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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Nuclear Proteins/chemistry | Purine Nucleotides/metabolism | Proto-Oncogene Proteins/antagonists & inhibitors | Enzyme Inhibitors/metabolism | Enzyme Inhibitors/pharmacology | Life Sciences | Antineoplastic Agents/pharmacology | N-Glycosyl Hydrolases/antagonists & inhibitors | Nuclear Proteins/antagonists & inhibitors | N-Glycosyl Hydrolases/metabolism | Nuclear Proteins/metabolism | Purine Nucleotides/chemistry | Enzyme Inhibitors/chemistry | Purine Nucleotides/chemical synthesis | Enzyme Inhibitors/chemical synthesis | Antineoplastic Agents/metabolism | N-Glycosyl Hydrolases/chemistry | Proto-Oncogene Proteins/chemistry | Biochemistry, Molecular Biology | Proto-Oncogene Proteins/metabolism | Purine Nucleotides/pharmacology | Antineoplastic Agents/chemistry | Antineoplastic Agents/chemical synthesis
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 368a - 368a
Journal Article
Magnetic Resonance in Chemistry, ISSN 0749-1581, 09/2018, Volume 56, Issue 9, pp. 852 - 859
Journal Article
Current Opinion in Allergy and Clinical Immunology, ISSN 1528-4050, 12/2013, Volume 13, Issue 6, pp. 630 - 638
PURPOSE OF THE REVIEWTo review the recent advances in the understanding and management of the immune and nonimmune effects of inherited adenosine deaminase... 
Purine nucleoside phosphorylase | Systemic | Adenosine deaminase | Immunodeficiency | systemic | SEVERE COMBINED IMMUNODEFICIENCY | BONE-MARROW-TRANSPLANTATION | COMBINED IMMUNE-DEFICIENCY | IMMUNOLOGY | TANDEM MASS-SPECTROMETRY | DRIED BLOOD SPOTS | PERFORMANCE LIQUID-CHROMATOGRAPHY | IN-VITRO | ALLERGY | adenosine deaminase | purine nucleoside phosphorylase | INTRACELLULAR DELIVERY | immunodeficiency | GENE-THERAPY | STEM-CELL TRANSPLANTATION | Purine-Nucleoside Phosphorylase - immunology | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | T-Lymphocytes - enzymology | Humans | Severe Combined Immunodeficiency - mortality | Purine-Nucleoside Phosphorylase - genetics | Purkinje Cells - enzymology | Purine-Pyrimidine Metabolism, Inborn Errors - mortality | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Agammaglobulinemia - drug therapy | Agammaglobulinemia - enzymology | Purine-Nucleoside Phosphorylase - deficiency | Purine-Nucleoside Phosphorylase - therapeutic use | Adenosine Deaminase - therapeutic use | Adenosine Deaminase - deficiency | Purkinje Cells - immunology | Macrophages, Alveolar - immunology | Purine-Pyrimidine Metabolism, Inborn Errors - diet therapy | Enzyme Replacement Therapy | Severe Combined Immunodeficiency - enzymology | Adenosine Deaminase - genetics | Purines - metabolism | Agammaglobulinemia - mortality | Severe Combined Immunodeficiency - drug therapy | Purine-Pyrimidine Metabolism, Inborn Errors - enzymology | Severe Combined Immunodeficiency - immunology | Macrophages, Alveolar - enzymology | Purines - immunology | Severe Combined Immunodeficiency - genetics | Animals | Purine-Pyrimidine Metabolism, Inborn Errors - immunology | Purine-Pyrimidine Metabolism, Inborn Errors - genetics | T-Lymphocytes - immunology | Adenosine Deaminase - immunology | Index Medicus
Journal Article
Russian Journal of General Chemistry, ISSN 1070-3632, 04/2019, Volume 89, Issue 4, p. 697
The reactions of bromine and iodine with 1-allyltheobromine and 1-methallyltheobromine were studied. Depending on the nature of the halogen and the initial... 
Purines
Journal Article
Sensors & Actuators: B. Chemical, ISSN 0925-4005, 07/2014, Volume 197, p. 172
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2015, Volume 95, p. 83
The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human... 
Purines
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 05/2013, Volume 54, Issue 20, p. 2525
Journal Article
Journal of Electroanalytical Chemistry, ISSN 1572-6657, 05/2013, Volume 697, p. 21
Display Omitted 
Purines
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 1, pp. 155 - 159.e3
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare form of autosomal recessive combined primary immunodeficiency caused by a enzyme defect... 
Allergy and Immunology | Purine nucleoside phosphorylase | tandem mass spectrometry | delayed-onset | inherited disorder | purine nucleoside phosphorylase–combined immunodeficiency | T-cell receptor excision circle | severe combined immunodeficiency | newborn screening | late-onset | purine nucleoside phosphorylase-combined immunodeficiency | IMMUNOLOGY | ALLERGY | PATIENT | MUTATIONS | ADENOSINE-DEAMINASE DEFICIENCY | Immunologic Deficiency Syndromes - pathology | Dried Blood Spot Testing | Humans | Child, Preschool | Infant | Male | Deoxyguanosine - analysis | Neonatal Screening | Purine-Nucleoside Phosphorylase - genetics | Purine-Pyrimidine Metabolism, Inborn Errors - diagnosis | Tandem Mass Spectrometry | Purine-Nucleoside Phosphorylase - deficiency | Inosine - analogs & derivatives | Female | Immunologic Deficiency Syndromes - diagnosis | Purine-Pyrimidine Metabolism, Inborn Errors - pathology | Infant, Newborn | Guanosine - analysis | Inosine - analysis | Inosine - metabolism | Guanosine - metabolism | Lymphocytes - pathology | DNA Repair | Adolescent | Purine-Pyrimidine Metabolism, Inborn Errors - genetics | Immunologic Deficiency Syndromes - genetics | Deoxyguanosine - metabolism | Mutation | Enzymes | Alkaloids | Neurosciences | Immunodeficiency | Nucleosides | Diagnosis | Children | Health aspects | Mass spectrometry | Genotype & phenotype | Metabolites | Disease | Newborn babies | Mortality | Infections | Medical screening | Patients | Clinical Medicine | Pediatrics | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Pediatrik
Journal Article
1978, Methods in enzymology, ISBN 0121819515, Volume 51, xxiv, 654
Book
Inorganica Chimica Acta, ISSN 0020-1693, 10/2011, Volume 376, Issue 1, p. 123
NbX.sub.5 reacts with [gamma]-butyrolactone, lactams or guanine, in variable molar ratio in chlorinated solvent, affording either neutral or ionic coordination... 
Purines
Journal Article
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 7/2018, Volume 54, Issue 7, pp. 675 - 679
Journal Article
Journal Article
2001, Handbook of experimental pharmacology, ISBN 9783540678496, Volume 151., 2 v.
Book
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2010, Volume 8, Issue 23, pp. 5280 - 5284
The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated... 
purines
Journal Article
Purinergic Signalling, ISSN 1573-9538, 06/2014, Volume 10, Issue 2, p. 369
Article History: 
Purines
Journal Article
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