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pvhl (169) 169
humans (135) 135
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von hippel-lindau tumor suppressor protein - genetics (63) 63
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vhl (34) 34
hypoxia-inducible factor (32) 32
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International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 2, pp. 396 - 403
In our study, we demonstrate that ccRCC cell lines with impaired function of pVHL to degrade HIFα express elevated levels of PD‐L1. In vitro analysis provided... 
ccRCC | HIF | pVHL | PD‐L1 | CANCER-CELLS | PATHWAYS | ANTIBODY | IDENTIFICATION | HIF1-ALPHA | ESCAPE | TUMOR-SUPPRESSOR PVHL | THERAPY | ONCOLOGY | PD-L1 | MUTATIONS | BLOCKADE | Immunohistochemistry | Gene Expression | Kidney Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Gene Expression Regulation, Neoplastic | Gene Silencing | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | B7-H1 Antigen - genetics | Case-Control Studies | Carcinoma, Renal Cell - metabolism | B7-H1 Antigen - metabolism | B7-H1 Antigen - blood | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mutation | Analysis | Cancer | Chemotherapy | Rodents | Kidney cancer | Hypoxia | Ligands | T cell receptors | Apoptosis | Drugs | Biotechnology | Hypoxia-inducible factor 1 | Correlation | Target recognition | PD-1 protein | Genes | Lymphocytes T | In vitro testing | Drug delivery | Inactivation | Immunosuppressive agents | Degradation | Inhibition | Hypoxia-inducible factors | Deactivation | Mortality | Immunosurveillance | Tumor cell lines | Patients | Surveillance | Cell death | PD-L1 protein | Reagents | VHL protein | Aberration | Neoplasia | Clear cell-type renal cell carcinoma | Tumors | Kidney transplantation
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 03/2015, Volume 26, Issue 3, pp. 553 - 564
von Hippel-Lindau (VHL) gene mutations are associated with clear cell renal cell carcinoma (ccRCC). A hallmark of ccRCC is loss of the primary cilium. Loss of... 
PROTEIN | WNT/BETA-CATENIN | SMALL-MOLECULE INHIBITORS | JADE-1 | COMPONENTS | UROLOGY & NEPHROLOGY | PROLIFERATION | CILIOGENESIS | CANCER | EXPRESSION | PVHL
Journal Article
PeerJ, ISSN 2167-8359, 2016, Volume 2016, Issue 12, p. e2757
Major research efforts have been devoted to the discovery and development of new chemical entities that could inhibit the protein protein interaction between... 
Shape-based screen | HIF-1α/pVHL interaction | Native-docking | Protein-protein interaction | Cross-docking | DESIGN | SMALL MOLECULES | RECOGNITION | MULTIDISCIPLINARY SCIENCES | VALIDATION | HIF-1 alpha/pVHL interaction | CDK2 STRUCTURES | HYPOXIA | PROTEIN-LIGAND DOCKING | AFFINITIES | E3 UBIQUITIN LIGASE | Protein–protein interaction
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 11/2015, Volume 26, Issue 11, pp. 2778 - 2788
A subset of familial and sporadic clear cell renal cell carcinomas (ccRCCs) is believed to develop from cystic precursor lesions. Loss of function of the von... 
INACTIVATION | POLYCYSTIN-1 | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | MTOR PATHWAY | PTEN | UROLOGY & NEPHROLOGY | TUMOR-SUPPRESSOR | CILIOGENESIS | PRIMARY CILIUM | CELL CARCINOMA | PVHL
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2016, Volume 34, Issue 18, pp. 2172 - 2181
Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia syndromes and is characterized by highly vascular tumors of the eyes, brain, and... 
RNA-POLYMERASE-II | VHL GENE | PROTEIN | ONCOLOGY | PHOSPHORYLATION | TUMOR-SUPPRESSOR GENE | GERMLINE MUTATIONS | HEMANGIOBLASTOMAS | CANCER | FAMILIAL PHEOCHROMOCYTOMA | PVHL | Genetic Testing | Humans | von Hippel-Lindau Disease - psychology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mutation | von Hippel-Lindau Disease - genetics | Genetic Counseling
Journal Article
PLOS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6
The study of uterine leiomyomata (fibroids) provides a unique opportunity to investigate the physiological and molecular determinants of hormone dependent... 
SUPPRESSOR PROTEIN | MULTIDISCIPLINARY SCIENCES | GROWTH | DIFFERENTIATION | FIBROIDS | ARRAYS | PREGNANCY | INSIGHTS | PVHL
Journal Article
Progress in Biophysics and Molecular Biology, ISSN 0079-6107, 08/2019, Volume 145, pp. 65 - 77
Renal cancer is the major cause of mortality due to abnormal functioning of von Hippel-Lindau (pVHL) and Jade Family PHD Finger 1 (JADE1) complex. E3 ubiquitin... 
Molecular dynamic simulations | JADE1 | Ubiquitination | Molecular docking | pVHL | VON-HIPPEL-LINDAU | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARTNER JADE-1 | PROTEIN MODELS | BIOPHYSICS | WEB | MUTATION | TUMOR-SUPPRESSOR
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2015, Volume 5, Issue 5, pp. 378 - 389
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong... 
Cancer drug discovery and development | HIF-1α inhibitors | HIF-1α | RCC, renal cell carcinoma | Ras, rat sarcoma | Raf, rapidly accelerated fibrosarcoma | EGF, epidermal growth factor | C-TAD, COOH-terminal TAD | HTS, high throughput screens | ARD-1, arrest-defective-1 | ELISA, enzyme-linked immunosorbent assay | pVHL, von Hippel-Lindau protein | LEP, leptin | ChIP, chromatin immunoprecipitation | IPAS, inhibitory PAS | IGF-BP3, IGF-factor-binding protein 3 | PAS, Per and Sim | mTOR, mammalian target of rapamycin | RT-PCR, reverse transcription polymerase chain reaction | CAC, circulating angiogenic cells | CoCl2, cobalt chloride | AKt, protein kinase B | TPT, topotecan | bHLH, basic-helix-loop-helix | LDHA, lactate dehydrogenase | GLUTs, glucose transporters | P, proline residue | ODDD, oxygen dependent degradation domain | TGF-α, transforming growth factor α | VEGF, vascular endothelial growth factor | CPTs, camptothecins | Mdm2, mouse double minute 2 homolog | PKM, pyruvate kinase M | AhR, aryl hydrocarbon receptor | K, lysine residue | IGF2, insulin-like growth factor 2 | GLUT3, glucose transporter 3 | CBP associated factor | eIF-4E, eukaryotic translation initiation factor 4E | MEK, MAPK | ADM, adrenomedullin | ARNT, aryl hydrocarbon nuclear translocator | HK2, hexokinase 2 | PHDs, prolyl-4-hydroxylases | PCAF, p300 | FIH-1, factor inhibiting HIF-1 | Review | SIRT 1, Sirtuin 1 | ERK kinase | C-MYC, myelocytomatosis virus oncogene cellular homolog | IGF-BP2, IGF-factor-binding protein 2 | N, asparagine residue | TAD, transactivation domains | HDAC, histone deacetylase | EMSA, electrophoretic mobility shift assay | LRP1, LDL-receptor-related protein 1 | Luc, luciferase | GAs, geldanamycins | HIF-1α, hypoxia-inducible factor-1α | HK1, hexokinase 1 | ID2, DNA-binding protein inhibitor | HPH, HIF-1 prolyl hydroxylases | NOS, nitric oxide synthase | N-TAD, NH2-terminal TAD | MNK, MAP kinase interacting kinase | MTs, microtubules | HRE, hypoxia response elements | ERK, extracellular signal-regulated kinase | EPO, erythropoietin | MAPK, mitogen-activated protein kinases | PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase | DFO, deferoxamine | Top I, topoisomerase I | GLUT1, glucose transporter 1 | Hsp90, heat shock protein 90 | TGF-β3, transforming growth factor beta3 | 4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K) | GA, geldanamycin
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 07/2006, Volume 397, Issue 1, pp. 109 - 120
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 6, pp. 10199 - 10212
Clear cell Renal Cell Carcinoma (ccRCC) formation is connected to functional loss of the von Hippel-Lindau (VHL) gene. Recent data identified its gene product,... 
VHL missense mutations | PVHL binding sites | Clear cell renal cell carcinoma | HIFα | P53 | clear cell renal cell carcinoma | UBIQUITIN LIGASE | GENE ALTERATIONS | IDENTIFICATION | pVHL binding sites | CANCER | HIF alpha | HIPPEL-LINDAU PROTEIN | p53 | PVHL | CELL BIOLOGY | ANTIANGIOGENIC THERAPY | TUMOR-SUPPRESSOR PROTEIN | NANOPARTICLE-DRUG CONJUGATE | EXPRESSION
Journal Article