuppressive Agents - administration & dosage | Lupus Nephritis - pathology | Administration, Oral | Treatment Outcome | Remission Induction | Mycophenolic Acid - analogs & derivatives | Mycophenolic Acid - therapeutic use | Adolescent | Creatinine - blood | Methylprednisolone - administration & dosage
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5. Full Text Methylprednisolone and Cyclophosphamide, Alone or in Combination, in Patients with Lupus Nephritis: A Randomized, Controlled Trial
by Gourley, Mark F and Austin III, Howard A and Scott, Dorothy and Yarboro, Cheryl H and Vaughan, Ellen M and Muir, Joanne and Boumpas, Dimitrios T and Klippel, John H and Balow, James E and Steinberg, Alfred D
Annals of Internal Medicine, ISSN 0003-4819, 10/1996, Volume 125, Issue 7, pp. 549 - 557
Background: Uncertainty exists about the efficacy and toxicity of bolus therapy with methylprednisolone or of the combination of methylprednisolone and... 
methylprednisolone | AZATHIOPRINE | PULSE CYCLOPHOSPHAMIDE | ERYTHEMATOSUS | MEDICINE, GENERAL & INTERNAL | PREDNISONE | THERAPY | DRUGS | lupus nephritis | cyclophosphamide | MICE | dose-response relationship, drug | drug therapy, combination | Cyclophosphamide - administration & dosage | Drug Administration Schedule | Follow-Up Studies | Methylprednisolone - therapeutic use | Humans | Middle Aged | Lupus Nephritis - drug therapy | Male | Methylprednisolone - adverse effects | Life Tables | Cyclophosphamide - adverse effects | Remission Induction | Cyclophosphamide - therapeutic use | Anti-Inflammatory Agents - adverse effects | Anti-Inflammatory Agents - therapeutic use | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Drug Therapy, Combination | Methylprednisolone - administration & dosage | Evaluation | Cyclophosphamide | Systemic lupus erythematosus | Complications | Kidney diseases | Drug therapy | Methylprednisolone
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6. Full Text Meta‐analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy
by Gao, Guohong and Dai, Jinhui and Qian, Yifeng and Ma, Fei
Clinical & Experimental Ophthalmology, ISSN 1442-6404, 11/2014, Volume 42, Issue 8, pp. 769 - 777
A meta‐analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for G raves' ophthalmopathy. Eight studies involving 376 patients... 
glucocorticoid | drug therapy | raves' ophthalmopathy | meta‐analysis | Graves' ophthalmopathy | Drug therapy | Glucocorticoid | Meta-analysis | RANDOMIZED CONTROLLED-TRIALS | THYROID-ASSOCIATED OPHTHALMOPATHY | INTRAVENOUS METHYLPREDNISOLONE | meta-analysis | AUTOIMMUNE HEPATITIS | EUROPEAN GROUP | ORBITAL RADIOTHERAPY | SINGLE-BLIND | CLINICAL-TRIALS | OPHTHALMOLOGY | ORBITOPATHY | CONSENSUS STATEMENT | Glucocorticoids - administration & dosage | Administration, Oral | Humans | Combined Modality Therapy | Infusions, Intravenous | Graves Ophthalmopathy - drug therapy | Pulse Therapy, Drug | Radiotherapy | Methylprednisolone - administration & dosage | Corticosteroids | Methylprednisolone | Analysis | Weapons of mass destruction | Confidence intervals | Medical research
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7. Full Text Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study
by Koskela, Mikael and Jahnukainen, Timo and Endén, Kira and Arikoski, Pekka and Kataja, Janne and Nuutinen, Matti and Ylinen, Elisa
Pediatric Nephrology, ISSN 0931-041X, 8/2019, Volume 34, Issue 8, pp. 1447 - 1456
Optimal treatment of Henoch-Schönlein purpura nephritis (HSN) remains unclear. We evaluated outcome of pediatric HSN patients treated initially with either... 
