Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (116) 116
life sciences & biomedicine (115) 115
pxr (102) 102
humans (85) 85
pharmacology & pharmacy (60) 60
pregnane x receptor (46) 46
animals (45) 45
receptors, steroid - genetics (45) 45
receptors, steroid - metabolism (42) 42
car (36) 36
biological and medical sciences (30) 30
male (29) 29
medical sciences (29) 29
receptors, cytoplasmic and nuclear - metabolism (29) 29
female (26) 26
toxicology (23) 23
cyp3a4 (19) 19
adult (18) 18
gene expression (18) 18
ligands (18) 18
middle aged (18) 18
pharmacology. drug treatments (18) 18
receptors, cytoplasmic and nuclear - genetics (18) 18
biochemistry & molecular biology (17) 17
nuclear receptor (17) 17
liver - metabolism (16) 16
polymorphism, single nucleotide (16) 16
nuclear receptors (15) 15
cytochrome p-450 cyp3a - genetics (14) 14
metabolism (14) 14
pharmacogenetics (14) 14
cancer (13) 13
mice (13) 13
physiological aspects (13) 13
aged (12) 12
ahr (12) 12
cell line, tumor (12) 12
digestive system (12) 12
drug interactions (12) 12
drug metabolism (12) 12
genes (12) 12
cell line (11) 11
cytochrome p-450 (11) 11
enzymes (11) 11
genetic aspects (11) 11
induction (11) 11
nr1i2 (11) 11
oncology (11) 11
polymorphism (11) 11
xenobiotics - metabolism (11) 11
analysis (10) 10
cell biology (10) 10
cytochrome p-450 cyp3a - biosynthesis (10) 10
digestive system diseases (10) 10
genotype (10) 10
liver (10) 10
proteins (10) 10
review (10) 10
xenobiotics (10) 10
cytochrome p-450 enzyme system - metabolism (9) 9
fxr (9) 9
gastroenterology & hepatology (9) 9
gene expression regulation - drug effects (9) 9
life sciences (9) 9
p-glycoprotein (9) 9
rats (9) 9
biomedicine (8) 8
care and treatment (8) 8
cytochrome p-450 enzyme system - genetics (8) 8
cytochrome p450 (8) 8
hepatocytes - metabolism (8) 8
neoplasms - drug therapy (8) 8
pharmacology (8) 8
pharmacology/toxicology (8) 8
rna, messenger - metabolism (8) 8
transcription factors - metabolism (8) 8
biology (7) 7
cytochrome p-450 cyp3a - metabolism (7) 7
gene frequency (7) 7
haplotypes (7) 7
health aspects (7) 7
receptors (7) 7
receptors, steroid - agonists (7) 7
young adult (7) 7
atp-binding cassette, sub-family b, member 1 - genetics (6) 6
bile acids (6) 6
cyp3a (6) 6
drug resistance (6) 6
gene expression regulation (6) 6
genes, reporter (6) 6
genetic research (6) 6
hep g2 cells (6) 6
hepatocytes - drug effects (6) 6
molecular sequence data (6) 6
pharmacy (6) 6
physical sciences (6) 6
polymerase chain reaction (6) 6
promoter regions, genetic (6) 6
pxr, pregnane x receptor (6) 6
receptors, cytoplasmic and nuclear - physiology (6) 6
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease
by Glas, Jürgen and Seiderer, Julia and Fischer, Daniel and Tengler, Barbara and Pfennig, Simone and Wetzke, Martin and Beigel, Florian and Olszak, Torsten and Weidinger, Maria and Göke, Burkhard and Ochsenkühn, Thomas and Folwaczny, Matthias and Müller‐Myhsok, Bertram and Diegelmann, Julia and Czamara, Darina and Brand, Stephan
Inflammatory bowel diseases, ISSN 1078-0998, 09/2011, Volume 17, Issue 9, pp. 1917 - 1924
haplotypes | MDR1 | genetics | pregnane X receptor | Crohn's disease | ulcerative colitis | polymorphism | PXR | CYP3A4 | inflammatory bowel disease | PXR/NR1I2 | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Biomarkers - metabolism | Crohn Disease - genetics | Genetic Predisposition to Disease | Prognosis | Humans | Middle Aged | Colitis, Ulcerative - genetics | Genotype | Male | Case-Control Studies | DNA - genetics | Young Adult | Haplotypes - genetics | Phenotype | Receptors, Steroid - genetics | Adolescent | Polymerase Chain Reaction | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Child | Cohort Studies | Haplotypes | Inflammatory bowel diseases | Pharmacogenetics | Intestine | Replication | genomics | Single-nucleotide polymorphism | pregnane X receptors | Metabolism | Ulcerative colitis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk
by Campa, Daniele and Butterbach, Katja and Slager, Susan L and Skibola, Christine F and de Sanjosé, Silvia and Benavente, Yolanda and Becker, Nikolaus and Foretova, Lenka and Maynadie, Marc and Cocco, Pierluigi and Staines, Anthony and Kaaks, Rudolf and Boffetta, Paolo and Brennan, Paul and Conde, Lucia and Bracci, Paige M and Caporaso, Neil E and Strom, Sara S and Camp, Nicola J and Cerhan, James R and Consortium, GEC and Canzian, Federico and Nieters, Alexandra and GEC Consortium
