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Journal of Clinical Investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 262 - 272
Background. The majority of patients receiving the platinum-based chemotherapy drug oxaliplatin develop peripheral neurotoxicity. Because this neurotoxicity... 
CHANNEL EXPRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | LEUCOVORIN | CISPLATIN | EXCITABILITY | MANGANESE | COLORECTAL-CANCER | PLATINUM | NEUROTOXICITY | CONTRAST AGENT | Peripheral Nervous System Diseases - chemically induced | Pyridoxal Phosphate - administration & dosage | Oxidative Stress | Humans | Middle Aged | Hypesthesia - prevention & control | Hypesthesia - chemically induced | Motor Activity - drug effects | Male | Muscle, Skeletal - innervation | Sciatic Nerve - physiopathology | Antineoplastic Agents - therapeutic use | Edetic Acid - analogs & derivatives | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Muscle, Skeletal - drug effects | Edetic Acid - pharmacology | Nociception - drug effects | Female | Pyridoxal Phosphate - analogs & derivatives | Action Potentials - drug effects | Colorectal Neoplasms - mortality | Pyridoxal Phosphate - pharmacology | Sciatic Nerve - pathology | Mice, Inbred C57BL | Antioxidants - pharmacology | Edetic Acid - administration & dosage | Peripheral Nervous System Diseases - metabolism | Administration, Intravenous | Animals | Muscle Contraction - drug effects | Muscle, Skeletal - physiopathology | Antioxidants - administration & dosage | Survival Analysis | Aged | Mice | In Vitro Techniques | Organoplatinum Compounds - therapeutic use | Organoplatinum Compounds - adverse effects | Peripheral Nervous System Diseases - drug therapy | Antioxidants | Mangafodipir | Complications and side effects | Chemotherapy | Prognosis | Polyneuropathies | Dosage and administration | Research | Drug therapy | Health aspects | Cancer | Clinical trials | Oxidative stress | Membranes | Neurotoxicity | Cold | Rodents | Index Medicus | Abridged Index Medicus | Organoplatinum Compounds | Neurons and Cognition | Neurobiology | Motor Activity | Action Potentials | Hypesthesia | Life Sciences | Colorectal Neoplasms | Sciatic Nerve | Nociception | Psychology and behavior | Antineoplastic Agents | Edetic Acid | Pyridoxal Phosphate | Muscle Contraction | Peripheral Nervous System Diseases | Cognitive Sciences | Muscle, Skeletal | Clinical Medicine
Journal Article
Drug Discovery Today, ISSN 1359-6446, 04/2015, Volume 20, Issue 4, pp. 411 - 421
•Preclinical safety assessment of the MRI contrast agent MnDPDP serendipitously revealed SOD activity.•SOD activity is a potentially useful property in the... 
OXIDATIVE STRESS | MANGANESE SUPEROXIDE-DISMUTASE | RELAXING FACTOR | REPERFUSION INJURY | ACUTE MYOCARDIAL-INFARCTION | INDUCED PERIPHERAL NEUROPATHY | NITRIC-OXIDE | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | PHARMACOLOGY & PHARMACY | CONTRAST AGENT | NORMAL TISSUE-INJURY | Pyridoxal Phosphate - chemistry | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Edetic Acid - metabolism | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Edetic Acid - analogs & derivatives | Pyridoxal Phosphate - metabolism | Myocardial Infarction - therapy | Colorectal Neoplasms - drug therapy | Molecular Structure | Pyridoxal Phosphate - analogs & derivatives | Ethylenediamines - metabolism | Superoxide Dismutase - metabolism | Pyridoxal Phosphate - therapeutic use | Ethylenediamines - chemistry | Treatment Outcome | Manganese - chemistry | Antineoplastic Agents - chemistry | Biological Mimicry | Ethylenediamines - therapeutic use | Antioxidants - therapeutic use | Animals | Edetic Acid - chemistry | Manganese - metabolism | Oxidative Stress - drug effects | Colorectal Neoplasms - pathology | Edetic Acid - therapeutic use | Percutaneous Coronary Intervention | Health aspects | Contrast media | Biological Sciences | Biochemistry and Molecular Biology | Naturvetenskap | Natural Sciences | Biokemi och molekylärbiologi | Biologiska vetenskaper
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 6, pp. 3198 - 3208
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, p. e0203889
The active form of vitamin B6, pyridoxal 5'-phosphate (PLP), plays an essential role in the catalytic mechanism of various proteins, including human... 