IgA glomerulonephritis | Pediatrics | Nephrology | Immunosuppression | Vasculitis | Medicine & Public Health | Outcome | Angiotensin-converting enzyme inhibitor | Nephrotic syndrome | Children | Urology | PROGNOSIS | FOLLOW-UP | PULSE THERAPY | UROLOGY & NEPHROLOGY | PEDIATRICS | PURPURA NEPHRITIS | Angiotensin-converting enzyme inhibitors | Urine | End-stage renal disease | Nephritis | Renal function | Epidermal growth factor receptors | Hematuria | Cyclosporins | Prednisone | Methylprednisolone | Patients | Peptidyl-dipeptidase A | Angiotensin | Kidney diseases | Schonlein-Henoch purpura | Proteinuria
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8. Full Text CD8+ Treg cells associated with decreasing disease activity after intravenous methylprednisolone pulse therapy in lupus nephritis with heavy proteinuria
by Tsai, Yi-Giien and Lee, Chia-Ying and Lin, Tze-Yi and Lin, Ching-Yuang
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e81344
We focus on the role of CD8(+) Treg cell in Intravenous methyl-prednisolone (IVMP) pulse therapy in forty patients with active Class III/IV childhood lupus... 
ACTIVATION | STIMULATION | MULTIPLE-SCLEROSIS | TOLERANCE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | MEDIATED SUPPRESSION | INDUCTION | CANCER | GRANZYME-B | ERYTHEMATOSUS | Forkhead Transcription Factors - immunology | RNA, Small Interfering - genetics | Methylprednisolone - therapeutic use | Proteinuria - immunology | Apoptosis - drug effects | Cell Count | Humans | RNA, Small Interfering - pharmacology | Lupus Nephritis - drug therapy | Lupus Nephritis - immunology | Forkhead Transcription Factors - genetics | Administration, Intravenous | Proteinuria - drug therapy | Adolescent | Granzymes - immunology | CD8-Positive T-Lymphocytes - immunology | Pulse Therapy, Drug - methods | Interleukin-10 - immunology | Proteinuria - complications | Lupus Nephritis - complications | Methylprednisolone - administration & dosage | Cell proliferation | Flow cytometry | Therapy | Pediatrics | Nephritis | Nephrology | Intravenous administration | Disease | CD8 antigen | Leukocytes (mononuclear) | Lymphocytes T | Lupus nephritis | Tissues | Methylprednisolone | Granzyme B | Immunology | Lymphocytes | Peripheral blood mononuclear cells | CD25 antigen | Foxp3 protein | Children | Stains | Prednisolone | Lupus | Antigens | Kidneys | Anemia | T cell receptors | Patients | CD4 antigen | Hospitals | Biopsy | Cell number | Interleukin 10 | Nucleosomes | Interferon | Autoimmune diseases | Proteinuria | Apoptosis | Kidney transplantation
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9. Full Text Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis
by Ratzer, Rikke and Iversen, Pernille and Börnsen, Lars and Dyrby, Tim B and Romme Christensen, Jeppe and Ammitzbøll, Cecilie and Madsen, Camilla Gøbel and Garde, Ellen and Lyksborg, Mark and Andersen, Birgit and Hyldstrup, Lars and Sørensen, Per Soelberg and Siebner, Hartwig R and Sellebjerg, Finn
Multiple Sclerosis Journal, ISSN 1352-4585, 6/2016, Volume 22, Issue 7, pp. 926 - 934
Background: There is a large unmet need for treatments for patients with progressive multiple sclerosis (MS). Phase 2 studies with cerebrospinal fluid (CSF)... 
clinical trial | Progressive multiple sclerosis | methylprednisolone | magnetization transfer ratio | osteopontin | cerebrospinal fluid | CORD | NEUROSCIENCES | BRAIN | CLINICAL NEUROLOGY | Predictive Value of Tests | Recurrence | Glucocorticoids - administration & dosage | Humans | Middle Aged | Male | Methylprednisolone - adverse effects | Multiple Sclerosis, Chronic Progressive - diagnostic imaging | Recovery of Function | Young Adult | Evoked Potentials, Motor | Inflammation Mediators - cerebrospinal fluid | Time Factors | Adult | Female | Multiple Sclerosis, Chronic Progressive - drug therapy | Glucocorticoids - adverse effects | Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid | Multiple Sclerosis, Chronic Progressive - physiopathology | Bone Density | Administration, Oral | Osteopontin - cerebrospinal fluid | Treatment Outcome | Pulse Therapy, Drug | Disease Progression | Diffusion Tensor Imaging | Magnetic Resonance Imaging | Neurologic Examination | Adolescent | Denmark | Aged | Biomarkers - cerebrospinal fluid | Methylprednisolone - administration & dosage | Multiple sclerosis | Nuclear magnetic resonance--NMR | Osteopontin | Cerebrospinal fluid | Motor evoked potentials | Motor task performance | Methylprednisolone | Side effects | Magnetic resonance imaging | Demyelination | Evoked potentials | Bone density | Bone imaging
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10. Full Text Efficacy and Safety of Three Different Cumulative Doses of Intravenous Methylprednisolone for Moderate to Severe and Active Graves' Orbitopathy
by Bartalena, L and Krassas, G. E and Wiersinga, W and Marcocci, C and Salvi, M and Daumerie, C and Bournaud, C and Stahl, M and Sassi, L and Veronesi, G and Azzolini, C and Boboridis, K. G and Mourits, M. P and Soeters, M. R and Baldeschi, L and Nardi, M and Currò, N and Boschi, A and Bernard, M and von Arx, G and for the European Group on Graves' Orbitopathy and European Grp Graves' Orbitopathy and European Group on Graves' Orbitopathy and for the European Group on Graves' Orbitopathy
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 12/2012, Volume 97, Issue 12, pp. 4454 - 4463
Background: Optimal doses of iv glucocorticoids for Graves' orbitopathy (GO) are undefined. Methods: We carried out a multicenter, randomized, double-blind... 
GLUCOCORTICOID PULSE THERAPY | SINGLE-BLIND | MANAGEMENT | OPHTHALMOPATHY | DISEASE | ENDOCRINOLOGY & METABOLISM | ACUTE MYOCARDIAL-INFARCTION | PATIENT | ORBITAL RADIOTHERAPY | Severity of Illness Index | Double-Blind Method | Humans | Middle Aged | Male | Methylprednisolone - adverse effects | Treatment Outcome | Graves Ophthalmopathy - epidemiology | Orbit - drug effects | Dose-Response Relationship, Drug | Administration, Intravenous | Anti-Inflammatory Agents - adverse effects | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Aged | Graves Ophthalmopathy - drug therapy | Orbit - pathology | Methylprednisolone - administration & dosage
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11. Full Text Blood pressure profile and N-terminal-proBNP dynamics in response to intravenous methylprednisolone pulse therapy of severe graves’ orbitopathy
by Miskiewicz, Piotr and Milczarek-Banach, Justyna and Bednarczuk, Tomasz and Opolski, Grzegorz and Glowczynska, Renata
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2018, Volume 19, Issue 10, p. 2918
Hypercortisolemia is associated with increased risk of hypertension. Natural and synthetic glucocorticoids (GCs) have different effects on blood pressure (BP).... 
