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British Journal of Cancer, ISSN 0007-0920, 09/2013, Volume 109, Issue 5, pp. 1252 - 1263
Background: Our previous study revealed that proline-rich tyrosine kinase 2 (Pyk2) is implicated in both anchorage-independent growth and anoikis resistance in... 
cancer stem cell; immunohistochemistry; non-small-cell lung cancer; phosphorylated Pyk2; prognosis; Pyk2 | EPITHELIAL-MESENCHYMAL TRANSDIFFERENTIATION | STEM-CELLS | ACTIVATED PROTEIN-KINASE | ADENOCARCINOMA | prognosis | GROWTH-FACTOR RECEPTOR | NASOPHARYNGEAL CARCINOMA PROGRESSION | cancer stem cell | ONCOLOGY | Pyk2 | phosphorylated Pyk2 | immunohistochemistry | FOCAL ADHESION KINASE | DIFFERENTIATION | EXPRESSION | non-small-cell lung cancer | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Up-Regulation | Phosphorylation | Humans | Lung Neoplasms - metabolism | Middle Aged | Aldehyde Dehydrogenase - biosynthesis | TYK2 Kinase - metabolism | Male | RNA, Messenger - metabolism | Biomarkers, Tumor | Polycomb Repressive Complex 1 - biosynthesis | Gene Knockdown Techniques | Polycomb Repressive Complex 1 - genetics | ATP-Binding Cassette Transporters - genetics | Aged, 80 and over | Adult | Female | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Aldehyde Dehydrogenase - genetics | Treatment Outcome | Disease Progression | ATP-Binding Cassette Transporters - biosynthesis | Cell Line, Tumor | Aged | TYK2 Kinase - genetics | Index Medicus | Molecular Diagnostics
Journal Article
Experimental Neurology, ISSN 0014-4886, 01/2019, Volume 311, pp. 313 - 317
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the most common cause of dementia and the 6th leading cause of death. Although... 
NERVOUS-SYSTEM | FAK | ACTIVATION | COMPLEX | PYK2 | GLUTAMATE | PYK2/CAK-BETA | FOCAL ADHESION KINASE | NEUROSCIENCES | CELLULAR PRION PROTEIN | BETA | Tyrosine | Alzheimer's disease | Drug discovery | Index Medicus
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 09/2018, Volume 16, Issue 9, pp. 1904 - 1905
Journal Article
Amino Acids, ISSN 0939-4451, 2014, Volume 46, Issue 11, pp. 2605 - 2614
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 868 - 884.e6
Heterotypic interactions across diverse cell types can enable tumor progression and hold the potential to expand therapeutic interventions. Here, combined... 
macrophages | glioblastoma | PYK2 | recruitment | SPP1 and YAP1 | PTEN | lysyl oxidase | Oxidases | Medical colleges | Gliomas | Analysis | Development and progression | Macrophages | Integrins
Journal Article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, ISSN 1756-9966, 05/2019, Volume 38, Issue 1, pp. 210 - 210
Journal Article
Journal of Reproduction and Development, ISSN 0916-8818, 2016
The non-receptor tyrosine kinase Pyk2 is a member of the focal adhesion kinase family and is highly expressed in oocytes. Using a combination of confocal... 
Fertilization | Pyk2 | Mouse oocyte | Early-embryo development
Journal Article
Journal of Cell Science, ISSN 0021-9533, 03/2004, Volume 117, Issue 8, pp. 1431 - 1441
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 01/2001, Volume 152, Issue 1, pp. 181 - 195
The signaling events downstream of integrins that regulate cell attachment and motility are only partially understood. Using osteoclasts and transfected 293... 
Vitronectin receptor (α | Osteoclast | Cbl | Src | Pyk2 | osteoclast | vitronectin receptor (αvβ3) | Original
Journal Article
by Lu, FJ and Sun, JW and Zheng, QX and Li, JH and Hu, YZ and Yu, P and He, HF and Zhao, Y and Wang, XH and Yang, SY and Cheng, HP
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 03/2019, Volume 132, Issue 6, p. jcs224923
STIM1- and Orai1-mediated store-operated Ca2+ entry (SOCE) constitutes the major Ca2+ influx in almost all electrically non-excitable cells. However, little is... 
MIGRATION | INVADOPODIA | LOCALIZATION | Store-operated Ca2+ entry | ACTIVATION | Ca2+ biosensor | Invasion | CELL BIOLOGY | CALCIUM-ENTRY | STIM1 | CONTRACTION | Pyk2 | ORAI1 | PODOSOMES | Ca2+ glows | OSCILLATIONS
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0131059 - e0131059
Glioblastoma is one of the most aggressive and fatal brain cancers due to the highly invasive nature of glioma cells. Microglia infiltrate most glioma tumors... 
GLIOBLASTOMA | INVASION | MULTIDISCIPLINARY SCIENCES | TYROSINE KINASE PYK2 | PROLIFERATION | TUMOR-GROWTH | EXPRESSION | BRAIN | CATHEPSIN-B | MOLECULAR-MECHANISMS | INFILTRATION | Up-Regulation | Humans | Mice, Inbred C57BL | Brain Neoplasms - pathology | Brain Neoplasms - physiopathology | Rats | Male | Mice, Transgenic | Tumor Microenvironment - physiology | Focal Adhesion Kinase 2 - antagonists & inhibitors | Cell Movement - physiology | Focal Adhesion Kinase 2 - physiology | Gene Knockdown Techniques | Neoplasm Invasiveness - physiopathology | Focal Adhesion Kinase 2 - genetics | Animals | Microglia - physiology | Neoplasm Invasiveness - pathology | Glioma - pathology | Cell Line, Tumor | Microglia - pathology | Signal Transduction - physiology | Mice | Glioma - physiopathology | Gliomas | Analysis | Brain | Biotechnology | Phosphorylation | Brain tumors | Glioblastoma | Proline | Kinases | Cell adhesion & migration | Degradation | PYK2 protein | Signal transduction | Ganciclovir | Epidermal growth factor | Rodents | Glioma cells | Dispersal | Microglial cells | Extracellular matrix | Conditioning | Protein-tyrosine kinase | Tyrosine | Biodegradation | CD11b antigen | Tumor cells | Invasiveness | Implantation | Pharmacology | siRNA | Ablation | Microglia | Signaling | Cell lines | Focal adhesion kinase | Cell migration | Tumors | Index Medicus
Journal Article
JOURNAL OF CELLULAR PHYSIOLOGY, ISSN 0021-9541, 03/2015, Volume 230, Issue 3, pp. 702 - 715
Sphingosine-1-phosphate (S1P) has been shown to regulate cyclooxygenase-2 (COX-2)/prostaglandin E-2 (PGE(2)) expression and IL-6 secretion in various... 
INDEPENDENT MECHANISM | OXIDATIVE STRESS | PHYSIOLOGY | PYK2 | LUNG EPITHELIAL-CELLS | INFLAMMATION | DISEASE | CIGARETTE-SMOKE | AIRWAY SMOOTH-MUSCLE | RECEPTORS | SPHINGOSINE 1-PHOSPHATE | CELL BIOLOGY
Journal Article
Journal of cell science, 03/2019, Volume 132, Issue 6
STIM1- and Orai1-mediated store-operated Ca entry (SOCE) constitutes the major Ca influx in almost all electrically non-excitable cells. However, little is... 
Store-operated Ca2+ entry | Ca2+ glows | Ca2+ biosensor | Pyk2 | Invasion
Journal Article
Journal Article