PYRIDOXAL-PHOSPHATE ENZYMES | ASPARTATE-AMINOTRANSFERASE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GENERALIZED BORN | VITAMIN-B-6 | DEPENDENT ENZYMES | ARABIDOPSIS | MOLECULAR-DYNAMICS SIMULATIONS | ROOT DEVELOPMENT | REACTION SPECIFICITY | Pyridoxal Phosphate - chemistry | Aspartate Aminotransferase, Cytoplasmic - genetics | Catalytic Domain | Vitamin B 6 - metabolism | Humans | Glutamates - genetics | Models, Molecular | Binding Sites - genetics | Protein Domains - genetics | Molecular Dynamics Simulation | Pyridoxal Phosphate - metabolism | Aspartate Aminotransferases - metabolism | Oxaloacetates - metabolism | Pyridoxal Phosphate - physiology | Aspartate Aminotransferase, Cytoplasmic - ultrastructure | Computer Simulation | Amino Acid Substitution - genetics | Aspartate Aminotransferase, Cytoplasmic - physiology | Catalysis | Glutamates - physiology | Dimerization | Principal Component Analysis | Arabidopsis thaliana | Physiological aspects | Molecular dynamics | Schiff bases | Aspartate aminotransferase | Research | Phosphates | Transaminase | Homeostasis | Amino acids | Biochemistry | Proteins | Pathways | Hydrogen bonds | Imines | Misalignment | Enzymes | Computer simulation | Principal components analysis | Stability analysis | Metabolism | Substrates | Chemistry | Acids | Computer applications | Affinity | Metabolic pathways | Dimers | Vitamin B6 | Binding sites
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 17, pp. 12873 - 12881
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e50235
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation of reactive oxygen species (ROS) upon revascularization.... 
ISCHEMIA-REPERFUSION INJURY | SUPEROXIDE-DISMUTASE DERIVATIVES | HEPATIC PRESERVATION | SINUSOIDAL ENDOTHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | WISCONSIN SOLUTION | HEME OXYGENASE-1 | COLD PRESERVATION | MANGANESE DIPYRIDOXYL-DIPHOSPHATE | HEPATOCELLULAR INJURY | CONTRAST AGENT | Heme Oxygenase-1 - metabolism | Liver Transplantation | Reactive Oxygen Species - metabolism | Gene Expression - drug effects | Apoptosis - drug effects | Organ Preservation | Male | Nitric Oxide Synthase - genetics | Edetic Acid - analogs & derivatives | Heme Oxygenase-1 - genetics | Liver - immunology | Liver - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adenosine Triphosphate - metabolism | Edetic Acid - pharmacology | Lipid Peroxidation - drug effects | Organ Preservation Solutions - chemistry | Pyridoxal Phosphate - analogs & derivatives | Organ Culture Techniques | Primary Graft Dysfunction - immunology | Pyridoxal Phosphate - pharmacology | Catalase - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Rats | Organ Preservation Solutions - pharmacology | Antioxidants - pharmacology | Transplantation Tolerance - drug effects | Catalase - metabolism | Primary Graft Dysfunction - prevention & control | Reactive Oxygen Species - antagonists & inhibitors | Animals | Nitric Oxide Synthase - metabolism | Primary Graft Dysfunction - metabolism | Graft Survival - drug effects | Antioxidants | Enzymes | Liver diseases | Ischemia | Liver | Nitric oxide | Transplantation | Contrast media | Oxidative stress | Reactive oxygen species | Transplants & implants | Syngeneic grafts | Lipid peroxidation | Grafting | Signal transduction | Mitochondria | Reperfusion | Allografts | Catalase | Cryopreservation | Rodents | Hepatology | Pretreatment | Carbon monoxide | Injuries | Peroxidation | Preservation | Organs | Gene expression | Immunological tolerance | Nitric-oxide synthase | Endothelial cells | Cell injury | Magnetic resonance imaging | Alzheimers disease | ATP | Liver transplantation | Apoptosis | Cancer | Bile | Reactive Oxygen Species | Adenosine Triphosphate | Hypoxia-Inducible Factor 1, alpha Subunit | Life Sciences | Transplantation Tolerance | Heme Oxygenase-1 | Primary Graft Dysfunction | Organ Preservation Solutions | Gene Expression | Hépatology and Gastroenterology | Edetic Acid | Graft Survival | Pyridoxal Phosphate | Human health and pathology | Nitric Oxide Synthase | Lipid Peroxidation
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