Hypertension | Pulse therapy | NT-proBNP | Glucocorticoids | Graves’ disease | Blood pressure | Methylprednisolone | Graves’ orbitopathy | Ambulatory blood pressure monitoring | blood pressure | SODIUM | BRAIN NATRIURETIC PEPTIDE | SYNTHETIC GLUCOCORTICOIDS | Graves' disease | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | methylprednisolone | CHEMISTRY, MULTIDISCIPLINARY | SOCIETY | ambulatory blood pressure monitoring | CUSHINGS-SYNDROME | graves' orbitopathy | pulse therapy | OPHTHALMOPATHY | GENE-EXPRESSION | glucocorticoids | hypertension | ASSOCIATION | Severity of Illness Index | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Natriuretic Peptide, Brain - analysis | Prospective Studies | Methylprednisolone - therapeutic use | Humans | Middle Aged | Male | Pulse Therapy, Drug | Peptide Fragments - analysis | Adult | Female | Blood Pressure - drug effects | Graves Ophthalmopathy - pathology | Infusions, Intravenous | Blood Pressure Monitoring, Ambulatory | Graves Ophthalmopathy - drug therapy | Methylprednisolone - administration & dosage | graves’ orbitopathy
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12. Full Text Methylprednisolone pulse therapy plus adjuvant therapy for pemphigus vulgaris: an analysis of 10 years' experience on 312 patients
by Gheisari, Mehdi and Faraji, Zahra and Dadras, Mohammad S and Nasiri, Soheila and Robati, Reza M and Moravvej, Hamideh and Tehranchinia, Zohreh and Ghalamkarpour, Fariba and Namazi, Nastaran and Nobari, Niloufar N
Dermatologic Therapy, ISSN 1396-0296, 09/2019, Volume 32, Issue 5, p. n/a
Steroid pulse therapy has shown satisfactory efficacy and safety in treating pemphigus vulgaris (PV). However, there is a paucity of data about the efficacy... 
methylprednisolone | steroid pulse therapy | pemphigus vulgaris
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13. Full Text Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica
by Yamasaki, Ryo and Matsushita, Takuya and Fukazawa, Toshiyuki and Yokoyama, Kazumasa and Fujihara, Kazuo and Ogino, Mieko and Yokota, Takanori and Miyamoto, Katsuichi and Niino, Masaaki and Nomura, Kyoichi and Tomioka, Ryo and Tanaka, Masami and Kawachi, Izumi and Ohashi, Takashi and Kaida, Ken-ichi and Matsui, Makoto and Nakatsuji, Yuji and Ochi, Hirofumi and Fukaura, Hikoaki and Kanda, Takashi and Nagaishi, Akiko and Togo, Kanae and Mizusawa, Hidehiro and Murai, Hiroyuki and Kira, Jun-ichi
Multiple Sclerosis Journal, ISSN 1352-4585, 9/2016, Volume 22, Issue 10, pp. 1337 - 1348
Background: No large-scale studies have compared the efficacy of intravenous methylprednisolone pulse therapy (IVMP) for multiple sclerosis (MS) and... 
methylprednisolone | Multiple sclerosis | pulse therapy | corticosteroids | neuromyelitis optica | Glucocorticoids - administration & dosage | Neuromyelitis Optica - drug therapy | Humans | Middle Aged | Male | Treatment Outcome | Young Adult | Administration, Intravenous | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Child | Methylprednisolone - administration & dosage | Multiple Sclerosis - drug therapy
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14. Full Text Methylprednisolone and Hepatotoxicity in Graves' Ophthalmopathy
by Wichary, Hanna and Gasińska, Teresa
Thyroid, ISSN 1050-7256, 01/2012, Volume 22, Issue 1, pp. 64 - 69
Background: Immunosuppressive therapy with glucocorticoids alone or in combination with radiotherapy is first-choice treatment for the active phase of Graves'... 
Immunology, Autoimmunity, and Graves' Ophthalmopathy | GLUCOCORTICOID PULSE THERAPY | PATHOGENESIS | THYROID-ASSOCIATED OPHTHALMOPATHY | MANAGEMENT | INTRAVENOUS METHYLPREDNISOLONE | DISEASE | ENDOCRINOLOGY & METABOLISM | AUTOIMMUNE HEPATITIS | STEROID-THERAPY | ORBITOPATHY | Liver Function Tests | Humans | Middle Aged | Male | Methylprednisolone - adverse effects | Liver - physiopathology | Pulse Therapy, Drug | Hepatitis B - immunology | Liver - drug effects | Female | Immunosuppressive Agents - adverse effects | Graves Ophthalmopathy - drug therapy | Immunosuppressive Agents - administration & dosage | Methylprednisolone - administration & dosage
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