International journal of cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 4, pp. 803 - 812
multidrug resistance protein 2 | pregnane x receptor | breast cancer resistance protein | multidrug resistance 1 | lymphoma | Life Sciences & Biomedicine | Oncology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Tumors | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Haplotypes | Genetic Predisposition to Disease | Lymphoma - classification | Humans | Risk Factors | Lymphoma - genetics | ATP-Binding Cassette Transporters - genetics | Receptors, Steroid - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B | Polymorphism, Single Nucleotide | Neoplasm Proteins - genetics | Breast cancer | Lymphoma | Genes | Risk factors | Polymorphism | Index Medicus | B-cell lymphoma | Life Sciences | Santé publique et épidémiologie | multidrug resistance 1 (MDR1) | breast cancer resistance protein (BCRP) | multidrug resistance protein 2 (MRP2) | pregnane X receptor (PXR)
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Transactivation assays that identify indirect and direct activators of human pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1i3)
by Pinne, Marija and Ponce, Elsa and Raucy, Judy L
Drug metabolism letters, ISSN 1872-3128, 06/2017, Volume 11, Issue 2, pp. 128 - 137
Full length nuclear receptor | Ligand binding assays | Phenobarbital | Phosphorylation | CAR | Indirect activators | DPX2 cells | Drug-drug interactions | PXR | Nuclear receptors | Side effects | Receptors | Transcription factors | Identification methods | Liabilities | Ligands | Activation | Assaying | Promoters
Journal Article
Details down arrow
4. Full Text Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR)
by Das, Bhaskar C and Madhukumar, Ankanahlli V and Anguiano, Jaime and Kim, Sean and Sinz, Michael and Zvyaga, Tatyana A and Power, Eoin C and Ganellin, C. Robin and Mani, Sridhar
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2008, Volume 18, Issue 14, pp. 3974 - 3977
Analogs | Azole | PXR | Ketoconazole | Nuclear receptors | Pregnane X receptor | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Pharmacology. Drug treatments | Chemistry, Pharmaceutical - methods | Models, Chemical | Humans | Ketoconazole - chemistry | Receptors, Steroid - antagonists & inhibitors | Ketoconazole - analogs & derivatives | Receptors, Steroid - chemistry | Cytochrome P-450 Enzyme System - chemistry | Drug Interactions | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A - chemistry | Drug Design | Cell Line, Tumor | Inhibitory Concentration 50 | Catalysis | Pregnane X Receptor | Binding Sites | Antiandrogens | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis
by Ho, G-T and Soranzo, N and Tate, S K and Drummond, H and Nimmo, E R and Tenesa, A and Arnott, I D and Satsangi, J
Gut, ISSN 0017-5749, 11/2006, Volume 55, Issue 11, pp. 1676 - 1677
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Haplotypes | Polymorphism, Single Nucleotide | Receptors, Steroid - genetics | Gene Frequency | Humans | Inflammatory Bowel Diseases - genetics | Inflammatory bowel diseases | Genetic aspects | Analysis | Risk factors | Genetic polymorphisms | Inflammatory bowel disease | Studies | Confidence intervals | Genotype & phenotype | Genes | Crohns disease | Index Medicus | Abridged Index Medicus | haplotype analysis | genetics | Letters | NR1I2 | pregnane X receptor | PXR | inflammatory bowel disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Clinical applications of small molecule inhibitors of Pregnane X receptor
by Staudinger, Jeff L
Molecular and cellular endocrinology, ISSN 0303-7207, 04/2019, Volume 485, pp. 61 - 71
Drug uptake | Drug metabolism | Drug efflux | Antagonist | Ligand | Pregnane X receptor (PXR, NR1I2) | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Small Molecule Libraries - pharmacology | Intestinal Mucosa - metabolism | Food-Drug Interactions | Humans | Liver - metabolism | Small Molecule Libraries - therapeutic use | Molecular Targeted Therapy | Intestinal Mucosa - drug effects | Neoplasms - drug therapy | Drug Synergism | Gene Expression Regulation - drug effects | Animals | Liver - drug effects | Pregnane X Receptor - antagonists & inhibitors | Herb-Drug Interactions | Drugs | Prescribing | Medical colleges | Chemotherapy | Liver | Physiological aspects | Fatty acids | Cancer | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Nuclear receptor-mediated induction of CYP450 by antiretrovirals: Functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans
by Svärd, Jenny and Spiers, J Paul and Mulcahy, Fiona and Hennessy, Martina
Journal of acquired immune deficiency syndromes (1999), ISSN 1525-4135, 12/2010, Volume 55, Issue 5, pp. 536 - 549
HIV protease inhibitor | polymorphism | drug interactions | PXR | CYP450 | antiretroviral therapy | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Miscellaneous | Infectious diseases | Microbiology | Viral diseases | Biological and medical sciences | Medical sciences | Human viral diseases | Epidemiology | Virology | Anti-HIV Agents - pharmacology | Aryl Hydrocarbon Hydroxylases - biosynthesis | Oxidoreductases, N-Demethylating - genetics | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Reverse Transcriptase Inhibitors - pharmacology | Male | HIV Protease Inhibitors - pharmacology | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Adult | Anti-HIV Agents - therapeutic use | Female | African Continental Ancestry Group - genetics | Reverse Transcriptase Inhibitors - therapeutic use | Cell Line | Cytochrome P-450 CYP3A - biosynthesis | Promoter Regions, Genetic | European Continental Ancestry Group - genetics | HIV Infections - genetics | Africa South of the Sahara | Genotype | HIV Protease Inhibitors - therapeutic use | Hep G2 Cells | Androstanes | Receptors, Steroid - genetics | HIV Infections - drug therapy | Polymorphism, Single Nucleotide | Oxidoreductases, N-Demethylating - biosynthesis | Pregnane X Receptor | Cytochrome P-450 CYP2B6 | Antiretroviral drugs | Acquired immune deficiency syndrome--AIDS | Drug therapy | Gene expression | Human immunodeficiency virus--HIV | Polymorphism | Index Medicus | AIDS/HIV
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
by Lamba, Vishal and Yasuda, Kazuto and Lamba, Jatinder K and Assem, Mahfoud and Davila, Julio and Strom, Stephen and Schuetz, Erin G
Toxicology and applied pharmacology, ISSN 0041-008X, 2004, Volume 199, Issue 3, pp. 251 - 265
PXR | SXR | CYP3A4 | Splice variants | steroid and xenobiotic receptor | pregnane X receptor | splice variant | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Tobacco, tobacco smoking | Cytochrome P-450 CYP3A | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Male | Macaca mulatta | Receptors, Steroid - agonists | Isomerism | Nicotine - pharmacology | Tissue Distribution | RNA, Messenger - biosynthesis | Transfection | Swine | Fishes | Neurotransmitter Agents - pharmacology | Plasmids - genetics | Conserved Sequence | Adult | Female | Steroids - pharmacology | Nicotinic Agonists - pharmacology | Brain Chemistry - genetics | Amino Acid Sequence | Rabbits | Alternative Splicing - genetics | Liver - metabolism | RNA, Messenger - genetics | Rats | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Biological Evolution | Smoking - metabolism | Animals | Receptors, Steroid - genetics | Dogs | Aged | Mice | Pregnane X Receptor | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination
by Mbatchi, Litaty Céphanoée and Schmitt, Antonin and Thomas, Fabienne and Cazaubon, Yoann and Robert, Jacques and Lumbroso, Serge and Brouillet, Jean-Paul and Pourquier, Philippe and Chatelut, Etienne and Boyer, Jean-Christophe and Evrard, Alexandre
Pharmacogenomics, ISSN 1462-2416, 08/2015, Volume 16, Issue 13, pp. 1439 - 1450
paclitaxel | hematotoxicity | SNP | carboplatin | drug metabolism | SLCO1B3 | pregnane X receptor | PXR | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Haplotypes | Thrombocytopenia - epidemiology | Organic Anion Transporters, Sodium-Independent - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Thrombocytopenia - genetics | Young Adult | Antineoplastic Agents, Phytogenic - administration & dosage | Aged, 80 and over | Adult | Female | Paclitaxel - administration & dosage | Solute Carrier Organic Anion Transporter Family Member 1B3 | Genetic Association Studies | Gene Frequency | Carboplatin - administration & dosage | Thrombocytopenia - chemically induced | Linkage Disequilibrium | Receptors, Steroid - genetics | Alleles | Aged | Polymorphism, Single Nucleotide | Cohort Studies
Journal Article
Details down arrow
10. Full Text Bile acid transporters and regulatory nuclear receptors in the liver and beyond
by Halilbasic, Emina and Claudel, Thierry and Trauner, Michael
Journal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights